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Role of Autophagy and the Molecule Targeting in Sepsis

Research Project

Project/Area Number 22249059
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Emergency medicine
Research InstitutionNagoya University

Principal Investigator

MATSUDA Naoyuki  名古屋大学, 医学系研究科, 教授 (50332466)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥48,750,000 (Direct Cost: ¥37,500,000、Indirect Cost: ¥11,250,000)
Fiscal Year 2012: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2011: ¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2010: ¥26,910,000 (Direct Cost: ¥20,700,000、Indirect Cost: ¥6,210,000)
Keywords敗血症 / セプシス / オートファジー / 蛋白異化 / 全身性炎症反応症候群 / siRNA / FADD / TAK-1 / ILAK1 / LC3 / 遺伝子治療 / アポトーシス / ATG / nuclear factor-κB / 細胞死
Research Abstract

Sepsis, known as a inducer of severe multiple organ diseases, has no established effective treatment except for antibiotics. Sepsis can lead multiple organ failure due to amid acid transformation to acute phase proteins such as inflammatory cytokines. In this study, I have found that some parts of autophagy-related gene family wereincreased at transcriptional and translated levels in the acute terms of sepsis of cultured human vascular endothelial cells and sepsis mouse models. LC3 was activated in particular, and promoted an autophagosome formation. It was concluded that FADD, TAK-1 andtranscriptional activity of NF-κB and AP-1 were significantly related with autophagy acceleration in the cultured human vascular endothelial cells and sepsis mouse model.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (15 results)

All 2013 2012 2011

All Journal Article (4 results) (of which Peer Reviewed: 1 results) Presentation (9 results) Book (2 results)

  • [Journal Article] 敗血症性多臓器不全に対する遺伝子治療~ Alert Cell Strategy ~2013

    • Author(s)
      松田直之,小西裕子,伊藤理恵,栃久保順平,足立裕史,村瀬吉郎
    • Journal Title

      実験医学

      Volume: 31 Pages: 773-779

    • Related Report
      2012 Final Research Report
  • [Journal Article] 敗血症性多臓器不全に対する遺伝子治療2013

    • Author(s)
      松田直之
    • Journal Title

      実験医学

      Volume: 31 Pages: 773-779

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 敗血症性ショックの病態と治療.2011

    • Author(s)
      松田直之
    • Journal Title

      名古屋内科医会会誌

      Volume: 137 Pages: 69-80

    • Related Report
      2012 Final Research Report
  • [Journal Article] 敗血症性急性肺傷害における Alert 細胞戦略.2011

    • Author(s)
      松田直之,都築通孝,市川 崇,杤久保順平,田村哲也,足立裕史.
    • Journal Title

      日本薬理学会誌

      Volume: 138 Pages: 151-154

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] 共催セミナー「救急領域における好中球の役割」2012

    • Author(s)
      松田直之
    • Organizer
      第40回日本救急医学会・学術集会
    • Place of Presentation
      国立京都国際会館 京都
    • Year and Date
      2012-11-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 教育セミナー「感染症性多臓器不全の病態と治療」2012

    • Author(s)
      松田直之
    • Organizer
      第39回日本集中治療医学会学術集会・総会
    • Place of Presentation
      幕張メッセ 千葉
    • Year and Date
      2012-02-29
    • Related Report
      2012 Final Research Report
  • [Presentation] STEP UP感染症性多臓器不全の病態と治療2012

    • Author(s)
      松田直之
    • Organizer
      第39回日本集中治療医学会学術集会
    • Place of Presentation
      千葉(幕張メッセ)(招待講演)
    • Year and Date
      2012-02-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] TAK-1 siRNA normalises autophagy and apoptosis in septic mouse lung2012

    • Author(s)
      Matsuda N, Tochikubo J, Tamura T, Tsuzuki M, Murase K, Adachi Y.
    • Organizer
      European Society of Intensive Care Medicine 25th Annual Congress
    • Place of Presentation
      Lisbon, Portugal
    • Related Report
      2012 Final Research Report
  • [Presentation] TAK-1 siRNA normalises autophagy and apoptosis in septic mouse lung.2012

    • Author(s)
      松田直之
    • Organizer
      European Society of Intensive Care Medicine
    • Place of Presentation
      Lisbon
    • Related Report
      2012 Annual Research Report
  • [Presentation] 周術期全身性炎症の病態と治療2011

    • Author(s)
      松田直之
    • Organizer
      第31回日本臨床麻酔学会
    • Place of Presentation
      琉球大学 沖縄
    • Year and Date
      2011-11-04
    • Related Report
      2012 Final Research Report
  • [Presentation] 教育セミナー「敗血症の病態と治療~組織再生におけるニッチ理論~ 」2011

    • Author(s)
      松田直之
    • Organizer
      第39回日本救急医学会学術集会
    • Place of Presentation
      京王プラザホテル 東京
    • Year and Date
      2011-10-20
    • Related Report
      2012 Final Research Report
  • [Presentation] FADD siRNA reduces autophagy and apoptosis in septic mice2011

    • Author(s)
      Matsuda N and Teramae H.
    • Organizer
      Society of Critical Care Medicine 40th Critical Care Congress
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] FADD siRNA reduces autophagy and apoptosis in septic mice.2011

    • Author(s)
      Naoyuki Matsuda
    • Organizer
      the Society of Critical Care Medicine
    • Place of Presentation
      San Diego, USA
    • Related Report
      2010 Annual Research Report
  • [Book] Protection from lethal cell death in cecal ligation and puncture-induced sepsis mouse model by in vivo delivery of FADD siRNA. In:Targets in Gene Therapy. ed. by Yongping You.2011

    • Author(s)
      Hattori Y, Matsuda N.
    • Publisher
      In Tech-Open Access Publisher
    • Related Report
      2012 Final Research Report
  • [Book] Targets in Gene Therapy2011

    • Author(s)
      Hattori Y, Matsuda N
    • Publisher
      InTech-Open Access Publisher
    • Related Report
      2011 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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