Elucidation of molecular mechanismsand physiologicalfunctions of presyanptic active zones
| Project/Area Number |
22300120
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
OHTSUKA Toshihisa 山梨大学, 大学院・医学工学総合研究部, 教授 (40401806)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2012: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | 神経伝達物質・受容体 / アクティブゾーン / シナプス小胞 / CAST / リン酸化 |
|---|
| Research Abstract |
The presynaptic active zone is thought to regulate release of neurotransmitter from nerve terminals in a spatially and temporally coordinated manner. In this research, it has been shown that the active zone protein CAST directly interacts with voltage-dependent calcium channels (VDCCs), regulating the opening of VDCCs. Moreover, using CAST knockout mice, CAST was demonstrated to regulate the size of specialize active zone in the retina, so called ribbon synapse and required for normal vision.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Deletion of the presynaptic scaffold CAST reduces active zone size in rod photoreceptors and impairs visual processing2012
Author(s)
tom Dieck, S., Specht, D., Strenzke, N., Hida, Y., Krishnamoorthy, V., Inoue, E., Ishizaki, H., Tanaka-Okamoto, M., Miyoshi, J., Hagiwara, A., Brandstatter, JH., Gollisch, T., Ohtsuka, T.*, Moser, T*
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Journal Title
J. Neurosci
Volume: 32
Pages: 12192-12203
Related Report
Peer Reviewed
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[Journal Article] Physical and Functional Interaction of the Active Zone Protein CAST/ERC2 and the β-subunit of the Voltage-dependent Ca2+Channel2012
Author(s)
Kiyonaka, S., Nakajima, H., Takada, Y., Hida, Y., Yoshioka, T., Hagiwara, A., Kitajima, I., Mori, Y., Ohtsuka, T
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Journal Title
J. Biochem
Volume: 152
Pages: 149-159
NAID
Related Report
Peer Reviewed
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[Journal Article] Prickle2 is localized in the postsynaptic density and interacts with PSD-95 and NMDA receptors in the brain2011
Author(s)
Hida, Y., Fukaya, M., Hagiwara, A., Deguchi-Tawarada, M., Yoshioka, T., Kitajima, I., Inoue, E., Watanabe, M., Ohtsuka, T
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Journal Title
J. Biochem
Volume: 149
Pages: 693-700
NAID
Related Report
Peer Reviewed
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[Journal Article] Reduced expression of the ATRXgene, a chromatin-remodeling factor, causes hippocampal dysfunction in mice2010
Author(s)
Nogami, T., Beppu, H., Tokoro, T., Moriguchi, S., Shioda, N., Fukunaga, K., Ohtsuka, T., Ishii, I., Sasahara, M., Shimada, Y., Nishijo, H., Li, E., Kitajima, I
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Journal Title
Hippocampus
Volume: 21
Pages: 678-687
Related Report
Peer Reviewed
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