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Molecular mechanisms of spinal neuro-glial interaction involving neuropathic pain

Research Project

Project/Area Number 22300115
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionHyogo Medical University

Principal Investigator

NOGUCHI Koichi  兵庫医科大学, 医学部, 教授 (10212127)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Keywords神経障害性疼痛 / 脊髄 / ATP受容体 / 脂質メディエーター / マイクログリア / 後根神経節 / PAF受容体 / 疼痛 / 侵害受容性疼痛 / 脊髄ニューロン / ロイコトルエン受容体 / 疼痛行動 / 脊髄後角
Research Abstract

In order to examine the novel mechanism of neuropathic pain, especially interaction between spinal glial cells and neurons, we have used the rat model of neuropathic pain and explored the expression and the role of several molecules in nociceptive pathway. As a result, we have found several new findings and hypotheses about ATP receptors and lipid mediators in dorsal root ganglion neurons, spinal dorsal horn neurons and spinal glial cells. These results were published in international high-level journals.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (42 results)

All 2013 2012 2011 2010

All Journal Article (24 results) (of which Peer Reviewed: 24 results) Presentation (17 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] Activation of p38 MAPK through transient receptor potential A1 in a rat model of gastric distention-induced visceral pain.2013

    • Author(s)
      Kondo T, Sakurai J, Miwa H, Noguchi K.
    • Journal Title

      Neuroreport

      Volume: 24 Pages: 68-72

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] COX-1-dependent prostaglandin D2 in microglia contributes to neuropathic pain via DP2 receptor in spinal neurons.2013

    • Author(s)
      Kanda H, Kobayashi K, Yamanaka H, Noguchi K.
    • Journal Title

      Glia

      Volume: 61 Pages: 943-56

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of TRP channels by resveratrol and other stilbenoids.2013

    • Author(s)
      Yu L, Wang S, Kogure Y, Yamamoto S, Noguchi K, Dai Y.
    • Journal Title

      Mol Pain

      Volume: 9 Pages: 3-3

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of Ezrin/Radixin/Moesin(ERM) protein in spinal microglia following peripheral nerve injury and lysophosphatidic acid administration.2012

    • Author(s)
      Kashimoto R, Yamanaka H, Kobayashi K, Okubo M, Yagi H, Mimura O, Noguchi K.
    • Journal Title

      Glia

      Volume: 61 Issue: 3 Pages: 338-48

    • DOI

      10.1002/glia.22436

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased expression of interleukin-18 in the trigeminalspinal subnucleus caudalis after inferior alveolar nerve injury in the rat.2012

    • Author(s)
      Daigo E, Sakuma Y, Miyoshi K, Noguchi K, Kotani J.
    • Journal Title

      Neurosci Lett

      Volume: 529 Issue: 1 Pages: 39-44

    • DOI

      10.1016/j.neulet.2012.09.007

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] An ultrastructural evidence for the expression of transient receptor potential ankyrin 1 (TRPA1) in astrocytes in the rat trigeminal caudal nucleus2012

    • Author(s)
      Lee SM, Cho YS, Kim TH, Jin MU, Ahn DK, Noguchi K, Bae YC.
    • Journal Title

      J Chem Neuroanat

      Volume: 45 Issue: 1-2 Pages: 45-9

    • DOI

      10.1016/j.jchemneu.2012.07.003

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Noguchi K. Multiple P2Y subtypes in spinal microglia are involved in neuropathic pain after peripheral nerve injury.2012

    • Author(s)
      Kobayashi K, Yamanaka H, Yanamoto F, Okubo M
    • Journal Title

      Glia

      Volume: 60 Issue: 10 Pages: 1529-39

    • DOI

      10.1002/glia.22373

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potentiation of the P2X3 ATP receptor by PAR-2 in rat DRG neurons, through protein kinase-dependent mechanisms, contributes to inflammatory pain.2012

    • Author(s)
      Wang S, Dai Y, Kobayashi K, Zhu W, Kogure Y, Yamanaka H, Wan Y, Zhang W, Noguchi K.
    • Journal Title

      Eur J Neurosci

      Volume: 36 Pages: 2293-301

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulation of platelet-activating factor synthases and its receptor in spinal cord contribute to development of neuropathic pain following peripheral nerve injury.2012

    • Author(s)
      Okubo M, Yamanaka H, Kobayashi K, Kanda H, Dai Y, Noguchi K.
    • Journal Title

      Mol Pain

      Volume: 8 Pages: 8-8

    • DOI

      10.1186/1744-8069-8-8

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Re-evaluation of the phenotypic changes in L4 dorsal root ganglion neurons after L5 spinal nerve ligation2012

    • Author(s)
      Fukuoka T, Yamanaka H, Kobayashi K, Okubo M, Miyoshi K, Dai Y, Noguchi K
    • Journal Title

      Pain

      Volume: 153 Issue: 1 Pages: 68-79

    • DOI

      10.1016/j.pain.2011.09.009

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potentiation of the P2X3 ATP receptor by PAR-2 in rat DRG neurons, through protein kinase-dependent mechanisms, contributes to inflammatory pain2012

    • Author(s)
      Wang S, Dai Y, Kobayashi K, Zhu W, Kogure Y, Yamanaka H, Wan Y, Zhang W, Noguchi K.
    • Journal Title

      Eur J Neurosci

      Volume: 36 Issue: 3 Pages: 2293-301

    • DOI

      10.1111/j.1460-9568.2012.08142.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increase of close homolog of cell adhesion molecule L1 in primary afferent by nerve injury and the contribution to neuropathic pain2011

    • Author(s)
      Yamanaka H, Kobayashi K, Okubo M, Fukuoka T, Noguchi K.
    • Journal Title

      Journal of Comparative Neurology

      Volume: 519 Issue: 8 Pages: 1597-615

    • DOI

      10.1002/cne.22588

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative study of voltage-gated sodium channel alpha-subunits in non-overlapping four neuronal populations in the rat dorsal root ganglion2011

    • Author(s)
      Fukuoka T, Noguchi K.
    • Journal Title

      Neuroscience Research

      Volume: 70 Issue: 2 Pages: 164-171

    • DOI

      10.1016/j.neures.2011.01.020

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of TRPA1 channel activity in sensory neurons by the glial cell line-derived neurotrophic factor family member, artemin.2011

    • Author(s)
      Yoshida N, Kobayashi K, Yu L, Wang S, Na R, Yamamoto S, Noguchi K, Dai Y.
    • Journal Title

      Mol Pain

      Volume: 7 Pages: 41-41

    • DOI

      10.1186/1744-8069-7-41

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of the P2X7 receptor in spinal microglia in a neuropathic painmodel.2011

    • Author(s)
      Kobayashi K, Takahashi E, Miyagawa Y, Yamanaka H, Noguchi K.
    • Journal Title

      Neurosci Lett

      Volume: 504 Issue: 1 Pages: 57-61

    • DOI

      10.1016/j.neulet.2011.08.058

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Leukotrienes in Nociceptive Pathway and Neuropathic/Inflammatory Pain2011

    • Author(s)
      Noguchi K, Okubo M.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 34 Issue: 8 Pages: 1163-1169

    • DOI

      10.1248/bpb.34.1163

    • NAID

      130000936581

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative study of voltage-gated sodium Channel α-subunits in non-overlapping four neuronal populations in the rat dorsal root ganglion2011

    • Author(s)
      Fukuoka T., et. al.
    • Journal Title

      Neurosci.Res.

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Leukotriene synthases and the receptors induced by peripheral nerve injury in the spinal cord contribute to the generation of neuropathic pain.2010

    • Author(s)
      Okubo M, Yamanaka H, Kobayashi K, Noguchi K.
    • Journal Title

      Glia

      Volume: 58 Issue: 5 Pages: 599-610

    • DOI

      10.1002/glia.20948

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of transient receptor potential ankyrin 1(TRPA1) in the rat trigeminal sensory afferents and spinal dorsal horn.2010

    • Author(s)
      Kim YS, Son JY, Kim TH, Paik SK, Dai Y, Noguchi K, Ahn DK, Bae YC.
    • Journal Title

      J Comp Neurol

      Volume: 518 Issue: 5 Pages: 687-98

    • DOI

      10.1002/cne.22238

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Noguchi K.Laminae-specific distribution of alpha-subunits of voltage-gated sodium channels in the adult rat spinal cord.2010

    • Author(s)
      Fukuoka T, Kobayashi K
    • Journal Title

      Neuroscience

      Volume: 169 Issue: 3 Pages: 994-1006

    • DOI

      10.1016/j.neuroscience.2010.05.058

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of transient receptor potential A1 in gastric nociception.2010

    • Author(s)
      Kondo T, Oshima T, Obata K, Sakurai J, Knowles CH, Matshmoto T, Noguchi K, Miwa H.
    • Journal Title

      Digestion

      Volume: 82 Issue: 3 Pages: 150-155

    • DOI

      10.1159/000310836

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Leukotriene synthases and the receptors induced by peripheral nerve injury in the spinal cord contribute to the generation of neuropathic pain2010

    • Author(s)
      Okubo M., et. al.
    • Journal Title

      Glia

      Volume: 58 Pages: 599-610

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of transient receptor potential ankyrin 1(TRPA1)in the rat trigeminal sensory afferents and spinal dorsal horn2010

    • Author(s)
      Kim YS., et. al.
    • Journal Title

      J Comp Neurol

      Volume: 518 Pages: 687-98

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Laminae-specific distribution of alpha-subunits of voltage-gated sodium channels in the adult rat spinal cord2010

    • Author(s)
      Fukuoka T., et. al.
    • Journal Title

      Neuroscience

      Volume: 169 Pages: 994-1006

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 神経障害性疼痛の動物モデルと遺伝子発現2012

    • Author(s)
      野口光一.
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-10-27
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 神経障害性疼痛の分子メカニズム.2012

    • Author(s)
      野口光一.
    • Organizer
      第21回日本末梢神経学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2012-09-04
    • Related Report
      2012 Final Research Report
  • [Presentation] Leukotriene synthases and the receptors in nociceptive pathway contribute to the neuropathic and inflammatory pain.2012

    • Author(s)
      Noguchi K.
    • Organizer
      14th World Cogress on Pain (IASP2012)
    • Place of Presentation
      Milan Italy
    • Year and Date
      2012-08-31
    • Related Report
      2012 Final Research Report
  • [Presentation] 痛み研究の目指すところ:今後の研究の方向性について2012

    • Author(s)
      野口光一
    • Organizer
      日本ペインクリニック学会第46回大会
    • Place of Presentation
      出雲
    • Year and Date
      2012-07-06
    • Related Report
      2012 Final Research Report
  • [Presentation] 痛みの科学神経障害性疼痛のメカニズムと神経可塑性(共催セミナー)2012

    • Author(s)
      野口光一.
    • Organizer
      日本ペインクリニック学会第46回大会
    • Place of Presentation
      出雲
    • Year and Date
      2012-07-05
    • Related Report
      2012 Final Research Report
  • [Presentation] Leukotriene synthases and the receptors in nociceptive pathway contribute to the neuropathic and inflammatory pain2012

    • Author(s)
      Noguchi K.
    • Organizer
      14th World Cogress on Pain (IASP 2012)
    • Place of Presentation
      Milan/Italy
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 痛みの科学―神経障害性疼痛のメカニズムと神経可塑性―2012

    • Author(s)
      野口光一
    • Organizer
      日本ペインクリニック学会第46回大会
    • Place of Presentation
      出雲
    • Related Report
      2012 Annual Research Report
  • [Presentation] 痛み研究の目指すところ:今後の研究の方向性について2012

    • Author(s)
      野口光一
    • Organizer
      日本ペインクリニック学会第46回大会
    • Place of Presentation
      出雲
    • Related Report
      2012 Annual Research Report
  • [Presentation] Detailed analysis of gene expression in primary afferent neurons in a rat model of neuropathic pain.2011

    • Author(s)
      Noguchi K.
    • Organizer
      The 9th IASP Research Symposium
    • Place of Presentation
      Shanghai China
    • Year and Date
      2011-10-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Detailed analysis of gene expression in primary afferent neurons in a rat model of neuropathic pain2011

    • Author(s)
      Noguchi K.
    • Organizer
      The 9th IASP Research Symposium
    • Place of Presentation
      Shanghai(招待講演)
    • Year and Date
      2011-10-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] The role of leukotrienes in spinal cord and DRG in pain mechanism2011

    • Author(s)
      Noguchi K.
    • Organizer
      The 4th Asian Pain Symposium
    • Place of Presentation
      Shanghai(招待講演)
    • Year and Date
      2011-05-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 痛みの分子メカニズム.2010

    • Author(s)
      野口光一.
    • Organizer
      第37回日本マイクロサージャリー学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-11-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 神経障害性疼痛の分子メカニズム2010

    • Author(s)
      野口光一
    • Organizer
      第21回日本末梢神経学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] IL-18-mediated microglia/astrocyte interaction contributes to neuropathic pain.2010

    • Author(s)
      Noguchi K.
    • Organizer
      (Symposium) 13th World Congress on Pain (IASP)
    • Place of Presentation
      Montreal Canada
    • Year and Date
      2010-08-31
    • Related Report
      2012 Final Research Report
  • [Presentation] IL-18-mediated microglia/astrocyte interaction contributes to neuropathic pain2010

    • Author(s)
      Noguchi K.
    • Organizer
      13th World Congress on Pain (IASP)
    • Place of Presentation
      Montreal
    • Year and Date
      2010-08-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] 炎症性疼痛の分子メカニズム2010

    • Author(s)
      野口光一
    • Organizer
      第20回大阪リウマチカンファレンス
    • Place of Presentation
      大阪
    • Year and Date
      2010-08-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 神経傷害性疼痛の分子メカニズム2010

    • Author(s)
      野口光一
    • Organizer
      第39回日本脊椎脊髄病学会教育研修講演
    • Place of Presentation
      高知
    • Year and Date
      2010-04-22
    • Related Report
      2010 Annual Research Report
  • [Book] 運動器の痛みの慢性化のメカニズム.山下敏彦編.運動器のペインマネジメント2011

    • Author(s)
      野口光一
    • Publisher
      中山書店
    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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