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Investigation of intracerebral processing of various somatosensory stimuli, mainlu painand itch.

Research Project

Project/Area Number 22300135
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Fusional brain recording science
Research InstitutionNational Institute for Physiological Sciences

Principal Investigator

KAKIGI Ryusuke  生理学研究所, 統合生理研究系, 教授 (10145196)

Project Period (FY) 2010-04-01 – 2013-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2012: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords痛み / 痒み / 体性感覚 / 脳波 / 脳磁図 / 機能的MRI / MRI / 触覚 / 視覚 / 注意 / ニコチン / 喫煙
Research Abstract

Concerning pain perception in humans, we developed a new stimulus electrode for selectively stimulating pain-specific receptors of the skin. This needle is highly evaluated throughout the world, and many researchers and clinicians are now using this not only for basic studies but also for clinical application.
Regarding itch perception in humans, we clarified intra-cerebral mechanisms for the following two unique phenomena: (1) Itch is contagious: When we look at other persons' skin appearing very itchy, we also feel that our skin is itchy and sometimes desire to scratch. (2) Feeling pleasantness while scratching itchy skin: When we scratch itchy skin, we usually feel pleasantness and desire to continue. We found that the reward system in our brain is activated in such a case.

Report

(4 results)
  • 2013 Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (49 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (18 results) (of which Peer Reviewed: 17 results) Presentation (26 results) (of which Invited: 6 results) Book (1 results) Remarks (4 results)

  • [Journal Article] Cortical responses to C-fiber stimulation by intra-epidermal electrical stimulation : an MEG study2014

    • Author(s)
      Motogi J, Kodaira M, Muragaki Y, Inui K, Kakigi R
    • Journal Title

      Neurosci Lett.

      Volume: (in press) Pages: 69-74

    • DOI

      10.1016/j.neulet.2014.04.001

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The cerebral representation of scratching-induced pleasantness.2014

    • Author(s)
      Mochizuki H, Tanaka S, Morita T, Wasaka T, Sadato N, Kakigi R
    • Journal Title

      J Neurophysiol

      Volume: 111 Issue: 3 Pages: 488-498

    • DOI

      10.1152/jn.00374.2013

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of nociceptive A-δ(delta) and C-fiber dysfunction with lidocaine using intraepidermal electrical stimulation2014

    • Author(s)
      Kodaira M, Inui K, Kakigi R
    • Journal Title

      Clin Neurophysiol.

      Volume: (in press) Issue: 9 Pages: 1870-1877

    • DOI

      10.1016/j.clinph.2014.01.009

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Treede RD (2013) Cortico-subcortical activation patterns for itch and pain imagery2013

    • Author(s)
      Mochizuki H, Baumgartner U, Kamping S, Ruttorf M, Schad LR, Flor H, Kakigi R
    • Journal Title

      Pain

      Volume: 154(10) Issue: 10 Pages: 1989-1998

    • DOI

      10.1016/j.pain.2013.06.007

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Somatotopic representation of pain in the primary somatosensory cortex (S1) in humans2013

    • Author(s)
      Omori S, Isose S, Otsuru N, Nishihara M, Kuwabara S, Inui K, Kakigi R
    • Journal Title

      Clin Neurophysiol.

      Volume: 124(7) Issue: 7 Pages: 1422-1430

    • DOI

      10.1016/j.clinph.2013.01.006

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pain perception in humans : use of intra-epidermal electrical stimulation2012

    • Author(s)
      Inui K, Kakigi R
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 83(5) Issue: 5 Pages: 551-556

    • DOI

      10.1136/jnnp-2011-301484

    • Related Report
      2013 Final Research Report 2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The relationship between reaction time and response variability and somatosensory No-go potentials2012

    • Author(s)
      Nakata H, Kakigi R, et al
    • Journal Title

      European Journal of Applied Physiology

      Pages: 207-214

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Painful muscle stimulation preferentially activates emotion-related brain regions compared to painful skin stimulation2011

    • Author(s)
      Takahashi K, Taguchi T, Tanaka S, Sadato N, Qiu, Y, Kakigi R, Mizumura K
    • Journal Title

      Neurosci Res.

      Volume: 70(3) Pages: 285-293

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Assessing A-delta fiber function with lidocaine using intra-epidermal electrical stimulaion2011

    • Author(s)
      Otsuru N, Inui K, Yamashiro K, Miyazaki T, Takeshima Y, Kakigi R
    • Journal Title

      J Pain

      Volume: 11, (7) Issue: 7 Pages: 621-627

    • DOI

      10.1016/j.jpain.2009.10.001

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The relationship in gating effects between short- and long-latency SEPs2011

    • Author(s)
      Nakata H, Kakigi R, et al
    • Journal Title

      NeuroReport

      Volume: 22 Issue: 18 Pages: 1000-1004

    • DOI

      10.1097/wnr.0b013e32834dc296

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conflict caused by visual feedback modulates activation in somatosensory areas during movement execution2011

    • Author(s)
      Wasaka T, Kakigi R
    • Journal Title

      Neuroimage

      Volume: 59 Pages: 1501-1507

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Painful muscle stimulation preferentially activates emotion-related brain regions compared to painful skin stimulation2011

    • Author(s)
      Takahashi K, Kakigi R, et al
    • Journal Title

      Neuroscience Research

      Volume: 70 Issue: 3 Pages: 285-293

    • DOI

      10.1016/j.neures.2011.04.001

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamics of within-, inter- and cross-modal attentional modulation2011

    • Author(s)
      Kida T, Kakigi R, et al
    • Journal Title

      Journal of Neurophysiology

      Volume: 105 Issue: 2 Pages: 674-686

    • DOI

      10.1152/jn.00807.2009

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neural representation of feature synergy2011

    • Author(s)
      Kida T, Kakigi R, et al
    • Journal Title

      Neuroimage

      Volume: 55 Issue: 2 Pages: 669-680

    • DOI

      10.1016/j.neuroimage.2010.11.054

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of smoking on pain-related evoked potentials2010

    • Author(s)
      Miyazaki T, Wang X, Inui K, Domino EF, Kakigi R
    • Journal Title

      Brain Res.

      Volume: 1313 Pages: 185-191

    • DOI

      10.1016/j.brainres.2009.12.022

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effect of smoking on pain-related evoked potentials.2010

    • Author(s)
      Miyazaki T, Kakigi R, 他3名
    • Journal Title

      Brain Research

      Volume: 1313 Pages: 185-191

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assessing A-delta fiber function with lidocaine using intra-epidermal electrical stimulation.2010

    • Author(s)
      Otsuru N, Kakigi R, 他4名
    • Journal Title

      Journal of Pain

      Volume: 11 Pages: 621-627

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 痛みと痒みの脳内認知機構2010

    • Author(s)
      柿木隆介、望月秀紀
    • Journal Title

      慢性疼痛

      Volume: 29 Pages: 7-12

    • NAID

      40018968221

    • Related Report
      2010 Annual Research Report
  • [Presentation] Pain and itch perception in humans2014

    • Author(s)
      Kakigi R
    • Organizer
      30th International Congress of Clinical Neurophysiology (ICCN2014) of the IFCN
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2013 Final Research Report
  • [Presentation] Pain and itch perception in humans.2014

    • Author(s)
      Kakigi R
    • Organizer
      5th Asian Pain Symposium
    • Place of Presentation
      Estrel Hotel, Berllin, Bermany
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 脳内研究の最前線~痛みとかゆみの脳内認知機能はどこまで解明されたか~2013

    • Author(s)
      柿木隆介
    • Organizer
      第58回日本透析医学会学術集会
    • Place of Presentation
      福岡市
    • Year and Date
      2013-06-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Pain and itch perception in humans2013

    • Author(s)
      Kakigi R
    • Organizer
      5th Asian Pain Symposium
    • Place of Presentation
      Okazaki, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] 【教育講演18疼痛の神経生理】疼痛関連脳電位の現況2013

    • Author(s)
      柿木隆介
    • Organizer
      第43回日本臨床神経学会学術大会
    • Place of Presentation
      高知市
    • Related Report
      2013 Final Research Report
  • [Presentation] Special Lecture III : Painful and itchy brain. 1st Joint CU-NIPS Symposium"Frontier in Physiological Sciences Research : From Basic Research to Diseases and Treatments2013

    • Author(s)
      Kakigi R
    • Organizer
      1st Joint CU-NIPS Symposium
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2013 Final Research Report
  • [Presentation] Evoked potentials and fields2013

    • Author(s)
      Kakigi R
    • Organizer
      The 5th Asian and Oceanian Congress of Clinical Neurophysiology
    • Place of Presentation
      Bali, Indonesia
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Pain and itch perception in humans.2013

    • Author(s)
      Kakigi R
    • Organizer
      5th Asian Pain Symposium
    • Place of Presentation
      National Institute for Physiological Sciences, Okazaki, Japan
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Painful and itchy brain.2013

    • Author(s)
      Kakigi R
    • Organizer
      1st Joint CU-NIPS Symposium
    • Place of Presentation
      Chulalongkorn University, Bangkok, Thailand.
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Evoked potentials and fields2013

    • Author(s)
      Kakigi R
    • Organizer
      Evoked potentials and fields
    • Place of Presentation
      Nusa Dua Conference Center, Bali, Indonesia.
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] The painful brain2012

    • Author(s)
      Kakigi R
    • Organizer
      The 2nd Joint Symposium of NIPS
    • Place of Presentation
      Tubingen University, Tubingen, Germany
    • Year and Date
      2012-11-29
    • Related Report
      2013 Final Research Report
  • [Presentation] The painful and itchy brain2012

    • Author(s)
      Kakigi R
    • Organizer
      The 1st NIPS / Tubingen University Joint Neuroscience Symposium
    • Place of Presentation
      Okazaki, Japan
    • Year and Date
      2012-02-25
    • Related Report
      2013 Final Research Report
  • [Presentation] シンポジウムヒトの脳内痛覚認知機構の解明2012

    • Author(s)
      柿木隆介
    • Organizer
      第17回日本心療内科学会総会・学術大会
    • Place of Presentation
      福岡市
    • Related Report
      2013 Final Research Report
  • [Presentation] 「痛みと音楽」について2012

    • Author(s)
      柿木隆介
    • Organizer
      コメディカル講演会第34回日本疼痛学会
    • Place of Presentation
      熊本市
    • Related Report
      2013 Final Research Report
  • [Presentation] The painful brain.2012

    • Author(s)
      Kakigi R
    • Organizer
      The 2nd Joint Symposium of NIPS / Tubingen University,
    • Place of Presentation
      Tubingen University, Tubingen, Germany
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Painful and itchy Brain2011

    • Author(s)
      Kakigi R
    • Organizer
      Germany-Japan Round Table 2011
    • Place of Presentation
      Heidelberg, Germany
    • Year and Date
      2011-12-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 痛みと痒みの脳内認知機構教育講演2011

    • Author(s)
      柿木隆介
    • Organizer
      第41回日本臨床神経生理学会
    • Place of Presentation
      静岡市
    • Related Report
      2013 Final Research Report
  • [Presentation] 脳が感じる:痛みとかゆみの脳機能2011

    • Author(s)
      柿木隆介
    • Organizer
      (シンポジウム)第49回全国大学保健管理協会関東甲信越地方部会研究集会
    • Place of Presentation
      東京都
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒトの脳内痛覚認知機構の解明2011

    • Author(s)
      柿木隆介
    • Organizer
      日本ペインクリニック学会第45回大会・第33回日本疼痛学会(愛媛ペイン2011)
    • Place of Presentation
      松山市
    • Related Report
      2013 Final Research Report
  • [Presentation] 神経イメージング手法を用いたヒトの痛覚認知機構の解明2010

    • Author(s)
      柿木隆介
    • Organizer
      第9回三重神経生理学研究所フォーラム
    • Place of Presentation
      津
    • Year and Date
      2010-10-15
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒトの痛みと痒みの脳内認知機構の解明2010

    • Author(s)
      柿木隆介
    • Organizer
      第24回日本歯科麻酔学会リフレッシャーコース
    • Place of Presentation
      日本歯科大学富士見ホール(東京都)
    • Year and Date
      2010-07-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Painful Brain2010

    • Author(s)
      Kakigi R
    • Organizer
      The 13th Scientific Meeting of Asian Academy of Craniomandibular Disorders(13th AACMD) and The 15th Scientific Meeting of Japanese Society of Orofacial Pain (15th JSOP)
    • Place of Presentation
      Fukuoka, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] 痒みと痛みの脳内認知機構2010

    • Author(s)
      柿木隆介
    • Organizer
      第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同学会(Neuro2010)
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] 喫煙(ニコチン)が痛覚認知に与える影響2010

    • Author(s)
      柿木隆介
    • Organizer
      第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同学会(Neuro2010)
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] 神経イメージング手法を用いたヒトの痛覚認知機構:特に心の痛みについて2010

    • Author(s)
      柿木隆介
    • Organizer
      第10回日本抗加齢医学会総会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 痛みと痒みの脳内認知機構の解明

    • Author(s)
      柿木隆介
    • Organizer
      第24回日本歯科麻酔学会
    • Place of Presentation
      東京都
    • Related Report
      2013 Final Research Report
  • [Book] 第6章痛みの仕組みと心身相関、ここまでわかった心身相関2013

    • Author(s)
      柿木隆介 編集久保千春
    • Publisher
      診断と治療社東京
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.nips.ac.jp/smf/index.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 生理学研究所感覚運動調節研究部門 webページ

    • URL

      http://www.nips.ac.jp/smf/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.nips.ac.jp/smf/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.nips.ac.jp/smf/

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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