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Blood-flow-mediated mechanotransduction in vascular endothelial cells

Research Project

Project/Area Number 22300150
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionThe University of Tokyo

Principal Investigator

YAMAMOTO Kimiko  東京大学, 大学院・医学系研究科, 講師 (00323618)

Co-Investigator(Kenkyū-buntansha) ANDO Joji  獨協大学, 医学部, 特任教授 (20159528)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Keywordsバイオメカニクス / shear stress / 血管内皮細胞 / 細胞膜 / カベオラ / ATP / 流れ剪断応力 / イオンチャネル / カルシウム・シグナリング / プリノセプター
Research Abstract

Endothelial cells(ECs)sense shear stress and transduce blood flow infbrmation into functionalresponses that play important roles in vascular homeostasis and pathophysiology. A unique feature ofshear-stress-sensing is the involvement of many different types of membrane-bound molecules, but themechanisms remain unknown. Shear stress evokes a rapid, dose-dependent increase in intracellular Ca2+concentration caused by an influx of extracellular Ca2+via ATP-operated P2×4 ion channels activatedby endogenous ArP released by ECs. To analyze the dynamics of ArP release, we visualized ArP at thecell surface. When exposed to shear stress, ECs simultaneously released ArP at caveolae. Immediatelyafter the ArP release, Ca2+wave occurred at the same site as the ArP release. Caveolar membranefluidity increased over the entire EC membranes in response to shear stress. These findings indicate thatEC membranes directly respond to shear stress and that these changes link to shear-stress-mechanotranuction mechnisms.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (74 results)

All 2013 2012 2011 2010 Other

All Journal Article (21 results) (of which Peer Reviewed: 17 results) Presentation (45 results) (of which Invited: 8 results) Book (6 results) Remarks (2 results)

  • [Journal Article] Fluid shear stress induces differentiation of circulating phenotype endothelial progenitor cells.2012

    • Author(s)
      S. Obi, H. Masuda, T. Shizuno, A. Sato, K. Yamamoto, J. Ando, Y. Abe and T. Asahara
    • Journal Title

      Am. J. Physiol. Cell Physiol.

      Volume: 303 Issue: 6 Pages: 595-606

    • DOI

      10.1152/ajpcell.00133.2012

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Arterial shear stress augments the differentiation of endothelial progenitor cells adhered to VEGF-bound surfaces.2012

    • Author(s)
      Y. Suzuki, K. Yamamoto, J. Ando, K. Matsumoto, T. Matsuda
    • Journal Title

      Biochem. Biopys. Res. Commun.

      Volume: 423 Issue: 1 Pages: 91-97

    • DOI

      10.1016/j.bbrc.2012.05.088

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differentiation of circulating endothelial progenitor cells induced by shear stress.2012

    • Author(s)
      S. Obi, K. Yamamoto, J. Ando, H. Masuda, T. Asahara.
    • Journal Title

      2012 International Symposium on Micro-NanoMechatronics and Human Science

      Volume: - Pages: 54-58

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Real-time imaging of flow-induced ATP release and Ca2+ signaling in vascular endothelial cells.2012

    • Author(s)
      K. Yamamoto and J. Ando.
    • Journal Title

      Biorheology

      Volume: 49 Pages: 115-116

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Arterial shear stress accelerates the differentiation of endothelial progenitor cells adhered on VEGF-bound surface.2012

    • Author(s)
      Y. Suzuki, K. Yamamoto, J. Ando, K. Matsumoto, and T. Matsuda.
    • Journal Title

      J. Tissue Eng. Regen. Med.

      Volume: 6 Pages: 241-241

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 血管のメカノバイオロジー:血管内皮細胞の血流センシングと循環調節2012

    • Author(s)
      安藤 譲二、山本 希美子
    • Journal Title

      細胞工学

      Volume: 31(6) Pages: 1017-1023

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Visualization of flow-induced ATP release and triggering of Ca2+ waves at caveolae in vascular endothelial cells.2011

    • Author(s)
      K.Yamamoto, K. Furuya, M. Nakamura, E.Kobatake, M. Sokabe, J. Ando.
    • Journal Title

      J. Cell Sci.

      Volume: 124 Pages: 3477-3483

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] New molecular mechanisms for cardiovascular disease:Blood flow sensing mechanism in vascular endothelial cells.2011

    • Author(s)
      K.Yamamoto, J. Ando.
    • Journal Title

      J. Pharmacol. Sci.

      Volume: 116 Pages: 323-331

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of shear stress and tretch on endothelial cells.Antioxid.2011

    • Author(s)
      J.Ando, K. Yamamoto.
    • Journal Title

      Redox Signal.

      Volume: 15 Pages: 1389-1403

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of shear stress on the gene expression of endothelial nitricoxide synthase, endothelin-1, and tbronmomodulin in human retinal microvascular endothelial cells2011

    • Author(s)
      A.Ishibazawa, K.Yamamoto, J.Ando, et al
    • Journal Title

      Invest.Ophthalmol.Vis.Sci.

      Volume: 52 Issue: 11 Pages: 8496-8504

    • DOI

      10.1167/iovs.11-7686

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New Molecular Mechanisms for Cardiovascular Disease:Blood Flow Sensing Mechanism in Vascular Endothelial Cells2011

    • Author(s)
      K.Yamamoto, J.Ando
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 116 Issue: 4 Pages: 323-331

    • DOI

      10.1254/jphs.10R29FM

    • NAID

      10029895377

    • ISSN
      1347-8613, 1347-8648
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visualization of flow-induced ATP release and triggering of Ca^<2+> waves at caveolae in vascular endothelial cells2011

    • Author(s)
      K.Yamamoto, J.Ando, et al
    • Journal Title

      J.Cell Sci.

      Volume: 124 Issue: 20 Pages: 3477-3483

    • DOI

      10.1242/jcs.087221

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PGE_2-EP_2 receptor signaling in endothelium is activated by hemodynamic stress and induces cerebral aneurysm through an amplifying loop via NF-κB2011

    • Author(s)
      T.Aoki, K.Yamamoto, J.Ando, et al
    • Journal Title

      Br.J.Pharmacol.

      Volume: 163 Issue: 6 Pages: 1237-1249

    • DOI

      10.1111/j.1476-5381.2011.01358.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic behavior and spontaneous differentiation of mouse embyoid bodies on hydrogel substrates of different surface charge and chemical structures2011

    • Author(s)
      J.F.Liu, K.Yamamoto, et al.
    • Journal Title

      Tissue Eng.Part A

      Volume: 17 Issue: 17-18 Pages: 2343-2357

    • DOI

      10.1089/ten.tea.2011.0034

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanosensing of blood flow in vascular endothelial cells2011

    • Author(s)
      山本希美子、安藤譲二
    • Journal Title

      Folia Pharmacologica Japonica

      Volume: 138 Issue: 5 Pages: 196-200

    • DOI

      10.1254/fpj.138.196

    • NAID

      10029896349

    • ISSN
      0015-5691, 1347-8397
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 血流刺激に対する内皮細胞応答とメカノセンシング機構2011

    • Author(s)
      山本希美子、安藤譲二
    • Journal Title

      細胞

      Volume: 46(9) Pages: 339-343

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Differentiation of stem/progenitor cells into vascular cells in response to fluid mechanical forces.2010

    • Author(s)
      K.Yamamoto, J.Ando
    • Journal Title

      J.Biorheology

      Volume: 24 Pages: 1-10

    • NAID

      40017399300

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Study on the sliding friction of endothelial cells cultured on hydrogel and the role of glycocalyx on friction reduction.2010

    • Author(s)
      Y.M Chen, et al.
    • Journal Title

      Adv.Eng.Mater.

      Volume: 12

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 血管内皮のカルシウム・シグナリングを介した血流感知機構2010

    • Author(s)
      山本希美子, 安藤譲二
    • Journal Title

      薬学雑誌

      Volume: 130 Pages: 1401-1411

    • NAID

      130000451688

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生体力学刺激によるES細胞の血管細胞への分化誘導2010

    • Author(s)
      山本希美子
    • Journal Title

      血管医学

      Volume: 11 Pages: 307-314

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 血流と内皮細胞機能2010

    • Author(s)
      山本希美子, 安藤譲二
    • Journal Title

      THE LUNG

      Volume: 18 Pages: 286-290

    • NAID

      10016757242

    • Related Report
      2010 Annual Research Report
  • [Presentation] Vascular endothelial cells respond to shear stress by rapidly decreasing the order of their lipid phases2013

    • Author(s)
      Kimiko Yamamoto and Joji Ando
    • Organizer
      35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society in conjunction with 52nd Annual Conference of JSMBE
    • Place of Presentation
      Osaka(Osaka International Convention Center)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Dynamic cellular mechanotransduction and nano-biomechanics2013

    • Author(s)
      Kimiko Yamamoto and Joji Ando
    • Organizer
      th Aso International Meeting (AIM)
    • Place of Presentation
      Kumamoto(Hotel Greenpia Mimamiaso)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 血管内皮P2X4受容体を介した循環機能調整・Endothelial P2X4 receptor-mediated regulation of vascular functions2013

    • Author(s)
      山本希美子、安藤譲二
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡(福岡国際会議場)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Shear-stress-mediated control of vascular functions through endothelial ATP release and P2×4 ion channels2012

    • Author(s)
      K.Yamamoto, J. Ando
    • Organizer
      14th lnternational Congress of Biorheology and 7th Intemational Conference on clinical Hemorheology
    • Place of Presentation
      Istanbul
    • Year and Date
      2012-06-04
    • Related Report
      2012 Final Research Report
  • [Presentation] 血管のメカノバイオロジー:血流刺激に対する内皮細胞応答2012

    • Author(s)
      山本希美子、安蝿二
    • Organizer
      第51回日本生体医工学会大会
    • Place of Presentation
      福岡(招待)
    • Year and Date
      2012-05-10
    • Related Report
      2012 Final Research Report
  • [Presentation] ATP-gated P2×4 ion channel serve as transducers for shear stress mechanotransduction in vascular endothelial cells"Purine 2012 in Fukuoka2012

    • Author(s)
      K.Yamamoto, J. Ando
    • Organizer
      International Symposium on Purinergic Signaling in New Strategy of Drag Discovery
    • Place of Presentation
      Fukuoka
    • Year and Date
      2012-05-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Shear stress mechanotransduction via ATP receptors in vascular endothelial cells2012

    • Author(s)
      K.Yamamoto, J.Ando
    • Organizer
      International Symposium on Cellular Mechanobiology
    • Place of Presentation
      京都大学百周年時計台記念館(京都府京都市)(招待講演)
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Vascular Mechanobiology : Endothelial Cell Responses to Fluid Shear Stress2012

    • Author(s)
      K.Yamamoto
    • Organizer
      熊本大学グローバルCOEリエゾンラボ研究会
    • Place of Presentation
      熊本大学発生医学研究所(熊本県熊本市)(招待講演)
    • Year and Date
      2012-02-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 血管内皮における流れずり応力のメカノトランスダクションと循環調節2012

    • Author(s)
      山本希美子
    • Organizer
      第18回分子病態医学セミナー(愛媛大学大学院医学系研究科)
    • Place of Presentation
      愛媛大学医学部(愛媛県東温市)(招待講演)
    • Year and Date
      2012-02-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 血管内皮におけるシェアストレスのメカノトランスダクションと循環調節2012

    • Author(s)
      山本希美子、安藤譲二
    • Organizer
      日本機械学会第24回バイオエンジニアリング部門講演会
    • Place of Presentation
      大阪大学豊中キャンパス(大阪府豊中市)(招待講演)
    • Year and Date
      2012-01-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Differentiation of circulating endothelial progenitor cells induced by shear stress2012

    • Author(s)
      Syotaro Obi, Kimiko Yamamoto, Joji Ando, Haruchika Masuda, and Takayuki Asahara,
    • Organizer
      MHS2012
    • Place of Presentation
      名古屋(名古屋大学)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Chemiluminescence imaging of flow-induced ATP release at caveolae in vascular endothelial cells2012

    • Author(s)
      Kimiko Yamamoto and Joji Ando
    • Organizer
      第50回生物物理学会年会
    • Place of Presentation
      名古屋(名古屋大学)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Vascular cells responses to biomechanical forces2012

    • Author(s)
      Kimiko Yamamoto and Joji Ando
    • Organizer
      9th International Conference on Flow Dynamics
    • Place of Presentation
      仙台(Hotel Metropolitan Sendai)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Shear-stress-mediated control of vascular functions through endothelial ATP release and P2X4 ion channels2012

    • Author(s)
      Kimiko Yamamoto and Joji Ando
    • Organizer
      14th International Congress of Biorheology and 7th International Conference on clinical Hemorheology
    • Place of Presentation
      Istanbul
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] in situ血管内皮前駆細胞捕捉・分化誘導バイオインターフェイスの開発:接着細胞へのシェアストレスの影響2012

    • Author(s)
      鈴木芳典、山本希美子、安藤譲二、松本邦夫、松田武久
    • Organizer
      第11回日本再生医療学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] ATP-gated P2X4 ion channel serve as transducers for shear stress mechanotransduction in vascular endothelial cells2012

    • Author(s)
      Kimiko Yamamoto and Joji Ando
    • Organizer
      Purine 2012 in Fukuoka: International Symposium on Purinergic Signaling in New Strategy of Drag Discovery
    • Place of Presentation
      福岡 (Centennial Hall Kyushu University School of Medicine)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Visualization of flow-induced ATP release and triggering of Ca2+ waves at caveolae in vascular endothelial cells2012

    • Author(s)
      Kimiko Yamamoto and Joji Ando
    • Organizer
      World Congress 2012, Medical Physics and Biomedical Engineering
    • Place of Presentation
      Beijing
    • Related Report
      2012 Annual Research Report
  • [Presentation] 血管のメカノバイオロジー:血流刺激に対する内皮細胞応答2012

    • Author(s)
      山本希美子、安藤譲二
    • Organizer
      第51回日本生体医工学会大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Fluid shear stress induces ATP release and triggering Ca^<2+> waves at caveolae in vascular endothelial cells2011

    • Author(s)
      山本希美子、安藤譲二
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)(招待講演)
    • Year and Date
      2011-12-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Real-time-imaging of shear-stress-induced ATP release and triggering of Ca^<2+> waves in vascular endothelial cells2011

    • Author(s)
      K.Yamamoto, J.Ando
    • Organizer
      第19回日本血管生物医学会学術集会
    • Place of Presentation
      東京ステーションコンファレンス(東京都千代田区)(招待講演)
    • Year and Date
      2011-12-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] シェアストレスが血管内皮増殖因子固定表面に接着した血管内皮前駆細胞の分化過程に与える影響2011

    • Author(s)
      鈴木芳典、山本希美子、安藤譲二, 他2名
    • Organizer
      平成23年度日本生体医工学会北陸支部大会
    • Place of Presentation
      金沢大学サテライトプラザ(石川県金沢市)
    • Year and Date
      2011-12-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Differential mechanism of mechanical stress in circulating endothelial progenitor cells2011

    • Author(s)
      Syotaro Obi, K.Yamamoto, J.Ando, et al.
    • Organizer
      第19回日本血管生物医学会学術集会
    • Place of Presentation
      東京ステーションコンファレンス(東京都千代田区)
    • Year and Date
      2011-12-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 血管内皮におけるP2X4イオンチャネルを介した流れずり応力のメカノトランスダクションと循環調節2011

    • Author(s)
      山本希美子、安藤譲二
    • Organizer
      生理学研究所研究会
    • Place of Presentation
      生理研究所岡崎コンファレンスセンター(愛知県岡崎市)(招待講演)
    • Year and Date
      2011-11-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Endothelial mechanotransduction and its role in the control of vascular functions2011

    • Author(s)
      K.Yamamoto, J.Ando
    • Organizer
      International Symposium on Mechanobiology, The 5^<th> Shanghai International Conference on Biophysics and Molecular Biology
    • Place of Presentation
      Shanghai Huashia Hotel (Shanghai, China)(招待講演)
    • Year and Date
      2011-11-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] Shear-stress-mediated control of vascular functions through endothelial ATP release and P2X4 receptors2011

    • Author(s)
      K.Yamamoto, J.Ando
    • Organizer
      International Symposium on Mechanobiology JSPS-NOW Joint Seminar
    • Place of Presentation
      昭和薬科大学(東京都町田市)(招待講演)
    • Year and Date
      2011-11-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Shear-stress-mediated control of vascular functions through endothelial ATP release and P2X4 ion channels2011

    • Author(s)
      Joji Ando, K.Yamamoto
    • Organizer
      9^<th> International Congress on Coronary Artery Disease (ICCAD)
    • Place of Presentation
      Convention Center (Venice, Italy)
    • Year and Date
      2011-10-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Shear Stress Mechanotransduction via Endogenous ATP Release in Vascular Endothelial Cells2011

    • Author(s)
      K.Yamamoto, J.Ando
    • Organizer
      The 5^<th> European Conference of the International Federation for Medical and Biomedical Engineering
    • Place of Presentation
      Budapest Congreee & World Trade Center (Budapest, Hungary)
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 流れずり応力による循環内皮前駆細胞の分化誘導2011

    • Author(s)
      小尾正太郎、山本希美子、安藤譲二, 他3名
    • Organizer
      第34回日本バイオレオロジー学会年会
    • Place of Presentation
      関西大学100周年記念会館(大阪府吹田市)
    • Year and Date
      2011-06-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] ProstaglandinE2-EP2シグナル伝達系は血流ストレスにより活性化され脳動脈瘤形成に関与する2011

    • Author(s)
      青木友浩、山本希美子, 他4名
    • Organizer
      第34回日本バイオレオロジー学会年会
    • Place of Presentation
      関西大学100周年記念会館(大阪府吹田市)
    • Year and Date
      2011-06-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 生体力学刺激によるES細胞の血管細胞への分化誘導2011

    • Author(s)
      山本希美子、安藤譲二
    • Organizer
      第50回日本生体医工学会大会
    • Place of Presentation
      東京電機大学神田キャンパス(東京都千代田区)(招待講演)
    • Year and Date
      2011-04-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 流れずり応力が内皮前駆細胞の分化に及ぼす効果2011

    • Author(s)
      小尾正太郎、山本希美子、安藤譲二, 他3名
    • Organizer
      第50回日本生体医工学会大会
    • Place of Presentation
      東京電機大学神田キャンパス(東京都千代田区)
    • Year and Date
      2011-04-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 内皮細胞における流れずり応力誘発生ATP放出とCa^<2+>波の画像化2011

    • Author(s)
      山本希美子
    • Organizer
      第45回Blood Vessel Club
    • Place of Presentation
      東京大学(東京都文京区)(招待講演)
    • Year and Date
      2011-04-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Shear stress mechanotransduction and its role in the control of blood pressure(血流の感知機構と血圧調節)2010

    • Author(s)
      山本希美子, 安藤譲二
    • Organizer
      BMB2010(第33回日本分子生物学会年会、第83回日本生化学会大会合同大会)
    • Place of Presentation
      神戸ポートピアアイランド(兵庫県神戸市)
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] ATP-gated P2X4 ion channel serve as transducers for shear stress mechanotransduction in vascular endothelial cells2010

    • Author(s)
      K.Yamamoto, J.Ando
    • Organizer
      Symposium, 8^<th> Korea-Japan Joint Symposium on Vascular Biology, 18^<th> Annual Meeting of the Japanese Vascular Biology and Medicine
    • Place of Presentation
      梅田スカイビル(大阪府大阪市)
    • Year and Date
      2010-12-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Membrane androgen receptor mediates the rapid activation of endothelial nitric oxide synthase by testosterone in vascular endothelial cells2010

    • Author(s)
      Jing Yu, et al.
    • Organizer
      The 8^<th> Korea-Japan Joint Symposium on Vascular Biology
    • Place of Presentation
      梅田スカイビル(大阪府大阪市)
    • Year and Date
      2010-12-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 流れ刺激が循環血管内皮前駆細胞に及ぼす効果2010

    • Author(s)
      小尾正太郎, 他
    • Organizer
      第18回日本血管生物学会、The 8^<th> Korea-Japan Joint Symposium on Vascular Biology
    • Place of Presentation
      梅田スカイビル(大阪府大阪市)
    • Year and Date
      2010-12-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血管細胞のメカノセンシングと循環調節2010

    • Author(s)
      山本希美子
    • Organizer
      第5回千駄木血管研究会
    • Place of Presentation
      日本医科大学(東京都)
    • Year and Date
      2010-11-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血液の流れが起こす摩擦力は血管の病気を防ぐ2010

    • Author(s)
      山本希美子
    • Organizer
      第58回レオロジー討論会(一般市民向け講座)
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2010-10-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Endothelial ATP receptor-mediated shear-stress-signal transduction and its physiological roles2010

    • Author(s)
      K.Yamamoto, J.Ando
    • Organizer
      6^<th> World Congress of Biomechanics
    • Place of Presentation
      Singapore Suntec Convention Centre(Singapore)
    • Year and Date
      2010-08-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 細胞表面結合性ルシフェラーゼタンパクを用いたATP放出現象のリアルタイムイメージング2010

    • Author(s)
      山本希美子, 安藤譲二
    • Organizer
      第49回日本生体医工学学会大会
    • Place of Presentation
      大阪国際交流センター(大阪府大阪市)
    • Year and Date
      2010-06-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 流れ誘発性細胞膜相転移の蛍光ライブイメージング2010

    • Author(s)
      山本希美子, 安藤譲二
    • Organizer
      第49回日本生体医工学学会大会
    • Place of Presentation
      大阪国際交流センター(大阪府大阪市)
    • Year and Date
      2010-06-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血流力学刺激によるES細胞の分化誘導に増殖因子受容体の活性化が関与する2010

    • Author(s)
      桝村智美, 山本希美子, 安藤譲二
    • Organizer
      第49回日本生体医工学学会大会
    • Place of Presentation
      大阪国際交流センター(大阪府大阪市)
    • Year and Date
      2010-06-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 流れずり応力による内皮細胞の応答と血管機能調節2010

    • Author(s)
      山本希美子, 安藤譲二
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      いわて県民交流センター(岩手県盛岡市)
    • Year and Date
      2010-05-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] 流れずり応力による内皮細胞の応答と血管機能調節2010

    • Author(s)
      山本希美子
    • Organizer
      第1回先端医療薬学研究センター講演会
    • Place of Presentation
      岩手医科大学八巾キャンパス(岩手県紫波郡)
    • Year and Date
      2010-05-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Biomedical force-induced differentiation of ES cells into vascular cells2010

    • Author(s)
      J.Ando, K.Yamamoto
    • Organizer
      XX World Congress of International Society for Heart Research, Symposium on Mechano-transduction and vascular biology
    • Place of Presentation
      京都国際会館(京都府京都市)
    • Year and Date
      2010-05-16
    • Related Report
      2010 Annual Research Report
  • [Book] Endothelial mechanotransduction and its role in the control of vascular functions"in Shu Chien and Shi Ybngde(eds.), Recent Advances in Mechanobiology2012

    • Author(s)
      K.Yamamoto, J. Ando
    • Publisher
      Shanghai Science and Technological Literature Publishing House,Shanghai
    • Related Report
      2012 Final Research Report
  • [Book] Endothelial mechanotransduction and its role in the control of vascular functions2012

    • Author(s)
      Kimiko Yamamoto and Joji Ando
    • Publisher
      Shanghai Science and Technological Literature Publishing House
    • Related Report
      2012 Annual Research Report
  • [Book] Molecular Mechanisms Underlying Mechanosensing in Vascular Biology"in Masaki Noda(ed.),2011

    • Author(s)
      K.Yamamoto, J. Ando
    • Publisher
      Mechanosensing Biology, Springer, Tokyo
    • Related Report
      2012 Final Research Report
  • [Book] Molecular Mechanisms Underlying Mechanosensing in Vascular Biology in "Mechanosensing Biology"2011

    • Author(s)
      K.Yamamoto, J.Ando
    • Total Pages
      17
    • Publisher
      Springer
    • Related Report
      2011 Annual Research Report
  • [Book] Molecular Mechansms Underlying Mechanosensing in Vascular Biology" in Mechanosensing Biology2011

    • Author(s)
      J.Ando, K.Yamamoto
    • Total Pages
      17
    • Publisher
      Springer
    • Related Report
      2010 Annual Research Report
  • [Book] Shear-stress-sensing and response mechanisms in vascular endothelial cells. In "Interface Oral Health Science 2009"2010

    • Author(s)
      J.Ando, K.Yamamoto
    • Total Pages
      7
    • Publisher
      Springer
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://bme-sysphysiolm.u-tokyo.ac.jp/

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.jst.go.jp/kisoken/presto/complete/sysbio/j/sakigake/saki-15.html

    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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