| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Research Abstract |
Daily rhythms in diverse activities are governed by transcriptional/translational feedback loops in clock genes. Also, it has been suggested that the circadian dynamics of intracellular signaling messengers such as Ca2+ may be critical both for the cellular physiological activities and gene transcriptional cycles. Based on these, the present study analyzed the clock gene transcriptional rhythms as well as cytosolic H+/Ca2+ in diverse models including Drosophila endocrine oscillators and SCN progenitor cells. The results demonstrated presence of clock gene oscillations but lack of apparent circadian cytosolic Ca2+ waves in these modes. Thus, the present results demonstrate cell-type specific mechanisms for the circadian rhythm generations.
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