Elucidation of a molecular mechanism controlling myelination in normal and disease states
| Project/Area Number |
22300123
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | National Research Institute for Child Health and Development |
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Principal Investigator |
YAMAUCH Junji 独立行政法人国立成育医療研究センター, 薬剤治療研究部, 室長 (20335483)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2010: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | ミエリン形成 / 脱ミエリン現象 / シグナル伝達 / キナーゼ / 低分子量GTP結合蛋白質 / 分子メカニズム / 遺伝子改変動物 / 標的分子 |
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| Research Abstract |
The myelin sheath consists of a unique multiple-layer structure that acts as an insulator between neuronal axons to enhance the propagation of the action potential. In the developing peripheral nervous system , myelin sheaths form as Schwann cells wrap individual axons. Yet, little is known about the intracellular signaling mechanisms, as well as those in demyelinating phenomena. Here we identify the signaling through new molecular networks to control myelination or demyelination. These results could provide a new therapeutic target for demyelination and dismyelination desieases.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] The atypical guanine-nucleotide exchange factor, Dock7, negatively regulates Schwann cell differentiation and myelination.2011
Author(s)
Junji Yamauchi, Yuki Miyamoto, Hajime Hamasaki, Atsushi Sanbe, Shinji Kusakawa, Akane Nakamura, Hideki Tsumura, Masahiro Maeda, Noriko Nemoto, Katsumasa Kawahara, Tomohiro Torii, and Akito Tanoue
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Journal Title
J. Neurosci
Volume: 31
Issue: 35
Pages: 12579-12592
DOI
Related Report
Peer Reviewed
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