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Maintenance and disturbance of osteonetwork: basic studies on clarification of pathophysiology of craniofacial bone diseases

Research Project

Project/Area Number 22249061
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

YAMAGUCHI Akira  東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (00142430)

Co-Investigator(Kenkyū-buntansha) IIMURA Tadahiro  東京医科歯科大学, 歯と骨の GCOE 拠点, 准教授 (20282775)
SAKAMOTO Kei  東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (00302886)
TAMAMURA Sadahiro  東京医科歯科大学, 大学院・医歯学総合研究科, 特認助教 (70431963)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥48,100,000 (Direct Cost: ¥37,000,000、Indirect Cost: ¥11,100,000)
Fiscal Year 2012: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2011: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2010: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Keywords骨芽細胞 / 骨細胞 / 破骨細胞 / 口腔癌 / 骨破壊 / ネットワーク / 顎顔面骨疾患 / オステネットワーク / Notch / CCN3 / 矯正的
Research Abstract

We conducted experiments to clarify the pathophysiology of craniofacial bone diseases based on the concept of osteonetwork, and the following results were published. 1. Development of bioimaging techniques to visualize the netwrork among osteoblasts, osteocytes and osteoclasts. 2. Osteocytes play crucial roles in orthodontic tooth movement. 3.CCN3 is a negative regulator in bone regeneration. $. RANKL plays crucial roles in bone destruction induced by oral squamous cell carcinoma.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (122 results)

All 2013 2012 2011 2010 Other

All Journal Article (60 results) (of which Peer Reviewed: 30 results,  Open Access: 1 results) Presentation (58 results) (of which Invited: 4 results) Book (4 results)

  • [Journal Article] Spatiotemporal disorder in endochondral ossification during axial skeleton development in the Mesp2-null mouse: A developmental etiology of spondylocostal dysostosis and spondylothoracic dysostosis2013

    • Author(s)
      Makino Y, Takahashi Y, Tanabe R, Tamamura Y, Watanabe T, Haraikawa M, Hamagaki M, Hata K, Kanno J, Yoneda T, Saga Y,Goseki-Sone M, Kaneko K, Yamaguchi A, Iimura T
    • Journal Title

      BONE

      Volume: 53 Pages: 248-258

    • Related Report
      2012 Final Research Report
  • [Journal Article] The role of osteocytes in bone resorption during orthodontic tooth movement2013

    • Author(s)
      Matsumoto T, Iimura T, Ogura K, Moriyama K, Yamaguchi A
    • Journal Title

      J Dent Res

      Volume: 92 Pages: 340-345

    • Related Report
      2012 Final Research Report
  • [Journal Article] The expression profiles of acidic epithelial keratins in Ameloblastoma2013

    • Author(s)
      Pal KS, Sakamoto K, Aragaki T, Akashi T, Yamaguchi A
    • Journal Title

      Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology

      Volume: 115 Pages: 523-531

    • Related Report
      2012 Final Research Report
  • [Journal Article] RANKL synthesized by both stromal cells and cancer cells plays a crucial role in osteoclastic bone resorption induced by oral cancer2013

    • Author(s)
      Sato K, Lee JW, Sakamoto K, Iimura T, Kayamori K, Yasuda H, Shindoh M, Ito M, Omura K, Yamaguchi A
    • Journal Title

      Amer J Pathol

      Volume: 182 Pages: 1890-1899

    • Related Report
      2012 Final Research Report
  • [Journal Article] Spatiotemporal disorder in endochondral ossification during axial skeleton development in the Mesp2-null mouse: A developmental etiology of spondylocostal dysostosis and spondylothoracic dysostosis.2013

    • Author(s)
      Makino Y, Takahashi Y, Tanabe R, Tamamura Y, Watanabe T, Haraikawa M, Hamagaki M, Hata K, Kanno J, Yoneda T, Saga Y, Goseki-Sone M, Kaneko K, Yamaguchi A, Iimura T
    • Journal Title

      BONE

      Volume: 53 Issue: 1 Pages: 248-258

    • DOI

      10.1016/j.bone.2012.11.033

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of osteocytes in bone resorption during orthodontic tooth movement.2013

    • Author(s)
      Matsumoto T, Iimura T, Ogura K, Moriyama K, Yamaguchi A
    • Journal Title

      J Dent Res

      Volume: 92 Issue: 4 Pages: 340-345

    • DOI

      10.1177/0022034513476037

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The expression profiles of acidic epithelial keratins in Ameloblastoma.2013

    • Author(s)
      Pal KS, Sakamoto K, Aragaki T, Akashi T, Yamaguchi A
    • Journal Title

      Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology

      Volume: 115 Issue: 4 Pages: 523-531

    • DOI

      10.1016/j.oooo.2013.01.017

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RANKL synthesized by both stromal cells and cancer cells plays a crucial role in osteoclastic bone resorption induced by oral cancer2013

    • Author(s)
      Kiyoshi Sato, Ji-Won Lee, Kei Sakamoto, Tadahiro Iimura, Kou Kayamori, Hisataka Yasuda, Masanobu Shindoh, Masako Ito, Ken Omura, Akira Yamaguchi
    • Journal Title

      American Journal of Pathology

      Volume: 182 Issue: 5 Pages: 1890-1899

    • DOI

      10.1016/j.ajpath.2013.01.038

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural differences in the osteocyte network between the calvaria and long bone revealed by three-dimensional fluorescence morphometry, possibly reflecting distinct mechano-adaptations and sensitivities2012

    • Author(s)
      Himeno-Ando A, Izumi Y, Yamaguchi A, Iimura T
    • Journal Title

      Biochem Bioph Res Co

      Volume: 417 Pages: 765-770

    • Related Report
      2012 Final Research Report
  • [Journal Article] Reduction of NOTCH1 expression pertains to maturation abnormalities of keratinocytes in squamous neoplasms2012

    • Author(s)
      Sakamoto K, Fujii T, Kawachi H, Miki Y, Omura K, Morita K, Kayamori K, Khanom R, Katsube K, Yamaguchi A
    • Journal Title

      Lob Invest

      Volume: 92 Pages: 688-702

    • Related Report
      2012 Final Research Report
  • [Journal Article] Expression of basal cell keratin 15 and keratin 19 in oral squamous cell carcinoma represent diverse phthophysiologies2012

    • Author(s)
      Khanom R, Sakamoto K, Pal SK, Shimada Y, Morita K-i, Omura K, Miki Y, Yamaguchi A
    • Journal Title

      Histol Histopathol

      Volume: 27 Pages: 949-959

    • Related Report
      2012 Final Research Report
  • [Journal Article] Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development2012

    • Author(s)
      Aizawa R, Yamada A, Suzuki D, Iimura T, Kassai H, Harada T, Tsukasaki M, Yamamoto G, Tachikawa T, Nakao K, Yamamoto M, Yamaguchi A, Aiba A, Kamijo R
    • Journal Title

      Mech Dev

      Volume: 129 Pages: 38-50

    • Related Report
      2012 Final Research Report
  • [Journal Article] Clinical significance of lymphatic and blood vessel invasion in oral tongue squamous cell carcinomas2012

    • Author(s)
      Michikawa C, Uzawa N, Kayamori K, Sonoda I, Ohyama Y, Okada N, Yamaguchi A, Amagasa T
    • Journal Title

      Oral Oncol

      Volume: 48 Pages: 320-324

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] Canine oral mucosal fibroblasts differentiate into osteoblastic cellsin response to BMP-22012

    • Author(s)
      Umehara K,Iimura T,Sakamoto K,Lin Z,Kasugai S,Igarashi Y,Yamaguchi A
    • Journal Title

      Anat Rec

      Volume: 295 Pages: 1327-1335

    • Related Report
      2012 Final Research Report
  • [Journal Article] Increasing participation of Sclerostin in postnatal bone development revealed by three-dimensional immunofluorescence morphometry2012

    • Author(s)
      Watanabe T, Tamamura Y, Hoshino A, Makino Y, Nishimura R, Kamioka H, Yoneda T, Amagasa T, Yamaguchi A, Iimura T
    • Journal Title

      BONE

      Volume: 51 Pages: 447-458

    • Related Report
      2012 Final Research Report
  • [Journal Article] Ectopic production of hair keratin constitutes Rushton's hyaline bodies in association with hematogenous deposits2012

    • Author(s)
      Sakamoto K, Khanom R, Hamagaki M, Yamaguchi A
    • Journal Title

      J Oral Pathol Med

      Volume: 27 Pages: 949-959

    • Related Report
      2012 Final Research Report
  • [Journal Article] CXCL2 synthesized by oral squamous cell carcinoma is involved in cancer-associated bone destruction.2012

    • Author(s)
      Oue E, Lee JW, Sakamoto K, Iimura T, Aoki K, Kayamori K, Michi Y, Yamashiro M,Yamaguchi A
    • Journal Title

      Biochem Bioph Res Co

      Volume: 424 Pages: 456-461

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] Osterix regulates calcification and degradation of chondrogenic matrices through matrix metalloproteinase (MMP13) expression in association with transcription factor Runx2 during endochondral ossification2012

    • Author(s)
      Nishimura R, Wakabayashi M, Hata K, Matsubara T, Honma H, Wakisaka S, Kiyonari H, Shioi G, Yamaguchi A, Tsumaki N, Akiyama H, Yoneda T
    • Journal Title

      J Biol Chem

      Volume: 287 Pages: 33179-33190

    • Related Report
      2012 Final Research Report
  • [Journal Article] Roles of chemokine receptor CX3CR1 in maintaining murine bone homeostasis through the regulation of both osteoblasts and osteoclasts2012

    • Author(s)
      Hoshino A, Ueha S, Hanada S, Imai T, Ito M, Yamamoto K, Matsushima K, Yamaguchi A, Iimura T
    • Journal Title

      J Cell Sci

      Volume: 258 Pages: 28826-28837

    • Related Report
      2012 Final Research Report
  • [Journal Article] Retention of bone strength by feeding of milk and dairy products in ovariectomized rats; involvement of changes in serum levels of 1alpha, 25(OH)2D3 and FGF232012

    • Author(s)
      Tanabe R, Haraikawa M, Sogabe N,Sugimoto A, Kawamura Y, Takasugi S, Nagata M, Nakane A, Yamaguchi A, Iimura T, Masae Goseki-Sone
    • Journal Title

      J Nutr Biochem

      Volume: 2012 [Epub ahead of print] 10.1016/j.jnutbio Pages: 4-4

    • Related Report
      2012 Final Research Report
  • [Journal Article] Effects of veraguensin and galgravin on osteoclast differentiation and function2012

    • Author(s)
      Asai M, Lee JW, Itakura Y, Choi BK, Yonezawa T, Teruya T, Cha BY, Ohnishi M, Yamaguchi A, Woo JT
    • Journal Title

      Cytotechnology

      Volume: 64 Pages: 315-322

    • Related Report
      2012 Final Research Report
  • [Journal Article] A fluorescence spotlight on the clockwork development and metabolism of bone2012

    • Author(s)
      Iimura T, Nakane A, Sugiyama M, Sato H, Makino Y, Watanabe T, Takagi Y, Numano R, Yamaguchi A
    • Journal Title

      J Bone Miner Metab

      Volume: 30 Pages: 254-269

    • NAID

      10031168777

    • Related Report
      2012 Final Research Report
  • [Journal Article] Reduction of NOTCH1 expression pertains to maturation abnormalities of keratinocytes in squamous neoplasms2012

    • Author(s)
      Sakamoto K, Fujii T, Kawachi H, Miki Y, Omura K, Morita KI, Kayamori K, Katsube KI, Yamaguchi A
    • Journal Title

      Laboratory investigation

      Volume: (Epub ahead of print) Issue: 5 Pages: 688-702

    • DOI

      10.1038/labinvest.2012.9

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of basal cell keratin 15 and keratin 19 in oral squamous cell carcinoma represent diverse phthophysiologies.2012

    • Author(s)
      Khanom R, Sakamoto K, Pal SK, Shimada Y, Morita K-i, Omura K, Miki Y, Yamaguchi A
    • Journal Title

      Histol Histopathol

      Volume: 27 Pages: 949-959

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Canine oral mucosal fibroblasts differentiate into osteoblastic cellsin response to BMP-2.2012

    • Author(s)
      Umehara K, Iimura T, Sakamoto K, Lin Z, Kasugai S, Igarashi Y, Yamaguchi A
    • Journal Title

      Anat Rec

      Volume: 295 Issue: 8 Pages: 1327-1335

    • DOI

      10.1002/ar.22510

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increasing participation of Sclerostin in postnatal bone development revealed by three-dimensional immunofluorescence morphometry.2012

    • Author(s)
      Watanabe T, Tamamura Y, Hoshino A, Makino Y, Nishimura R, Kamioka H, Yoneda T, Amagasa T, Yamaguchi A, Iimura T
    • Journal Title

      BONE

      Volume: 51 Issue: 3 Pages: 447-458

    • DOI

      10.1016/j.bone.2012.06.019

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osterix regulates calcification and degradation of chondrogenic matrices through matrix metalloproteinase (MMP13) expression in association with transcription factor Runx2 during endochondral ossification.2012

    • Author(s)
      Nishimura R, Wakabayashi M, Hata K, Matsubara T, Honma H, Wakisaka S, Kiyonari H, Shioi G, Yamaguchi A, Tsumaki N, Akiyama H, Yoneda T
    • Journal Title

      J Biol Chem

      Volume: 287 Issue: 40 Pages: 33179-33190

    • DOI

      10.1074/jbc.m111.337063

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of chemokine receptor CX3CR1 in maintaining murine bone homeostasis through the regulation of both osteoblasts and osteoclasts.2012

    • Author(s)
      Hoshino A, Ueha S, Hanada S, Imai T, Ito M, Yamamoto K, Matsushima K, Yamaguchi A, Iimura T
    • Journal Title

      10.1242/jcs.113910.

      Volume: 258 Pages: 28826-28837

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retention of bone strength by feeding of milk and dairy products in ovariectomized rats; involvement of changes in serum levels of 1alpha, 25(OH)2D3 and FGF23.2012

    • Author(s)
      Tanabe R, Haraikawa M, Sogabe N, Sugimoto A, Kawamura Y, Takasugi S, Nagata M, Nakane A, Yamaguchi A, Iimura T, Masae Goseki-Sone
    • Journal Title

      J Nutr Biochem

      Volume: in press Issue: 6 Pages: 1000-7

    • DOI

      10.1016/j.jnutbio.2012.07.004

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Down-regulation ofkeratin 4 and keratin 13 expression in oral squamous cell carcinoma and epithelialdysplasia: a clue for histopathogenesis2011

    • Author(s)
      Sakamoto K, Aragaki T, Kawachi H, KatsubeK, Miki Y, Takizawa T, Omura K, Morita K,Okada N, Yamaguchi A
    • Journal Title

      Histopathol

      Volume: 58 Pages: 531-542

    • Related Report
      2012 Final Research Report
  • [Journal Article] Acerogenin A, a natural compound isolated from Acer nikoense Maxim,stimulates osteoblast differentiation through bone morphogenetic protein action2011

    • Author(s)
      Kihara K, Ichikawa S, Yonezawa T, Lee JW,Akihisa T, Woo JT, Michi Y, Amagasa T, Yamaguchi A
    • Journal Title

      Biochem Bioph Res Co

      Volume: 406 Pages: 211-217

    • Related Report
      2012 Final Research Report
  • [Journal Article] Comparative morphology of osteocytes in aquatic and land vertebrates2011

    • Author(s)
      Cao L, Moriishi T, Miyazaki T, Iimura T, Tamamura S, Komori T, Yamaguchi A
    • Journal Title

      J Bone Miner Metab

      Volume: 29 Pages: 662-670

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] TGF-β drivesepithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP2011

    • Author(s)
      Horiguchi K, Sakamoto K, Koinuma D,Semba K, Inoue A, Inoue S, Fujii H,Yamaguchi A, Miyazawa K, Miyazono K, Saitoh M
    • Journal Title

      Oncogene

      Volume: 31 Pages: 3190-3201

    • Related Report
      2012 Final Research Report
  • [Journal Article] Illumination of vertebrate development by fluorescence live imaging2011

    • Author(s)
      Iimura T, Sugiyama M, Makino Y, Nakane A, Watanabe T, Yamaguchi A
    • Journal Title

      Cytometry Research

      Volume: 21 Pages: 57-63

    • NAID

      10028165409

    • Related Report
      2012 Final Research Report
  • [Journal Article] Structural differences in the osteocyte networ between the calvaria and long bone revealed by three-dimensional fluorescence morphometry, possibly reflecting dstinct mechano-adaptations and sensitivities2011

    • Author(s)
      Himeno-Ando A, Izumi Y, Yamaguchi A, Iimura T
    • Journal Title

      Biochem Bioph Res Commun

      Volume: 417 Issue: 2 Pages: 765-770

    • DOI

      10.1016/j.bbrc.2011.12.031

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development2011

    • Author(s)
      Aizawa R, Yamada A, Suzuki D, Iimura T, Kassai H, Harada T, Tsukasaki M, Yamamoto G, Tachikawa T, Nakao K, Yamamoto M, Yamagchi A, Aiba A, Kamijo R
    • Journal Title

      AMech Dev

      Volume: (In press) Issue: 1-4 Pages: 38-50

    • DOI

      10.1016/j.mod.2012.02.002

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of lymphatic and blood vessel invasion in oral tongue squamous cell carcinomas2011

    • Author(s)
      Michikawa C, Uzawa N, Kayamori K, Sonoda I, Ohyama Y, Okada N, Yamaguchhi A, Amagasa T
    • Journal Title

      Oral Oncol

      Volume: 48 Issue: 4 Pages: 320-324

    • DOI

      10.1016/j.oraloncology.2011.11.014

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A fluorescence spotlight on the clockwork development and metabolism of bone2011

    • Author(s)
      Tadahiro Iimura
    • Journal Title

      J Bone Miner Metab

      Volume: 30 Issue: 3 Pages: 254-269

    • DOI

      10.1007/s00774-011-0295-3

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Down-regulation of keratin 4 and keratin 13 expression in oral squamous cell carcinoma and epithelial dysplasia : a clue for histopathogenesis2011

    • Author(s)
      Sakamoto K, Aragaki T, Kawachi H, Katsube K, Miki Y, Takizawa T, Omura K, Morita K, Okada N, Yamaguchi A
    • Journal Title

      Histopathol

      Volume: 58 Pages: 531-542

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acerogenin A, a natural compound isolated from Acer nikoense Maxim, stimulates osteoblast differentiation through bone morphogenetic protein action2011

    • Author(s)
      Kihara K, Ichikawa S, Yonezawa T, Lee JW, Akihisa T, Woo JT, Michi Y, Amagasa T, Yamaguchi A
    • Journal Title

      Biochem Bioph Res Commun

      Volume: 406 Issue: 2 Pages: 211-217

    • DOI

      10.1016/j.bbrc.2011.02.017

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TGF-β derives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP2011

    • Author(s)
      堀口華奈
    • Journal Title

      Oncogene

      Volume: (掲載確定)(印刷中) Issue: 26 Pages: 3190-3201

    • DOI

      10.1038/onc.2011.493

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduction of NOTCH1 expression pertains to maturation abnormalities of keratinocytes in squamous neoplasms2011

    • Author(s)
      Sakamoto K, Aragaki T, Kawachi H, Katsube K, Miki Y, Takizawa T, Omura K, Morita K, Okada N, Yamaguchi A
    • Journal Title

      Lob Invest

      Volume: 92 Issue: 4 Pages: 688-702

    • DOI

      10.1111/j.1365-2559.2011.03759.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of basal cell keratin 15 and Keratin 19 in oral squamous cell carcinoma represent diverse phthophysiologies2011

    • Author(s)
      Khanom R, Sakamoto K, Pal SK, Shimada Y, Morita K-i, Omura K, Miki Y, Yamaguchi A
    • Journal Title

      Histol Histopathol

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Canine oral mucosal fibroblasts differentiate into osteoblastic cellsin response to BMP-22011

    • Author(s)
      Umehara K, Iimura T, Sakamoto K, Lin Z, Kasugai S, Igarashi Y, Yamaguchi A
    • Journal Title

      Anat Rec

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ectopic production of hair keratin constitutes Rushton's hyaline bodies in association with hematogenous deposits°2011

    • Author(s)
      Sakamoto K, Khanom R, Hamagaki M, Yamaguchi A
    • Journal Title

      J Oral Pathol Med

      Volume: (In press) Issue: 8 Pages: 637-641

    • DOI

      10.1111/j.1600-0714.2012.01150.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Concurrent downregulation of keratin an keratin 13 expression eines the neoplastic lesion of oral.epithelium and serves as an ideal marker for oral squamous cell carcinoma and oral epithelial dysplasia.2011

    • Author(s)
      Sakamoto K, Aragaki T, Kawachi H, Katsube K, Miki Y, Takizawa T, Omura K, MoritaK, Okada N, Yamaguchi A
    • Journal Title

      Histopathology

      Volume: 58 Pages: 531-542

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acerogenin A, a natural compound isolated from Acer ni oense Maxim, stimulates osteoblast differentiation through bone morphogenetic protem action.2011

    • Author(s)
      Kihara K, Ichikawa S, Yonezawa T, Lee JW, Akihisa T, Woo JT, Michi Y, Amagasa T, Yamaguchi A
    • Journal Title

      Biochem Bioph Res Commun

      Volume: 406 Pages: 211-217

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative morphology of osteocytes in aquatic an an vertebrates.2011

    • Author(s)
      Cao L, Moriishi T, Miyazaki T, Iimura T, Tamamura S, Komori T, Yamaguchi A
    • Journal Title

      J Bone Miner Met

      Volume: In press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of IL-6 and PTHrP in osteoclast formation associated with oral cancers:The significance of IL-6 synthesized by stromal cells in response to cancer cells2010

    • Author(s)
      Kayamori K, Sakamoto K, Nakashima T,Takayanagi T, Morita K, Omura K, Nguyen ST,Miki Y, Iimura T, Himeno A, Akashi T, Yamada-Okabe H, Ogata E, Yamaguchi A
    • Journal Title

      Amer JPathol

      Volume: 176 Pages: 968-980

    • Related Report
      2012 Final Research Report
  • [Journal Article] Repetition ofcontinuous PTH treatments followed byperiodic withdrawals exerts anabolic effects on rat bone2010

    • Author(s)
      Etoh M, Yamaguchi A
    • Journal Title

      J Bone Miner Metab

      Volume: 28 Pages: 641-649

    • Related Report
      2012 Final Research Report
  • [Journal Article] Deficiency of chemokine receptor CCR1 causesosteopenia due to impaired functions of osteoclasts and osteoblasts2010

    • Author(s)
      Hoshino A, Iimura T, Ueha S, Hanada S, Maruoka Y, Mayahara M, Suzuki K, Imai T,Ito M, Manome Y, Yasuhara M, Kirino T, Yamaguchi A, Matsushima K, Yamamoto K
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 28826-28837

    • Related Report
      2012 Final Research Report
  • [Journal Article] Comprehensive keratin profiling reveals distinctions between keratocysticodontogenic tumor and orthokeratinized odontogenic cyst2010

    • Author(s)
      Aragaki T, Michi Y, Katsube K, Uzawa N,Okada N, Akashi T, Amagasa T, Yamaguchi A,Sakamoto K
    • Journal Title

      Human Pathol

      Volume: 42 Pages: 1718-1725

    • Related Report
      2012 Final Research Report
  • [Journal Article] Maf mediates the age-related switch in mesenchymal cell2010

    • Author(s)
      Nishikawa K, Isogai M, Nakashima T, TakedaS, Michito, Hamada M, Kimura A, Kodama T, Yamaguchi A, Owen MJ, Takahashi S,Takayanagi H
    • Journal Title

      J Clin Invest

      Volume: 120 Pages: 3455-3465

    • Related Report
      2012 Final Research Report
  • [Journal Article] Hox genes, a molecular constraint for development and evolution of vertebrate bodyplan2010

    • Author(s)
      Iimura T, Himeno A, Nakane A, YamaguchiA
    • Journal Title

      J Oral Biosci

      Volume: 52 Pages: 155-163

    • Related Report
      2012 Final Research Report
  • [Journal Article] Maf mediates the age-related switch in mesenchymal cell.2010

    • Author(s)
      Nishikawa K, Isogai M, Nakashima T, Takeda S, Michito, Hamada M, Kimura A, Kodama T, Yamaguchi A, Owen MJ, Takahashi S, Takayanagi H
    • Journal Title

      J Clin Invest

      Volume: 120 Pages: 3455-3465

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Repetition of continuous PTH treatments followed by periodic withdrawals exerts anabolic effects on rat bone_2010

    • Author(s)
      Etoh M, Yamaguchi A
    • Journal Title

      J Bone Miner Metab

      Volume: 28 Pages: 641-649

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of IL-6 an r in osteoc ast formation associate with oralcancers: The significance of IL-6 synthesized by stromal cells in response to cancer cells.2010

    • Author(s)
      Kayamori K, Sakamoto K Nakashima T, Takayanagi T, Morita K, Omura K, Nguyen ST, Miki Y, Iimura T, Himeno A, Akashi T, Yamada-Okabe H, Ogata E, Yamaguchi A
    • Journal Title

      Amer J Pathol

      Volume: 176 Pages: 968-980

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of chemokine receptor CCR1 causes osteopenia due to impaired functions of osteoclasts and osteoblasts.2010

    • Author(s)
      Hoshino A, limura T Ueha S, Hanada S, Maruoka Y, Mayahara M, Suzuki K, Imai T, Ito M, Manome Y, Yasuhara M, Kirino T, Yamaguchi A, Matsushima K, Yamamoto K
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 28826-28837

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive keratin profiling reveals distinctions between keratocystic odontogenic tumor and orthokeratinized odontogenic cyst.2010

    • Author(s)
      Aragaki T, Michi Y, Katsube K, Uzawa N, Okada N, Akashi T, Amagasa T Yamaguchi A, Sakamoto K
    • Journal Title

      Human Pathol

      Volume: 42 Pages: 1718-1725

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CCN3 participates in bone regeneration as an inhibitory factor

    • Author(s)
      Matsushita Y, Sakamoto K, Tamamura Y, Shibata Y, Minamizato T, Kihara T, Ito M, Katsube K, Hiraoka S, Koseki H, Harada K, Yamaguchi A
    • Journal Title

      J Biol Chem

      Volume: (in press)

    • Related Report
      2012 Final Research Report
  • [Presentation] 顎骨壊死の最新情報2013

    • Author(s)
      山口朗
    • Organizer
      第5回口腔先端応用科学研究会
    • Place of Presentation
      日本大学会館大講堂(招待講演)
    • Year and Date
      2013-01-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 顎骨壊死の最新情報2013

    • Author(s)
      山口 朗
    • Organizer
      第5回口腔先端応用科学研究会
    • Place of Presentation
      東京、日本大学会館大講堂
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 病理組織学的立場から見たBMA関連顎骨病変の成因と診断、口腔三学会合同シンポジウム、「Bone-modifying Agents (BMA)関連顎骨病変の病態・診断・治療」2012

    • Author(s)
      山口朗
    • Organizer
      第57回日本口腔外科学会総会・学術大会、パシフィコ横浜会議センター
    • Year and Date
      2012-10-20
    • Related Report
      2012 Final Research Report
  • [Presentation] オステオネットワークの維持と破綻:骨疾患の病態解明を目指して2012

    • Author(s)
      山口朗
    • Organizer
      第27回長崎骨粗鬆症研究会、長崎県医師会館
    • Place of Presentation
      長崎
    • Year and Date
      2012-05-09
    • Related Report
      2012 Final Research Report
  • [Presentation] オステオネットワークの獲得・維持・破綻2012

    • Author(s)
      山口朗
    • Organizer
      米田俊之教授退官記念講演会、大阪大学中之島センター
    • Place of Presentation
      大阪
    • Year and Date
      2012-05-05
    • Related Report
      2012 Final Research Report
  • [Presentation] Bisphosphonate-related osteonecrosis, updates2012

    • Author(s)
      Yamaguchi A
    • Organizer
      2012 Sino-Japan Dental Conference
    • Place of Presentation
      Chengdu, Sichaun, China
    • Year and Date
      2012-04-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 顎骨壊死の病態の最新知見2012

    • Author(s)
      山口朗
    • Organizer
      第10回日本歯科骨粗鬆症研究会、シンポジウム「ビスフォスフォネート製剤の長期治療による光と影-顎骨壊死は回避できるのかー」
    • Place of Presentation
      大阪
    • Year and Date
      2012-03-18
    • Related Report
      2012 Final Research Report
  • [Presentation] オステオネットワークの維持と破壊:顎骨疾患の病態解明と新たな治療法の開発を目指して2012

    • Author(s)
      山口朗
    • Organizer
      第30回北海道医療大学歯学会、特別講演
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 口腔癌の骨破壊、第30回日本口腔腫瘍学会2012

    • Author(s)
      山口朗
    • Organizer
      教育講演
    • Place of Presentation
      大宮
    • Year and Date
      2012-01-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 口腔癌の骨破壊2012

    • Author(s)
      山口朗
    • Organizer
      第30回日本口腔腫瘍学会
    • Place of Presentation
      大宮(教育講演)
    • Year and Date
      2012-01-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Bone destruction by oral cancer2012

    • Author(s)
      Yamaguchi A
    • Organizer
      The 6th Global COE international Symposium at TMDU
    • Place of Presentation
      Tokyo
    • Year and Date
      2012-01-22
    • Related Report
      2012 Final Research Report
  • [Presentation] Expression of keratin (K)15 and K19 in oral squamous neoplasms represents diverse phthophysiologies.2012

    • Author(s)
      Khanom Rumana、坂本 啓、山口 朗
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京 京王プラザホテル
    • Related Report
      2012 Annual Research Report
  • [Presentation] TSP1 in stroma promotes invasion of oral cancer.2012

    • Author(s)
      Samir Pal、坂本 啓、山口 朗
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京 京王プラザホテル
    • Related Report
      2012 Annual Research Report
  • [Presentation] Rushtonの硝子体の起源2012

    • Author(s)
      坂本 啓、山口 朗
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京 京王プラザホテル
    • Related Report
      2012 Annual Research Report
  • [Presentation] Bisphosphonate-related osteonecrosis, updates.2012

    • Author(s)
      Yamaguchi A
    • Organizer
      2012 Sino-Japan Dental Conference
    • Place of Presentation
      Chengdu, Sichaun, China
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] オステオネットワークの維持と破綻:骨疾患の病態解明を目指して2012

    • Author(s)
      山口 朗
    • Organizer
      第27回長崎骨粗鬆症研究会
    • Place of Presentation
      長崎県医師会館
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Bone-modifying Agents (BMA)関連顎骨病変の病態・診断・治療2012

    • Author(s)
      山口 朗
    • Organizer
      第57回日本口腔外科学会総会・学術大会
    • Place of Presentation
      パシフィコ横浜会議センター
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] インプラントをみすえた骨の形態学的解析;骨のリモデリングを中心として2011

    • Author(s)
      山口朗
    • Organizer
      Dentistry, Ouo Vadis?, 特別講演
    • Place of Presentation
      東京
    • Year and Date
      2011-12-10
    • Related Report
      2012 Final Research Report
  • [Presentation] 口腔癌による骨破壊の分子メカニズム、口腔三学会合同シンポジウム「顎骨浸潤を伴う口腔癌の病態・診断・治療」2011

    • Author(s)
      山口朗
    • Organizer
      第56回に本口腔外科学会総会・学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2011-10-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 腔癌による骨破壊の分子メカニズム2011

    • Author(s)
      山口朗
    • Organizer
      第56回日本口腔外科学会総会
    • Place of Presentation
      大阪(シンポジウム)
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] オステオネットワークの構築・維持・破壊2011

    • Author(s)
      山口 朗
    • Organizer
      第41回骨・カルシウム代謝研究会(特別講演)
    • Place of Presentation
      ホテルグランビィア京都
    • Year and Date
      2011-10-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Role of BMP, Notch, and CCN3 in osteoblast differentiation and bone regeneration. Lecture2011

    • Author(s)
      Yamaguchi A
    • Organizer
      International Summer Program 2011
    • Place of Presentation
      Tokyo Medical and Dental University, Tokyo
    • Year and Date
      2011-08-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Histopathological characteristics of bisphosphonate-related osteomyelitis (osteonecrosis) of jaw2011

    • Author(s)
      Akira Yamaguchi
    • Organizer
      5^<th> Meeting of Asian Society of Oral and Maxillofacial Pathology
    • Place of Presentation
      福岡(Keynote Lecture)
    • Year and Date
      2011-08-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Histopathological characteristics of bisphosphonate-related osteomyelitis (osteonecrosis) of jaw. Keynote Lecture2011

    • Author(s)
      Yamaguchi A
    • Organizer
      5th Meeting of Asian Society of Oral and Maxillofacial Pathology
    • Place of Presentation
      Fukuoka
    • Year and Date
      2011-08-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Molecular mechanism of bone destruction by oral cancer2011

    • Author(s)
      Yamaguchi A
    • Organizer
      The Second Chinese National Conference on Oral Maxillofacial Development and Regeneration
    • Place of Presentation
      Wuyishan city, Fujian Province, China
    • Year and Date
      2011-07-29
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 血管石灰化と骨・軟骨関連因子、シンポジウム:CDKにおける異所性石灰化:基礎と臨床2011

    • Author(s)
      山口朗
    • Organizer
      第56回日本透析医学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-06-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 血管石灰化と骨・軟骨関連因子2011

    • Author(s)
      山口朗
    • Organizer
      第56回日本透析医学会学術総会
    • Place of Presentation
      横浜市(シンポジウム)
    • Year and Date
      2011-06-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] ビスフォスフォネート関連顎骨壊死(骨髄炎)の病理学的所見、シンポジウム2011

    • Author(s)
      山口朗
    • Organizer
      第31回日本骨形態計測学会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-05-20
    • Related Report
      2012 Final Research Report
  • [Presentation] ビスフォスフォネート関連顎骨壊死(骨髄炎)の病理学的所見2011

    • Author(s)
      山口朗
    • Organizer
      第31回日本骨形態計測学会
    • Place of Presentation
      岐阜市(シンポジウム)
    • Year and Date
      2011-05-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] 骨再生の分子基盤(シンポジウム:骨の再生医療)2011

    • Author(s)
      山口朗
    • Organizer
      第65回日本口腔科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-04-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 骨再生の分子基盤2011

    • Author(s)
      山口朗
    • Organizer
      第65回日本口腔科学会学術集会
    • Place of Presentation
      東京(シンポジウム)
    • Year and Date
      2011-04-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] ビスホスホネート関連顎骨壊死(骨髄炎)、(シンポジウム:難治性骨髄炎の治療戦略)2011

    • Author(s)
      山口朗
    • Organizer
      第65回日本口腔科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-04-14
    • Related Report
      2012 Final Research Report
  • [Presentation] ビスホスホネート関連顎骨壊死(骨髄炎)2011

    • Author(s)
      山口朗
    • Organizer
      第65回日本口腔科学会学術集会
    • Place of Presentation
      東京(シンポジウム)
    • Year and Date
      2011-04-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Molecular mechanism ofbone destruction by oral squamouscells carcinoma2011

    • Author(s)
      Yamaguchi A
    • Organizer
      The Firstinternational Oral Pathology UpdateSymposium
    • Place of Presentation
      Taipei
    • Year and Date
      2011-03-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 再生医療「骨再生」-そのメ カニズムと応用-2011

    • Author(s)
      山口朗
    • Organizer
      平成22年日本歯科医師会生涯研修セミナー
    • Place of Presentation
      京都
    • Year and Date
      2011-03-06
    • Related Report
      2012 Final Research Report
  • [Presentation] オステオネットワークの維持と破綻:骨再生の分子基盤を中心として2011

    • Author(s)
      山口朗
    • Organizer
      第11回産学連携フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2011-02-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 骨再生のメカニズムと骨再生療法、招待講演、DENTISTRY, QUOVADIS?2010

    • Author(s)
      山口朗
    • Organizer
      東京(野口英世記念会館)
    • Place of Presentation
      東京
    • Year and Date
      2010-12-05
    • Related Report
      2012 Final Research Report
  • [Presentation] 骨再生のメカニズムと骨再生療法2010

    • Author(s)
      山口朗
    • Organizer
      DENTISTRY, QUO VADIS?
    • Place of Presentation
      東京都
    • Year and Date
      2010-12-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨代謝の基礎と骨再生、特別講演2010

    • Author(s)
      山口朗
    • Organizer
      平成22年度日本小児歯科学会秋期大会、郡山市民文化センター
    • Place of Presentation
      郡山
    • Year and Date
      2010-12-02
    • Related Report
      2012 Final Research Report
  • [Presentation] 骨代謝の基礎と骨再生2010

    • Author(s)
      山口朗
    • Organizer
      平成22年度日本小児歯科学会秋期大会
    • Place of Presentation
      郡山市
    • Year and Date
      2010-12-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] オステオネットワークの維持と破綻:顎顔面骨疾患の病態解明を目指して2010

    • Author(s)
      山口朗
    • Organizer
      第58回NPO法人日本口腔科学会中国・四国地方部会
    • Place of Presentation
      広島市 招待講演
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] オステオネットワークの維持と破綻:顎顔面骨疾患の病態解明を目指して、教育講演2010

    • Author(s)
      山口朗
    • Organizer
      第58回 NPO 法人日本口腔科学会中国・四国地方部会
    • Place of Presentation
      広島
    • Year and Date
      2010-11-06
    • Related Report
      2012 Final Research Report
  • [Presentation] 再生医療「骨再生」-そのメカニズムと応用-2010

    • Author(s)
      山口朗
    • Organizer
      平成22年日本歯科医師会生涯研修セミナー
    • Place of Presentation
      岡山
    • Year and Date
      2010-10-31
    • Related Report
      2012 Final Research Report
  • [Presentation] 再生医療「骨再生」-そのメカニズムと応用-2010

    • Author(s)
      山口朗
    • Organizer
      平成22年日本歯科医師会生涯研修セミナー
    • Place of Presentation
      東京
    • Year and Date
      2010-09-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 歯科領域における再生研究の現状:骨・歯の再生を中心に2010

    • Author(s)
      山口朗
    • Organizer
      第24回東京医科歯科大学大学院セミナー
    • Place of Presentation
      東京
    • Year and Date
      2010-07-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 骨形成と血管石灰化の共通点と相違点、シンポジウム「Bone andVascular Calcification」2010

    • Author(s)
      山口朗
    • Organizer
      第28回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 骨形成と血管石灰化の共通点と相違点2010

    • Author(s)
      山口朗
    • Organizer
      第28回日本骨代謝学会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2010-07-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 再生医療「骨再生」-そのメカニズムと応用-2010

    • Author(s)
      山口朗
    • Organizer
      平成22年日本歯科医師会生涯研修セミナー
    • Place of Presentation
      高松
    • Year and Date
      2010-07-04
    • Related Report
      2012 Final Research Report
  • [Presentation] 口腔癌の顎骨浸潤メカニズム2010

    • Author(s)
      山口朗
    • Organizer
      九州歯科大学大学院セミナー
    • Place of Presentation
      小倉
    • Year and Date
      2010-07-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 再生医療「骨再生」-そのメカニズムと応用-2010

    • Author(s)
      山口朗
    • Organizer
      平成22年日本歯科医師会生涯研修セミナー
    • Place of Presentation
      津、三重県
    • Year and Date
      2010-06-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 再生医療「骨再生」-そのメカニズムと応用-2010

    • Author(s)
      山口朗
    • Organizer
      平成22年日本歯科医師会生涯研修セミナー
    • Place of Presentation
      津市
    • Year and Date
      2010-06-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] ビスフォスフォネート関連顎骨壊死(骨髄炎)の病理2010

    • Author(s)
      山口朗
    • Organizer
      市民公開シンポジウム「ビスフォスフォネート系製剤に起因した顎骨骨髄炎・顎骨壊死の現状と対策」、日本学術会議主催、第64回日本口腔科学会学術集会共催
    • Place of Presentation
      札幌
    • Year and Date
      2010-06-25
    • Related Report
      2012 Final Research Report
  • [Presentation] ビスフォスフォネート関連顎骨壊死(骨髄炎)の病理2010

    • Author(s)
      山口朗
    • Organizer
      第64回日本口腔科学会学術集会共催
    • Place of Presentation
      札幌市
    • Year and Date
      2010-06-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 再生医療「骨再生」-そのメ カニズムと応用-2010

    • Author(s)
      山口朗
    • Organizer
      平成22年日本歯科医師会生涯研修セミナー
    • Place of Presentation
      水戸
    • Year and Date
      2010-05-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 再生医療「骨再生」-そのメカニズムと応用-2010

    • Author(s)
      山口朗
    • Organizer
      平成22年日本歯科医師会生涯研修セミナー
    • Place of Presentation
      水戸市
    • Year and Date
      2010-05-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] ビスフォスフォネート関連顎骨壊死の病理2010

    • Author(s)
      山口朗
    • Organizer
      東京都臨床整形外科医会統合研修会(招待講演)
    • Place of Presentation
      東京
    • Year and Date
      2010-05-15
    • Related Report
      2012 Final Research Report
  • [Presentation] ビスフォスフォネート関連顎骨壊死の病理2010

    • Author(s)
      山口朗
    • Organizer
      東京都臨床整形外科医会統合研修会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 蛍光イメージングによる骨細胞の形態・機能分化の計測2010

    • Author(s)
      姫野彰子、仲根綾子、和泉雄一、山口朗、飯村忠浩
    • Organizer
      第30回日本骨形態計測学会
    • Place of Presentation
      米子市
    • Year and Date
      2010-05-14
    • Related Report
      2010 Annual Research Report
  • [Book] IL-62013

    • Author(s)
      山口朗
    • Publisher
      最新の骨粗鬆症学-骨粗鬆症の最新知見-、日本臨床社
    • Related Report
      2012 Final Research Report
  • [Book] BMA(Bone-modifying agents)による顎骨壊死2013

    • Author(s)
      山口朗
    • Publisher
      口腔外科ハンドマニュアル2013、(日本口腔外科学会編)、クインテッセンス出版株式会社
    • Related Report
      2012 Final Research Report
  • [Book] 血管石灰化と骨・軟骨関連因子2012

    • Author(s)
      山口朗
    • Publisher
      変革する透析医学、医薬ジャーナル社
    • Related Report
      2012 Final Research Report
  • [Book] 骨生物医学の新たな潮流;オス テオネットワークの獲得・維持・破綻2012

    • Author(s)
      山口朗
    • Publisher
      口腔と全身の健康、医歯薬出版株式会社
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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