| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2010: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Research Abstract |
The myelin sheath consists of a unique multiple-layer structure that acts as an insulator between neuronal axons to enhance the propagation of the action potential. In the developing peripheral nervous system , myelin sheaths form as Schwann cells wrap individual axons. Yet, little is known about the intracellular signaling mechanisms, as well as those in demyelinating phenomena. Here we identify the signaling through new molecular networks to control myelination or demyelination. These results could provide a new therapeutic target for demyelination and dismyelination desieases.
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