Local circuit of a motor areas: For network analysis to theoretical modeling
Project/Area Number |
22300113
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Nerve anatomy/Neuropathology
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Research Institution | Kyoto University |
Principal Investigator |
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
|
Keywords | 神経解剖学 / 運動皮質 / 神経回路網 / 遺伝子工学 / 理論構築 |
Research Abstract |
We examined the local circuit of the motor-associated cerebral cortex morphologically by combining the molecular biological technique, such as transgenic animals and viral vectors, with the intracellular labeling method of sharp electrode and whole cell recording. From the experimental results, we propose that partially overlapping two circuits are embedded in the cerebral cortex:1) thalamic nuclei -> layer 4 -> layer 2/3 -> layer 5 -> subcortical output, or thalamic nuclei -> layer 4 -> layer 2/3 -> other cortical areas;2) thalamic nuclei -> layer 4 -> layer 6 -> thalamic nuclei.The former circuit is likely to be used for the feedforward information processing, and the latter one constitutes a dynamical system which may be associated with the autonomous activity of the corticothalamic loop. In addition to the information processing circuit for the cerebellar inputs in motor-associated areas, the basal ganglia information to layer 1 separately enters the apical dendrites of layer 2/3 and layer 5 pyramidal neurons via motor thalamic nuclei (IZ and VM), and probably prepares the cortical activity for motor control. Finally, the dynamical system may be helpful in keeping the autonomous activity that is required for the motor control system.
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Report
(4 results)
Research Products
(76 results)
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[Journal Article] Differential expression of VGLUT1 or VGLUT2 in the trigeminothalamic or trigeminocerebellar projection neurons in the rat2013
Author(s)
Ge S-N, Li Z-H, Tang J, Ma Y, Hioki H, Zhang T, Lu Y-C, Zhang F-X, Mizuno N, Kaneko T, Liu Y-Y, Lung MSY, Gao G-D,Li J-L
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Journal Title
Brain Structure and Function
Volume: (in press)
Issue: 1
Pages: 211-229
DOI
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Peer Reviewed
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[Journal Article] Visualization of cortical projection neurons with retrograde TET-Off lentiviral vector.2012
Author(s)
Watakabe A, Kato S, Kobayashi K, Takaji M, Nakagami Y, Sadakane O, Ohtsuka M, Hioki H, Kaneko T, Okuno H, Kawashima T, Bito H, Kitamura Y, Yamamori T
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Local connections of excitatory neurons to corticothalamic neurons in the rat barrel cortex.2011
Author(s)
Tanaka YR, Tanaka YH, Konno M,Fujiyama F, Sonomura T, Okamoto-FurutaK, Kameda H, Hioki H, Furuta T,Nakamura KC, Kaneko T
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Journal Title
Journal of Neuroscience
Volume: vol. 31 (no. 50)
Issue: 50
Pages: 18223-28236
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] PKG dynamically modulates TASK1-mediated leak K^+ currents in cholinergic neurons of the basal forebrain.2010
Author(s)
Toyoda H, Saito M, Okazawa M, Hirao K, Sato H, Abe H, Takada K, Funabiki K, Takada M, Kaneko T, Kang Y.
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Journal Title
The Journal of Neuroscience
Volume: 30
Pages: 5677-5689
Related Report
Peer Reviewed
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[Presentation] 運動系視床皮質投射の神経回路2013
Author(s)
倉本恵梨子, 藩世秀, 大野幸, 田中康裕、 雲財知, 古田貴寛, 日置寛之, 中村公一、 藤山文乃, 金子武嗣
Organizer
第118回 日本解剖学会・全国学術集会
Place of Presentation
高松
Related Report
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[Presentation] 皮質視床投射神経細胞への局所回路内興奮性入力2012
Author(s)
田中康裕, 田中康代, 今野美知輝, 藤山文乃, 薗村貴弘, 岡本-古田敬子, 亀田浩司, 日置寛之, 古田貴寛, 中村公一, 金子武嗣
Organizer
第89回日本生理学会大会
Place of Presentation
長野県松本文化会館
Year and Date
2012-03-29
Related Report
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[Presentation] 皮質視床投射神経細胞への局所回路内興奮性入力2012
Author(s)
田中康裕, 田中康代, 今野美知輝, 藤山文乃, 薗村貴弘, 岡本-古田敬子, 亀田浩司, 日置寛之, 古田貴寛, 中村公一, 金子武嗣
Organizer
第117回日本解剖学会・全国学術集会
Place of Presentation
山梨大学甲府キャンパス
Year and Date
2012-03-26
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[Presentation] The loss of mDia, a Rho effector and actin nucleator, disrupts Ephrin-mediated axon guidance, leading to defective left-right limb alternation during locomotion.2012
Author(s)
豊田洋輔 , 篠原亮太, Thumkeo Dean, 上條博史, 西村浩氏, 日置寛之 , 金子武嗣 ,石崎敏政 , 古屋敷智之, 成宮周
Organizer
第35回日本神経科学大会
Place of Presentation
名古屋国際会議場
Related Report
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[Presentation] mDia, a Rho effector and actin nucleator, is critical for growth cone retraction in ephrin-induced axonal repulsion2011
Author(s)
豊田洋輔, 篠原亮太, タムケオディーン, 上條博史, 日置寛之, 金子武嗣, 石崎敏理, 古屋敷智之, 成宮周
Organizer
第54回日本神経化学会
Place of Presentation
瑠璃光,石川県加賀市
Year and Date
2011-09-26
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