Neural mechanisms of long-term memory formation and memory retrieval in the human temporal cortex

• Project/Area Number: 22300134
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Fusional brain recording science
• Research Institution: The University of Tokyo
• Principal Investigator: KONISHI Seiki 東京大学, 医学(系)研究科(研究院), 准教授 (90323609)
• Project Period (FY): 2010-04-01 – 2013-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000); Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
• Keywords: 機能的磁気共鳴画像法 / 記憶固定 / 側頭葉 / 長期記憶 / 記憶想起 / 海馬 / 高次脳機能計測

Research Abstract

Long-term memory is thought to be consolidated into the lateral temporal cortex long after encoding into the hippocampus. However, the details about its neural mechanisms are not well understood. We explored the neural mehcanisms of long-term memory consolidation and retrieval in the human temporal cortex using fMRI.
By employing a pair association task, memory-retlated areas were revealed in the 1) visual areas for faces and places, 2) himmpocampus, 3) posterior lateral temporal cortex, 4) anterior lateral temporal cortex. Analyses of the regional interaction revealed that new visual information was initially encoded into the hippocampus, and was later consolidated in the posterior lateral temporal cortex, and was retreived via integration from the posterior to anterior lateral temporal cortex.

Research Products

• [Journal Article] Functional relevance of micromodules in the human association cortex delineated with high- resolution fMRI (2013)
  • Author(s): Hirose S., Watanabe T., Wada H., Imai Y., Machida T., Shirouzu I., Miyashita Y., Konishi S
  • Journal Title: Cerebral Cortex Volume: 23 Issue: 12 Pages: 2863-2871
  • DOI: 10.1093/cercor/bhs268
  • Peer Reviewed / Open Access
• [Journal Article] Dissociable temporo-parietal memory networks revealed by functional connectivity during episodic retrieval (2013)
  • Author(s): Hirose S., Kimura H. M., Jimura K., Kunimatsu A., Abe O, Ohtomo K., Miyashita Y., Konishi S
  • Journal Title: PLoS ONE Volume: 8 Issue: 8 Pages: e71210-e71210
  • DOI: 10.1371/journal.pone.0071210
  • Peer Reviewed
• [Journal Article] A pairwise maximum entropy model accurately describes resting-state human brain networks. (2013)
  • Author(s): 渡部喬光
  • Journal Title: Nature Communications Volume: 4 Issue: 1 Pages: 1370-1370
  • DOI: 10.1038/ncomms2388
  • Peer Reviewed
• [Journal Article] Functional dissociation between anterior and posterior temporal cortical regions during retrieval of remote memory (2012)
  • Author(s): Watanabe T., Kimura H. M., Hirose S., Wada H., Imai Y., Machida T., Shirouzu I., Miyashita Y., Konishi S
  • Journal Title: Journal of Neuroscience Volume: 32 Issue: 28 Pages: 9659-9670
  • DOI: 10.1523/jneurosci.5553-11.2012
  • Peer Reviewed
• [Journal Article] Efficiency of go/no-go task performance implemented in the left hemisphere (2012)
  • Author(s): Hirose S., Chikazoe J., Watanabe T., Jimura K., Kunimatsu A., Abe O., Ohtomo K., Miyashita Y., Konishi S
  • Journal Title: Journal of Neuroscience Volume: 32 Issue: 26 Pages: 9059-9065
  • DOI: 10.1523/jneurosci.0540-12.2012
  • Peer Reviewed
• [Journal Article] Local signal time-series during rest used for areal boundary mapping in individual human brains (2012)
  • Author(s): Hirose S., Watanabe T., Jimura K., Katsura M., Kunimatsu A., Abe O., Ohtomo K., Miyashita Y., Konishi S
  • Journal Title: PLoS ONE Volume: 7 Issue: 5 Pages: e36496-e36496
  • DOI: 10.1371/journal.pone.0036496
  • Peer Reviewed
• [Journal Article] Prediction of Subsequent Recognition Performance Using Brain Activity in the Medial Temporal Lobe (2011)
  • Author(s): Watanabe, T., et al.
  • Journal Title: NeuroImage Volume: 54 Issue: 4 Pages: 3085-3092
  • DOI: 10.1016/j.neuroimage.2010.10.066
  • Peer Reviewed
• [Journal Article] Role for presupplementary motor area in inhibition of cognitive set interference (2011)
  • Author(s): Konishi, S., Watanabe, T., Jimura, K., Chikazoe, J., Hirose, S., Kimura, H. M. and Miyashita, Y.
  • Journal Title: J. Cogn. Neurosci Volume: 23 Issue: 3 Pages: 737-745
  • DOI: 10.1162/jocn.2010.21480
  • Peer Reviewed
• [Journal Article] Medial prefrontal activity during shifting under novel situations (2010)
  • Author(s): Konishi S., Hirose S., Jimura K., Chikazoe J., Watanabe T., Kimura H. M., Miyashita Y
  • Journal Title: Neuroscience Letters Volume: 484 Issue: 3 Pages: 182-186
  • DOI: 10.1016/j.neulet.2010.08.047
  • Peer Reviewed
• [Journal Article] Temporal pole activity during understanding other persons' mental state correlated with neuroticism trait (2010)
  • Author(s): Jimura K., Konishi S., Asari T., Miyashita Y
  • Journal Title: Brain Research Volume: 1328 Pages: 104-112
  • DOI: 10.1016/j.brainres.2010.03.016
  • Peer Reviewed
• [Journal Article] Amygdalar modulation of frontotemporal connectivity during the inkblot test (2010)
  • Author(s): Asari, T., Konishi, S., Jimura, K., Chikazoe, J., Nakamura, N. and Miyashita, Y.
  • Journal Title: Psychiatry Research : Neuroimaging Volume: 182 Issue: 2 Pages: 103-110
  • DOI: 10.1016/j.pscychresns.2010.01.002
  • Peer Reviewed
• [Journal Article] Differential temporo- parietal cortical networks that support relational and item-based recency judgments (2010)
  • Author(s): Kimura H. M., Hirose S., Kunimatsu A., Chikazoe J., Jimura K., Watanabe T., Abe O., Ohtomo K., Miyashita Y., Konishi S
  • Journal Title: Neuroimage Volume: 49 Issue: 4 Pages: 3474-3480
  • DOI: 10.1016/j.neuroimage.2009.11.003
  • Peer Reviewed
• [Journal Article] Amygdalar enlargement associated with unique perception (2010)
  • Author(s): Asari, T., Konishi, S., Jimura, K., Chikazoe, J., Nakamura, N. and Miyashita, Y.
  • Journal Title: Cortex Volume: 46 Issue: 1 Pages: 94-99
  • DOI: 10.1016/j.cortex.2008.08.001
  • Peer Reviewed
• [Presentation] Human association cortex is composed of functionally relevant micro-modules : a high- resolution fMRI study using resting-state functional connectivity (2013)
  • Author(s): Hirose S., Watanabe T., Wada H., Imai Y., Machida T., Shirouzu I., Miyashita Y., Konishi S
  • Organizer: Physiological Society of Japan Conference
• [Presentation] Simplicity of human brain networks : resting-state functional brain networks can be accurately described by a pairwise maximum entropy model (2013)
  • Author(s): Watanabe T., Hirose S., Wada H., Imai Y., Machida T., Shirouzu I., Konishi S., Miyashita Y., Masuda N
  • Organizer: Japan Neuroscience Society Conference
• [Presentation] Inter-regional task- related functional correlation in temporo-parietal networks : A functional MRI study of recency judgments (2013)
  • Author(s): Hirose S., Kimura H. M., Kunimatsu A., Abe O., Ohtomo K., Miyashita Y., Konishi S
  • Organizer: Japan Neuroscience Society Conference
• [Presentation] Neural mechanisms of memory retrieval revealed by fMRI (2013)
  • Author(s): Konishi S
  • Organizer: Japan Neuroscience Society Conference
• [Presentation] QPS施行による安静時機能的結合の変化 (2013)
  • Author(s): 小西清貴
  • Organizer: 日本ヒト脳マッピング学会
• [Presentation] Human association cortex is composed of functionally relevant micro-modules: a high-resolution fMRI study using resting-state functional connectivity (2013)
  • Author(s): Hirose S., Watanabe T., Wada H., Imai Y., Machida T., Shirouzu I., Miyashita Y., Konishi S.
  • Organizer: 日本生理学会
  • Place of Presentation: タワーホール船堀、東京
• [Presentation] Simplicity of human brain networks: resting-state functional brain networks can be accurately described by a pairwise maximum entropy model. (2013)
  • Author(s): Watanabe T., Hirose S., Wada H., Imai Y., Machida T., Shirouzu I., Konishi S., Miyashita Y., Masuda N.
  • Organizer: 日本神経科学学会
  • Place of Presentation: 国立京都国際会館
• [Presentation] Inter-regional task-related functional correlation in temporo-parietal networks: A functional MRI study of recency judgments (2013)
  • Author(s): Hirose S., Kimura H. M., Kunimatsu A., Abe O., Ohtomo K., Miyashita Y., Konishi S.
  • Organizer: 日本神経科学学会
  • Place of Presentation: 国立京都国際会館
• [Presentation] Neural mechanisms of memory retrieval revealed by fMRI (2013)
  • Author(s): Konishi. S
  • Organizer: 日本神経科学学会
  • Place of Presentation: 国立京都国際会館
  • Invited
• [Presentation] Temporal neocortex shows antero-posterior functional dissociation during retrieval of remote memory (2012)
  • Author(s): Watanabe T., Kimura H. M., Hirose S., Wada H., Imai Y., Machida T., Shirouzu I., Miyashita Y., Konishi S
  • Organizer: Human Brain Mapping Conference
• [Presentation] Antero- posterior functional difference in the temporal neocortex during retrieval of remote memory (2012)
  • Author(s): Watanabe T., Kimura H. M., Hirose S., Wada H., Imai Y., Machida T., Shirouzu I., Miyashita Y., Konishi S
  • Organizer: Japan Neuroscience Society Conference
• [Presentation] Convergence of category-specific information in the temporal neocortex during retrieval of remote memory (2012)
  • Author(s): Watanabe T., Kimura H. M., Hirose S., Wada H., Katsura M., Imai Y., Machida T., Shirouzu I., Miyashita Y., Konishi S
  • Organizer: Society for Neuroscience Conference
• [Presentation] Large-scale brain networks specific to different bands of brain waves : application of a pairwise maximum entropy model to EEG-fMRI data (2012)
  • Author(s): Hirose S., Watanabe T., Misaki M., Kan S., Koike T., Miyauchi S., Konishi S
  • Organizer: Society for Neuroscience Conference
• [Presentation] Temporal neocortex shows antero-posterior functional dissociation during retrieval of remote memory (2012)
  • Author(s): Watanabe T., Kimura H. M., Hirose S., Wada H., Imai Y., Machida T., Shirouzu I., Miyashita Y., Konishi S.
  • Organizer: Human Brain Mapping
  • Place of Presentation: China National Convention Center Beijing, China
• [Presentation] Antero-posterior functional difference in the temporal neocortex during retrieval of remote memory (2012)
  • Author(s): Watanabe T., Kimura H. M., Hirose S., Wada H., Imai Y., Machida T., Shirouzu I., Miyashita Y., Konishi S.
  • Organizer: 日本神経科学学会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] Convergence of category-specific information in the temporal neocortex during retrieval of remote memory (2012)
  • Author(s): Watanabe T., Kimura H. M., Hirose S., Wada H., Katsura M., Imai Y., Machida T., Shirouzu I., Miyashita Y., Konishi S.
  • Organizer: Society for Neuroscience
  • Place of Presentation: New Orleans Ernest N. Morial Convention Center, USA
• [Presentation] Large-scale brain networks specific to different bands of brain waves: application of a pairwise maximum entropy model to EEG-fMRI data (2012)
  • Author(s): Hirose S., Watanabe T., Misaki M., Kan S., Koike T., Miyauchi S., Konishi S.
  • Organizer: Society for Neuroscience
  • Place of Presentation: New Orleans Ernest N. Morial Convention Center, USA
• [Presentation] Functional areas in human inferior frontal cortex as revealed by combination of resting-state functional connectivity and high-resolution fMRI (2011)
  • Author(s): Hirose S, et al.
  • Organizer: Society for Neuroscience
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-11-16
• [Presentation] Functional areas in the inferior frontal cortex based on brain activity and functional connectivity (2011)
  • Author(s): Konishi S
  • Organizer: The Japan Neuroscience Society
  • Place of Presentation: パシフィコ横浜、神奈川県
  • Year and Date: 2011-09-16
• [Presentation] Role of amygdala in retrograde memory enhancement induced by emotional arousal (2011)
  • Author(s): Chikazoe J, et al.
  • Organizer: The Japan Neuroscience Society
  • Place of Presentation: パシフィコ横浜、神奈川県
  • Year and Date: 2011-09-16
• [Presentation] Prediction of future memory cognition by multivariate pattern analysis (2011)
  • Author(s): Watanabe T, et al.
  • Organizer: Association for the Scientific Study of Consciousness
  • Place of Presentation: 京都大学百周年時計台記念館京都府
  • Year and Date: 2011-06-11
• [Presentation] 記憶の貯蔵庫:側頭葉 (2011)
  • Author(s): 小西清貴
  • Organizer: 日本医学放射線学会
  • Place of Presentation: パシフィコ横浜、神奈川県(招待講演)
  • Year and Date: 2011-04-09
• [Presentation] 機能的MRIによるヒト高次脳機能解析 (2011)
  • Author(s): 小西清貴
  • Organizer: 日本神経放射線学会
  • Place of Presentation: 東京コンファレンスセンター、東京都(招待講演)
  • Year and Date: 2011-02-26
• [Presentation] Analyses of human higher- order brain functions using functional MRI (2011)
  • Author(s): Konishi S
  • Organizer: Japanese Society of Neuroradiology Conference Conference
• [Presentation] Memory store : The temporal lobe (2011)
  • Author(s): Konishi S
  • Organizer: Jap Radiological Society Conference
• [Presentation] Prediction of future memory cognition by multivariate pattern analysis (2011)
  • Author(s): Watanabe T., Hirose S., Wada H., Katsura M., Chikazoe J., Jimura K., Imai Y., Machida T., Shirouzu I., Miyashita Y., Konishi S
  • Organizer: Association for the Scientific Study of Consciousness Conference
• [Presentation] Functional areas in the inferior frontal cortex based on brain activity and functional connectivity (2011)
  • Author(s): Konishi S
  • Organizer: Japan Neuroscience Society Conference
• [Presentation] Role of amygdala in retrograde memory enhancement induced by emotional arousal (2011)
  • Author(s): Chikazoe J., Anderson A., Hirose S., Yamashita K., Miyashita Y., Konishi S
  • Organizer: Japan Neuroscience Society Conference
• [Presentation] Functional areas in human inferior frontal cortex as revealed by combination of resting-state functional connectivity and high-resolution fMRI (2011)
  • Author(s): Hirose S., Watanabe T., Wada H., Katsura M., Jimura K., Kunimatsu A., Abe O., Ohtomo K., Imai Y., Machida T., Shirouzu I., Miyashita Y., Konishi S
  • Organizer: Society for Neuroscience Conference
• [Presentation] Multivoxel pattern analysis of brain activity in the medial temporal lobe and prediction of subsequent recognition performance (2010)
  • Author(s): Watanabe, et al
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-11-15
• [Presentation] Temporo-parietal cortical networks for recency judgments as revealed by a resting-state functional connectivity analysis (2010)
  • Author(s): Kimura, et al
  • Organizer: The Japan Neuroscience Society
  • Place of Presentation: 神戸国際会議場、兵庫県
  • Year and Date: 2010-09-04
• [Presentation] 抑制機能と前頭葉 (2010)
  • Author(s): 小西清貴
  • Organizer: 日本認知神経科学学会
  • Place of Presentation: 松江テルサ、島根県
  • Year and Date: 2010-07-17
• [Presentation] Medial Prefrontal Activation during Shifting in the Wisconsin Card Sorting Test (2010)
  • Author(s): Konishi, et al
  • Organizer: Organization for Human Brain Mapping
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-06-07
• [Presentation] Neural correlates of inhibition of proactive interference from cognitive set (2010)
  • Author(s): Konishi, et al
  • Organizer: Cognitive Neuroscience Society
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2010-04-19
• [Presentation] Neural correlates of inhibition of proactive interference from cognitive set (2010)
  • Author(s): Konishi S., Jimura K., Chikazoe J., Hirose S., Watanabe T., Kimura H., Miyashita Y
  • Organizer: Cognitive Neuroscience Society Conference
• [Presentation] Medial Prefrontal Activation during Shifting in the Wisconsin Card Sorting Test (2010)
  • Author(s): Konishi S., Hirose S., Jimura K., Chikazoe J., Watanabe T., Kimura H. M., Miyashita Y
  • Organizer: Human Brain Mapping Conference
• [Presentation] Inhibitory functions and the frontal lobe (2010)
  • Author(s): Konishi S
  • Organizer: Japanese Society of Cognitive Neuroscience Conference
• [Presentation] Temporo-parietal cortical networks for recency judgments as revealed by a resting-state functional connectivity analysis (2010)
  • Author(s): Kimura H. M., Hirose S., Kunimatsu A., Chikazoe J., Jimura K., Watanabe T., Abe O., Ohtomo K., Miyashita Y., Konishi S
  • Organizer: Japan Neuroscience Society Conference
• [Presentation] Multivoxel pattern analysis of brain activity in the medial temporal lobe and prediction of subsequent recognition performance (2010)
  • Author(s): Watanabe T., Hirose S., Katsura M., Imai Y., Chikazoe J., Kimura H. M., Jimura K., Machida T., Shirouzu I., Miyashita Y., Konishi S
  • Organizer: Society for Neuroscience Conference
• [Remarks]
  • URL: http://square.umin.ac.jp/physiol1/