Molecular mechanisms of spinal neuro-glial interaction involving neuropathic pain
Project/Area Number |
22300115
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Nerve anatomy/Neuropathology
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Research Institution | Hyogo Medical University |
Principal Investigator |
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
|
Keywords | 神経障害性疼痛 / 脊髄 / ATP受容体 / 脂質メディエーター / マイクログリア / 後根神経節 / PAF受容体 / 疼痛 / 侵害受容性疼痛 / 脊髄ニューロン / ロイコトルエン受容体 / 疼痛行動 / 脊髄後角 |
Research Abstract |
In order to examine the novel mechanism of neuropathic pain, especially interaction between spinal glial cells and neurons, we have used the rat model of neuropathic pain and explored the expression and the role of several molecules in nociceptive pathway. As a result, we have found several new findings and hypotheses about ATP receptors and lipid mediators in dorsal root ganglion neurons, spinal dorsal horn neurons and spinal glial cells. These results were published in international high-level journals.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Potentiation of the P2X3 ATP receptor by PAR-2 in rat DRG neurons, through protein kinase-dependent mechanisms, contributes to inflammatory pain.2012
Author(s)
Wang S, Dai Y, Kobayashi K, Zhu W, Kogure Y, Yamanaka H, Wan Y, Zhang W, Noguchi K.
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Journal Title
Eur J Neurosci
Volume: 36
Pages: 2293-301
Related Report
Peer Reviewed
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[Journal Article] Potentiation of the P2X3 ATP receptor by PAR-2 in rat DRG neurons, through protein kinase-dependent mechanisms, contributes to inflammatory pain2012
Author(s)
Wang S, Dai Y, Kobayashi K, Zhu W, Kogure Y, Yamanaka H, Wan Y, Zhang W, Noguchi K.
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Journal Title
Eur J Neurosci
Volume: 36
Issue: 3
Pages: 2293-301
DOI
Related Report
Peer Reviewed
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