Study of molecular mechanisms of germline mutation by using DNA repair deficient mice
| Project/Area Number |
22300144
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Kyushu University |
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Principal Investigator |
OHNO Mixuki 九州大学, 医学研究院, 助教 (70380524)
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| Co-Investigator(Kenkyū-buntansha) |
TSUZUKI Teruhisa 九州大学, 大学院・医学研究院, 基礎放射線医学分野 (40155429)
NAKATSU Yoshimichi 九州大学, 大学院・医学研究院, 基礎放射線医学分野 (00207820)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2010: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Keywords | DNA修復 / グノム変異 / 継世代影響 / 遺伝子改変マウス / DNA損傷 / 生殖細胞ゲノム変異 / ゲノム変異 |
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| Research Abstract |
We established an "oxidative DNA damage repair deficient inbred mouse line", which is useful for the efficient detection and analysis of de novo germline mutation. We showed the 8-oxoguanine is a major source of de novo germline G to T transversion mutati
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Oxidative stress-induced tumorigenesis in the small intestine of various types of DNA repair-deficient mice (Note).2011
Author(s)
Tsuzuki, T., Piao, J., Isoda, T., Sakumi, K., Nakabeppu, Y., Nakatsu. Y.
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Journal Title
Health Physics
Volume: 100
Pages: 293-294
Related Report
Peer Reviewed
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[Journal Article] Oxidative stress-induced tumorigenesis in the small intestine of various types of DNA repair-deficient mice2011
Author(s)
Tsuzuki, T., Piao, J., Isoda, T., Sakumi, K., Nakabeppu, Y., Nakatsu, Y
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Journal Title
Health Physics
Volume: 100
Issue: 3
Pages: 293-294
DOI
NAID
Related Report
Peer Reviewed
-
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[Journal Article] NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals2010
Author(s)
Abolhassani, N, Iyama, T, Tsuchimoto, D, Sakumi, K, Ohno, M, Behmanesh, M, Nakabeppu, Y.
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Journal Title
Nucleic Acids Research
Volume: 9
Pages: 2891-2903
NAID
Related Report
Peer Reviewed
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