| Co-Investigator(Kenkyū-buntansha) |
KATO Koichi 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 教授 (20211849)
MURAYAMA Shigeo 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 老年病理学研究チーム・神経病理学(ブレインバンク), 部長 (50183653)
MATSUBARA Teruhiko 慶應義塾大学, 理工学部, 講師 (10325251)
YAMAMOTO Naoki 立命館大学, 薬学部, 助教 (90393157)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Research Abstract |
We demonstrated that brain region-specific deposition of amyloid ss-protein (Ass) exclusively depends on the nature of lipid molecules consisting of the neuronal membrane of the given brain region. We also established a system to explore molecular mechanism underlying interaction between Ass and ganglioside, leading to generation of ganglioside-bound Ass, an endogenous seed for amyloid in AD brains.
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