Study on enhancement of transdermal vaccination by photothermaleffect

• Project/Area Number: 22300158
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Kumamoto University (2012); Kyushu University (2010-2011)
• Principal Investigator: NIIDOME Takuro 熊本大学, 大学院・自然科学研究科, 教授 (20264210)
• Co-Investigator(Renkei-kenkyūsha): GOTO Masahiro 九州大学, 大学院・工学研究院, 教授 (10211921)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
• Keywords: 生体制御 / 治療 / 薬物送達システム / 金ナノ粒子 / 金ナノロッド / 近赤外光 / フォトサーマル治療 / バイオイメージング / フォトサーマル治療_

Research Abstract

Stratum corneum is major barrier of transdermal protein delivery. We tried enhancingpermeability of stratum corneum by photothermal effect of gold nanorods. Ovalbumin wasmixed with gold nanorods, then, applied on skin. After irradiation of near infrared light,translocation of ovalbumin into skin and production of anti-ovalbumin antibody wereobserved. When a pulsed-laser was used, protein translocation without heating deeper partof skin was detected. These data would be important for development of dermal vaccinationsystem.

Research Products

• [Journal Article] Thermalenhancement of gene transfection in tumorcells mediated by the photothermal effect ofgold nanorods (2013)
  • Author(s): Y . Sakamura, M. Y oshiura, H. Tang, T. Mori,Y . Katayama, T. Niidom
  • Journal Title: Chem. Lett Volume: (in press)
  • Peer Reviewed
• [Journal Article] Thermal enhancement of gene transfection in tumor cells mediated by the photothermal effect of gold nanorods (2013)
  • Author(s): Y. Sakamura, M. Yoshiura, H. Tang, T. Mori, Y. Katayama, T. Niidome
  • Journal Title: Chem. Lett. Volume: in press
  • NAID: 10031183288
  • Peer Reviewed
• [Journal Article] Biodistribution and tumor localization of PEG-modified dendritic poly(L-lysine) oligonucleotide complexes (2013)
  • Author(s): R. Kurihara, D. Pissuwan, T. Mori, Y. Katayama, T. Niidome
  • Journal Title: J. Biomater. Sci.-Polym. Ed. Volume: 23 Pages: 2369-2380
  • Peer Reviewed
• [Journal Article] Biodistribution andtumor localization of PEG-modifieddendritic poly(L-lysine) oligonucleotidecomplexes (2012)
  • Author(s): R. Kurihara, D. Pissuwan, T. Mori, Y .Katayama, T. Niidome
  • Journal Title: J. Biomater . Sci.-Polym. Ed Volume: 23 Pages: 2369-2380
  • Peer Reviewed
• [Journal Article] Conversion of rod-shaped goldnanoparticles to spherical forms and theireffect on biodistribution in tumor-bearingmice (2012)
  • Author(s): Y . Akiyama, T. Mori, Y . Katayama, T.Niidome
  • Journal Title: Nanoscale Res. Lett Volume: 7 Pages: 565-565
  • Peer Reviewed
• [Journal Article] Sequential release ofsingle-stranded DNAs from gold nanorodstriggered by near-infrared light irradiation (2012)
  • Author(s): H. Fukushima, S. Y amashita, T. Mori, Y .Katayama, T. Niidome
  • Journal Title: Chem. Lett Volume: 41 Pages: 711-712
  • Peer Reviewed
• [Journal Article] activity based on phosphorylation-induceddissociation of a polyion complex (2012)
  • Author(s): R. Toita, T. Mori, Y . Naritomi, J.-H. Kang, S.Shiosaki, T. Niidome, Y . Katayama
  • Journal Title: Anal.Biochem Volume: 424 Pages: 130-136
  • Peer Reviewed
• [Journal Article] Gold nanorods in anoil-base formulation for transdermaltreatment of Type 1 diabetes in mice (2012)
  • Author(s): K. Nose, D. Pissuwan, M. Goto, Y .Katayama, T. Niidome
  • Journal Title: Nanoscale Volume: 4 Pages: 3776-3780
  • Peer Reviewed
• [Journal Article] onversion of rod-shaped gold nanoparticles to spherical forms and their effect on biodistribution in tumor-bearing mice (2012)
  • Author(s): Y. Akiyama, T. Mori, Y. Katayama, T. Niidome
  • Journal Title: Nanoscale Res. Lett. Volume: 7 Issue: 1 Pages: 565-565
  • DOI: 10.1186/1556-276x-7-565
  • Peer Reviewed
• [Journal Article] Folate-PEG-appended dendrimer conjugate with α-cyclodextrin as a novel cancer cell-selective siRNA delivery carrier (2012)
  • Author(s): H. Arima, A. Yoshimatsu, H. Ikeda, A. Ohyama, K. Motoyama, T. Higashi, A. Tsuchiya, T. Niidome, Y. Katayama, K. Hattori, T. Takeuchi
  • Journal Title: Mol. Pharmaceutics Volume: 9 Issue: 9 Pages: 2591-2604
  • DOI: 10.1021/mp300188f
  • Peer Reviewed
• [Journal Article] A novel double-coating carrier produced by solid-in-oil and solid-in-water nanodispersion technology for delivery of genes and proteins into cells (2012)
  • Author(s): Y. Tahara, T. Kaneko, R. Toita, C. Yoshiyama, T. Kitaoka, T. Niidome, Y. Katayama, N. Kamiya M. Goto
  • Journal Title: J. Controlled Release Volume: 161 Issue: 3 Pages: 713-721
  • DOI: 10.1016/j.jconrel.2012.05.001
  • Peer Reviewed
• [Journal Article] Sequential release of single-stranded DNAs from gold nanorods triggered by near-infrared light irradiation (2012)
  • Author(s): H. Fukushima, S. Yamashita, T. Mori, Y. Katayama, T. Niidome
  • Journal Title: Chem. Lett. Volume: 41 Issue: 7 Pages: 711-712
  • DOI: 10.1246/cl.2012.711
  • NAID: 130004426624
  • Peer Reviewed
• [Journal Article] Gold nanoparticles for the development of transdermal delivery systems (2012)
  • Author(s): D. Pissuwan, T. Niidome
  • Journal Title: ACS Symposium Series, Functional Nanoparticles for Bioanalysis, Nanomedicine and Bioelectronic Devices Volume: 2
  • Peer Reviewed
• [Journal Article] 金ナノロッドと近赤外光を組み合わせた新しい治療技術 (2012)
  • Author(s): 新留琢郎
  • Journal Title: 光学 Volume: 41 Pages: 568-572
  • NAID: 10031128102
  • Peer Reviewed
• [Journal Article] Controlled-release system mediated by aretro Diels-Alder reaction induced by thephotothermal effect of gold nanorods (2011)
  • Author(s): S. Y amashita, H. Fukushima, Y . Niidome, T.Mori, Y . Katayama, T. Niidom
  • Journal Title: Langmuir Volume: 27 Pages: 14621-14626
  • Peer Reviewed
• [Journal Article] Controlled- release system ofsingle-stranded DNA triggered by thephotothermal effect of gold nanorods and itsin vivo application (2011)
  • Author(s): S. Y amashita, H. Fukushima, Y . Akiyama, Y .Niidome, T. Mori, Y . Katayama, T. Niidome
  • Journal Title: Bioorg. Med. Chem Volume: 19 Pages: 2130-2135
  • Peer Reviewed
• [Journal Article] A solid-in-oildispersion of gold nanorods can enhancetrandermal protein delivery and skinvaccination (2011)
  • Author(s): D. Pissuwan, K. Nose, R. Kurihara, K.Kaneko, Y . Tahara, N. Kamiya, M. Goto, Y .Katayama, T. Niidome
  • Journal Title: Small Volume: 7 Pages: 215-220
  • Peer Reviewed
• [Journal Article] Controlled-Release System Mediated by a Retro Diels Alder Reaction Induced by the Photothermal Effect of Gold Nanorods (2011)
  • Author(s): Shuji Yamashita
  • Journal Title: Langmuir Volume: 27 Issue: 23 Pages: 14621-14626
  • DOI: 10.1021/la2036746
  • Peer Reviewed
• [Journal Article] A simple set-and-mix assay for screening of protein kinase inhibitors in cell lysates (2011)
  • Author(s): Asami, Y., Oishi, J., Kitazaki, H., Kamimoto, J., Kang, J.-H., Niidome, T., Mori, T., Katayama, Y.
  • Journal Title: Analytical Biochemistry Volume: 418 Issue: 1 Pages: 44-49
  • DOI: 10.1016/j.ab.2011.06.041
  • Peer Reviewed
• [Journal Article] Transgene regulation system responding to Rho associated coiled-coil kinase (ROCK) activation (2011)
  • Author(s): Akira Tsuchiya, et al
  • Journal Title: Journal of Controlled Release Volume: 155 Issue: 1 Pages: 40-46
  • DOI: 10.1016/j.jconrel.2011.05.002
  • Peer Reviewed
• [Journal Article] Fluorescent nanoparticles consisting of lipopeptides and fluorescein-modified polyanions for monitoring of protein kinase activity (2011)
  • Author(s): Koga, H., Toita, R., Mori, T., Tomiyama, T., Kang, J.-H., Niidome, T., Katayama, Y.
  • Journal Title: Bioconjugate Chemistry Volume: 22 Issue: 8 Pages: 1526-1534
  • DOI: 10.1021/bc200066w
  • Peer Reviewed
• [Journal Article] Peptide substrates for Rho-associated kinase 2 (Rho-kinase 2/ROCK2) (2011)
  • Author(s): Jeong-Hun Kang, et al
  • Journal Title: PLOS One Volume: 6 Issue: 7 Pages: e22699-e22699
  • DOI: 10.1371/journal.pone.0022699
  • Peer Reviewed
• [Journal Article] A hydrophilic polymer grafted with a histone tail peptide as an artificial gene regulator (2011)
  • Author(s): Shiosaki, S., Kuramoto, M., Toita, R., Mori, T.,Niidome, T., Katayama, Y.
  • Journal Title: Bioorganic and Medicinal Chemistry Volume: 19 Issue: 13 Pages: 4101-4105
  • DOI: 10.1016/j.bmc.2011.05.011
  • Peer Reviewed
• [Journal Article] Controlled-release system of single-stranded DNA triggered by the photothermal effect of gold nanorods and its in vivo application (2011)
  • Author(s): Yamashita, S., Fukushima, H., Akiyama, Y., Niidome, Y., Mori, T., Katayama, Y., Niidome, T.
  • Journal Title: Bioorganic and Medicinal Chemistry Volume: 19 Issue: 7 Pages: 2130-2135
  • DOI: 10.1016/j.bmc.2011.02.042
  • Peer Reviewed
• [Journal Article] A solid-in-oil dispersion of gold nanorods can enhance transdermal protein delivery and skin vaccination (2011)
  • Author(s): Pissuwan, D., Nose, K., Kurihara, R., Kaneko, K., Tahara, Y., Kamiya, N., Goto, M., Katayama, Y., Niidome, T.
  • Journal Title: Small Volume: 7 Issue: 2 Pages: 215-220
  • DOI: 10.1002/smll.201001394
  • Peer Reviewed
• [Journal Article] Optimization of Peptide Density on Microarray Surface for Quantitative Phosphoproteomics (2011)
  • Author(s): Shimomura, T., Han, X., Hata, A., Niidome, T., Mori, T., Katayama, Y.
  • Journal Title: Analytical Sciences Volume: 27 Issue: 1 Pages: 13-17
  • DOI: 10.2116/analsci.27.13
  • NAID: 10027739412
  • ISSN: 0910-6340, 1348-2246
  • Peer Reviewed
• [Journal Article] Active accumulation of gold nanorods intumor in response to near-infrared laserirradiation (2010)
  • Author(s): A. Shiotani, Y . Akiyama, T. Kawano, Y .Niidome, T. Mori, Y . Katayama, T. Niidome
  • Journal Title: Bioconjugate Chem Volume: 21 Pages: 2049-2054
  • Peer Reviewed
• [Journal Article] Controlled release of PEG chain from gold nanorods: targeted delivery totumor (2010)
  • Author(s): T. Niidome, A. Ohga, Y . Akiyama, K.Watanabe, Y . Niidome, T. Mori, Y .Katayama
  • Journal Title: Bioorg. Med. Chem Volume: 18 Pages: 4453-4458
  • Peer Reviewed
• [Journal Article] Active accumulation of gold nanorods in tumor in response to near-infrared laser irradiation (2010)
  • Author(s): A.Shiotani, Y.Akiyama, T.Kawano, Y.Niidome, T.Mori, Y.Katayama, T.Niidome
  • Journal Title: Bioconjugate Chem. Volume: 21 Pages: 2049-2054
  • Peer Reviewed
• [Journal Article] Controlled release of PEG chain from gold nanorods : targeted delivery to tumor (2010)
  • Author(s): T.Niidome, A.Ohga, Y.Akiyama, K.Watanabe, Y.Niidome, T.Mori, Y.Katayama
  • Journal Title: Bioorg.Med.Chem. Volume: 18 Pages: 4453-4458
  • Peer Reviewed
• [Journal Article] ナノロッドと近赤外光を用いた診断・治療システム (2010)
  • Author(s): 新留琢郎、塩谷淳、秋山泰之、大賀晃、野瀬圭介、ピスワン ダークロン、新留康郎
  • Journal Title: 薬学雑誌 Volume: 130 Pages: 1671-1677
  • Peer Reviewed
• [Journal Article] 金ナノ粒子を用いたバイオイメージングおよびフォトサーマル治療;Bioimaging and Photothermal Therapy Using Gold Nanoparticles (2010)
  • Author(s): 新留琢郎、新留康郎
  • Journal Title: レーザー研究 Volume: 36 Pages: 421-426
  • Peer Reviewed
• [Presentation] 金属ナノ材料とポリマーを組み合わせた新しい医療材料の構築 (2012)
  • Author(s): 新留琢郎
  • Organizer: 高分子学会第21回ポリマー材料フォーラム
  • Place of Presentation: 北九州市 (北九州国際会議場)
  • Year and Date: 2012-11-01
• [Presentation] 金ナノロッドのフォトサーマル効果を利用した薬物デリバリーシステム (2012)
  • Author(s): 新留琢郎
  • Organizer: 第4回マイクロ・ナノ工学シンポジウム
  • Place of Presentation: 北九州市 (北九州国際会議場)
  • Year and Date: 2012-10-22
• [Presentation] 近赤外光照射に応答して薬物を放出する金ナノロッド (2012)
  • Author(s): 新留琢郎、 山下秀治、 福島寛満、 森 健、片山佳樹
  • Organizer: 第61回高分子討論会
  • Place of Presentation: 名古屋市 (名古屋工業大学)
  • Year and Date: 2012-09-20
• [Presentation] Development of NovelTherapeutic Techniques usingPhotothermal Effect of GoldNanorods (2012)
  • Author(s): T. Niidome
  • Organizer: PT-BMES 2012
  • Place of Presentation: 台 湾 新 竹 市 (National Tsing HuaUniversity)
  • Year and Date: 2012-09-06
• [Presentation] DRUG RELEASE SYSTEMCONTROLLED BY PHOTOTHERMAL EFFECT OFGOLD NANORODS (2012)
  • Author(s): T. Niidome
  • Organizer: PEM
  • Place of Presentation: 中国吉林省長春市 (ChangchunInstitute of Applied Chemistry)
  • Year and Date: 2012-08-21
• [Presentation] TransdermalInsulin Delivery Enhanced byPhotothermal Effect of GOLDNanorods (2012)
  • Author(s): D. Pissuwan, K. Nose, T. Mori, Y.Katayama, T. Niidome
  • Organizer: The 39th Annual Meeting &Exposition of The Controlled ReleaseSociet
  • Place of Presentation: カナダ ケベックシティ(Centre des congres de Quebec)
  • Year and Date: 2012-07-16
• [Presentation] Controlled release systemresponding heat produced byphotothermal effect of gold nanorods (2012)
  • Author(s): T. Niidome, S. Yamashita, T. Mori, Y.Katayama
  • Organizer: 9th World Biomaterials Congress
  • Place of Presentation: 中国成都 (The Century CityNew International Convention &Exhibition Center)
  • Year and Date: 2012-06-04
• [Presentation] Transdermal Insulin Delivery Enhanced by Photothermal Effect of Gold Nanorods (2012)
  • Author(s): Takuro Niidome
  • Organizer: The 39th Annual Meeting & Exposition of The Controlled Release Society
  • Place of Presentation: Centre des congres de Quebec, Canada
• [Presentation] 金ナノロッドからの核酸のコントロールドリリースシステム (2012)
  • Author(s): 新留琢郎
  • Organizer: 第12回遺伝子・デリバリー研究会 夏季セミナー
  • Place of Presentation: 北九州市若松区かんぽの宿北九州
• [Presentation] Drug Release System Controlled by Photothermal Effect of Gold Nanorods (2012)
  • Author(s): Takuro Niidome
  • Organizer: PEM 2012
  • Place of Presentation: Changchun Institute of Applied Chemistry, China
• [Presentation] Development of Novel Therapeutic Techniques using Photothermal Effect of Gold Nanorods (2012)
  • Author(s): Takuro Niidome
  • Organizer: PT-BMES 2012
  • Place of Presentation: National Tsing Hua University, Taiwan
  • Invited
• [Presentation] 金ナノロッドと近赤外線を組み合わせた新しいDDS (2012)
  • Author(s): 新留琢郎
  • Organizer: 日本バイオマテリアル学会九州地区講演会
  • Place of Presentation: 九州大学
• [Presentation] 近赤外光照射に応答して薬物を放出する金ナノロッド (2012)
  • Author(s): 新留琢郎
  • Organizer: 第61回高分子討論会
  • Place of Presentation: 名古屋工業大学
• [Presentation] 金ナノロッドのフォトサーマル効果を利用した薬物デリバリーシステム (2012)
  • Author(s): 新留琢郎
  • Organizer: 第4回マイクロ・ナノ工学シンポジウム
  • Place of Presentation: 北九州国際会議場
• [Presentation] 金属ナノ材料とポリマーを組み合わせた新しい医療材料の構築 (2012)
  • Author(s): 新留琢郎
  • Organizer: 高分子学会第21回ポリマー材料フォーラム
  • Place of Presentation: 北九州国際会議場
  • Invited
• [Presentation] Controlled Release Systemsfrom Gold Nanorods Responding to NearInfrared Light Irradiation (2011)
  • Author(s): T. Niidome, S. Yamashita, H.Fukushima, Y. Niidome, T. Mori and Y.Katayama
  • Organizer: 第21回日本 MRS 学術シンポジウム
  • Place of Presentation: 神奈川県横浜市 横浜情報文化センター
  • Year and Date: 2011-12-20
• [Presentation] Controlled Release Systems from Gold Nanorods Responding to Near Infrared Light Irradiation (2011)
  • Author(s): T.Niidome, S.Yamashita, H.Fukushima, Y.Niidome, T.Mori, Y.Katayama
  • Organizer: 第21回日本MRS学術シンポジウム
  • Place of Presentation: 神奈川県横浜市(招待講演)
  • Year and Date: 2011-12-02
• [Presentation] Transdermal Insulin delivery using asolid-in-oil dispersion of goldnanorods (2011)
  • Author(s): D. Pissuwan, K. Nose, Y. Tahara, M.Goto, Y. Katayama, T. Niidome
  • Organizer: 2011 MRS Fall Meeting &Exhibit
  • Place of Presentation: 米国マサチューセッツ州ボストン
  • Year and Date: 2011-11-30
• [Presentation] Transdermal Insulin delivery using a solid-in-oil dispersion of gold nanorods (2011)
  • Author(s): Dakrong Pissuwan, Keisuke Nose, Yoshiro Tahara, Masahiro Goto, Yoshiki Katayama, Takuro Niidome
  • Organizer: 2011 MRS Fall Meeting & Exhibit
  • Place of Presentation: Boston, MA, USA
  • Year and Date: 2011-11-30
• [Presentation] Release ofSingle Stranded DNA Responding to NearInfrared Light Irradiation (2011)
  • Author(s): S. Yamashita, H. Fukushima, T. Mori,Y. Katayama, T. Niidome
  • Organizer: The 38thInternational Symosium on NucleicAcid Chemistry
  • Place of Presentation: 北海道札幌市北海道大学
  • Year and Date: 2011-11-11
• [Presentation] Release of Single Stranded DNA Responding to Near Infrared Light Irradiation (2011)
  • Author(s): Shuji Yamashita, Hiromitsu Fukushima, Takeshi Mori, Yoshiki Katayama, Takuro Niidome
  • Organizer: The 38th International Symosium on Nucleic Acid Chemistry
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2011-11-11
• [Presentation] Preparation ofThermoresponsive Polymer-modifiedGold Nanorods and Their Delivery toSpecific Tissue (2011)
  • Author(s): T. Niidome, A. Shiotani, T. Mori, andY. Katayama
  • Organizer: Pusan-Kyushu JointSymposium on High Polymers (15th) andFibers (13th)
  • Place of Presentation: 韓国プサン
  • Year and Date: 2011-10-28
• [Presentation] Preparation of Thermoresponsive Polymer-modified Gold Nanorods and Their Delivery to Specific Tissue (2011)
  • Author(s): Takuro Niidome, Atsushi Shiotani, Takeshi Mori, Yoshiki Katayama
  • Organizer: Pusan-Kyushu Joint Symposium on High Polymers (15th) and Fibers (13th)
  • Place of Presentation: 韓国プサン(招待講演)
  • Year and Date: 2011-10-28
• [Presentation] Controlled Release System Mediated byRetro Diels-Alder Reaction on GoldNanorods (2011)
  • Author(s): T. Niidome, S. Yamashita, H. Fukushima,Y. Niidome, T. Mori, and Y. Katayama
  • Organizer: 8TH ANNUAL MEETING &EXPOSITION OF THE CONTROLLED RELEASESOCIETY
  • Place of Presentation: 米国メリーランド州ナショナルハーバー
  • Year and Date: 2011-07-02
• [Presentation] Controlled Release System Mediated by Retro Diels-Alder Reaction on Gold Nanorods (2011)
  • Author(s): T.Niidome, S.Yamashita, H.Fukushima, Y.Niidome, T.Mori, Y.Katayama
  • Organizer: 38th Annual Meeting & Exposition Of The Controlled Release Society
  • Place of Presentation: National Harbor, MD, USA
  • Year and Date: 2011-07-02
• [Presentation] デンドリティックポリリジンをベースにしたオーバーハウザー効果MRI (OMRI)造影剤の設計 (2011)
  • Author(s): 新留琢郎、御供田理沙、渡部和人、森健、長沼辰弥、内海英雄、市川和洋、片山佳樹
  • Organizer: 第27回日本DDS学会学術集会
  • Place of Presentation: 東京都文京区
  • Year and Date: 2011-06-09
• [Presentation] Biomedical applications of gold nanorods: active accumulation system to tumor and enhancement of skin vaccination (2011)
  • Author(s): T.Niidome, D.Pissuwan, A.Shiotani, K.Nose, T.Mori, Y.Katayama
  • Organizer: The 10th China-Japan-Korea Foresight Joint Symposium on Gene Delivery and International Symposium on Biomaterials 2011
  • Place of Presentation: 中国桂林(招待講演)
  • Year and Date: 2011-05-30
• [Presentation] Enhancement of TransdermalProtein Delivery by PhotothermalEffect of Gold Nanorods (2011)
  • Author(s): D. PISSUWAN, K. NOSE, R. KURIHARA, Y.NIIDOME, K. KANEKO, Y. TAHARA, N.KAMIYA, M. GOTO, Yoshiki KATAYAMA, T.NIIDOM
  • Organizer: 第60回高分子学会年次大会
  • Place of Presentation: 大阪市北区、大阪国際会議場
  • Year and Date: 2011-05-25
• [Presentation] Biomedical applications of goldnanorods: active accumulation systemto tumor and enhancement of skinvaccination (2011)
  • Author(s): T. Niidome, D. Pissuwan, A. Shiotani,K. Nose, T. Mori, and Y. Katayama
  • Organizer: The 10th China-JapanKorea Foresight Joint Symposium onGene Delivery and InternationalSymposium on Biomaterials2011
  • Place of Presentation: 中国桂林
  • Year and Date: 2011-05-03
• [Presentation] 金ナノロッドと近赤外光を組み合わせた新しいイメージング・治療技術の開発 (2011)
  • Author(s): 新留琢郎、新留康郎、ピスワン ダークロン、森 健、片山佳樹
  • Organizer: 第50回日本生体医工学会大会
  • Place of Presentation: 東京都千代田区、東京電機大学
  • Year and Date: 2011-04-29
• [Presentation] 金ナノロッドと近赤外光を組み合わせた新しいイメージング・治療技術の開発 (2011)
  • Author(s): 新留琢郎、新留康郎、ピスワン ダークロン、森健、片山佳樹
  • Organizer: 第50回日本生体医工学会大会
  • Place of Presentation: 東京都千代田区(招待講演)
  • Year and Date: 2011-04-29
• [Presentation] Active accumulation of goldnanorods in tumor mediated by theirphotothermal effect (2011)
  • Author(s): T. Niidome, A. Shiotani, T. Mori, Y.Katayama
  • Organizer: InternationalConference on Biomaterials Science2011
  • Place of Presentation: つくば市 TsukubaInternational Congress Center
  • Year and Date: 2011-03-15
• [Presentation] 金ナノ粒子と近赤外光を組み合わせた新しい診断・治療法,日本学術振興会「未踏・ナノデバイステクノロジー」 (2011)
  • Author(s): 新留琢郎
  • Organizer: 第151 委員会研究会
  • Place of Presentation: 東京都文京区 東京大学
  • Year and Date: 2011-01-31
• [Presentation] Functional goldnanorods for bioimaging andphotothermal therapy (2010)
  • Author(s): T. Niidome, A. Shiotani, Y. Niidome,T. Mori, Y. Katayama
  • Organizer: InternationalChemistry Congress of Pacific BasinSocieties
  • Place of Presentation: 米国ハワイ州ホノルル
  • Year and Date: 2010-12-15
• [Presentation] Functional gold nanorods for bioimaging and photothermal therapy (2010)
  • Author(s): Takuro Niidome, Atsushi Shiotani, Yasuro Niidome, Takeshi Mori, Yoshiki Katayama
  • Organizer: International Chemistry Congress of Pacific Basin Societies
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2010-12-15
• [Presentation] Preparation ofthermo-responsive polymer-coatedgold nanorods and their accumulationto light irradiated site (2010)
  • Author(s): T. Niidome, A. Shiotani, Y. Niidome,T. Mori, Y. Katayama
  • Organizer: 2010Materials Research Society FallMeeting
  • Place of Presentation: 米国マサチューセッツ州ボストン
  • Year and Date: 2010-11-29
• [Presentation] Preparation of thermo-responsive polymer-coated gold nanorods and their accumulation to light irradiated site (2010)
  • Author(s): Takuro Niidome, Atsushi Shiotani, Yasuro Niidome, Takeshi Mori, Yoshiki Katayama
  • Organizer: 2010 Materials Research Society Fall Meeting
  • Place of Presentation: Boston, USA
  • Year and Date: 2010-11-29
• [Presentation] 金ナノロッドのフォトサーマル効果を利用したデリバリーと治療システム (2010)
  • Author(s): 新留琢郎、塩谷 淳、ピスワン ダークロン、新留康郎、片山佳樹
  • Organizer: 第31回 日本レーザー医学会 総会
  • Place of Presentation: 名古屋市中区 ウインクあいち
  • Year and Date: 2010-11-13
• [Presentation] 金ナノロッドのフォトサーマル効果を利用したデリバリーと治療システム (2010)
  • Author(s): 新留琢郎、塩谷淳、ピスワン ダークロン、新留康郎、片山佳樹
  • Organizer: 第31回 日本レーザー医学会 総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2010-11-13
• [Presentation] Gold Nanorods Combined with Solid in Oil Dispersions for Transdermal Macromolecules Protein Delivery In Vitro (2010)
  • Author(s): Dakrong Pissuwan, Keisuke Nose, Kenji Kaneko, Takuro Niidome
  • Organizer: The 37th Annual Meeting & Exposition of the Controlled Release Society
  • Place of Presentation: Portland, USA
  • Year and Date: 2010-07-10
• [Presentation] Preparation of pNIPAM-modified Gold Nanorods and Their Delivery to Specific Tissue (2010)
  • Author(s): Takuro Niidome, Atsushi Shiotani, Takeshi Mori, Yatayama Katayama
  • Organizer: The 37th Annual Meeting & Exposition of the Controlled Release Society
  • Place of Presentation: Portland, USA
  • Year and Date: 2010-07-10
• [Presentation] Delivery of gold nanorods totumor in response to near-infraredirradiation (2010)
  • Author(s): T. Niidome, A. Shiotani, T. Mori, Y.Katayam
  • Organizer: The 9thChina-Japan-Korea Foresight JointSymposium on Gene Delivery and theInternational Workshop onBiomaterials2010
  • Place of Presentation: 長春、中国
  • Year and Date: 2010-06-21
• [Presentation] Delivery of gold nanorods to tumor in response to near-infrared irradiation (2010)
  • Author(s): Takuro Niidome, Atsushi Shiotani, Takeshi Mori, Yoshiki Katayama
  • Organizer: The 9th China-Japan-Korea Foresight Joint Symposium on Gene Delivery and the International Workshop on Biomaterials 2010
  • Place of Presentation: Changchun, China
  • Year and Date: 2010-06-21
• [Presentation] 温度感受性ポリマーゲルで修飾した金ナノロッドの体内デリバリー (2010)
  • Author(s): 新留琢郎、 塩谷 淳、 森 健、 新留康郎、片山佳樹
  • Organizer: 第26回日本DDS学会学術集会
  • Place of Presentation: 大阪市天王寺区、 大阪国際交流センター
  • Year and Date: 2010-06-17
• [Presentation] 温度感受性ポリマーゲルで修飾した金ナノロッドの調製と光照射することによる腫瘍への集積 (2010)
  • Author(s): 新留琢郎、塩谷淳、森健、新留康郎、片山佳樹
  • Organizer: 第59回高分子学会年次大会
  • Place of Presentation: 横浜市
  • Year and Date: 2010-05-27
• [Presentation] Targeted Delivery of Gold Nanorods Modified with Thermo-Sensitive Polymer (2010)
  • Author(s): Takuro Niidome, Atsushi Shiotani, Takeshi Mori, Yoshiki Katayama
  • Organizer: The 11th European Symposium on Controlled Drug Delivery
  • Place of Presentation: Amsterdam, Netherland
  • Year and Date: 2010-04-08
• [Book] 近赤外光によりコントロールできる薬物放出,薬学雑誌 (2013)
  • Author(s): 新留琢郎
• [Book] Goldnanoparticles for the development oftransdermal delivery systems.ACSSymposium Series, FunctionalNanoparticles for Bioanalysis,Nanomedicine and BioelectronicDevices, Volume 2, Chapter 5 (2012)
  • Author(s): D. Pissuwan, T. Niidome
• [Book] 金ナノロッドと近赤外光を組み合わせた新しい治療技術,光学 (2012)
  • Author(s): 新留琢郎
• [Book] The forthcoming applications of goldnanoparticles in drug and genedelivery systemsJ. ControlledRelease (2011)
  • Author(s): D. Pissuwan, T. Niidome, M. B. Cortie
• [Book] はじめて学ぶ生命科学の基礎 (2011)
  • Author(s): 畠山智充、小田達也
  • Total Pages: 195
  • Publisher: 化学同人
• [Book] ピスワン ダークロン、新留康郎、金ナノロッドと近赤外光を用いた診断・治療システム薬学雑誌 (2010)
  • Author(s): 新留琢郎、塩谷 淳、秋山泰之、大賀 晃、野瀬圭介
  • Publisher: 薬学雑誌
• [Book] 金ナノ粒子を用いたバイオイメージングおよびフォトサーマル治療;Bioimaging and PhotothermalTherapy Using Gold Nanoparticles、レーザー研究 (2010)
  • Author(s): 新留琢郎、新留康郎
• [Remarks]
  • URL: http://www.chem.kumamoto-u.ac.jp/~niidome
• [Remarks] 新留研究室ホームページ
  • URL: http://www.chem.kumamoto-u.ac.jp/~niidome
• [Remarks]
  • URL: http://www.chem.kyushu-u.ac.jp/~katayama/
• [Remarks]
  • URL: http://www.chem.kyushu-u.ac.jp/~katayama/
• [Patent(Industrial Property Rights)] 核酸デリバリー方法および核酸デリバリーデバイス (2012)
  • Inventor(s): 新留琢郎、和田冨美夫、片山佳樹、薬丸康介、河野喬仁、山下修蔵
  • Industrial Property Rights Holder: 国立大学法人九州大学、株式会社日本ステントテクノロジー
  • Acquisition Date: 2012-10-12
• [Patent(Industrial Property Rights)] 光応答性のパターニングに用いるための基板およびその利用 (2010)
  • Inventor(s): 君塚信夫、新留琢郎、金 仁華、飯田誠之、副島哲朗、渡部和人
  • Industrial Property Rights Holder: 独立行政法人科学技術振興機構
  • Patent Publication Number: 2012-095626
  • Filing Date: 2010-11-05
• [Patent(Industrial Property Rights)] プロテインキナーゼの検出及び活性測定方法 (2010)
  • Inventor(s): 片山佳樹、新留琢郎、森 健
  • Industrial Property Rights Holder: 国立大学法人九州大学
  • Filing Date: 2010-09-13
  • Overseas
• [Patent(Industrial Property Rights)] タンパク質キナーゼの新規基質ペプチド (2010)
  • Inventor(s): 片山佳樹、 新留琢郎、 森 健、 韓 暁明、秦 彬斗、矢山由洋、下村 隆
  • Industrial Property Rights Holder: 国立大学法人九州大学
  • Industrial Property Number: 2010-137453
  • Filing Date: 2010-06-16
  • Overseas
• [Patent(Industrial Property Rights)] 金ナノロッドを含有する S/O 製剤 (2010)
  • Inventor(s): 新留琢郎、新留康郎、神谷典穂、後藤雅宏、片山佳樹、ダークロン・ピスワン、野瀬圭介、栗原亮介
  • Industrial Property Rights Holder: 国立大学法人九州大学
  • Industrial Property Number: 2010-136286
  • Filing Date: 2010-06-15
• [Patent(Industrial Property Rights)] 金ナノロッドを含有するS/O製剤 (2010)
  • Inventor(s): 新留琢郎、新留康郎、神谷典穂、後藤雅宏、片山佳樹、ダークロン・ピスワン、野瀬圭介、栗原亮介
  • Industrial Property Rights Holder: 国立大学法人九州大学
  • Industrial Property Number: 2010-136286
  • Filing Date: 2010-06-15