| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2012: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Research Abstract |
The presynaptic active zone is thought to regulate release of neurotransmitter from nerve terminals in a spatially and temporally coordinated manner. In this research, it has been shown that the active zone protein CAST directly interacts with voltage-dependent calcium channels (VDCCs), regulating the opening of VDCCs. Moreover, using CAST knockout mice, CAST was demonstrated to regulate the size of specialize active zone in the retina, so called ribbon synapse and required for normal vision.
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