| Budget Amount *help |
¥47,970,000 (Direct Cost: ¥36,900,000、Indirect Cost: ¥11,070,000)
Fiscal Year 2012: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2011: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2010: ¥20,670,000 (Direct Cost: ¥15,900,000、Indirect Cost: ¥4,770,000)
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| Research Abstract |
The goal of this study was to identify the molecular basis of the high invasiveness and aggressiveness of malignant gliomas in order to develop novel therapeutic strategies. Using our syngeneic murine model of glioblastoma, we
(1) established an assay for the real-time monitoring of glioma cell invasion into the normal brain and identified the main invasion patterns;
(2) showed that inhibition of mesenchymal characteristics of glioma cells effectively reduces invasion and identified potential targeting agents. Furthermore, we uncovered the co-option of endothelial cells by tumor cells and the formation of invasion com
(3) analyzed the mechanism of aquired radioresistance during repeated radiation and identified one of its key regulators.
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