Preparation of porous ceramic microspheres for multiple minimally invasive treatments of deep-seated cancer

• Project/Area Number: 22300163
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Tohoku University
• Principal Investigator: KAWASHITA Masakazu 東北大学, 大学院・医工学研究科, 准教授 (70314234)
• Co-Investigator(Kenkyū-buntansha): KANETAKA Hiroyasu 東北大学, 大学院・歯学研究科, 准教授 (50292222)
• Co-Investigator(Renkei-kenkyūsha): MITSUMORI Michihide 京都大学, 大学院・医学研究科, 准教授 (10263089)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000); Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2010: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
• Keywords: イットリウム / リン / マグネタイト / 微小球 / 放射線治療 / 温熱治療 / 中空 / 薬剤徐放 / 多孔質

Research Abstract

We revealed that chemically durable porous yttrium oxide microparticles 500 μm in diameter or yttrium phosphate microspheres 25 μm in diameter can be obtained by gelatin suspension method. Also, we found that hollow ceramic microspheres containing large amount of yttrium and phosphorus 30 μm in diameter can be obtained by spray-dry method. It is believed that the present microspheres are useful for intra-arterial multiple treatment of deep-seated cancer.

Research Products

• [Journal Article] Structure of yttrium and phosphorus-containingmicrospheres prepared by spray dry method (2013)
  • Author(s): M. Kawashita, K. Nakamura, T. Miyazaki and H. Kanetaka
  • Journal Title: Int. J. Mater. Chem. Volume: Vol. 3 Pages: 16-20
  • Peer Reviewed
• [Journal Article] Structure of yttrium and phosphorus-containing microspheres prepared by spray dry method (2013)
  • Author(s): M. Kawashita
  • Journal Title: Int. J. Mater. Chem. Volume: 印刷中
  • NAID: 120005890550
  • Peer Reviewed
• [Journal Article] Sol-gel synthesis, characterization and in vitro compatibility evaluation of iron nanoparticle encapsulating-silica microspheres for hyperthermia of cancer (2012)
  • Author(s): Z. Li, M. Kawashita, T. Kudo and H.Kanetaka
  • Journal Title: J. Mater. Sci.: Mater. Med Volume: Vol. 23 Issue: 10 Pages: 2461-2469
  • DOI: 10.1007/s10856-012-4735-y
  • Peer Reviewed
• [Journal Article] Preparation of ferromagneticmicrocapsules for hyperthermia using water/oil emulsion as a reaction field (2012)
  • Author(s): T. Miyazaki, A. Miyaoka, E. Ishida, Z.Li, M. Kawashita and M. Hiraoka
  • Journal Title: Mater. Sci. Engin. C Volume: Vol. 32 Issue: 4 Pages: 692-696
  • DOI: 10.1016/j.msec.2012.01.010
  • Peer Reviewed
• [Journal Article] Preparation, structure, and in vitro chemical durability of yttrium phosphate microspheres for intra-arterial radiotherapy (2011)
  • Author(s): M. Kawashita, N. Matsui, Z. Li, T.Miyazaki, H. Kanetaka
  • Journal Title: J. Biomed. Mater. Res. Part B: Appl. Biomater Volume: Vol. 99B Issue: 1 Pages: 45-50
  • DOI: 10.1002/jbm.b.31870
  • NAID: 120005972068
  • Peer Reviewed
• [Journal Article] Preparation, structure, and in vitro chemical durability of yttrium phosphate microspheres for intra-arterial radiotherapy (2011)
  • Author(s): M.Kawashita, N.Matsui, Z.Li, T.Miyazaki, H.Kanetaka
  • Journal Title: J.Biomed.Mater.Res.Part B : Appl.Biomater. Volume: 99B Pages: 45-50
  • NAID: 120005972068
  • Peer Reviewed
• [Journal Article] Preparation of porous yttrium oxide microparticles by gelation of ammonium alginate in aqueous solution containing yttrium ions (2010)
  • Author(s): M. Kawashita, N. Matsui, Z. Li, T. Miyazaki
  • Journal Title: J. Mater. Sci.: Mater. Med Volume: Vol. 21 Issue: 6 Pages: 1837-1843
  • DOI: 10.1007/s10856-010-4050-4
  • NAID: 120002721931
  • Peer Reviewed
• [Journal Article] Fabrication of yttria microcapsules for radiotherapy from water/oil emulsion (2010)
  • Author(s): T. Miyazaki, T. Kai, E. Ishida, M. Kawashita and M. Hiraoka
  • Journal Title: J. Ceram. Soc. Japan Volume: Vol. 118 Pages: 479-482
  • NAID: 130000304772
  • URL: https://www.jstage.jst.go.jp/article/jcersj2/118/1378/118_1378_479/_pdf
  • Peer Reviewed
• [Journal Article] Preparation of porous yttrium oxide microparticles by gelation of ammonium alainate in aqueous solution containine yttriumions (2010)
  • Author(s): M.Kawashita, N.Matsui, Z.Li, T.Miyazaki
  • Journal Title: J.Mater.Sci.Mater.Med. Volume: 21 Pages: 1837-1843
  • Peer Reviewed
• [Journal Article] Fabrication of yttria microcapsules for radiotherapy from water/oil emulsion (2010)
  • Author(s): T.Miyazaki, T.Kai, E.Ishida, M.Kawashita, M.Hiraoka
  • Journal Title: J.Ceram.Soc.Jpn. Volume: 118 Pages: 479-482
  • NAID: 130000304772
  • Peer Reviewed
• [Presentation] 噴霧乾燥法による深部癌血管内放射線治療用リン酸イットリウム微小球の作製 (2012)
  • Author(s): 中村梢、川下将一、宮崎敏樹、金高弘恭
  • Organizer: 日本バイオマテリアル学会シンポジウム2012
  • Place of Presentation: 仙台
• [Presentation] Preparation of YPO_4 microspheres for embolic radiotherapyof cancer by spray drying method (2012)
  • Author(s): K. Nakamura, M. Kawashita, T. Miyazaki and H. Kanetaka
  • Organizer: 12th Asian BioCeramics (ABC2012) Symposium
  • Place of Presentation: Tainan, Taiwan
• [Presentation] YPO_4 microcapsules as a beta-emitter for cancer radiotherapy (2012)
  • Author(s): T. Miyazaki, T. Suda, M. Kawashita
  • Organizer: 12th Asian BioCeramics (ABC2012) Symposium
  • Place of Presentation: Tainan, Taiwan
• [Presentation] 噴霧乾燥法による深部癌血管内放射線治療用リン酸イットリウム微小球の作製 (2012)
  • Author(s): 中村梢
  • Organizer: 日本バイオマテリアル学会シンポジウム2012
  • Place of Presentation: 仙台市
• [Presentation] Preparation of YPO4 microspheres for embolic radiotherapy of cancer by spray-drying method (2012)
  • Author(s): K. Nakamura
  • Organizer: 12th Asian BioCeramics (ABC2012) Symposium
  • Place of Presentation: 台南市（台湾）
• [Presentation] YPO4 microcapsules as a beta-emitter for cancer radiotherapy (2012)
  • Author(s): T. Miyazaki
  • Organizer: 12th Asian BioCeramics (ABC2012) Symposium
  • Place of Presentation: 台南市（台湾）
• [Presentation] Preparation of microspheres for embolic radiotherapy of cancer by a spray-drying method (2011)
  • Author(s): K.Nakamura, Z.Li, M.Kawashita, T.Miyazaki, H.Kanetaka
  • Organizer: The 11th Asian BioCeramics Symposium in conjunction with the 22nd Symposium on Apatite
  • Place of Presentation: つくば市(日本)
  • Year and Date: 2011-12-01
• [Presentation] 噴霧乾燥法による深部癌血管内治療用微小球の作製 (2011)
  • Author(s): 中村梢、李志霞、川下将一、宮崎敏樹、金高弘恭
  • Organizer: 第33回日本バイオマテリアル学会大会
  • Place of Presentation: 京都市(日本)
  • Year and Date: 2011-11-22
• [Presentation] Ceramic Microspheres for Arterial Embolization Therapy (2011)
  • Author(s): M.Kawashita
  • Organizer: Composites at Lake Louise 2011
  • Place of Presentation: レイクルイーズ(カナダ)(招待講演)
  • Year and Date: 2011-11-03
• [Presentation] Preparation of microspheres for embolic radiotherapy of cancer by a spray-drying method (2011)
  • Author(s): K. Nakamura, Z. Li, M. Kawashita, T.Miyazaki and H. Kanetaka
  • Organizer: 11th Asian BioCeramics (ABC2011) Symposium
  • Place of Presentation: Tsukuba, Japan
• [Presentation] 噴霧乾燥法による深部癌血管内放射線治療用微小球の作製 (2011)
  • Author(s): 中村梢、李志霞、川下将一、宮崎敏樹、金高弘恭
  • Organizer: 第33回日本バイオマテリアル学会大会
  • Place of Presentation: 京都
• [Presentation] Ceramic microspheres for arterial embolization therapy (2011)
  • Author(s): M. Kawashita
  • Organizer: Composites at Lake Louise2011
  • Place of Presentation: Lake Louise, Canada
• [Presentation] Deign of ceramic beads for intra-arterial therapy (2010)
  • Author(s): M. Kawashita
  • Organizer: The 27th International Korea-Japan Seminar on Ceramics
  • Place of Presentation: Incheon, Korea
  • Year and Date: 2010-11-24
• [Presentation] Deign of Ceramic Beads for Intra-Arterial Therapy (2010)
  • Author(s): M.Kawashita
  • Organizer: The 27th International Korea-Japan Seminar on Ceramics
  • Place of Presentation: 仁川(韓国)
  • Year and Date: 2010-11-24
• [Book] 深部がん血管内治療用セラミック微小球,先端バイオマテリアルハンドブック (2012)
  • Author(s): 川下将一,李志霞
  • Publisher: エヌ・ティー・エス
• [Book] 放射線治療に用いられるセラミック材料,セラミック機能化ハンドブック (2011)
  • Author(s): 川下将一,李志霞
  • Publisher: エヌ・ティー・エス