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Brain information processing mechanism of reward-seeking behavior and decision-making.

Research Project

Project/Area Number 22300138
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Fusional social brain science
Research InstitutionUniversity of Tsukuba

Principal Investigator

SHIDARA Munetaka  筑波大学, 医学医療系, 教授 (10357189)

Co-Investigator(Kenkyū-buntansha) MATSUMOTO Narihisa  独立行政法人産業技術総合研究所, ヒューマンライフテクノロジー研究部門, 主任研究員 (00392663)
HIGO Noriyuki  独立行政法人産業技術総合研究所, ヒューマンライフテクノロジー研究部門, 主任研究員 (80357839)
Co-Investigator(Renkei-kenkyūsha) SUGASE Yasuko  独立行政法人産業技術総合研究所, ヒューマンライフテクノロジー研究部門, 主任研究員 (40357257)
MIZUHIKI Takashi  筑波大学, 医学医療系, 助教 (60463824)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2010: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywords報酬価値 / 行動決定 / 労働負荷 / 単一ニューロン記録 / アカゲザル / 報酬系 / 自己選択効果
Research Abstract

We investigated information processing mechanism of decision-making by using the task of choosing one of two alternatives that have different work load and reward amount. The error rate of the task performance was well explained by the exponential discounting model of the reward value. Neurons in the orbitofrontal cortex responded to the differential value of the two alternatives. On the other hand, in reward schedules, neurons in the dorsal raphe coded the beginning of the schedule and the reward information not only by the spike strengths but also by their temporal patterns.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (38 results)

All 2013 2012 2011 2010 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (28 results) Remarks (1 results)

  • [Journal Article] Neurons in monkey dorsal raphe nucleus code beginning and progress of step-by-step schedule, reward expectation, and amount of reward outcome in the reward schedule task.2013

    • Author(s)
      Inaba K, Mizuhiki T, Setogawa T, Toda K, Richmond BJ, Shidara M.
    • Journal Title

      The Journal of Neuroscience

      Volume: 33(8) Issue: 8 Pages: 3477-3491

    • DOI

      10.1523/jneurosci.4388-12.2013

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional Annotation of Genes Differentially Expressed Between Primary Motor and Prefrontal Association Cortices of Macaque Brain2013

    • Author(s)
      Toshio Kojima
    • Journal Title

      Neurochemical Research

      Volume: 38 Issue: 1 Pages: 133-140

    • DOI

      10.1007/s11064-012-0900-4

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Encoding of reward expectation by monkey anterior insular neurons.2012

    • Author(s)
      Mizuhiki T, Richmond BJ, Shidara M.
    • Journal Title

      Journal of Neurophysiology

      Volume: vol.107 Issue: 11 Pages: 2996-3007

    • DOI

      10.1152/jn.00282.2011

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential encoding of factors influencing predicted reward value in monkey rostral anterior cingulate cortex.2012

    • Author(s)
      Toda K, Sugase-Miyamoto Y, Mizuhiki T, Inaba K, Richmond BJ, Shidara M.
    • Journal Title

      PLoS One

      Volume: vol.7(1) Issue: 1 Pages: e30190-e30190

    • DOI

      10.1371/journal.pone.0030190

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The influence of passband limitation on the waveform of extracellular action potential.2012

    • Author(s)
      Mizuhiki T, Inaba K, Setogawa T, Toda K, Ozaki S, Shidara M.
    • Journal Title

      Neuroscience Research

      Volume: vol.72(3) Issue: 3 Pages: 214-220

    • DOI

      10.1016/j.neures.2011.12.004

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stimulus-Related Activity during Conditional Associations in Monkey Perirhinal Cortex Neurons Depends on Upcoming Reward Outcome2012

    • Author(s)
      Kaoru Ohyama
    • Journal Title

      The Journal of Neuroscience

      Volume: 32 Issue: 48 Pages: 17407-17419

    • DOI

      10.1523/jneurosci.2878-12.2012

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of temporal processing stages by inferior temporal neurons in facial recognition2011

    • Author(s)
      Sugase-Miyamoto Y, Matsumoto N, Kawano K
    • Journal Title

      Front Psychol

      Volume: 2 Pages: 141-141

    • DOI

      10.3389/fpsyg.2011.00141

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SPP1 expression in spinal motor neurons of the macaque monkey.2011

    • Author(s)
      Yamamoto T, Higo N, Sato A, Nishimura Y, Oishi T, Murata Y, Yoshino-Saito K, Isa T, Kojima T
    • Journal Title

      Neuroscience Research

      Volume: 69 Pages: 81-86

    • NAID

      10028190361

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] c-Fos expression during temporal order judgment in mice.2010

    • Author(s)
      Wada M, Higo N, Moiaumi S, Kitazawa S
    • Journal Title

      PloS one

      Volume: 5(5)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Single neuronal activity in the rhesus monkey orbitofrontal cortex related to reward value processing during the decision-making schedule task.2012

    • Author(s)
      Setogawa T, Mizuhiki T, Inaba K, Akizawa F, Shidara M.
    • Organizer
      42nd Annual meeting of the Society for Neuroscience
    • Place of Presentation
      Ernest N. Morial Convention Center, New Orleans (USA).
    • Year and Date
      2012-10-16
    • Related Report
      2012 Final Research Report
  • [Presentation] アカゲザル背側縫線核は報酬スケジュール課題遂行中に無報酬・報酬の予測,結果,不確実性と関連した活動を示す2012

    • Author(s)
      稲葉清規, 水挽貴至, 瀬戸川剛, 秋澤文香, 兎田幸司, 設楽宗孝
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本文化会館(長野県)
    • Year and Date
      2012-03-31
    • Related Report
      2011 Annual Research Report
  • [Presentation] 行動決定課題および報酬スケジュール課題遂行中におけるサルの行動成績の報酬価値時間割引モデルによる比較2012

    • Author(s)
      瀬戸川剛、水挽貴至、稲葉清規、設楽宗孝
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本文化会館(長野県)
    • Year and Date
      2012-03-31
    • Related Report
      2011 Annual Research Report
  • [Presentation] 報酬スケジュール中のサル前部帯状皮質、前部島皮質、腹側線条体間における単一ニューロン活動の比較2012

    • Author(s)
      水挽貴至、リッチモンド・バリー、設楽宗孝
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本文化会館(長野県)
    • Year and Date
      2012-03-31
    • Related Report
      2011 Annual Research Report
  • [Presentation] Comparison of monkeys' behavioral performances in reward schedule task with and without decision-making by temporal discounting model of reward value.2011

    • Author(s)
      Setogawa T, Mizuhiki T, Inaba K,Shidara M.
    • Organizer
      41st Annual meeting of the Society for Neuroscience
    • Place of Presentation
      Washington DC Convention center , Washington DC (USA).
    • Year and Date
      2011-11-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Comparison of monkeys' behavioral performances in reward schedule task with and without decision-making by temporal discounting model of reward value2011

    • Author(s)
      T.SETOGAWA, T.MIZUHIKI, K. INABA, M.SHIDARA
    • Organizer
      41th Annual meeting of the Society for Neuroscience
    • Place of Presentation
      Washington DC Convention center (USA)
    • Year and Date
      2011-11-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Neurons in monkey dorsal raphe nucleus showed activity related to unreward/reward expectancy and acquisition, and reward uncertainty in the reward schedule task.2011

    • Author(s)
      Inaba K, Mizuhiki T, Setogawa T, Toda K, Shidara M.
    • Organizer
      41st Annual meeting of the Society for Neuroscience
    • Place of Presentation
      Washington DC Convention center, Washington DC (USA)
    • Year and Date
      2011-11-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Neurons in monkey dorsal raphe nucleus showed activity related to unreward/reward expectancy and acquisition, and reward uncertainty in the reward schedule task2011

    • Author(s)
      K.INABA, T.MIZUHIKI, T.SETOGAWA, K.TODA, M.SHIDARA
    • Organizer
      41th Annual meeting of the Society for Neuroscience
    • Place of Presentation
      Washington DC Convention center (USA)
    • Year and Date
      2011-11-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Specific neuron represents combinations of visual stimuli in area TE and reward contingency in perirhinal cortex2011

    • Author(s)
      K.OHYAMA, Y.SUGASE-MIYAMOTO, N.MATSUMOTO, M.SHIDARA, C.SATQU
    • Organizer
      41th Annual meeting of the Society for Neuroscience
    • Place of Presentation
      Washington DC Convention center (USA)
    • Year and Date
      2011-11-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Plastic changes in the ventral premotor area after primary motor cortex lesion in macaque monkeys : Possible involvement in functional compensation of manual dexterity2011

    • Author(s)
      Y.MURATA, N.HIGO, T.HAYASHI, Y.NISHIMURA, Y.SUGIYAMA, T.OISHI, H.TSUKADA, T.ISA, H.ONOE
    • Organizer
      41th Annual meeting of the Society for Neuroscience
    • Place of Presentation
      Washington DC Convention center (USA)
    • Year and Date
      2011-11-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] サルの背側縫線核で記録した細胞外活動電位の波形に対する帯域制限の影響2011

    • Author(s)
      水挽貴至, 稲葉清規, 瀬戸川剛, 兎田幸司, 尾崎繁, 設楽宗孝
    • Organizer
      第34回日本神経科学学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] A comparative analysis of results from intracortical microstimulation and single-unit recording in the primary motor cortex2011

    • Author(s)
      Hirofumi Nozaki, Ichiro Takashima, Noriyuki Higo
    • Organizer
      第34回日本神経科学学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 行動決定課題および報酬スケジュール課題遂行中のサルの行動成績における報酬価値の時間割引比較2011

    • Author(s)
      瀬戸川剛, 水挽貴至, 稲葉清規, 設楽宗孝
    • Organizer
      第34回日本神経科学学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Temporal discounting of reward value can account for probabilistic choice by monkeys.2011

    • Author(s)
      Setogawa T, Mizuhiki T, Inaba K, Shidara M
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      誌上開催
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] The behavioral performance of the rhesus monkey during reward schedule task with and without decision-making.2010

    • Author(s)
      Setogawa T, Mizuhiki T, Inaba K,Shidara M.
    • Organizer
      40th Annual meeting of the Society forNeuroscience
    • Place of Presentation
      San Diego Convention center, San Diego(USA).
    • Year and Date
      2010-11-17
    • Related Report
      2012 Final Research Report
  • [Presentation] The behavioral performance of the rhesus monkey during reward schedule task with and without decision-making.2010

    • Author(s)
      Setogawa T, Mizuhiki T, Inaba K, Shidara M
    • Organizer
      40th Annual meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego(米国)
    • Year and Date
      2010-11-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Doubly sparse factor models for selecting relevant neurons from multiple spike trains2010

    • Author(s)
      片平健太郎, 松本有央, 菅生康子, 岡ノ谷一夫, 岡田真人
    • Organizer
      40th Annual meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego(米国)
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Differential SPP1 expression between two New World monkeys : correlation with the ability of dexterous finger movement2010

    • Author(s)
      Yamamoto T, Oishi T, Higo N, Sato A, Murayama S, Nishimura Y, Murata Y, Yoshino-Saito K, Isa T, Kojima T
    • Organizer
      40th Annual meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego(米国)
    • Year and Date
      2010-11-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] 多点同時記録されたスパイク系列から関連するニューロンを選択するための 統計的手法2010

    • Author(s)
      片平健太郎, 松本有央, 菅生康子, 岡ノ谷一夫, 岡田真人
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] The comparison in behavior among decision-making task, probability matched schedule task and unmatched schedule task in rhesus2010

    • Author(s)
      Setogawa T, Mizuhiki T, Inaba K, Shidara M
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Self-choice encourages behavioral reactions during decision-making schedule task in rhesus monkey.2010

    • Author(s)
      Setogawa T, Mizuhiki T, Inaba K, Shidara M
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Neuronal activity in the monkey orbitofrontal cortex during the decision-making schedule task.

    • Author(s)
      Setogawa T, Mizuhiki T, Inaba K, Akizawa F, Shidara M.
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Neural substrates for the training-induced recovery of dexterous movements after motor cortex lesion in macaque monkeys.

    • Author(s)
      Higo N.
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Differential localization of secreted phosphoprotein 1 (SPP1) in intact and damaged motor cortex of the macaque monkey: expression in neurons and microglia.

    • Author(s)
      Sugiyama Y, Oishi T, Yamashita A, Murata Y, Yamamoto T, Isa T, Higo N.
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Related Report
      2012 Annual Research Report
  • [Presentation] SPP1 expression in the primary motor cortex of human with amyotrophic lateral sclerosis.

    • Author(s)
      Yamamoto T, Murayama S, Takao M, Isa T, Higo N.
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Single neuronal activity in the rhesus monkey orbitofrontal cortex related to reward value processing during the decision-making schedule task.

    • Author(s)
      Setogawa T, Mizuhiki T, Inaba K, Akizawa F, Shidara M.
    • Organizer
      42nd Annual meeting of the Society for Neuroscience
    • Place of Presentation
      Ernest N. Morial Convention Center, New Orleans (USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Correlation between neural activity and motor representation derived from intracortical microstimulation (ICMS) in the primary motor and ventral premotor cortex of the macaque monkey.

    • Author(s)
      Higo N, Kunori N, Takashima I.
    • Organizer
      42nd Annual meeting of the Society for Neuroscience
    • Place of Presentation
      Ernest N. Morial Convention Center, New Orleans (USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Single unit activity in the monkey orbitofrontal cortex related to reward value processing during the decision-making schedule task.

    • Author(s)
      Setogawa T, Mizuhiki T, Inaba K, Akizawa F, Matsumoto N, Shidara M.
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.md.tsukuba.ac.jp/basic-med/physiology/sys-neurosci/

    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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