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The role of carbohydrates including galactose and sialic acids in higher brain functions

Research Project

Project/Area Number 22300142
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory animal science
Research InstitutionKanazawa University

Principal Investigator

ASANO Masahide  金沢大学, 学際科学実験センター, 教授 (50251450)

Co-Investigator(Kenkyū-buntansha) YOSHIHARA Toru  金沢大学, 子どものこころの発達研究セン ター, 特任助教 (00401935)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywords糖鎖 / 糖転移酵素 / 高次脳機能 / 行動実験 / 遺伝子改変動物
Research Abstract

To elucidate the role of carbohydrates in higher brain functions, we investigated glycogene-manipulated mice using behavioral analysis. β4GalT-2 KO mice and C6ST-1 Tg mice showed hypersensitive to novel stimuli and disturbed attention, and were suggested to be impaired in the dopamine system. β4GalT-5 KO mice and β4GalT-6 KO mice showed abnormal activity and disturbed attention, and were suggested to be impaired in myelin formation. These results indicated that carbohydrates play an important role in higher brain functions.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (45 results)

All 2013 2012 2011 2010 Other

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (28 results) Remarks (3 results)

  • [Journal Article] EXTL2, a member of EXT family of tumor suppressors, controls glycosaminoglycan biosynthesis in a xylose kinase-dependent manner2013

    • Author(s)
      Nadanaka, S., Zhou, S., Kagiyama, S., Shoji, N., Sugahara, K., Sugihara, K., Asano, M.and Kitagawa, H.
    • Journal Title

      J. Biol. Chem

      Volume: 288 Issue: 13 Pages: 9321-9333

    • DOI

      10.1074/jbc.m112.416909

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Displays of paternal mouse pup retrieval following communicative interaction with maternal mates2013

    • Author(s)
      Liu, H-X., Lopatina, O., Higashida, C., Fujimoto, H., Akther, S., Inzhutova, A., Liang, M., Zhong, J., Tsuji, T., Yoshihara, T., Sumi, K., Ishiyama, M., Ma, W-J., Ozaki, M., Yagitani, S., Yokoyama, S., Mukaida, N., Sakurai, T., Hori, O., Yoshioka, K., Hirao, A., Kato, Y., Ishihara, K., Kato, I., Okamoto, H., Cherepanov, S.M., Salmina, A.B., Hirai, H., Asano, M., Brown, D.A., Nagano, I., and Higashida, H.
    • Journal Title

      Nat. Commun

      Volume: 4 Issue: 1 Pages: 1346-1346

    • DOI

      10.1038/ncomms2336

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Large-scale identification of target proteins of a glycosyltransferase isozyme by Lectin-IGOT-LC/MS, an LC/MS-based glycoproteomic approach2012

    • Author(s)
      Sugahara, D., Kaji, H., Sugihara, K., Asano, M., and Narimatsu, H.
    • Journal Title

      Scientific Reports

      Volume: 2 Issue: 1 Pages: 680-680

    • DOI

      10.1038/srep00680

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced susceptibility to colitis-associated colon carcinogenesis in mice lacking plasma membrane-associated sialidase2012

    • Author(s)
      Yamaguchi, K., Shiozaki, K., Moriya, S., Koseki, K., Wada, T., Tateno, H., Sato, I., Asano, M., Iwakura, Y., and Miyagi, T.
    • Journal Title

      PLoS ONE

      Volume: 7 Issue: 7 Pages: e41132-e41132

    • DOI

      10.1371/journal.pone.0041132

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered oligosaccharide structures contribute to ameliorate murine colitis defective in beta 1,4 galactosyltransferase I.2012

    • Author(s)
      Shinzaki S, Miyoshi E, et al.
    • Journal Title

      Gastroenterology

      Volume: 142(5) Issue: 5 Pages: 1172-82

    • DOI

      10.1053/j.gastro.2012.02.008

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glycoprotein hyposialylation gives rise to a nephrotic-like syndrome that is prevented by sialic acid administration in GNE V572L point-mutant mice2012

    • Author(s)
      Ito, M., Sugihara, K., Asaka, T., Toyama, T., Yo sh ih ar a, T., Furuichi, K., Wada, T. and Asano, M.
    • Journal Title

      PLoS ONE

      Volume: 7 Issue: 1 Pages: 1-13

    • DOI

      10.1371/journal.pone.0029873

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 4-galactosyltransferase-II and GlcAT-PFacilitates Biosynthesis of N-linked HNK-1Carbohydrate2011

    • Author(s)
      N. Nakagawa, T. Yoshihara, M. Asano, and S. Oka
    • Journal Title

      J. Biol. Chem

      Volume: 286(36) Issue: 36 Pages: 31337-46

    • DOI

      10.1074/jbc.m111.233353

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Septic shock is associated with receptor for advanced glycationend products ligation of LPS.2011

    • Author(s)
      Yamamoto, Y., et al.
    • Journal Title

      J.Immunol.

      Volume: 186 Pages: 3248-3257

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] β4-Galactosyltransferase-5 is a lactosylceramide synthase essential for mouse extra-embryonic development2010

    • Author(s)
      Nishie, T., Hikimochi, Y., Zama, K., Fukusumi, Y., Ito, M., Yokoyama, H., Naruse, C., Ito, M. and Asano, M.
    • Journal Title

      Glycobiology

      Volume: 20 Issue: 10 Pages: 1311-1322

    • DOI

      10.1093/glycob/cwq098

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impairment of embryonic cell division and glycosaminoglycan biosynthesis in glucuronyltransferase-I deficient mice2010

    • Author(s)
      Izumikawa, T., Kanagawa, N., Watamoto, Y., Okada, M., Saeki, M., Sakano, M., Sugahara, K., Sugihara, K., Asano, M., and Kitagawa, H.
    • Journal Title

      J. Biol. Chem.

      Volume: 285 Issue: 16 Pages: 12190-12196

    • DOI

      10.1074/jbc.m110.100941

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impairment of embryonic cell division and glycosaminoglycan biosynthesis in glucuronyltransferase-I deficient mice.2010

    • Author(s)
      Izumikawa, T., et al.
    • Journal Title

      J.Biol.Chem.

      Volume: 285 Pages: 12190-12196

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene knockout and metabolome analysis of carnitine/organic cation transporter OCTN1.2010

    • Author(s)
      Kato, Y., et al.
    • Journal Title

      Pharm. Res.

      Volume: 27 Pages: 832-840

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] β4-Galactosyltransferase-5 is a lactosylceramide synthaseessential for mouse extra-embryonic development.2010

    • Author(s)
      Nishie, T., et al.
    • Journal Title

      Glycobiology

      Volume: 20 Pages: 1311-1322

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice.2010

    • Author(s)
      Wang, F., et al.
    • Journal Title

      J.Clin.Invest.

      Volume: 120 Pages: 3979-3995

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] ラクトシルセラミド合成に関わるガラクトース転移酵素群欠損マウスの行動解析と脳の組織学的・生化学的解析2013

    • Author(s)
      吉原亨,佐武寛之,鈴木紘史,神村栄吉,沖野望,伊東信,徳田典代,古川圭子,古川鋼一,浅野雅秀
    • Organizer
      第60回日本実験動物学会
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Year and Date
      2013-05-16
    • Related Report
      2012 Final Research Report
  • [Presentation] 脳・神経系特異的β-1,4-ガラクトース転移酵素-5欠損マウスにおけるミエリン鞘形成障害の検討2012

    • Author(s)
      吉原亨,鈴木紘史,西江敏和,引持陽子,神村栄吉,沖野望,伊東信,浅野雅秀
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2012-12-12
    • Related Report
      2012 Final Research Report
  • [Presentation] Reduction of lactosylceramide synthase activity and behavioral abnormalities in brain-specific β4-galactosyltransferase-5-deficient mouse.2012

    • Author(s)
      Yo sh ih ar a, T., Suzuki, H., Nishie, T., Hikimochi, Y., Kamimura, E., Okino, N., Ito, M. and Asano, M.
    • Organizer
      The 8th FENS Forum of Neuroscience, International Convention Center Barcelona
    • Place of Presentation
      Spain
    • Year and Date
      2012-07-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 脳・神経系特異的β-1,4-ガラクトース転移酵素-5欠損マウスにおける活動性・注意機能の障害2012

    • Author(s)
      吉原亨,鈴木紘史,西江敏和,引持陽子,神村栄吉,沖野望,伊東信,浅野雅秀
    • Organizer
      第59回日本実験動物学会
    • Place of Presentation
      別府国際コンベンションセンター(大分県)
    • Year and Date
      2012-05-25
    • Related Report
      2012 Final Research Report
  • [Presentation] シアル酸糖鎖欠損による腎疾患モデルマウスの病態解析とシアル酸投与による治療効果2012

    • Author(s)
      伊藤光俊,浅賀知也,杉原一司,吉原亨,和田隆志,浅野雅秀
    • Organizer
      第2回分子腎臓フォーラム
    • Place of Presentation
      京都リサーチパーク(京都府)
    • Year and Date
      2012-01-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 行動テストバッテリーによる神経特異的β4GalT-5欠損マウスの高次脳機能の解析2011

    • Author(s)
      鈴木紘史, 吉原亨, 西江敏和, 引 陽子, 神村栄吉, 浅野雅秀
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-12-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 行動テストバッテリーによる神経特異的b4GalT-5欠損マウスの高次脳機能の解析2011

    • Author(s)
      鈴木紘史, ら
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-12-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Hyposialylation of glycoproteins in the UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (GNE) point mutant mice gives rise to a renal impairment that is prevented by sialic acid administration.2011

    • Author(s)
      Ito, M., Asaka, T., Sugihara, K., Yoshihara, T., Wada, T. and Asano, M.
    • Organizer
      Kidney Week 2011
    • Place of Presentation
      Pennsylvania Convention CenterPennsylvania Convention CenterPennsylvania Convention Center, Philadelphia (USA)
    • Year and Date
      2011-11-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Hyposialylation of glycoproteins in the UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (GNE) point mutant mice gives rise to a renal impairment that is prevented by sialic acid administration2011

    • Author(s)
      Ito, M., et al.
    • Organizer
      Kidney Week 2011
    • Place of Presentation
      Pennsylvania Convention Center (USA)
    • Year and Date
      2011-11-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] GNE V572L 点変異マウスにおける腎臓の病態解析とシアル酸糖鎖の関与2011

    • Author(s)
      伊藤光俊,浅賀知也,杉原一司,吉原亨,和田隆志,浅野雅秀
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2011-09-24
    • Related Report
      2012 Final Research Report
  • [Presentation] GNE V572L点変異マウスにおける腎臓の病態解析とシアル酸糖鎖の関与2011

    • Author(s)
      伊藤光俊, ら
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Behavioral analysis of CNS-specific ・4GalT-5-deficient mice2010

    • Author(s)
      Toru Yoshihara, Toshikazu Nishie, Yoko Hikimochi, Hiroshi Suzuki and Masahide Asano
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2010-12-10
    • Related Report
      2012 Final Research Report
  • [Presentation] β4-galactosyltransferase-5 is a lactosylceramide synthase essential for mouse extra-embryonic development.2010

    • Author(s)
      Toshikazu Nishie, Yoko Hikimochi, Kota Zama, Yoshiyasu Fukusumi Mitutoshi Ito, Haruka Yokoyama, Chie Naruse, Makoto Ito, and Masahide Asano
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2010-12-10
    • Related Report
      2012 Final Research Report
  • [Presentation] HNK-1糖鎖の生合成過程におけるbeta4-galactosyltransferase-IIの役割2010

    • Author(s)
      河野哲也, ら
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] β4-galactosyltransferase-5 is a lactosylceramide synthase essential for mouse extra-embryonic development2010

    • Author(s)
      浅野雅秀, ら
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      陣戸ポートアイランド(兵庫県)
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Behavioral analysis of CNS-specific β4Ga1T-5-deficient mice2010

    • Author(s)
      吉原亨, ら
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Learning/memory impairment and reduced expression of the HNK-1 carbohydrate in β-1,4-Galactosyltransferase-2-deficient mice.2010

    • Author(s)
      Yoshihar a, T., Sugihara, K., Kizuka, Y., Oka, S. and Asano, M.
    • Organizer
      The Society for Neuroscience Annual Meeting 2010 (Neuro2010)
    • Place of Presentation
      Sandiego (USA)
    • Year and Date
      2010-11-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Glycosylation of glycoproteins and glycolipids plays important roles in the nervous system and embryogenesis.2010

    • Author(s)
      Asano, M.
    • Organizer
      2010 Chonbuk-Kanazawa Joint Symposium
    • Place of Presentation
      Jeonju (Korea)
    • Year and Date
      2010-10-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Glycosylation of glycoproteins and glycolipids plays important roles in the nervous system and embrvoeenesis2010

    • Author(s)
      Asano, M., et al.
    • Organizer
      2010 Chonbuk-Kanazawa Joint Symposium
    • Place of Presentation
      Chonbuk University, Jeonju, Korea 招待講演
    • Year and Date
      2010-10-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] β1-4結合型ガラクトース糖鎖は造血幹細胞の骨髄へのホーミングに必須である2010

    • Author(s)
      高垣聡一郎, 西江敏和, 浅野雅秀
    • Organizer
      第57回日本実験動物学会
    • Place of Presentation
      京都テルサ(京都府)
    • Year and Date
      2010-05-13
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] 中枢神経系特異的β1,4ガラクトース転移酵素-5欠損マウスにおける活動性の亢進2010

    • Author(s)
      吉原亨,西江敏和,引持陽子,浅野雅秀
    • Organizer
      第57回日本実験動物学会
    • Place of Presentation
      京都テルサ(京都府)
    • Year and Date
      2010-05-13
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] GNE V572L 点変異マウスにおける腎臓の病態解析とシアル酸糖鎖の関与2010

    • Author(s)
      伊藤光俊,浅賀知也。杉原一司,吉原亨,和田隆志,浅野雅秀
    • Organizer
      第57回日本実験動物学会
    • Place of Presentation
      京都テルサ(京都府)
    • Year and Date
      2010-05-13
    • Related Report
      2012 Final Research Report
  • [Presentation] GNE V572L点変異マウスにおける腎臓の病態解析とシアル酸糖鎖の関与2010

    • Author(s)
      伊藤光俊, ら
    • Organizer
      第57回日本実験動物学会
    • Place of Presentation
      京都テルサ(京都府)
    • Year and Date
      2010-05-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] β-1,4-ガラクトース転移酵素-Iが作る糖鎖は造血幹細胞の骨髄ニッチへのホーミングに必須である

    • Author(s)
      田畑佳祐,高垣聡一郎,西江敏和,浅野雅秀
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2012 Final Research Report
  • [Presentation] Reduction of lactosylceramide synthase activity and behavioral abnormalities in brain-specific beta4-galactosyltransferase-5-deficient mouse.

    • Author(s)
      Yoshihara, T., Suzuki, H., Nishie, T., Hikimochi, Y., Kamimura, E., Okino, N., Ito, M. and Asano, M.
    • Organizer
      The 8th FENS Forum of Neuroscience
    • Place of Presentation
      International Convention Center Barcelona (Spain)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 脳・神経系特異的β-1,4-ガラクトース転移酵素-5欠損マウスにおける活動性・注意機能の障害

    • Author(s)
      吉原亨,鈴木紘史,西江敏和,引持陽子,神村栄吉,沖野望,伊東信,浅野雅秀
    • Organizer
      第59回日本実験動物学会
    • Place of Presentation
      別府国際コンベンションセンター(大分県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 脳・神経系特異的β-1,4-ガラクトース転移酵素-5欠損マウスにおけるミエリン鞘形成障害の検討

    • Author(s)
      吉原亨,鈴木紘史,西江敏和,引持陽子,神村栄吉,沖野望,伊東信,浅野雅秀
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ラクトシルセラミド合成に関わるガラクトース転移酵素群欠損マウスの行動解析と脳の組織学的・生化学的解析

    • Author(s)
      吉原亨,佐武寛之,鈴木紘史,神村栄吉,沖野望,伊東信,徳田典代,古川圭子,古川鋼一,浅野雅秀
    • Organizer
      第60回日本実験動物学会
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://asrc.w3.kanazawa-u.ac.jp/

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://asrc.w3.kanazawa-u.ac.jp/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://web.kanazawa-u.ac.jp/~asrc/index.html

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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