Study on molecular mechanism underlying brain region-specific Ass deposition
| Project/Area Number |
22300118
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Nerve anatomy/Neuropathology
|
|---|
| Research Institution | National Center for Geriatrics and Gerontology |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KATO Koichi 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 教授 (20211849)
MURAYAMA Shigeo 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 老年病理学研究チーム・神経病理学(ブレインバンク), 部長 (50183653)
MATSUBARA Teruhiko 慶應義塾大学, 理工学部, 講師 (10325251)
YAMAMOTO Naoki 立命館大学, 薬学部, 助教 (90393157)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
|
|---|
| Keywords | 神経変性疾患 / 蛋白質 / 痴呆 / 糖鎖 / アルツハイマー病 / アミロイドベータ蛋白質 / 認知症 / 老人斑 / 質量分析 / NMR |
|---|
| Research Abstract |
We demonstrated that brain region-specific deposition of amyloid ss-protein (Ass) exclusively depends on the nature of lipid molecules consisting of the neuronal membrane of the given brain region. We also established a system to explore molecular mechanism underlying interaction between Ass and ganglioside, leading to generation of ganglioside-bound Ass, an endogenous seed for amyloid in AD brains.
|
Report
(4 results)
Research Products
(144 results)
-
-
-
-
-
-
-
-
[Journal Article] Lysosomal dysfunction in a mouse model of Sandhoff disease leads to accumulation of ganglioside-bound Ass.2012
Author(s)
Keilani S., Lun Y., Stevens A.C., Williams H.N., Sjoberg E.R., Khanna R., Valenzaro K.J., Checler F., Buxbaum J.D., Yanagisawa K., Lockhart D.J., Wustman B.A. and Gandy S.
-
Journal Title
J Neurosci
Volume: 32
Issue: 15
Pages: 5223-5236
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
[Journal Article] Altered Y-secretase activity in mild cognitive impairment and Alzheimer's disease2012
Author(s)
Kakuda N, Shoji M, Arai H, Furukawa K, Ikeuchi T, Akazawa K, Takami M, Hatsuta H, Murayama s, Hashimoto Y, Miyajima M, Arai H, Nagashima Y Yamaguchi H, Kuwano R, Nagaike K, Ihara Y ; the Japanese Alzheimer's Disease Neuroimaging Initiative
-
Journal Title
Eur J Neurol
Volume: 4
Issue: 4
Pages: 344-352
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Reduced brain-derived neurotrophic factor (BDNF) mRNA expression and presence of BDNF-immunoreactive granules in the spinocerebellar ataxia type 6 (SCA6) cerebellum2012
Author(s)
Takahashi M, Ishikawa K, Sato N, Obayashi M, Niimi Y, Ishiguro T, Yamada M, Toyoshima Y, Takahashi H, Kato T, Takao M, Murayama M, Mori O, Eishi Y, Mizusawa H
-
Journal Title
Neuropathology
Volume: (in press)
Issue: 6
Pages: 593-603
DOI
Related Report
Peer Reviewed
-
-
-
[Journal Article] Multicentre multiobserver study of diffusion-weighted and fluid-attenuated inversion recovery MRI for the diagnosis of sporadic Creutzfeldt Jakob disease2012
Author(s)
Fujita K, Harada M, Sasaki M, Yuasa T, Sakai K, Hamaguchi T, Sanjo N, Shiga Y, Satoh K, Atarashi R, Shirabe S, Nagata K, Maeda T, Murayama S, Izumi Y, Kaji R, Yamada M, Mizusawa H
-
Journal Title
BMJ Open Journal
Volume: 2
Issue: 1
Pages: e000649-e000649
DOI
Related Report
Peer Reviewed
-
-
-
-
-
[Journal Article] Extracellular and intraneuronal HMW-AbetaOs represent a molecular basis of memory loss in Alzheimer's disease model mouse2011
Author(s)
Takamura A, Okamoto Y, Kawarabayashi T, Yokoseki T, Shibata M, Mouri A, Nabeshima T, Sun H, Abe K, Urisu T, Yamamoto N, Shoji M, Yanagisawa K, Michikawa M, Matsubara E
-
Journal Title
Mol Neurodegener
Volume: 6
Issue: 1
Pages: 20-20
DOI
Related Report
Peer Reviewed
-
-
-
-
-
[Journal Article] Dissociation of beta-amyloid from lipoprotein in cerebrospinal fluid from Alzheimer' s disease accelerates beta-amyloid-422011
Author(s)
Takamura A, Kawarabayashi T, Yokoseki T, Shibata M, Morishima-Kawashima M, Saito Y, Murayama S, Ihara Y, Abe K, Shoji M, Michikawa M, Matsubara E
-
Journal Title
assembly. Neurosci Res
Volume: 89
Issue: 6
Pages: 815-821
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] FUS-immunopositive Inclusions and Compound Pick Bodies in Two Cases of Frontotemporal Lobar Degeneration with Motor Neuron Disease (FTLDMND).2012
Author(s)
Nakamoto F, Takao M, Ikemura M, Hayashi T, Ito S, Maeda D, SaitoY, Takahashi Y, Hasegawa M, Fukayama M, Tsuji S, Murayama S
Organizer
The 8th International Conference on Frontotemporal Dementias.
Place of Presentation
Manchester, UK
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Japanese Consortium for Research in motor Neuron Disease and Frontotemporal Dementia.2011
Author(s)
Murayama S, Saito Y, Takao M, Hatsuta H, Shimizu J, Kihira T, Kokubo Y, Akiyama H, Suzuki, Hasegawa M.
Organizer
87th Annual Meeting of the American Association of Neuropathologists
Place of Presentation
Seattle, USA.
Related Report
-
[Presentation] Japanese Consortium for Research in motor Neuron Disease and Frontotemporal Dementia2011
Author(s)
Murayama S, Saito Y, Takao M, Hatsuta H, Shimizu J, Kihira T, Kokubo Y, Akiyama H, Suzuki, Hasegawa M
Organizer
87^<th> Annual Meeting of the American Association of Neuropathologists
Place of Presentation
Seattle, Washington
Related Report
-
[Presentation] Presence of Somatic Dendrites and Reduction of Apical Dendrites of Purkinje Cells in Spinocerebellar Ataxia Type 312011
Author(s)
Takao M, Ghetti B, Mihara T, Ishikawa K, Tokumaru A, Funabe S, Kimura H, Mihara B, Fujita M, Suzuki K, Murayama S
Organizer
87^<th> Annual Meeting of the American Association of Neuropathologists
Place of Presentation
Seattle, Washington
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 複合糖質の構造・機能解析2010
Author(s)
加藤晃一
Organizer
岡崎統合バイオサイエンスセンター・サマースクール
Place of Presentation
岡崎統合バイオサイエンスセンター(愛知県)
Year and Date
2010-08-18
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
