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Functional analysis of the BRAG3-Arf6 pathway in the inhibitory synapse

Research Project

Project/Area Number 22300114
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionKitasato University

Principal Investigator

SAKAGAMI Hiroyuki  北里大学, 医学部, 教授 (90261528)

Co-Investigator(Renkei-kenkyūsha) TAMAKI Hideaki  北里大学, 医学部, 講師 (30155246)
HARA Yoshinobu  北里大学, 医学部, 助教 (40558467)
Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Keywords抑制性シナプス / 低分子量GTP結合タンパク質 / シナプス後肥厚部 / 足場タンパク質 / シナプス可塑性 / 低分子量GTP結合蛋白質 / 低分子量G蛋白質 / 細胞骨格 / 神経可塑性 / GABA / グリシン / 樹状突起
Research Abstract

The aim of this study is to provide anatomincal evidence for the BRAG3-Arf6 pathway as a novel regulator of membrane traffic and actin cytoskeleton in the inhibitory synapse. First, we immunohistochemically demonstrated that BRAG3 localizes preferentially at postsynaptic specializations of symmetric synapses. Using yeast two-hybrid and pull down assays, we identified that BRAG3 can interact with utrophin/dystrophin and S-SCAM/MAGI-2, scaffolding proteins that localize at inhibitory synapses. Taken together, these findings suggest that BRAG3 may regulate the membrane traffic and actin cytoskeleton at inhibitory synapses through the interaction with scaffold proteins such as dystrophin and S-SCAM.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (71 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (37 results) (of which Peer Reviewed: 37 results,  Open Access: 1 results) Presentation (30 results) Remarks (4 results)

  • [Journal Article] CaMKII activity is essential for improvement of memory-related behaviors by chronic rivastigmine treatment.2014

    • Author(s)
      Shigeki Moriguchi
    • Journal Title

      J Neurochem.

      Volume: 128(6) Issue: 6 Pages: 927-937

    • DOI

      10.1111/jnc.12510

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] EFA6A, a gunanine nucleotide exchange factor for Arf6, interacts with sorting nexin-1 and regulates neurite outgrowth2014

    • Author(s)
      Fukaya M, Fukushima D, Hara Y, Sakagami H
    • Journal Title

      J. Neurochem

      Volume: 129 Issue: 1 Pages: 21-36

    • DOI

      10.1111/jnc.12524

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endosomal localization of FIP3/Arfophilin-1 and its involvement in dendritic formation of mouse hippocampal neurons2014

    • Author(s)
      Yazaki Y, Hara Y, Tamaki H, Fukaya M, Sakagami H
    • Journal Title

      Brain Res

      Volume: 1557 Pages: 55-65

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endosomal localization of FIP3/Arfophilin-1 and its involvement in dendritic formation of mouse hippocampal neurons.2014

    • Author(s)
      Yazaki Y, Hara Y, Tamaki H, Fukaya M, Sakagami H.
    • Journal Title

      Brain Research

      Volume: 1557 Pages: 55-65

    • DOI

      10.1016/j.brainres.2014.02.018

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct synaptic localization patterns of brefeldin A-resistant guanine nucleotide exchange factors BRAG2 and BRAG3 in the mouse retina2013

    • Author(s)
      Sakagami H, Katsumata O, Hara Y, Tamaki H, Watanabe M, Harvey RJ, Fukaya M
    • Journal Title

      J. Comp. Neurol

      Volume: 521 Issue: 4 Pages: 860-876

    • DOI

      10.1002/cne.23206

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of CaMKIV in neurogenic effect with chronic fluoxetine treatment2013

    • Author(s)
      Song N, Nakagawa S, Izumi T, Toda H, Kato A, Boku S, Inoue T, Sakagami H, Li X, Koyama T
    • Journal Title

      Int J Neuropsychopharmacol

      Volume: 16(4) Issue: 4 Pages: 803-812

    • DOI

      10.1017/s1461145712000570

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] EFA6 activates Arf6 and participates in its targeting to the Flemming body during cytokinesis2013

    • Author(s)
      Ueda T, Hanai A, Takei T, Kubo K, Ohgi M, Sakagami H, Takahashi S, Shin HW, Nakayama K
    • Journal Title

      FEBS Lett

      Volume: 583 Issue: 11 Pages: 1617-1623

    • DOI

      10.1016/j.febslet.2013.03.042

    • NAID

      120005293580

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Type I phosphatidylinositol 4-phosphate 5-kinase γ is required for neuronal migration in the mouse developing cerebral cortex2013

    • Author(s)
      Hara Y, Fukaya M, Tamaki H, Sakagami H
    • Journal Title

      Eur. J. Neurosci

      Volume: 38 Issue: 5 Pages: 2659-2671

    • DOI

      10.1111/ejn.12286

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inducible and Conditional Deletion of Extracellular Signal-regulated Kinase 5 Disrupts Adult Hippocampal Neurogenesis2012

    • Author(s)
      Pan YW, Zou J, Wang W, Sakagami H, Garelick MG, Abel G, Kuo CT, Storm DR, Xia Z
    • Journal Title

      J Biol Chem

      Volume: 287(28) Issue: 28 Pages: 23306-23317

    • DOI

      10.1074/jbc.m112.344762

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pilt is a coiled-coil domain-containing protein that localizes at the trans-Golgi complex and regulates its structure2012

    • Author(s)
      Tamaki H, Sanda M, Katsumata O, Hara Y, Fukaya M, Sakagami H
    • Journal Title

      FEBS Lett

      Volume: 586 Issue: 19 Pages: 3064-3070

    • DOI

      10.1016/j.febslet.2012.07.051

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accumulation of a-synuclein triggered by presynaptic dysfunction2012

    • Author(s)
      Nakata Y, Yasuda T, Fukaya M, Yamamori S, Itakura M, Nihira T, Hayakawa H, Kawanami A, Kataoka M, Nagai M, Sakagami H, Takahashi M, Mizuno Y, Mochizuki H
    • Journal Title

      J. Neurosci

      Volume: 32 Issue: 48 Pages: 17186-17196

    • DOI

      10.1523/jneurosci.2220-12.2012

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calcium/calmodulin-dependent protein kinases in the carotid body : an immunohistochemical study2012

    • Author(s)
      Pokorski M, Sakagami H, Okada Y
    • Journal Title

      Springerplus

      Volume: 1 Issue: 1 Pages: 16-16

    • DOI

      10.1186/2193-1801-1-16

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic Silencing of HOPX Promotes Cancer Progression in Colorectal Cancer2012

    • Author(s)
      Katoh Hiroshi
    • Journal Title

      NEOPLASIA

      Volume: 14 Issue: 7 Pages: 559-559

    • DOI

      10.1593/neo.12330

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thromboxane A(2) receptor signaling promotes liver tissue repair after toxic injury through the enhancement of macrophage recruitment2012

    • Author(s)
      Minamino T, Ito Y, Ohkubo H, Hosono K, Suzuki T, Sato T, Ae T, Shibuya A, Sakagami H, Narumiya S, Koizumi W, Majima M
    • Journal Title

      Toxicol Appl Pharmacol

      Volume: 259(1) Issue: 1 Pages: 104-14

    • DOI

      10.1016/j.taap.2011.12.013

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SynArfGEF is a guanine nucleotide exchange factor for Arf6 and localizes preferentially at post-synaptic specializations of inhibitory synapses2011

    • Author(s)
      Fukaya, M.; Kamata, A.; Hara, Y., et al
    • Journal Title

      Journal of Neurochemistry

      Volume: 116(6) Issue: 6 Pages: 1122-1137

    • DOI

      10.1111/j.1471-4159.2010.07167.x

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential expression of SNAP-25 family proteins in the mouse brain2011

    • Author(s)
      Yamamori S, Itakura M, Sugaya D, Katsumata O, Sakagami H, Takahashi M
    • Journal Title

      J. Comp. Neurol

      Volume: 519 Issue: 5 Pages: 916-932

    • DOI

      10.1002/cne.22558

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Locomotor-related activity of GABAergic interneurons localized in the ventrolateral region in the isolated spinal cord of neonatal mice2011

    • Author(s)
      Nishimaru H, Sakagami H, Kakizaki M, Yanagawa Y
    • Journal Title

      J Neurophysiol

      Volume: 106(4) Issue: 4 Pages: 1782-1792

    • DOI

      10.1152/jn.00385.2011

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microsomal prostaglandin E synthase-1 enhances bone cancer growth and bone cancer-related pain behaviors in mice2011

    • Author(s)
      Isono M, Suzuki T, Hosono K, Hayashi I, Sakagami H, Uematsu S, Akira S, DeClerck YA, Okamoto H, Majima M
    • Journal Title

      Life Sci

      Volume: 88(15-16) Issue: 15-16 Pages: 693-700

    • DOI

      10.1016/j.lfs.2011.02.008

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of prostaglandin E2-EP3/EP4 receptor signaling in the enhancement of lymphangiogenesis during fibroblast growth factor-2-induced granulation formation2011

    • Author(s)
      Hosono K, Suzuki T, Tamaki H, Sakagami H, Hayashi I, Narumiya S, Alitalo K, Majima M
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 31(5) Issue: 5 Pages: 1049-58

    • DOI

      10.1161/atvbaha.110.222356

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vascular endothelial growth factor receptor-1 signalingpromotes liver repair through restoration of liver microvasculature afteracetaminophen hepatotoxicity2011

    • Author(s)
      Kato T, Ito Y, Hosono K, Suzuki T, Tamaki H, Minamino T, Kato S, Sakagami H, Shibuya M, Majima M
    • Journal Title

      Toxicol Sci

      Volume: 120(1) Issue: 1 Pages: 218-29

    • DOI

      10.1093/toxsci/kfq366

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SynArfGEF is a guanine nucleotide exchage factor for Arf6 and localizes preferentially at post-synaptic specialization of inhibitory synapses.2011

    • Author(s)
      Fukaya M, Kamata A, Hara Y, Tamaki H, Katsumata O, Ito N, Takeda S, Hata Y, Suzuki T, Watanabe M, Harvey RJ, Sakagami H.
    • Journal Title

      Journal of Neurochemistry

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Less invasive and less technically demanding decompressive procedure for lumbar spinal stenosis-appropriate for general orthopaedic surgeons?2011

    • Author(s)
      Takaso M, Nakazawa T, Imura T, Fukushima K, Ueno M, Saito W, Shintani R, Sakagami H, et al.
    • Journal Title

      International Orthopaedics

      Volume: 35 Pages: 867-873

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vezatin, a potential target for ADP-ribosylation factor 6, regulates the dendritic formation of hippocampal neurons2010

    • Author(s)
      Sanda M, Ohara N, Kamata A, Hara Y, Tamaki H, Sukegawa J, Yanagisawa T, Fukunaga K, Kondo H, Sakagami H
    • Journal Title

      Neurosci. Res

      Volume: 67(2) Issue: 2 Pages: 126-136

    • DOI

      10.1016/j.neures.2010.02.008

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive behavioral analysis of calcium/calmodulin-dependent protein kinase IV knockout mice2010

    • Author(s)
      Takao K, Tanda K, Nakamura K, Kasahara J, Nakao K, Katsuki M, Nakanishi K, Yamasaki N, Toyama K, Adachi M, Umeda M, Araki T, Fukunaga K, Kondo H, Sakagami H, Miyakawa T
    • Journal Title

      PLoS ONE

      Volume: Vol.5, No.3 Issue: 3 Pages: e9460-e9460

    • DOI

      10.1371/journal.pone.0009460

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] USP9x-mediated deubiquitination of EFA6 regulates de novo tight junction assembly2010

    • Author(s)
      Théard D, Labarrade F, Partisani M, Milanini J, Sakagami H, Fon EA, Wood SA, Franco M, Luton F
    • Journal Title

      EMBO J

      Volume: 29 Issue: 9 Pages: 1499-1509

    • DOI

      10.1038/emboj.2010.46

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of the serum response factor coactivator megakaryoblastic leukemia (MKL) in the activin-regulated dendritic complexity of rat cortical neurons2010

    • Author(s)
      Ishikawa M, Nishijima N, Shiota J, Sakagami H, Tsuchida K, Mizukoshi M, Fukuchi M, Tsuda M, Tabuchi A
    • Journal Title

      J Biol Chem

      Volume: 285 Issue: 43 Pages: 32734-32743

    • DOI

      10.1074/jbc.m110.118745

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of PRG-1 as a neuronal calmodulin-binding protein2010

    • Author(s)
      Tokumitsu H, Hatano N, Tsuchiya M, Yurimoto S, Fujimoto T, Ohara N, Kobayashi R, Sakagami H
    • Journal Title

      Biochem J

      Volume: 43 Issue: 1 Pages: 81-91

    • DOI

      10.1042/bj20100637

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vezatin, a potential target for ADP-ribosylation factor 6, regulates the dendritic formation of hippocampal neurons.2010

    • Author(s)
      Sanda M, Ohara N, Kamata A, Hara Y, Tamaki H, Sukegawa J, Yanagisawa T, Fukunaga K, Kondo H, Sakagami H.
    • Journal Title

      Neurosci.Research

      Volume: 67 Pages: 126-136

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive behavioral analysis of calcium/calmodulin-dependent protein kinase IV knockout mice.2010

    • Author(s)
      Takao K, Tanda K, Nakamura K, Kasahara J, Nakao K, Katsuki M, Nakanishi K, Yamasaki N, Toyama K, Adachi M, Umeda M, Araki T, Fukunaga K, Kondo H, Sakagami H, Miyakawa T.
    • Journal Title

      PLoS ONE

      Volume: 5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] USP9x-mediated deubiquitination of EFA6 regulates de novo tight junction assembly.2010

    • Author(s)
      Theard D, Labarrade F, Partisani M, Milanini J, Sakagami H, et al.
    • Journal Title

      EMBO Journal

      Volume: 29 Pages: 1499-1509

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of the serum response factor coactivator megakaryoblastic leukemia (MKL) in the activin-regulated dendritic complexity of rat cortical neurons.2010

    • Author(s)
      Ishikawa M, Nishijima N, Shiota J, Sakagami H, et al.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 285 Pages: 32734-32743

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of PRG-1 as a neuronal calmodulin-binding protein.2010

    • Author(s)
      Tokumitsu H, Hatano N, Tsuchiya M, Yurimoto S, Fujimoto T, Ohara N, Kobayashi R, Sakagami H.
    • Journal Title

      Biochem Journal

      Volume: 43 Pages: 81-91

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress in mature rat testis and its developmental changes2010

    • Author(s)
      Sakai Y, Aminaka M, Takata A, Kudou Y, Yamauchi H, Aizawa Y, Sakagami H.
    • Journal Title

      Dev.Growth Differ.

      Volume: 52 Pages: 657-663

    • NAID

      10027566227

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of erythropoietin on angiogenesis with the increased adhesion of platelets to the microvessels in the hind-limb ischemia model in mice.2010

    • Author(s)
      Kato S, Amano H, Ito Y, Eshima K, Aoyama N, Tamaki H, Sakagami H, et al.
    • Journal Title

      J Pharmacol Sci.

      Volume: 112 Pages: 167-175

    • NAID

      10029888784

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] COX-2 and Prostaglandin EP3/EP4 Signaling Regulate the Tumor Stromal Proangiogenic Microenvironment via CXCL12-CXCR4 Chemokine Systems.2010

    • Author(s)
      Katoh H, Hosono K, Ito Y, Suzuki T, Ogawa Y, Kubo H, Kamata H, Mishima T, Tamaki H, Sakagami H, et al.
    • Journal Title

      American Journal of Pathology

      Volume: 176 Pages: 1469-1483

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Host prostaglandin EP3 receptor signaling relevant to tumor-associated lymphangiogenesis.2010

    • Author(s)
      Kubo H, Hosono K, Suzuki T, Ogawa Y, Kato H, Kamata H, Ito Y, Amano H, Kato T, Sakagami H, et.al.
    • Journal Title

      Biomed Pharmacotherapy

      Volume: 64 Pages: 101-106

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Surgical management of severe scoliosis with high risk pulmonary dysfunction in Duchene muscular dystrophy : patient function, quality of life and satisfaction.2010

    • Author(s)
      Takaso M, Nakazawa T, Imura T, Okada T, Fukushima K, Ueno M, Takahira N, Takahashi K, Yamazaki M, Ohtori S, Okamoto H, Okutomi T, Okamato M, Masaki T, Uchinuma E, Sakagami H
    • Journal Title

      International Orthopaedics

      Volume: 34 Pages: 695-702

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 脳層形成における低分子量GTP 結合タンパク質Arf6の機能的役割2014

    • Author(s)
      原芳伸、深谷昌弘、阪上洋行
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      自治医大
    • Year and Date
      2014-03-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 海馬錐体細胞の棘突起内部における低分子量Gタンパク質Arf6 のペリシナプス性局在2014

    • Author(s)
      深谷昌弘、阪上洋行
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      自治医大
    • Year and Date
      2014-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] シナプス局在からみたArf6グアニンヌクレオチド交換因子の分子多様性の機能的意義2013

    • Author(s)
      阪上洋行
    • Organizer
      第86回日本生化学大会
    • Place of Presentation
      横浜
    • Year and Date
      2013-09-13
    • Related Report
      2013 Final Research Report
  • [Presentation] スパインにおけるArf6 活性化制御因子EFA6Aとsorting nexin-1との相互作用2013

    • Author(s)
      阪上洋行、福島大輔、深谷昌弘
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都
    • Year and Date
      2013-06-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Expression and functional roles of phosphatidylinositol 4-phosphate 5-kinase (PIP5K) γ in the developing cerebral cortex.2013

    • Author(s)
      原 芳伸
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      香川
    • Related Report
      2012 Annual Research Report
  • [Presentation] Splice variant-dependent subcellular localization of the Arf6 activator BRAG2 in the adult mouse brain2013

    • Author(s)
      深谷 昌弘
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      香川
    • Related Report
      2012 Annual Research Report
  • [Presentation] Arf6の下流効果分子Rab11-FIP3/Arfophilin-1の神経細胞の樹状突起における役割2013

    • Author(s)
      矢崎 佑紀
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      香川
    • Related Report
      2012 Annual Research Report
  • [Presentation] Expression and functional roles of phosphatidylinositol 4-phosphate 5-kinase (PIP5K) γ in the developing cerebral cortex2012

    • Author(s)
      原芳伸、阪上洋行
    • Organizer
      欧州神経科学会
    • Place of Presentation
      バルセロナ
    • Year and Date
      2012-07-15
    • Related Report
      2013 Final Research Report
  • [Presentation] DISTINCT LOCALIZATION OF THE BRAG/IQSEC FAMILY OF GUANINE NUCLEOTIDE EXCHANGE FACTORS FOR ARF6 IN THE MOUSE RETINA2012

    • Author(s)
      阪上洋行、原芳伸、深谷昌弘
    • Organizer
      欧州神経科学会議
    • Place of Presentation
      バルセロナ
    • Year and Date
      2012-07-15
    • Related Report
      2013 Final Research Report
  • [Presentation] 成熟マウス脳におけるArf6活性化制御因子EFA6Aの細胞内局在解析2012

    • Author(s)
      福島大輔、深谷昌弘、阪上洋行
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨大学(山梨県)
    • Year and Date
      2012-03-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 成体マウス脳におけるARF6活性化因子BRAG2/IQSEC1の細胞内局在解析2012

    • Author(s)
      深谷昌弘、原芳伸、阪上洋行
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨大学(山梨県)
    • Year and Date
      2012-03-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 大脳皮質層形成におけるホスファチジルイノシトール4-リン酸5キナーゼの機能解析2012

    • Author(s)
      原芳伸、阪上洋行
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨大学(山梨県)
    • Year and Date
      2012-03-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] マウス小脳プルキンエ細胞の生後発生過程におけるゴルジ装置の動態2012

    • Author(s)
      玉木英明、阪上洋行
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨大学(山梨県)
    • Year and Date
      2012-03-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Expression and functional roles of phosphatidylinositol 4-phosphate 5-kinase (PIP5K) γ in the developing cerebral cortex.2012

    • Author(s)
      原 芳伸
    • Organizer
      第8回欧州神経科学大会(FENS2012)
    • Place of Presentation
      バルセロナ、スペイン
    • Related Report
      2012 Annual Research Report
  • [Presentation] DISTINCT LOCALIZATION OF THE BRAG/IQSEC FAMILY OF GUANINE NUCLEOTIDE EXCHANGE FACTORS FOR ARF6 IN THE MOUSE RETINA2012

    • Author(s)
      阪上 洋行
    • Organizer
      第8回欧州神経科学大会(FENS2012)
    • Place of Presentation
      バルセロナ、スペイン
    • Related Report
      2012 Annual Research Report
  • [Presentation] ARF6活性制御因子BRAG2/IQSEC1のスプライスバリアント依存的なシナプス局在2012

    • Author(s)
      深谷 昌弘
    • Organizer
      第35回日本神経科学会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] 成熟マウス脳におけるEFA6Aとおよびその結合分子SNX1の細胞内局在解析2012

    • Author(s)
      福島 大輔
    • Organizer
      第35回日本神経科学会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] 大脳皮質形成におけるホスファチジルイノシトール4-リン酸5キナーゼの機能解析2011

    • Author(s)
      原芳伸、西村伸彦、深谷昌弘、玉木英明、阪上洋行
    • Organizer
      第99回日本解剖学関東支部学術集会
    • Place of Presentation
      日本大学松戸歯学部(千葉県)
    • Year and Date
      2011-10-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 中枢神経系におけるARF6活性化制御因子EFA6Aの細胞内局在解析2011

    • Author(s)
      福島大輔、深谷昌弘、阪上洋行
    • Organizer
      第99回日本解剖学関東支部学術集会
    • Place of Presentation
      日本大学松戸歯学部(千葉県)
    • Year and Date
      2011-10-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 成熟期マウス脳におけるBRAG2/GEP100の細胞内局在解析2011

    • Author(s)
      深谷昌弘、原芳伸、阪上洋行
    • Organizer
      第34回日本神経科学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 大脳皮質層形成におけるPIP5Kgammaの発現機能解析2011

    • Author(s)
      原芳伸、西村伸彦、阪上洋行
    • Organizer
      第34回日本神経科学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 低分子量G蛋白質ARF6特異的グアニンヌクレオチド交換因子GEP100/BRAG2の神経系における発現と樹状突起形成への機能関与2010

    • Author(s)
      阪上洋行、小原直樹
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター、神戸市、兵庫県
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] スパインにおけるArf6活性化制御因子EFA6Aとsorting nexin-1との相互作用

    • Author(s)
      阪上洋行、福島大輔、深谷昌弘
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] Arf6活性調節因子BRAG2/OQSEC1のスプライスバリアント依存的なシナプス局在

    • Author(s)
      深谷昌弘、阪上洋行
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] Phosphatidylinositol 4-phosphate kinase 5g は大脳皮質層形成において神経細胞の移動を制御する

    • Author(s)
      原芳伸、深谷昌弘、阪上洋行
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] 阪上 洋行

    • Author(s)
      シナプス局在からみたArf6グアニンヌクレオチド交換因子の分子多様性の機能的意義
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Arf6活性化因子EFA6Dのマウス脳における局在解析

    • Author(s)
      太田慎吾、深谷昌弘、阪上洋行
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      自治医科大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 海馬錐体細胞の棘突起内部における低分子量Gタンパク質Arf6のペリシナプス性局在

    • Author(s)
      深谷昌弘、阪上洋行
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      自治医科大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脳層形成における低分子量GTP結合タンパク質Arf6の機能的役割

    • Author(s)
      原芳伸、阪上洋行
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      自治医科大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] Piltはゴルジ装置に局在し構造維持に関与する

    • Author(s)
      阪上洋行、勝又修、玉木英明
    • Organizer
      第116回日本解剖学会総会
    • Place of Presentation
      (東北地方太平洋沖地震によりJournal of Physiological Sciences誌による誌上開催)
    • Related Report
      2010 Annual Research Report
  • [Remarks] 北里大学医学部解剖学(阪上)単位ホームページ

    • URL

      http://www.med.kitasato-u.ac.jp/~sakagami/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 北里大学医学部解剖学(阪上)単位ホームページ

    • URL

      http://www.med.kitasato-u.ac.jp/~sakagami

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.kitasato-u.ac.jp/~sakagami/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.kitasato-u.ac.jp/~sakagami/

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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