| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Research Abstract |
GABA is a major inhibitory neurotransmitter and is synthesized by glutamate decarboxylases, GAD65 and GAD67. We tried to generate inducible GAD67 knockout mice in order to clarify the role of GAD67 in the CNS. We characterized GAD67-tTA2 mice used for inducible knockout mice, and demonstrated that the GAD67-tTA2 mice were useful for expressing functional probes or fluorescent proteins in a part of GABAergic neurons.
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