Towards the establishment of hemolysis simulator by a multi-scale analysis and experimental observations of damages on a red blood cell membrane and
| Project/Area Number |
22300155
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Saitama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
WADA Shigeo 大阪大学, 大学院・基礎工学研究科, 教授 (70240546)
MIYAZAKI Hiroshi 大阪大学, 大学院・基礎工学研究科, 教授 (00263228)
KOSHIYAMA Kenichiro 大阪大学, 大学院・基礎工学研究科, 助教 (80467513)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2010: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Keywords | 赤血球 / 溶血 / 計算力学 / 数値流体力学 / メゾスコピック解析 / 蛍光イメージング / 可視化 / バイオメカニクス / 血液 |
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| Research Abstract |
The present study mainly carried out the following three projects; (1) deformation analysis of a red blood cell at continuum scale, (2) molecular dynamics simulations of the rupture of a red blood cell membrane and (3) establishment of the visualization technique of heymolysis by chemiluminescence. From project (1), it is revealed that conventional hemolysis indices is not well correlated with the amount of red blood cell deformation in complex flows including unsteady flow, addressing the necessity of the analysis of RBC deformation for better prediction of hemolysis. Project (2) clarified the mechanism and conditions of breaking open of a red blood cell membrane at the molecular level. In project (3), we identified the condition that luminol can be activated in neutral media, serving as a basefor visualizing hemolysis occurring from one red blood cell.
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Report
(4 results)
Research Products
(39 results)
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[Book]2012
Author(s)
Masao Tanaka, Shigeo Wada, Masanori Nakamura
Publisher
Computational Biomechanics, Springer
Related Report
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