| Project/Area Number |
22300162
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
YADA Toyotaka 川崎医科大学, 医学部, 講師 (00210279)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMOTO Hiroshi 川崎医科大学, 医学部, 助教 (10299183)
MORITA Yoshitaka 川崎医科大学, 医学部, 教授 (50346441)
OGASAWARA Yasuo 川崎医科大学, 医学部, 准教授 (10152365)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMOKAWA Hiroaki 東北大学, 医学部, 教授 (00235681)
KAJIYA Fumihiko 川崎医療福祉大学, 医療技術学部, 教授 (70029114)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2010: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
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| Keywords | 糖尿病 / 冠微小循環 / 過酸化水素 / 内皮由来過分極因子 / 冠血管予備能 / 急性心筋梗塞 / 内因性過酸化水素 / アンジオテンシン受容体拮抗薬 / 血管内皮機能 |
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| Research Abstract |
DM significantly decreased the coronary vasodilatation compared with Control in both coronary small arteries and arteries, whereas DM+ARB (angiotensin receptor inhibitor, olmesartan) +L-NMMA (DAL) DAL significantly improved the vasodilatation compared with DM in coronary small arteries and was significantly decreased by DAL+Apamin+Charybdotoxin (DALAC,both KCa channel blocker) in coronary arterioles. DAL ameliorated myocardial injury and oxidative stress compared with DM, as assessed by 8-OHdG, myocardial troponin-I and apoptosis, respectively.
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