| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2012: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2011: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2010: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Research Abstract |
In the present study, it was elucidated that parvoviral nonstructure (NS) protein induced DNA methylation in T lymphocytes and caused change of apoptosis resistancy and cell proliferation. Moreover, a possible effect of NS for incidence of collagen-induced arthritis was examined in vivo. The most of mouse T lymphocytes infected with NS-EGFP expression vector caused apoptosis, and the survived cells suppressed Bmper expression by DNA methylation. These cells acquired to be resistant for parvoviral re-infection. DBA/1 mice infected with NS-EGFP expression vector developed collagen-induced arthritis, though there was no significant difference on incidence of them to that of the control.
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