Genetic basis of difference in gene expression in the mouse model for behavioral diversity
| Project/Area Number |
22300146
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
KOIDE Tsuyoshi 国立遺伝学研究所, 系統生物研究センター, 准教授 (20221955)
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| Co-Investigator(Renkei-kenkyūsha) |
UMEMORI Juzoh 藤田保健衛生大学, 総合医科学研究所, 助教 (20462913)
SUGIMOTO Hiroki 自治医科大学, 医学部, 助教 (70515866)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2010: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Keywords | 野生由来マウス / 行動 / コンソミック系統 / 遺伝子発現量 / 多様性 / マウス / QTL / ホームケージ活動性 / 野生系統 / マッピング |
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| Research Abstract |
We successfully mapped locus for each of chromosome 6, 15, and 17, for home-cage activity, social behavior, and anxiety-like behavior, respectively. In each of the locus, we found a strong candidate gene, and analyzed gene expression level. In the case of the candidate gene for anxiety-like behavior on chromosome 17, we found that repeat sequence associate with regulation of the expression by conducting luciferase assay using cultured cells. Furthermore, we confirmed that the difference of gene expression of the candidate gene resulted in different level of the protein product in the mice, thus possibly associate with the difference in anxiety-like behavior.
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Report
(4 results)
Research Products
(57 results)
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[Journal Article] Behavioral characterization of escalated aggression induced by GABA(B) receptor activation in the dorsal raphe nucleus2012
Author(s)
Takahashi, A., Schilit, A.N., Kim, J., Debold, J.F., Koide, T., Miczek, K.A.
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Journal Title
Psychopharmacology
Volume: 224
Issue: 1
Pages: 155-166
DOI
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Peer Reviewed
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[Journal Article] SDOP-DB: A comparative standardised-protocol database for mouse phenotypic analyses2010
Author(s)
Tanaka N., Waki K., Kaneda H., Suzuki T., Yamada I., Furuse T, Kobayashi K., Motegi H., Toki H., Inoue M., Minowa O., Noda N., Takao K., Miyakawa T., Takahashi A., Koide T., Wakana S., Masuya H.
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Journal Title
Bioinformatics
Volume: 26(8)
Pages: 1133-1134
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Peer Reviewed
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[Presentation] Genetic dissection of clustered QTLs related to strain difference of home-cage activity2012
Author(s)
Ishii, A., Nishi, A., Shiroishi, T., Takahashi, A., Koide, T.
Organizer
14th Annual Meeting for International Behavioural and Neural Genetics Sociaty
Place of Presentation
Boulder, USA
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[Presentation] GABAB receptor modulation of serotonin neurons in the dorsal raphe nucleus escalates aggression in mice2010
Author(s)
Takahashi, A., Shimamoto, A., Boyson, C. 0., Koide, T., DeBold, J. F., Miczek, K. A.
Organizer
第33回日本分子生物学会年会
Place of Presentation
神戸
Year and Date
2010-09-03
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[Presentation] GABA(B) receptor modulation of serotonin neurons in the dorsal raphe nucleus: escalation of aggression in mice.2010
Author(s)
Takahashi, A., Shimamoto, A., Boyson, C. 0., DeBold, J. F., Koide, T., Miczek, K. A.
Organizer
Neuroscience
Place of Presentation
San Diego, USA
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[Presentation] Consomic analysis of genetic factors related to temporal difference of home-cage activity between B6 and MSMM2010
Author(s)
Ishii, A., Nishi, A., Shiroishi, T., Takahashi, A., Koide, T.
Organizer
4th International Mammalian Genome Conference
Place of Presentation
Crete, Greece
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