Sleep and arousal regulation in Drosophila melanogaster
Project/Area Number |
22300132
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Fusional basic brain science
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Research Institution | Kumamoto University |
Principal Investigator |
KUME Kazuhiko 熊本大学, 発生医学研究所, 准教授 (30251218)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2012: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2010: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
|
Keywords | 睡眠 / 覚醒 / 概日周期 / ショウジョウバエ / ドーパミン / 時系列解析 / モザイク解析 / 代謝 / 加齢 / 寿命 / 温度嗜好性 / 記憶 / 麻酔 / 摂食 / ドパミン |
Research Abstract |
Using Drosophila melanogaster as a model animal for sleep research,we identified calcineurin and others as novel sleep related genes and showed therelationship between sleep and memory retention. By the analysis of dopamine functions,which is an arousal regulator, we showed its role in rest length regulation, metabolismand temperature preference. We also identified arousal regulating dopamine circuit infly brain at the single cell level.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Isolation of the bioactive peptides CCHamide-1 and CCHamide-2 from Drosophila and their putative role in appetite regulation as ligands for G protein-coupled receptors2012
Author(s)
Ida T, Takahashi T, Tominaga H, Sato T, Sano H, Kume K, Ozaki M, Hiraguchi T, Shiotani H, Terajima S, Nakamura Y, Mori K, Yoshida M, Kato J, Murakami N, Miyazato M, Kangawa K, Kojima M
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Journal Title
Front Endocrinol (Lausanne)
Volume: 3
Pages: 177-177
DOI
Related Report
Peer Reviewed
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[Journal Article] Identification of the novel bioactive peptides dRYamide-1 and dRYamide-2, ligands for a neuropeptide Y-like receptor in Drosophila2011
Author(s)
Ida T, Takahashi T, Tominaga H, Sato T, Kume K, Ozak Mi, Hiraguchi T, Maeda T, Shiotani H, Terajima S, Sano H, Mori K, Yoshida M, Miyazato M, Kato J, Murakami N, Kangawa K, Kojima M
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Journal Title
Biochem Biophys Res Commun
Volume: 410
Issue: 4
Pages: 872-877
DOI
Related Report
Peer Reviewed
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[Journal Article] Identification of the endogenous cysteine-rich peptide trissin, ligand for an orphan G-protein-coupled receptor in Drosophila2011
Author(s)
Ida T, Takahashi T, Tominaga H, Sato T, Kume K, Yoshizawa-Kumagae K, Nishio H, Kato J, Murakami N, Miyazato M, Kangawa K, Kojima M
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Journal Title
Biochem Biophys Res Commun
Volume: 414
Issue: 1
Pages: 44-48
DOI
Related Report
Peer Reviewed
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