Development of amyloid imaging using fluorine-MRI
| Project/Area Number |
22300153
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
TOOYAMA Ikuo 滋賀医科大学, 分子神経科学研究センター, 教授 (20207533)
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| Co-Investigator(Kenkyū-buntansha) |
TAGUCHI Hiroyasu 滋賀医科大学, 分子神経科学研究センタ ー, 特任教授 (90102912)
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| Co-Investigator(Renkei-kenkyūsha) |
INUBUSHI Toshiro 滋賀医科大学, MR医学総合研究センタ ー, 教授 (20213142)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2013: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
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| Keywords | 神経科学 / アルツハイマー病 / 核磁気共鳴画像 / 分子イメージング / 画像診断 / 核磁気共鳴医学 / 神経変性疾患 / 診断 / MR画像 / フッ素 / 診断薬 |
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| Research Abstract |
The aim of this study is to develop amyloid imaging using 19F MRI. We have developed a novel 19F-containing curcumin derivative (named FMeC1 or Shiga-Y5) as a potential 19F MRI probe for amyloid imaging. When Tg2576 mice, a transgenic mouse model of Alzheimer's disease, at 20-22 months of age were peripherally injected with FMeC1, dose-dependent increasing in the level of 19F signal was observed in 19F MR spectra obtained from the whole head. 19F MR image showed remarkable levels of 19F signal in the brain of Tg2576 mice after the injection of FMeC1 at a dose of 200 mg/kg. There are no significant 19F signals in the brain of FMeC1-injected wild-type mice. Histological analysis of FMeC1-injected Tg2576 mouse brain showed strong fluorescence signal for FMeC1, and most of this signal was co-localized with beta-amyloid peptide-immunoreactivity. These results suggest the potential benefit of 19F MRI with FMeC1 for amyloid imaging.
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Report
(5 results)
Research Products
(41 results)
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[Journal Article] Relationship between the tautomeric structures of curcumin derivatives and their A β-binding activities in the context of therapies for Alzheimer's disease.2010
Author(s)
Yanagisawa D, Shirai N, Amatsubo T, Taguchi H, Hirao K, Urushitani M, Morikawa S, Inubushi T, Kato M, Kato F, Morino K, Kimura H, Nakano I, Yoshida C, Okada T, Sano M, Wada Y, Wada K N, Yamamoto A, Tooyama I
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Journal Title
Biomaterials
Volume: 31
Pages: 4179-4185
Related Report
Peer Reviewed
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[Presentation] Curcumin binding activity to B-amyloid oligomer2011
Author(s)
Yanagisawa D, Shirai N, Amatsubo T, Taguchi H, Hirao K, Urushitani M, Morikawa S, Inubushi T, Wada Y, Wada K, Yamamoto A, Tooyama I
Organizer
第13回国際アルツハイマー病会議(ICAD2011)
Place of Presentation
フランスパリ市
Related Report
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[Presentation] Curcumin binding activity to ss-amyloid oligomer2011
Author(s)
Yanagisawa D, Shirai N, Amatsubo, T, Taguchi H, Hirao K, Urushitani M, Morikawa S, Inubushi T, Wada Y, Wada K, Yamamoto A, Tooyama I
Organizer
第13回国際アルツハイマー病会議(ICAD2011)
Place of Presentation
フランスパリ市
Related Report
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[Presentation] Binding form of curcumin derivatives to B-amyloid aggregates2010
Author(s)
Ynagisawa D, Shirai N, Amatsubo T, Taguchi H, Hirao K, Urushitani M, Morikawa S, Inubushi T, Wada Y, Wada K, Yamamoto A, Tooyama I
Organizer
第12回国際アルツハイマー病会議(ICAD2010)
Place of Presentation
米国ホノルル市
Related Report
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