Roles of maturation of presynaptic functions in the postnatal refinement of neuronal circuits.
Project/Area Number |
22300125
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurophysiology and muscle physiology
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Research Institution | Hiroshima University |
Principal Investigator |
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2012: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
|
Keywords | ニューロン / シナプス / 神経回路 / 小脳 / 生後発達 |
Research Abstract |
Postnatal changes of electrophysiological properties of inferior olivery (IO) neurons are examined by the patch clamp recording using slices prepared from mouse medulla. The threshold of action potential was increasedand input resistance was decreased from postnatal day 7 (P7) to P15. These developmental changes proceeded coincident with the formation of the gap junction. Moreover, the subthreshold oscillation also started during this postnatal period. These results suggestthat IO neurons gain their adult type membrane properties from P7 to P15.
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] Organotypic Coculture Preparation for the Study of Developmental Synapse Elimination in Mammalian Brain2012
Author(s)
Uesaka, N., Mikuni, T., Hashimoto, K., Hirai, H., Sakimura, K. & Kano, M
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Journal Title
J Neurosci
Volume: 32
Pages: 11657-11670
Related Report
Peer Reviewed
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[Journal Article] Synapse type-independent degradation of the endocannabinoid 2-arachidonoylglycerol after retrograde synaptic suppression.2012
Author(s)
Tanimura, A., Uchigashima, M., Yamazaki, M., Uesaka, N., Mikuni, T., Abe, M., Hashimoto, K., Watanabe, M., Sakimura, K. & Kano, M
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 109
Pages: 12195-12200
Related Report
Peer Reviewed
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[Journal Article] GABAergic inhibition regulates developmental synapse elimination in the cerebellum2012
Author(s)
Nakayama, H., Miyazaki, T., Kitamura, K., Hashimoto, K., Yanagawa, Y., Obata, K., Sakimura, K., Watanabe, M. & Kano, M
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Journal Title
Neuron
Volume: 74
Pages: 384-396
Related Report
Peer Reviewed
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[Journal Article] Cav2.1 in cerebellar Purkinje cells regulates competitive excitatory synaptic wiring, cell survival, and cerebellar biochemical compartmentalization2012
Author(s)
Miyazaki, T., Yamasaki, M., Hashimoto, K., Yamazaki, M., Abe, M., Usui, H., Kano, M., Sakimura, K. & Watanabe, M
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Journal Title
J. Neurosci
Volume: 32
Pages: 1311-1328
NAID
Related Report
Peer Reviewed
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[Journal Article] Developmental switching of perisomatic innervation from climbing fibers to Basket cell fibers in cerebellar Purkinje cells2011
Author(s)
Ichikawa, R., Yamasaki, M., Miyazaki, T., Konno, K., Hashimoto, K., Tatsumi, H., Inoue, Y., Kano, M. & Watanabe, M
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Journal Title
J Neurosci
Volume: 31
Pages: 16916-16927
NAID
Related Report
Peer Reviewed
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[Journal Article] Postsynaptic P/Q-type Ca2+ channels in cerebellar Purkinje cells mediate synaptic competition among multiple climbing fiber inputs during postnatal development.2011
Author(s)
Hashimoto, K., Tsujita, M., Miyazaki, T., Kitamura, K., Yamazaki, M., Shin, H.S., Watanabe, M., Sakimura, K. & Kano, M
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Journal Title
Proc. Natl. Acad. Sci. USA.
Volume: 108
Pages: 9987-9992
Related Report
Peer Reviewed
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[Journal Article] A Role for Myosin Va in Cerebellar Plasticity and Motor Learning: A Possible Mechanism Underlying Neurological Disorder in Myosin Va Disease2011
Author(s)
Miyata, M., Kishimoto, Y., Tanaka, M., Hashimoto, K., Hirashima, N., Murata, Y., Kano, M. & Takagishi, Y
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Journal Title
J Neurosci.
Volume: 31
Pages: 6067-6078
Related Report
Peer Reviewed
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[Journal Article] TARPs γ-2 and γ-7 are essential for AMPA receptor expression in the cerebellum.2010
Author(s)
Yamazaki, M., Fukaya, M., Hashimoto, K., Yamasaki, M., Tsujita, M., Itakura, M., Abe, M., Natsume, R., Takahashi, M., Kano, M., Sakimura, K. & Watanabe, M
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Journal Title
Eur. J. Neurosci
Volume: 31
Pages: 2204-2220
Related Report
Peer Reviewed
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[Journal Article] TARPs gamma-2 and gamma-7 are essential for AMPA receptor expression in the cerebellum.2010
Author(s)
Yamazaki M, Fukaya M, Hashimoto K, Yamasaki M, Tsujita M, Itakura M, Abe M, Natsume R, Takahashi M, Kano M, Sakimura K, Watanabe M
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Journal Title
European Journal of Neuroscience
Volume: 31
Pages: 2204-2220
Related Report
Peer Reviewed
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[Presentation] 2-Arachidonoylglycerol produced by diacylglycerol lipase α mediates retrograde suppression of synaptic transmission in the CNS.2010
Author(s)
Tanimura A, Yamazaki M, Hashimotodani Y, Uchigashima M, Kawata S, Abe M, Kita Y, Hashimoto K, Shimizu T, Watanabe M, Sakimura K, Kano M
Organizer
第33回日本神経科学大会、第53回日本神経化学会大会および第20回日本神経回路学会大会 合同大会
Place of Presentation
神戸
Related Report
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[Presentation] Retrograde synaptic suppression in the cerebellum, hippocampus and striatum is mediated by 2-arachidonoylglycerol produced by diacylglycerol lipase alpha2010
Author(s)
Tanimura A, Yamazaki M, Hashimotodani Y, Uchigashima M, Kawata S, Abe M, Kita Y, Hashimoto K, Shimizu T, Watanabe M, Sakimura K, Kano M
Organizer
7th FENS forum of European Neuroscience
Place of Presentation
Amsterdam, Netherlands
Related Report
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[Presentation] 2-Arachidonoylglycerol produced by diacylglycerol lipase α mediates retrograde suppression of synaptic transmission in the CNS.2010
Author(s)
Tanimura A, Yamazaki M, Hashimotodani Y, Uchigashima M, Kawata S, Abe M, Kita Y, Hashimoto K, Shimizu T, Watanabe M, Sakimura K, Kano M
Organizer
第33回日本神経科学大会、第53回日本神経化学会大会および第20回日本神経回路学会大会 合同大会
Place of Presentation
神戸コンベンションセンター
Related Report
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[Presentation] Retrograde synaptic suppression in the cerebellum, hippocampus and striatum is mediated by 2-arachidonoylglycerol produced by diacylglycerol lipase alpha2010
Author(s)
Tanimura A, Yamazaki M, Hashimotodani Y, Uchigashima M, Kawata S, Abe M, Kita Y, Hashimoto K, Shimizu T, Watanabe M, Sakimura K, Kano M
Organizer
7^<th> FENS forum of European Neuroscience
Place of Presentation
Amsterdam, Netherlands
Related Report
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