| Project/Area Number |
22300160
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tokyo Denki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUNAKUBO Akio 東京電機大学, 理工学部, 教授 (00307670)
OHGOE Yasuharu 東京電機大学, 理工学部, 助教 (10408643)
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| Co-Investigator(Renkei-kenkyūsha) |
HIGAMI Tetsuya 札幌医科大学, 医学部, 教授 (60335429)
HIRAKURI Kenji 東京電機大学, 工学部, 教授 (60225505)
SUMIKURA Hirohito 国立循環器病研究センター研究所, 特任研究員 (20433998)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2010: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | 人工臓器工学 / 再生医工学 / 軸流血液ポンプ / 非晶質炭素被膜 / 数値流体解析 / 遺伝的アルゴリズム / 補助人工心臓 / フッ素ドープa-C:H被膜 / 表面処理 / 溶血低減効果 / 表面エネルギー / a-C : H被膜 / 小型高機能性 / CFD解析 / MOGA / 溶血低減 |
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| Research Abstract |
Enclosed-impeller type flow blood pump design was optimized by using Computational Fluid Dynamics (CFD) analysis and Multi Object Genetic Algorithm (MOGA), and surface of the optimized impeller of the blood pump was covered by hydrogenated amorphous carbon (a-C:H). The combination of optimization of impeller design using CFD / MOGA and surface modification by a-C:H film coating reduced the amount of hemolysis and improved the hemolytic performance.
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