Association of life-style related risk factors with the pathology of dementia

• Project/Area Number: 22300116
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Kyushu University
• Principal Investigator: IWAKI Toru 九州大学, 医学研究院, 教授 (40221098)
• Research Collaborator: KIYOHARA Yutaka 九州大学, 大学院医学研究院, 教授 (80161602) ; SASAKI Kensuke 九州大学, 大学院医学研究院, 助教 (80380616)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
• Keywords: 老化性痴呆疾患 / 認知症 / アルツハイマー病 / 耐糖能異常 / インスリン抵抗性 / 脂質代謝異常 / 老人斑 / 脳血管性認知症 / 病理解剖 / 神経原線維変化 / タウ蛋白質 / 数理解析ソフト / 生活習慣病 / コレステロール / 糖尿病

Research Abstract

The epidemiological studies indicate that the prevalence of Alzheimer disease is increasing at an accelerating pace in parallel with an increase of metabolic disorders. We reported that insulin resistance is associated with the plaque-type pathology of Alzheimer disease. Next, we have shown that dyslipidemia may also be an independent risk factor for neuritic plaque formation.

Research Products

• [Journal Article] Protease-resistant PrP and PrP oligomers in the brain in human prion diseases after intraventricular pentosan polysulfate infusion (2012)
  • Author(s): Honda H, Sasaki K, Minaki H, Masui K, Suzuki SO, Doh-Ura K, Iwaki T
  • Journal Title: Neuropathology Volume: 32 Issue: 2 Pages: 124-132
  • DOI: 10.1111/j.1440-1789.2011.01245.x
  • Peer Reviewed
• [Journal Article] Autosomal dominant tauopathy with parkinsonism and central hypoventilation (2012)
  • Author(s): Omoto M, Suzuki SO, Ikeuchi T, Ishihara T, Kobayashi T, Tsuboi Y, Ogasawara J, Koga M, Kawai M, Iwaki T, Kanda T
  • Journal Title: Neurology Volume: 78 Issue: 10 Pages: 762-764
  • DOI: 10.1212/wnl.0b013e318248e531
  • Peer Reviewed
• [Journal Article] Extensive distribution of glialcytoplasmic inclusions in an autopsied case of multiple system atrophy with prolonged 18 years clinical course (2012)
  • Author(s): Masui K, Nakata Y, Fujii N, Iwaki T
  • Journal Title: Neuropathology Volume: 32 Issue: 1 Pages: 69-76
  • DOI: 10.1111/j.1440-1789.2011.01222.x
  • Peer Reviewed
• [Journal Article] Alzheimer病危険因子としての耐糖能異常. (2012)
  • Author(s): 岩城 徹
  • Journal Title: 医学のあゆみ Volume: 242 Pages: 604-605
• [Journal Article] Association of Alzheimer disease pathology with abnormal lipid metabolism : the Hisayama Study (2011)
  • Author(s): Matsuzaki, T., et.al.
  • Journal Title: Neurology Volume: 77(11) Issue: 11 Pages: 1068-75
  • DOI: 10.1212/wnl.0b013e31822e145d
  • Peer Reviewed
• [Journal Article] Glucose tolerance status and risk of dementia in the community : the Hisayama Study (2011)
  • Author(s): Ohara, T., et.al.
  • Journal Title: Neurology Volume: 77(12) Issue: 12 Pages: 1126-34
  • DOI: 10.1212/wnl.0b013e31822f0435
  • Peer Reviewed
• [Journal Article] Midlife and late-life blood pressure and dementia in Japanese elderly : the Hisayama study (2011)
  • Author(s): Ninomiya T, et al
  • Journal Title: Hypertension Volume: 58 Issue: 1 Pages: 22-28
  • DOI: 10.1161/hypertensionaha.110.163055
  • Peer Reviewed
• [Journal Article] Apolipoprotein genotype for prediction of Alzheimer's disease in older Japanese : the Hisayama Study (2011)
  • Author(s): Ohara, T., et.al.
  • Journal Title: J Am Geriatr Soc Volume: 59(6) Issue: 6 Pages: 1074-9
  • DOI: 10.1111/j.1532-5415.2011.03405.x
  • Peer Reviewed
• [Journal Article] Insulin resistance is associated with the pathology of Alzheimer's disease : the Hisayama Study (2010)
  • Author(s): Matsuzaki T, et al.
  • Journal Title: Neurology Volume: 75 Pages: 764-770
  • Peer Reviewed
• [Journal Article] Trends in prevalence of Alzheimer's disease and vascular dementia in a Japanese community : the Hisayama study (2010)
  • Author(s): Sekita A, et al.
  • Journal Title: Acta Psychiatr.Scand. Volume: 122 Pages: 319-325
  • Peer Reviewed
• [Presentation] アルツハイマー病脳におけるc-Metの発現変化 (2012)
  • Author(s): 濱崎英臣
  • Organizer: 第35回日本分子生物学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-11
• [Presentation] Computational morphological analyses of abnormal tau deposits in human brains (2012)
  • Author(s): Honda H
  • Organizer: Neuroscience 2012
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2012-10-14
• [Presentation] V180I CJDの剖検例における特異なプリオン蛋白沈着パターン (2012)
  • Author(s): 本田裕之
  • Organizer: 第53回日本神経病理学会
  • Place of Presentation: 新潟
  • Year and Date: 2012-06-30
• [Presentation] 左脳優位の萎縮を示し、皮質基底核症候群を呈した Alzheimer 病の剖検例 (2012)
  • Author(s): 若宮富浩
  • Organizer: 第53回日本神経病理学会
  • Place of Presentation: 新潟
  • Year and Date: 2012-06-29
• [Presentation] 認知症の病理疫学:久山町研究 (2011)
  • Author(s): 岩城徹
  • Organizer: 第41回新潟神経学夏期セミナー(招待講演)
  • Place of Presentation: 新潟
  • Year and Date: 2011-07-31
• [Presentation] 認知症の病理疫学:久山町研究 (2011)
  • Author(s): 岩城徹
  • Organizer: 第41回新潟神経学夏期セミナー
  • Place of Presentation: 新潟(招待講演)
  • Year and Date: 2011-07-31
• [Presentation] 6カ月の経過で進行性の行動異常と運動障害を示した23歳男性 (2011)
  • Author(s): 鈴木諭
  • Organizer: 第52回日本神経病理学会
  • Place of Presentation: 京都
  • Year and Date: 2011-06-02
• [Presentation] ALSとAGDを合併し情動障害を示した1剖検例 (2010)
  • Author(s): 本田裕之
  • Organizer: 第38回臨床神経病理懇話会、第1回日本神経病理学会中国四国地方会
  • Place of Presentation: 宇部
  • Year and Date: 2010-10-31
• [Presentation] 18年の長期経過を経た多系統萎縮症の1剖検例 (2010)
  • Author(s): 増井憲太
  • Organizer: 第38回臨床神経病理懇話会、第1回日本神経病理学会中国四国地方会
  • Place of Presentation: 宇部
  • Year and Date: 2010-10-31
• [Presentation] 認知症の病理疫学研究:久山町研究.第38回臨床神経病理懇話会 (2010)
  • Author(s): 岩城徹
  • Organizer: 第1回日本神経病理学会中国四国地方会
  • Place of Presentation: 宇部
  • Year and Date: 2010-10-31
• [Presentation] 久山町疫学調査と神経病理 (2010)
  • Author(s): 佐々木健介
  • Organizer: 第51回日本神経病理学会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-24
• [Presentation] 脂質代謝異常とアルツハイマー病の病理所見との関連 (2010)
  • Author(s): 松崎尊信
  • Organizer: 第51回日本神経病理学会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-24
• [Presentation] 久山町疫学調査と神経病理 (2010)
  • Author(s): 佐々木健介、岩城徹
  • Organizer: 第51回日本神経病理学会
  • Place of Presentation: 砂防会館別館(東京都)
  • Year and Date: 2010-04-24
• [Presentation] ラット・ミクログリア細胞株SMK の機能的解析 (2010)
  • Author(s): 関善弘
  • Organizer: 第51回日本神経病理学会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-23
• [Presentation] 情動障害を伴うALS におけるtauopathy およびTDP-43 proteinopathy の検討 (2010)
  • Author(s): 本田裕之
  • Organizer: 第51回日本神経病理学会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-23
• [Presentation] Association of Alzheimer disease pathologies with abnormal lipid metabolism (2010)
  • Author(s): Matsuzaki T
  • Organizer: The XVIIth International Congress of Neuropathology
  • Place of Presentation: Salzburg, Austria
• [Presentation] Computational morphological analyses of abnormal tau deposits in human brains.
  • Author(s): Honda H
  • Organizer: Neuroscience 2012
  • Place of Presentation: New Orleans, USA
• [Presentation] 左脳優位の萎縮を示し、皮質基底核症候群を呈した Alzheimer 病の剖検例.
  • Author(s): 若宮富浩
  • Organizer: 第53回日本神経病理学会
  • Place of Presentation: 新潟
• [Presentation] V180I CJDの剖検例における特異なプリオン蛋白沈着パターン.
  • Author(s): 本田裕之
  • Organizer: 第53回日本神経病理学会
  • Place of Presentation: 新潟
• [Presentation] アルツハイマー病脳におけるc-Metの発現変化.
  • Author(s): 濱崎英臣
  • Organizer: 第35回日本分子生物学会
  • Place of Presentation: 福岡
• [Remarks] 読売新聞(2011年11月6日)コレステロール高いと脳にシミ.アルツハイマー病の恐れ
• [Remarks] American Academy of Neurology, Press Release (2011年9月12日)Study Reveals Link Between High Cholesterol and Alzheimer's Disease
• [Remarks] MedlinePlus (U.S. National Library of Medicine, NIH) (2011年9月12日)High Cholesterol Might Be Linked to Alzheimer's Disease
  • URL: http://www.nlm.nih.gov/medlineplus/news/fullstory_116365.html
• [Remarks] 読売新聞(2010年9月5日)血糖値が下がらない人.アルツハイマー病にも注意.
• [Remarks] Neurology Today, vol. 10, issue 17 (2010年9月2日)Insulin resistance linked to AD plague 15 years later
• [Remarks] American Academy of Neurology, Press Release (2010年8月15日)Insulin Resistance, Type 2 Diabetes Linked to Plaques Associated with Alzheimer's Disease.
• [Remarks] Luchsinger JA. Insulin resistance, type 2 diabetes, and AD. Cerebrovascular disease or neurodegeneration? (Editorial) Neurology 75: 758-759, 2010