Strategic research for elucidation of molecular pathophysiology and identification of therapeutic target of lumbar spondylosis

• Project/Area Number: 22249056
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: The University of Tokyo
• Principal Investigator: KAWAGUCHI Hiroshi 東京大学, 医学部附属病院, 准教授 (40282660)
• Co-Investigator(Kenkyū-buntansha): TOKUNAGA Katsushi 東京大学, 医学系研究科, 教授 (40163977) ; AKUNE Toru 東京大学, 医学部附属病院, 特任准教授 (60282662) ; TAKESHITA Katsushi 東京大学, 医学部附属病院, 准教授 (30262009) ; SAITO Taku 東京大学, 医学部附属病院, 特任准教授 (30456107)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥47,580,000 (Direct Cost: ¥36,600,000、Indirect Cost: ¥10,980,000); Fiscal Year 2012: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000); Fiscal Year 2011: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000); Fiscal Year 2010: ¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
• Keywords: 脊椎脊髄病学 / 変形性腰椎症 / ゲノムワイド関連解析

Research Abstract

We identified two candidate genes associated with lumbar spondylosis by GWAS of our cohort. These genes were abundantly expressed in mouse and human anulus fibrosus of intervertebral disc, and their expression was decreased with the degeneration of intervertebral disc. We have established conditional knockout mice of the two genes and are analyzing their functional roles.

Research Products

• [Journal Article] Nanog promotes osteogenic differentiation of the mouse mesenchymal cell line C3H10T1/2 by modulating bone morphogenetic protein(BMP) signaling. (2013)
  • Author(s): Ogasawara T, Ohba S, Yano F, Kawaguchi H, Chung UI, Saito T, Yonehara Y, Nakatsuka T, Mori Y, Takato T, and Hoshi K
  • Journal Title: J Cell Physiol Volume: (in press) Issue: 1 Pages: 163-71
  • DOI: 10.1002/jcp.24116
  • Peer Reviewed
• [Journal Article] Poly(2-methacryloyloxyethyl phosphorylcholine)-grafted highlycross-linked polyethylene liner in primary total hip replacement: One-year results of a prospective cohort study. (2013)
  • Author(s): Takatori Y, Moro T, Kamogawa M, Oda H, Morimoto S, Umeyama T, Minami M, Sugimoto H, Nakamura S, Karita T, Kim J, Koyama Y, Ito H, Kawaguchi H, and Nakamura K
  • Journal Title: J Artif Organs Volume: (in press) Issue: 2 Pages: 170-175
  • DOI: 10.1007/s10047-012-0681-1
  • Peer Reviewed
• [Journal Article] Physical performance, bone and joint diseases, and incidence of falls in Japanese men and women: A longitudinal cohort study. (2013)
  • Author(s): Muraki S, Kawaguchi H, et al.
  • Journal Title: Osteoporosis Int Volume: 24 Pages: 459-466
  • Peer Reviewed
• [Journal Article] A novel disease-modifying osteoarthritis drug candidate targeting Runx1. (2013)
  • Author(s): Yano F, Kawaguchi H, et al.
  • Journal Title: Ann Rheum Dis Volume: 72 Pages: 748-753
  • Peer Reviewed
• [Journal Article] β-catenin regulates PTH/PTHrP receptor signals and chondrocyte hypertrophy through binding to its intracellular C-terminal region (2013)
  • Author(s): Yano F, Kawaguchi H, et al.
  • Journal Title: Arthritis Rheum Volume: 65 Pages: 429-435
  • Peer Reviewed
• [Journal Article] Lack of a chondroprotective effect of cyclooxygenase 2 inhibition in a surgically induced model of osteoarthritis in mice. (2012)
  • Author(s): Fukai A, Kamekura S, Chikazu D, Nakagawa T, Hirata M, Saito T, Hosaka Y, Ikeda T, Nakamura K, Chung UI, and Kawaguchi H:
  • Journal Title: Arthritis Rheum-US Volume: 64 Pages: 198-203
• [Journal Article] C/EBP-β and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as theinducer in chondrocytes. (2012)
  • Author(s): Hirata M, Kugimiya F, Fukai A, Saito T, Yano F, Ikeda T, Mabuchi A, Sapkota BR, Akune T, Nishida N, Yoshimura N, Nakagawa T, Tokunaga K, Nakamura K, Chung UI, and Kawaguchi H
  • Journal Title: Hum Mol Genet Volume: 21 Pages: 1111-1123
• [Journal Article] SP7 inhibits osteoblast differentiation at a latestage in mice. (2012)
  • Author(s): Yoshida CA, Komori H, Maruyama Z, Miyazaki T, Kawasaki K, Furuichi T, Fukuyama R, Mori M, Yamana K, Nakamura K, Liu W, Toyosawa S, MoriishiT, Kawaguchi H, Takada K, Komori T
  • Journal Title: PLoS ONE Volume: 7
• [Journal Article] Incidenceand risk factors for radiographic knee osteoarthritis and knee pain in Japanese men and women: A longitudinal population-based cohort study. (2012)
  • Author(s): Muraki S, Akune T, Oka H, Ishimoto Y, Nagata K, Yoshida M, Tokimura F, Nakamura K, Kawaguchi H, Yoshimura N
  • Journal Title: Arthritis Rheum-US Volume: 64 Pages: 1447-1456
• [Journal Article] Biomimetic hydration lubrication with various polyelectrolyte layers on cross-linked polyethylene orthopedic bearing materials. (2012)
  • Author(s): Kyomoto M, Moro T, Saiga K, Hashimoto M, Ito H, Kawaguchi H, Takatori Y, Ishihara K
  • Journal Title: Biomaterials Volume: 33 Pages: 4451-4459
• [Journal Article] Incidenceand risk factors for radiographic lumbar spondylosis and lower back pain in Japanese men and women: The ROAD study. (2012)
  • Author(s): Muraki S, Akune T, Oka H, Ishimoto Y, Nagata K, Yoshida M, Tokimura F, Nakamura K, Kawaguchi H, Yoshimura N
  • Journal Title: Osteoarthr Cartilage Volume: 20 Pages: 712-718
• [Journal Article] Gli1 participates in the hedgehog-mediated specification of the osteoblast lineage during endochondralossification. (2012)
  • Author(s): Hojo H, Ohba S, Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N, Suzuki K, Takato T, Kawaguchi H, and Ung-il Chung
  • Journal Title: J Biol Chem Volume: 287 Pages: 17860-17869
• [Journal Article] GSK-3α and GSK-3β are involved in early stages of chondrocyte differentiation with functional redundancy through RelA phosphorylation. (2012)
  • Author(s): Itoh S, Saito T, Hirata M, Ushita M, Ikeda T, Woodgett JR, Algul H, Schmid RM, Chung UI, and Kawaguchi H
  • Journal Title: J Biol Chem Volume: 287 Pages: 29227-29236
• [Journal Article] Prevalence of symptomatic lumbar spinal stenosis and its association with physical performance in apopulation-based cohort in Japan: The Wakayama Spine Study. (2012)
  • Author(s): Ishimoto Y, Yoshimura N, Muraki S, Yamada H, Nagata K, Hashizume H, Takiguchi N, Minamide A, OkaH, Kawaguchi H, Nakamura K, Akune T, Yoshida M
  • Journal Title: Osteoarthritis Cartilage Volume: 20 Pages: 1103-1108
• [Journal Article] Physical performance, bone and joint diseases, and incidence of falls in Japanese men and women (2012)
  • Author(s): Muraki S, Akune T, Oka H, Ishimoto Y, Nagata K, Yoshida M, Tokimura F, Nakamura K, Kawaguchi H, Yoshimura N
  • Journal Title: A longitudinal cohort study. Osteoporosis Int (inpress) Volume: 21(Epub ahead of print) Issue: 2 Pages: 459-466
  • DOI: 10.1007/s00198-012-1967-0
  • Peer Reviewed
• [Journal Article] Prevalence of cervical cord compression and its association with physical performance in a population-based cohort in Japan: The Wakayama Spine Study. (2012)
  • Author(s): Nagata K, Yoshimura N, Muraki S, Hashizu
  • Journal Title: Spine (in press) Volume: 37 Issue: 22 Pages: 1892-1898
  • DOI: 10.1097/brs.0b013e31825a2619
  • Peer Reviewed
• [Journal Article] Does mild cognitive impairment affect the occurrence of radiographic knee osteoarthritis? A 3-year follow-up in the ROAD study. (2012)
  • Author(s): Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Tanaka S, and Akune T
  • Journal Title: BMJ Open (in press) Volume: 2 Issue: 6 Pages: 2001520-2001520
  • DOI: 10.1136/bmjopen-2012-001520
  • Peer Reviewed
• [Journal Article] Lack of a chondroprotective effect of cyclooxygenase 2 inhibition in a surgically induced model of osteoarthritis in mice. (2012)
  • Author(s): Fukai A, Kawaguchi H, et al.
  • Journal Title: Arthritis Rheum Volume: 64 Pages: 198-203
  • Peer Reviewed
• [Journal Article] C/EBP-β and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes. (2012)
  • Author(s): Hirata M, Kawaguchi H, et al.
  • Journal Title: Hum Mol Genet Volume: 21 Pages: 1111-1123
  • Peer Reviewed
• [Journal Article] Incidence and risk factors for radiographic knee osteoarthritis and knee pain in Japanese men and women: A longitudinal population-based cohort study. (2012)
  • Author(s): Muraki S, Kawaguchi H, et al.
  • Journal Title: Arthritis Rheum Volume: 64 Pages: 1447-1456
  • Peer Reviewed
• [Journal Article] Incidence and risk factors for radiographic lumbar spondylosis and lower back pain in Japanese men and women: The ROAD study. (2012)
  • Author(s): Muraki S, Kawaguchi H, et al.
  • Journal Title: Osteoarthr Cartilage Volume: 20 Pages: 712-718
  • Peer Reviewed
• [Journal Article] Prevalence of symptomatic lumbar spinal stenosis and its association with physical performance in a population-based cohort in Japan: The Wakayama Spine Study. (2012)
  • Author(s): Ishimoto Y, Kawaguchi H, et al.
  • Journal Title: Osteoarthritis Cartilage Volume: 20 Pages: 1103-1108
  • Peer Reviewed
• [Journal Article] Prevalence of cervical cord compression and its association with physical performance in a population-based cohort in Japan: The Wakayama Spine Study. (2012)
  • Author(s): Nagata K, Kawaguchi H, et al.
  • Journal Title: Spine Volume: 37 Pages: 1892-1898
  • NAID: 10031169860
  • Peer Reviewed
• [Journal Article] Incidence and risk factors for radiographic knee osteoarthritis and knee pain in Japanese men and women : A longitudinal population-based cohort study (2012)
  • Author(s): Muraki S, Kawaguchi H, et al.
  • Journal Title: Arthritis Rheum
  • Peer Reviewed
• [Journal Article] C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and,HIF-2α as the inducer in chondrocytes (2012)
  • Author(s): Hirata M, Kawaguchi H, et al.
  • Journal Title: Hum Mol Genet Volume: 21 Pages: 1111-23
  • Peer Reviewed
• [Journal Article] Lack of a chondroprotective effect of cyclooxygenase 2 inhibition in a surgically induced model of osteoarthritis in mice (2012)
  • Author(s): Fukai A, Kawaguchi H, et al.
  • Journal Title: Arthritis Rheum Volume: 64 Pages: 198-203
  • Peer Reviewed
• [Journal Article] Reference values for hand grip strength, muscle mass, walking time, and one-leg standing time as indices for locomotive syndrome and associated disability : the second survey of the ROAD study (2011)
  • Author(s): Yoshimura N, Kawaguchi H, et al.
  • Journal Title: J Orthop Sci Volume: 16 Pages: 768-77
  • Peer Reviewed
• [Journal Article] Independent association of joint space narrowing and osteophyte formation at the knee with health-related quality of life in Japan : a cross-sectional study (2011)
  • Author(s): Muraki S, Kawaguchi H, et al.
  • Journal Title: Arthritis Rheum Volume: 63 Pages: 3859-64
  • Peer Reviewed
• [Journal Article] Prevalence of falls and the association with knee osteoarthritis and lumbar spondylosis as well as knee and lower back pain in Japanese men and women (2011)
  • Author(s): Muraki S, Kawaguchi H, et al.
  • Journal Title: Arthritis Care Res Volume: 63 Pages: 1425-31
  • Peer Reviewed
• [Journal Article] Changes in serum levels of biochemical markers of bone turnover durihg 10 years among Japanese men and women : associated factors and birth-cohort effect. The Taiji Study (2011)
  • Author(s): Yoshimura N, Kawaguchi H, et al.
  • Journal Title: J Bone Miner Metab. Volume: 29 Pages: 699-708
  • Peer Reviewed
• [Journal Article] Health-related quality of life in subjects with low back pain and knee pain in a population-based cohort study of Japanese men : the Research on Osteoarthritis Against Disability study (2011)
  • Author(s): Muraki S, Kawaguchi H, et al.
  • Journal Title: Spine Volume: 36 Pages: 1312-9
  • NAID: 10030716059
  • Peer Reviewed
• [Journal Article] Biochemical markers of bone turnover as predictors of osteoporosis and osteoporotic fractures in men and women : 10-year follow-up of the Taiji cohort (2011)
  • Author(s): Yoshimura N, Kawaguchi H, et al.
  • Journal Title: Mod Rheumatol Volume: 21 Pages: 608-20
  • NAID: 10030206069
  • Peer Reviewed
• [Journal Article] G alpha(q) signal in osteoblasts is inhibitory to the osteoanabolic action of parathyroid hormone (2011)
  • Author(s): Ogata N, Kawaguchi H, et al.
  • Journal Title: J Biol Chem Volume: 286 Pages: 13733-40
  • Peer Reviewed
• [Journal Article] Association of Occupational Activity with Joint Space Narrowing and Osteophytosis in the Medial Compartment of the Knee : The ROAD study (2011)
  • Author(s): Muraki S, Kawaguchi H, et al.
  • Journal Title: Osteoarthritis Cartilage Volume: (Epub)(掲載確定)
  • Peer Reviewed
• [Journal Article] The G&alphaq signal in osteoblasts is inhibitory to the osteoanabolic action of PTH. (2011)
  • Author(s): Ogata N, Kawaguchi H, et al.
  • Journal Title: J Biol Chem. Volume: (Epub)(掲載確定)
  • Peer Reviewed
• [Journal Article] Association of Knee Osteoarthritis with the Accumulation of Metabolic Risk Factors Such as Overweight, Hypertension, Dyslipidemia, and Impaired Glucose Tolerance in Japanese Men and Women : The ROAD Study (2011)
  • Author(s): Yoshimura N, Kawaguchi H, et al.
  • Journal Title: J Rheumatol. Volume: (Epub)(掲載確定)
  • Peer Reviewed
• [Journal Article] Reduction of Peritendinous adhesions by hydrogel containing biocompatible phospholipid polymer MPC for tendon repair. (2011)
  • Author(s): Ishiyama N, Kawaguchi H, et al.
  • Journal Title: J Bone Joint Surg Am. Volume: 93 Pages: 142-149
  • Peer Reviewed
• [Journal Article] Capacity of endogenous sex steroids to predict bone loss in Japanese men : 10-year follow-up of the Taiji Cohort Study. (2011)
  • Author(s): Yoshimura N, Kawaguchi H, et al.
  • Journal Title: J Bone Miner Metab. Volume: 29 Pages: 96-102
  • NAID: 10029023846
  • Peer Reviewed
• [Journal Article] Normal and threshold values of radiographic parameters for knee osteo arthritis using a computer-assisted measuring system(KOACAD) : the ROAD study. (2010)
  • Author(s): Oka H, Kawaguchi H, et al.
  • Journal Title: J Orthop Sci. Volume: 15 Pages: 781-789
  • Peer Reviewed
• [Journal Article] A local application of recombinant human fibroblast growth factor 2 for tibial shaft fractures : Arandomized, placebo-controlled trial. (2010)
  • Author(s): Kawaguchi H, et al.
  • Journal Title: J Bone Miner Res. Volume: 25 Pages: 2459-2467
  • Peer Reviewed
• [Journal Article] Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development. (2010)
  • Author(s): Saito T, Kawaguchi H, et al.
  • Journal Title: Nat Med. Volume: 16 Pages: 678-686
  • Peer Reviewed
• [Journal Article] Impact of knee and low back pain on health-related quality of life in Japanese women : the Research on Osteoarthritis Against Disability(ROAD). (2010)
  • Author(s): Muraki S, Kawaguchi H, et al.
  • Journal Title: Mod Rheumatol. Volume: 20 Pages: 444-451
  • NAID: 10027646934
  • Peer Reviewed
• [Journal Article] Identification of oxytetracycline as a chondrogenic compound using a cell-based screening system. (2010)
  • Author(s): Hojo H, Kawaguchi H, et al.
  • Journal Title: J Bone Miner Metab. Volume: 28 Pages: 627-633
  • NAID: 10027845798
  • Peer Reviewed
• [Journal Article] Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis: A 3-year follow-up of the ROAD study.
  • Author(s): Yoshimura N, Muraki S, Oka H, TanakaS, Kawaguchi H, Nakamura K, and Akune T
  • Journal Title: Osteoarthr Cartilage (in press)
• [Journal Article] The mid-term efficacy of intra-articular hyaluronic acid injections on joint structure: a nested case control study.
  • Author(s): Oka H, Akune T, Muraki S, Tanaka S, Kawaguchi H, Nakamura K, Yoshimura N:
  • Journal Title: Mod Rheumatol (in press).
  • NAID: 10031189167
• [Journal Article] A novel disease-modifying osteoarthritis drug candidate targeting Runx1.
  • Author(s): Yano F, Hojo H, Ohba S, Fukai A, Hosaka Y, Ikeda T, Saito T, Hirata M, Chikuda H,Takato T, Kawaguchi H, and Chung UI
  • Journal Title: Ann Rheum Dis(in press).
• [Journal Article] β-catenin regulates PTH/PTHrP receptor signals and chondrocyte hypertrophy through binding to its intracellular C-terminal region.
  • Author(s): Yano F, Saito T, Ogata N, Yamazawa T, Iino M, Chung UI, and Kawaguchi H
  • Journal Title: Arthritis Rheum-US Volume: (in press)
• [Journal Article] Risk factors for falls in a longitudinal population-based cohort study of Japanese men and women
  • Author(s): Muraki S, Akune T, Ishimoto Y, Nagata K, Yoshida M, Tanaka S, Oka H, Kawaguchi H, Nakamura K, and Yoshimura N
  • Journal Title: The ROAD Study. Bone (in press)
• [Presentation] NF-κB ファミリーRelAは、ADAMTS5の転写誘導因子として変形性関節症の進行に作用する (2012)
  • Author(s): 小林寛、川口浩, 他
  • Organizer: 日本軟骨代謝学会
  • Place of Presentation: 名古屋(招待講演)
  • Year and Date: 2012-03-09
• [Presentation] Notch/Rbpl/Hes1 signal in chondrocytes modulates osteoarthritis development. (2012)
  • Author(s): Sugita S, Hosaka Y, Hikata T, Akiyama H, Long F, Chung UI, Saito T, Kawaguchi H:
  • Organizer: 2012 World Congress on Osteoarthritis (OARSI).
  • Place of Presentation: Barcelona, Spain
• [Presentation] Prevention and repair of cartilage degeneration by a novel thienoindazole-derivative compound. (2012)
  • Author(s): Yano F, Hosaka Y, Fukai A, Saito T, Hojo H, Ohba S, Kawaguchi H, Chung UI
  • Organizer: 2012 World Congress on Osteoarthritis (OARSI).
  • Place of Presentation: Barcelona, Spain
• [Presentation] Endochondral ossification signal: A potential therapeutic target for osteoarthritis (Invited Lecture). (2012)
  • Author(s): Kawaguchi H
  • Organizer: 2012 ColdSpring Harbor Asia Conference: Bone & Cartilage: From Development to Human Diseases.
  • Place of Presentation: Suzhou, China
• [Presentation] Hes1, a transcriptional target of Notch signaling, modulates endochondral ossification during osteoarthritis development. (2012)
  • Author(s): Sugita S, Hosaka Y, Saito T, Nakamura K, Chung UI, and Kawaguchi H
  • Organizer: 2012 Cold Spring Harbor Asia Conference: Bone & Cartilage: From Development to Human Diseases.
  • Place of Presentation: Suzhou, China
• [Presentation] Transcriptional induction of ADAMTS5 by NF-κΒ family member RelA in chondrocytes during osteoarthritis development. (2012)
  • Author(s): Kobayashi H, Hirata M, Itoh S, Saito T, Nakamura K, Chung UI, and Kawaguchi H
  • Organizer: 2012 Cold Spring Harbor Asia Conference: Bone & Cartilage: From Development to Human Diseases.
  • Place of Presentation: Suzhou, China
• [Presentation] 大規模コホートにおける変形性膝関 節症に関する生化学的マーカーの有用性. (2012)
  • Author(s): 森田充浩、山田治基、吉村典子、伊達秀 樹、岡敬之、村木重之、阿久根徹、川口浩
  • Organizer: 第25回日本軟骨代謝学会
  • Place of Presentation: ウィル愛知、愛知
• [Presentation] Notch/Rbpjシグナルは骨格形成と変形性関節症の進行において軟骨内骨化の後期分化過程を制御する(シンポジウム:軟骨変性). (2012)
  • Author(s): 保坂陽子、斎藤琢、杉田守礼、深井厚、日方智宏、秋山治彦、中村孝志、中村耕三、鄭雄一、川口浩
  • Organizer: 第25回日本軟骨代謝学会
  • Place of Presentation: ウィル愛知、愛知
• [Presentation] NF-κBファミ リー分子RelA/p65 は軟骨細胞においてADAMTS5を転写誘導して変形性関節症の 発症に関与する(シンポジウム:軟骨変性). (2012)
  • Author(s): 小林寛、平田真、伊藤祥三、斎藤琢、鄭 雄一、中村耕三、川口浩
  • Organizer: 第25回日本軟骨代謝学会
  • Place of Presentation: ウィル愛知、愛知
• [Presentation] 変形性膝関節症および膝痛の危険因子 -The ROAD study. (2012)
  • Author(s): 村木重之、阿久根徹、岡敬之、中村耕三、川口浩、吉村典子
  • Organizer: 第25回日本軟骨代謝学会.
  • Place of Presentation: ウィル愛知、愛知
• [Presentation] メタボリックシンドローム構成要因が変形性膝関節症の発症・進行に及ぼす影響 -The ROAD study 3年目の追跡. (2012)
  • Author(s): 吉村典子、村木重之、岡敬之、中村耕三、川口浩、阿久根徹
  • Organizer: 第25回日本軟骨代謝学会
  • Place of Presentation: ウィル愛知、愛知
• [Presentation] コンピュータ自動計 測を用いた定量評価に基づく 3 年間での 膝X線画像縦断変化に関する研究 - TheROAD study -. (2012)
  • Author(s): 岡敬之、村木重之、阿久根徹、中村耕三、 川口浩、吉村典子
  • Organizer: 第85回日本整形外科学会学術総会
  • Place of Presentation: 国立京都国際 会館、京都
• [Presentation] 変形性膝関節症の発 生率およびその危険因子 - The ROAD study -. (2012)
  • Author(s): 村木重之、阿久根徹、岡敬之、中村耕三、 川口浩、吉村典子
  • Organizer: 第85回日本整形外科学会学術 総会.
  • Place of Presentation: 国立京都国際会館、 京都
• [Presentation] 要介護移行の予測 におけるロコチェックの有用性の検討 - The ROAD study -. (2012)
  • Author(s): 吉村典子、村木重之、岡敬之、川口浩、 中村耕三、阿久根徹
  • Organizer: 第85回日本整形外科 学会学術総会.
  • Place of Presentation: 国立京都国際会館、京都
• [Presentation] マウスモデルをベースにした変形性関節症の分子メカニズムの解明 (2012)
  • Author(s): 斎藤琢、川口浩
  • Organizer: 第30回日本骨代謝学会
  • Place of Presentation: 京王プラザホテル、東京
• [Presentation] 高骨密度は動脈硬化および変形性腰椎症発症のリスクとなる:ROAD追跡調査より (2012)
  • Author(s): 吉村典子、村木重之、岡敬之、田中栄、川口浩、阿久根徹
  • Organizer: 第30回日本骨代謝学会
  • Place of Presentation: 京王プラザホテル、東京
• [Presentation] 複数回転倒の危険因子:ROAD追跡調査より. (2012)
  • Author(s): 村木重之、阿久根徹、岡敬之、田中栄、川 口浩、中村耕三、吉村典子
  • Organizer: 第30回 日本骨代謝学会.
  • Place of Presentation: 京王プ ラザホテル、東京
• [Presentation] Notch/Rbpj/Hes1 シグナルによる軟骨内 骨化および変形性関節症の制御(優秀演 題賞受賞). (2012)
  • Author(s): 杉田守礼、斎藤琢、保坂陽子、深井厚、 秋山治彦、中村孝志、鄭雄一、川口浩
  • Organizer: 第30回日本骨代謝学会
  • Place of Presentation: 京王プラザホテル、東京
• [Presentation] ポリエチレン摺動面のMPCポリマー処理(シンポジウム:人工 関節成績改善に繋がる近未来の医療用素 材). (2012)
  • Author(s): 高取吉雄、茂呂徹、京本政之、石原一彦、川口浩、中村耕三
  • Organizer: 第27回日本整形外科学会基礎学術 集会.
  • Place of Presentation: 名古屋国際会議 場、愛知
• [Presentation] Notch/Rbpj/Hes1 シグナルによる軟骨内骨化および変形性関節症の制御 (2012)
  • Author(s): 杉田守礼、斎藤琢、保坂陽子、秋山治彦、鄭雄一、川口浩
  • Organizer: 第27回日本整形外科学会基礎学 術集会(最優秀演題賞受賞)
  • Place of Presentation: 名古屋国際会議場、愛知
• [Presentation] Endochondral ossification signal: A potential therapeutic target for osteoarthritis (2012)
  • Author(s): Kawaguchi H
  • Organizer: Cold Spring Harbor Asia Conference
  • Place of Presentation: Suzhou, China
  • Invited
• [Presentation] C/EBPb and RUNX2 Cooperatively Control Cartilage Degradation with MMP-13 as the Target and HIF-2a as the Inducer in Chondrocytes (2011)
  • Author(s): Hirata M, Kawaguchi H, et al.
  • Organizer: The American Society for Bone and Mineral Research(ASBMR)
  • Place of Presentation: San Diego, USA(招待講演)
  • Year and Date: 2011-09-17
• [Presentation] Notch/Rbpj/Hes1 Signal in Chondrocytes Modulates the Terminal Stage of Endochondral Ossification during Skeletal Growth and Osteoarthritis Development (2011)
  • Author(s): Hosaka Y, Kawaguchi H, et al.
  • Organizer: The American Society for Bone and Mineral Research(ASBMR)
  • Place of Presentation: San Diego, USA(招待講演)
  • Year and Date: 2011-09-17
• [Presentation] Functional Redundancy of GSK-3α and GSK-3βto Control Chondrocyte Differentiation through Phosphorylation of RelA/NF-κB p65 (2011)
  • Author(s): Itoh S, Kawaguchi H, et al.
  • Organizer: Osteoarthritis Research Society International (OARSI)
  • Place of Presentation: San Diego, USA(招待講演)
  • Year and Date: 2011-09-16
• [Presentation] Transcriptional induction of ADAMTS5 by NF-κB family member RelA/p65 in chondrocytes during osteoarthritis development (2011)
  • Author(s): Kobayashi H, Kawaguchi H, et al.
  • Organizer: International Osteoporosis Federation/Australian and New Zealand Bone & Mineral Society(IOF/ANZBMS)
  • Place of Presentation: Gold coast (AUS)(招待講演)
  • Year and Date: 2011-09-07
• [Presentation] NF-κB ファミリーRelAは、ADAMTS5の転写誘導因子として変形性関節症の進行に作用する (2011)
  • Author(s): 小林寛、川口浩, 他
  • Organizer: 日本骨代謝学会
  • Place of Presentation: 大阪(招待講演)
  • Year and Date: 2011-07-30
• [Presentation] 軟骨細胞のNotch/Rbpj/Hes1シグナルは骨格形成および変形性関節症における軟骨内骨化の後期過程を制御する (2011)
  • Author(s): 保坂陽子、川口浩, 他
  • Organizer: 日本骨代謝学会
  • Place of Presentation: 大阪(招待講演)
  • Year and Date: 2011-07-30
• [Presentation] GSK-3αとGSK-3βは協調的にRelA/NF-κB p65のリン酸化を介して軟骨細胞初期分化を制御する (2011)
  • Author(s): 伊藤祥三、川口浩, 他
  • Organizer: 日本骨代謝学会
  • Place of Presentation: 大阪(招待講演)
  • Year and Date: 2011-07-29
• [Presentation] 住民疫学調査ROADからみえてきた日本のOA (2011)
  • Author(s): 吉村典子、村木重之、岡敬之、川口浩、中村耕三、阿久根徹
  • Organizer: 第56回 日本 リウマチ学会総会
  • Place of Presentation: グラ ンドプリンスホテル新高輪、東京
• [Presentation] KOACADの臨床的意義(シンポジウム:OAの画像診断と評価). (2011)
  • Author(s): 川口浩
  • Organizer: 第40回日本関節病学会
  • Place of Presentation: 鹿児島市民文化ホール、鹿児島
• [Presentation] 単純X線画像における変形性膝関節症のコンピュータ支援 診断システムKOACADの臨床利用(パネル ディスカッション:関節症マーカー・画 像診断と関節症の疫学). (2011)
  • Author(s): 岡敬之、川口浩、村木重之、阿久根徹、中村耕三、吉村典子
  • Organizer: 第40回 日本関節病学会
  • Place of Presentation: 鹿児島市民 文化ホール、鹿児島
• [Presentation] 大規模コホートにおける変形性膝関 節症と関節マーカー(パネルディスカッ ション:関節症マーカー・画像診断と関 節症の疫学). (2011)
  • Author(s): 森田充浩、山田治基、吉村典子、伊達秀 樹、岡敬之、村木重之、阿久根徹、川口 浩
  • Organizer: 第40回 日本関節病学会
  • Place of Presentation: 鹿児島市民文化ホール、 鹿児島
• [Presentation] Endochondral ossification signal : A potential therapeutic target for osteo arthritis. (2010)
  • Author(s): Kawaguchi H, et al.
  • Organizer: 2010 World Congress on Osteoarthritis
  • Place of Presentation: Brussels, Belgium
  • Year and Date: 2010-09-24
• [Presentation] RBPjκ-dependent Notch signaling in chondrocytes modulates skeletal growth and osteoarthritis development.
  • Author(s): Hosaka Y, Saito T, Sugita S, Fukai A, Hikata T, Akiyama H, Nakamura T, Nakamura K, Chung UI, Kawaguchi H
  • Organizer: 2012 Cold Spring Harbor Asia Conference: Bone & Cartilage: From Development to Human Diseases. 2012. 6. 11-15 (Suzhou, China).
• [Presentation] Rbpj-dependent Notch signaling in chondrocytes modulates endochondral ossification during osteoarthritis development through transcriptional induction by Hes1 (Young Investigator Award).
  • Author(s): Sugita S, Hosaka Y, Saito T, Akiyama H, Chung UI, Kawaguchi H
  • Organizer: 2012 American Society for Bone and Mineral Research (ASBMR).2012. 10.12-15 (Minneaplis, Minnesota, USA).
• [Presentation] Gli1 participates in the Indian Hedgehog-mediated osteogenesis during endochondral ossification. 2012 American Society for Bone and Mineral Research (ASBMR).
  • Author(s): Hojo H, Ohba S, Yano F, Saito T, Ikeda T,Nakajima K, Komiyama Y, Nakagata N, Suzuki K, Takato T, Kawaguchi H, Chung UI
  • Organizer: 2012. 10.12-15 (Minneaplis, Minnesota, USA).
• [Presentation] Osteo-chondrogenic function of BMP isdirected toward osteogenesis by Hh-Gli1 in the perichondrium.
  • Author(s): Hojo H, Ohba S, Taniguchi K, Shirai M,Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N, Suzuki K, Mishina Y, Yamada M, Konno T, Takato T, Kawaguchi H, Kambara H, Chung UI
  • Organizer: 2012 American Society for Bone and Mineral Research (ASBMR).2012. 10.12-15 (Minneaplis, Minnesota, USA).
• [Book] 整形外科専門医テキスト (2010)
  • Author(s): 川口浩, ら
  • Publisher: 南江堂
• [Remarks]
  • URL: http://www.u-tokyo-ortho.jp/
• [Remarks] 東京大学整形外科・脊椎外科
  • URL: http://www.u-tokyo-ortho.jp/
• [Remarks]
  • URL: http://www.h.u-tokyo.ac.jp/ortho/
• [Remarks]
  • URL: http://www.h.u-tokyo.ac.jp/ortho/