| Project/Area Number |
22249058
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Osaka University |
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Principal Investigator |
FUJIKADO Takashi 大阪大学, 医学(系)研究科(研究院), 教授 (50243233)
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| Co-Investigator(Kenkyū-buntansha) |
森本 壮 大阪大学, 医学(系)研究科(研究院), 准教授 (00530198)
瓶井 資弘 大阪大学, 医学(系)研究科(研究院), 准教授 (40281125)
松下 賢治 大阪大学, 医学(系)研究科(研究院), 講師 (40437405)
神田 寛行 大阪大学, 医学(系)研究科(研究院), 助教 (50570248)
三好 智満 大阪大学, 医学(系)研究科(研究院), 助教 (70314309)
辻川 元一 大阪大学, 医学(系)研究科(研究院), 教授 (70419472)
坂口 裕和 大阪大学, 医学(系)研究科(研究院), 講師 (80379172)
藤田 克昌 大阪大学, 工学研究科, 准教授 (80362664)
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥47,970,000 (Direct Cost: ¥36,900,000、Indirect Cost: ¥11,070,000)
Fiscal Year 2012: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2011: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2010: ¥20,670,000 (Direct Cost: ¥15,900,000、Indirect Cost: ¥4,770,000)
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| Keywords | 神経保護 / 電気刺激 / 人工視覚 / 網膜機能画像 / ラマン分光 / 網膜機能イメージング |
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| Research Abstract |
IGF1 mRNA was increased by the electrical stimulation on cultured RGC5, which suggests that IGF1 is involved in the neuro-protection mechanism by electrical stimulation (ES). The process of neuronal cell-death was demonstrated sequentially and 2-dimensionally by Raman microscope by probing the intracellular changes of cytochrome C. Trans-corneal electrical stimulation (TES) on rabbit model of retinal degeneration showed a decrease of OPL thickness, which suggests the neuro-protective effect of ES on photoreceptors. Clinical study on the artificial vision by optic nerve stimulation showed the efficacy of ES to elicit phosphine for 2 years for advanced retinitis pigmentosa patients.
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