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Neural mechanisms of long-term memory formation and memory retrieval in the human temporal cortex

Research Project

Project/Area Number 22300134
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Fusional brain recording science
Research InstitutionThe University of Tokyo

Principal Investigator

KONISHI Seiki  東京大学, 医学(系)研究科(研究院), 准教授 (90323609)

Project Period (FY) 2010-04-01 – 2013-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Keywords機能的磁気共鳴画像法 / 記憶固定 / 側頭葉 / 長期記憶 / 記憶想起 / 海馬 / 高次脳機能計測
Research Abstract

Long-term memory is thought to be consolidated into the lateral temporal cortex long after encoding into the hippocampus. However, the details about its neural mechanisms are not well understood. We explored the neural mehcanisms of long-term memory consolidation and retrieval in the human temporal cortex using fMRI.
By employing a pair association task, memory-retlated areas were revealed in the 1) visual areas for faces and places, 2) himmpocampus, 3) posterior lateral temporal cortex, 4) anterior lateral temporal cortex. Analyses of the regional interaction revealed that new visual information was initially encoded into the hippocampus, and was later consolidated in the posterior lateral temporal cortex, and was retreived via integration from the posterior to anterior lateral temporal cortex.

Report

(4 results)
  • 2013 Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (53 results)

All 2013 2012 2011 2010 Other

All Journal Article (13 results) (of which Peer Reviewed: 13 results,  Open Access: 1 results) Presentation (39 results) (of which Invited: 1 results) Remarks (1 results)

  • [Journal Article] Functional relevance of micromodules in the human association cortex delineated with high- resolution fMRI2013

    • Author(s)
      Hirose S., Watanabe T., Wada H., Imai Y., Machida T., Shirouzu I., Miyashita Y., Konishi S
    • Journal Title

      Cerebral Cortex

      Volume: 23 Issue: 12 Pages: 2863-2871

    • DOI

      10.1093/cercor/bhs268

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dissociable temporo-parietal memory networks revealed by functional connectivity during episodic retrieval2013

    • Author(s)
      Hirose S., Kimura H. M., Jimura K., Kunimatsu A., Abe O, Ohtomo K., Miyashita Y., Konishi S
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 8 Pages: e71210-e71210

    • DOI

      10.1371/journal.pone.0071210

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A pairwise maximum entropy model accurately describes resting-state human brain networks.2013

    • Author(s)
      渡部喬光
    • Journal Title

      Nature Communications

      Volume: 4 Issue: 1 Pages: 1370-1370

    • DOI

      10.1038/ncomms2388

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional dissociation between anterior and posterior temporal cortical regions during retrieval of remote memory2012

    • Author(s)
      Watanabe T., Kimura H. M., Hirose S., Wada H., Imai Y., Machida T., Shirouzu I., Miyashita Y., Konishi S
    • Journal Title

      Journal of Neuroscience

      Volume: 32 Issue: 28 Pages: 9659-9670

    • DOI

      10.1523/jneurosci.5553-11.2012

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficiency of go/no-go task performance implemented in the left hemisphere2012

    • Author(s)
      Hirose S., Chikazoe J., Watanabe T., Jimura K., Kunimatsu A., Abe O., Ohtomo K., Miyashita Y., Konishi S
    • Journal Title

      Journal of Neuroscience

      Volume: 32 Issue: 26 Pages: 9059-9065

    • DOI

      10.1523/jneurosci.0540-12.2012

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Local signal time-series during rest used for areal boundary mapping in individual human brains2012

    • Author(s)
      Hirose S., Watanabe T., Jimura K., Katsura M., Kunimatsu A., Abe O., Ohtomo K., Miyashita Y., Konishi S
    • Journal Title

      PLoS ONE

      Volume: 7 Issue: 5 Pages: e36496-e36496

    • DOI

      10.1371/journal.pone.0036496

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prediction of Subsequent Recognition Performance Using Brain Activity in the Medial Temporal Lobe2011

    • Author(s)
      Watanabe, T., et al.
    • Journal Title

      NeuroImage

      Volume: 54 Issue: 4 Pages: 3085-3092

    • DOI

      10.1016/j.neuroimage.2010.10.066

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role for presupplementary motor area in inhibition of cognitive set interference2011

    • Author(s)
      Konishi, S., Watanabe, T., Jimura, K., Chikazoe, J., Hirose, S., Kimura, H. M. and Miyashita, Y.
    • Journal Title

      J. Cogn. Neurosci

      Volume: 23 Issue: 3 Pages: 737-745

    • DOI

      10.1162/jocn.2010.21480

    • Related Report
      2013 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Medial prefrontal activity during shifting under novel situations2010

    • Author(s)
      Konishi S., Hirose S., Jimura K., Chikazoe J., Watanabe T., Kimura H. M., Miyashita Y
    • Journal Title

      Neuroscience Letters

      Volume: 484 Issue: 3 Pages: 182-186

    • DOI

      10.1016/j.neulet.2010.08.047

    • Related Report
      2013 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temporal pole activity during understanding other persons' mental state correlated with neuroticism trait2010

    • Author(s)
      Jimura K., Konishi S., Asari T., Miyashita Y
    • Journal Title

      Brain Research

      Volume: 1328 Pages: 104-112

    • DOI

      10.1016/j.brainres.2010.03.016

    • Related Report
      2013 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amygdalar modulation of frontotemporal connectivity during the inkblot test2010

    • Author(s)
      Asari, T., Konishi, S., Jimura, K., Chikazoe, J., Nakamura, N. and Miyashita, Y.
    • Journal Title

      Psychiatry Research : Neuroimaging

      Volume: 182 Issue: 2 Pages: 103-110

    • DOI

      10.1016/j.pscychresns.2010.01.002

    • Related Report
      2013 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential temporo- parietal cortical networks that support relational and item-based recency judgments2010

    • Author(s)
      Kimura H. M., Hirose S., Kunimatsu A., Chikazoe J., Jimura K., Watanabe T., Abe O., Ohtomo K., Miyashita Y., Konishi S
    • Journal Title

      Neuroimage

      Volume: 49 Issue: 4 Pages: 3474-3480

    • DOI

      10.1016/j.neuroimage.2009.11.003

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amygdalar enlargement associated with unique perception2010

    • Author(s)
      Asari, T., Konishi, S., Jimura, K., Chikazoe, J., Nakamura, N. and Miyashita, Y.
    • Journal Title

      Cortex

      Volume: 46 Issue: 1 Pages: 94-99

    • DOI

      10.1016/j.cortex.2008.08.001

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Human association cortex is composed of functionally relevant micro-modules : a high- resolution fMRI study using resting-state functional connectivity2013

    • Author(s)
      Hirose S., Watanabe T., Wada H., Imai Y., Machida T., Shirouzu I., Miyashita Y., Konishi S
    • Organizer
      Physiological Society of Japan Conference
    • Related Report
      2013 Final Research Report
  • [Presentation] Simplicity of human brain networks : resting-state functional brain networks can be accurately described by a pairwise maximum entropy model2013

    • Author(s)
      Watanabe T., Hirose S., Wada H., Imai Y., Machida T., Shirouzu I., Konishi S., Miyashita Y., Masuda N
    • Organizer
      Japan Neuroscience Society Conference
    • Related Report
      2013 Final Research Report
  • [Presentation] Inter-regional task- related functional correlation in temporo-parietal networks : A functional MRI study of recency judgments2013

    • Author(s)
      Hirose S., Kimura H. M., Kunimatsu A., Abe O., Ohtomo K., Miyashita Y., Konishi S
    • Organizer
      Japan Neuroscience Society Conference
    • Related Report
      2013 Final Research Report
  • [Presentation] Neural mechanisms of memory retrieval revealed by fMRI2013

    • Author(s)
      Konishi S
    • Organizer
      Japan Neuroscience Society Conference
    • Related Report
      2013 Final Research Report
  • [Presentation] QPS施行による安静時機能的結合の変化2013

    • Author(s)
      小西清貴
    • Organizer
      日本ヒト脳マッピング学会
    • Related Report
      2013 Final Research Report
  • [Presentation] Human association cortex is composed of functionally relevant micro-modules: a high-resolution fMRI study using resting-state functional connectivity2013

    • Author(s)
      Hirose S., Watanabe T., Wada H., Imai Y., Machida T., Shirouzu I., Miyashita Y., Konishi S.
    • Organizer
      日本生理学会
    • Place of Presentation
      タワーホール船堀、東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Simplicity of human brain networks: resting-state functional brain networks can be accurately described by a pairwise maximum entropy model.2013

    • Author(s)
      Watanabe T., Hirose S., Wada H., Imai Y., Machida T., Shirouzu I., Konishi S., Miyashita Y., Masuda N.
    • Organizer
      日本神経科学学会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2012 Annual Research Report
  • [Presentation] Inter-regional task-related functional correlation in temporo-parietal networks: A functional MRI study of recency judgments2013

    • Author(s)
      Hirose S., Kimura H. M., Kunimatsu A., Abe O., Ohtomo K., Miyashita Y., Konishi S.
    • Organizer
      日本神経科学学会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2012 Annual Research Report
  • [Presentation] Neural mechanisms of memory retrieval revealed by fMRI2013

    • Author(s)
      Konishi. S
    • Organizer
      日本神経科学学会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Temporal neocortex shows antero-posterior functional dissociation during retrieval of remote memory2012

    • Author(s)
      Watanabe T., Kimura H. M., Hirose S., Wada H., Imai Y., Machida T., Shirouzu I., Miyashita Y., Konishi S
    • Organizer
      Human Brain Mapping Conference
    • Related Report
      2013 Final Research Report
  • [Presentation] Antero- posterior functional difference in the temporal neocortex during retrieval of remote memory2012

    • Author(s)
      Watanabe T., Kimura H. M., Hirose S., Wada H., Imai Y., Machida T., Shirouzu I., Miyashita Y., Konishi S
    • Organizer
      Japan Neuroscience Society Conference
    • Related Report
      2013 Final Research Report
  • [Presentation] Convergence of category-specific information in the temporal neocortex during retrieval of remote memory2012

    • Author(s)
      Watanabe T., Kimura H. M., Hirose S., Wada H., Katsura M., Imai Y., Machida T., Shirouzu I., Miyashita Y., Konishi S
    • Organizer
      Society for Neuroscience Conference
    • Related Report
      2013 Final Research Report
  • [Presentation] Large-scale brain networks specific to different bands of brain waves : application of a pairwise maximum entropy model to EEG-fMRI data2012

    • Author(s)
      Hirose S., Watanabe T., Misaki M., Kan S., Koike T., Miyauchi S., Konishi S
    • Organizer
      Society for Neuroscience Conference
    • Related Report
      2013 Final Research Report
  • [Presentation] Temporal neocortex shows antero-posterior functional dissociation during retrieval of remote memory2012

    • Author(s)
      Watanabe T., Kimura H. M., Hirose S., Wada H., Imai Y., Machida T., Shirouzu I., Miyashita Y., Konishi S.
    • Organizer
      Human Brain Mapping
    • Place of Presentation
      China National Convention Center Beijing, China
    • Related Report
      2012 Annual Research Report
  • [Presentation] Antero-posterior functional difference in the temporal neocortex during retrieval of remote memory2012

    • Author(s)
      Watanabe T., Kimura H. M., Hirose S., Wada H., Imai Y., Machida T., Shirouzu I., Miyashita Y., Konishi S.
    • Organizer
      日本神経科学学会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Convergence of category-specific information in the temporal neocortex during retrieval of remote memory2012

    • Author(s)
      Watanabe T., Kimura H. M., Hirose S., Wada H., Katsura M., Imai Y., Machida T., Shirouzu I., Miyashita Y., Konishi S.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      New Orleans Ernest N. Morial Convention Center, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Large-scale brain networks specific to different bands of brain waves: application of a pairwise maximum entropy model to EEG-fMRI data2012

    • Author(s)
      Hirose S., Watanabe T., Misaki M., Kan S., Koike T., Miyauchi S., Konishi S.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      New Orleans Ernest N. Morial Convention Center, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Functional areas in human inferior frontal cortex as revealed by combination of resting-state functional connectivity and high-resolution fMRI2011

    • Author(s)
      Hirose S, et al.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-11-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Functional areas in the inferior frontal cortex based on brain activity and functional connectivity2011

    • Author(s)
      Konishi S
    • Organizer
      The Japan Neuroscience Society
    • Place of Presentation
      パシフィコ横浜、神奈川県
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of amygdala in retrograde memory enhancement induced by emotional arousal2011

    • Author(s)
      Chikazoe J, et al.
    • Organizer
      The Japan Neuroscience Society
    • Place of Presentation
      パシフィコ横浜、神奈川県
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Prediction of future memory cognition by multivariate pattern analysis2011

    • Author(s)
      Watanabe T, et al.
    • Organizer
      Association for the Scientific Study of Consciousness
    • Place of Presentation
      京都大学百周年時計台記念館京都府
    • Year and Date
      2011-06-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] 記憶の貯蔵庫:側頭葉2011

    • Author(s)
      小西清貴
    • Organizer
      日本医学放射線学会
    • Place of Presentation
      パシフィコ横浜、神奈川県(招待講演)
    • Year and Date
      2011-04-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] 機能的MRIによるヒト高次脳機能解析2011

    • Author(s)
      小西清貴
    • Organizer
      日本神経放射線学会
    • Place of Presentation
      東京コンファレンスセンター、東京都(招待講演)
    • Year and Date
      2011-02-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analyses of human higher- order brain functions using functional MRI2011

    • Author(s)
      Konishi S
    • Organizer
      Japanese Society of Neuroradiology Conference Conference
    • Related Report
      2013 Final Research Report
  • [Presentation] Memory store : The temporal lobe2011

    • Author(s)
      Konishi S
    • Organizer
      Jap Radiological Society Conference
    • Related Report
      2013 Final Research Report
  • [Presentation] Prediction of future memory cognition by multivariate pattern analysis2011

    • Author(s)
      Watanabe T., Hirose S., Wada H., Katsura M., Chikazoe J., Jimura K., Imai Y., Machida T., Shirouzu I., Miyashita Y., Konishi S
    • Organizer
      Association for the Scientific Study of Consciousness Conference
    • Related Report
      2013 Final Research Report
  • [Presentation] Functional areas in the inferior frontal cortex based on brain activity and functional connectivity2011

    • Author(s)
      Konishi S
    • Organizer
      Japan Neuroscience Society Conference
    • Related Report
      2013 Final Research Report
  • [Presentation] Role of amygdala in retrograde memory enhancement induced by emotional arousal2011

    • Author(s)
      Chikazoe J., Anderson A., Hirose S., Yamashita K., Miyashita Y., Konishi S
    • Organizer
      Japan Neuroscience Society Conference
    • Related Report
      2013 Final Research Report
  • [Presentation] Functional areas in human inferior frontal cortex as revealed by combination of resting-state functional connectivity and high-resolution fMRI2011

    • Author(s)
      Hirose S., Watanabe T., Wada H., Katsura M., Jimura K., Kunimatsu A., Abe O., Ohtomo K., Imai Y., Machida T., Shirouzu I., Miyashita Y., Konishi S
    • Organizer
      Society for Neuroscience Conference
    • Related Report
      2013 Final Research Report
  • [Presentation] Multivoxel pattern analysis of brain activity in the medial temporal lobe and prediction of subsequent recognition performance2010

    • Author(s)
      Watanabe, et al
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-11-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Temporo-parietal cortical networks for recency judgments as revealed by a resting-state functional connectivity analysis2010

    • Author(s)
      Kimura, et al
    • Organizer
      The Japan Neuroscience Society
    • Place of Presentation
      神戸国際会議場、兵庫県
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 抑制機能と前頭葉2010

    • Author(s)
      小西清貴
    • Organizer
      日本認知神経科学学会
    • Place of Presentation
      松江テルサ、島根県
    • Year and Date
      2010-07-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Medial Prefrontal Activation during Shifting in the Wisconsin Card Sorting Test2010

    • Author(s)
      Konishi, et al
    • Organizer
      Organization for Human Brain Mapping
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-06-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Neural correlates of inhibition of proactive interference from cognitive set2010

    • Author(s)
      Konishi, et al
    • Organizer
      Cognitive Neuroscience Society
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2010-04-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Neural correlates of inhibition of proactive interference from cognitive set2010

    • Author(s)
      Konishi S., Jimura K., Chikazoe J., Hirose S., Watanabe T., Kimura H., Miyashita Y
    • Organizer
      Cognitive Neuroscience Society Conference
    • Related Report
      2013 Final Research Report
  • [Presentation] Medial Prefrontal Activation during Shifting in the Wisconsin Card Sorting Test2010

    • Author(s)
      Konishi S., Hirose S., Jimura K., Chikazoe J., Watanabe T., Kimura H. M., Miyashita Y
    • Organizer
      Human Brain Mapping Conference
    • Related Report
      2013 Final Research Report
  • [Presentation] Inhibitory functions and the frontal lobe2010

    • Author(s)
      Konishi S
    • Organizer
      Japanese Society of Cognitive Neuroscience Conference
    • Related Report
      2013 Final Research Report
  • [Presentation] Temporo-parietal cortical networks for recency judgments as revealed by a resting-state functional connectivity analysis2010

    • Author(s)
      Kimura H. M., Hirose S., Kunimatsu A., Chikazoe J., Jimura K., Watanabe T., Abe O., Ohtomo K., Miyashita Y., Konishi S
    • Organizer
      Japan Neuroscience Society Conference
    • Related Report
      2013 Final Research Report
  • [Presentation] Multivoxel pattern analysis of brain activity in the medial temporal lobe and prediction of subsequent recognition performance2010

    • Author(s)
      Watanabe T., Hirose S., Katsura M., Imai Y., Chikazoe J., Kimura H. M., Jimura K., Machida T., Shirouzu I., Miyashita Y., Konishi S
    • Organizer
      Society for Neuroscience Conference
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://square.umin.ac.jp/physiol1/

    • Related Report
      2013 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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