| Project/Area Number |
22300164
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Hiroshima University (2011-2012)
Kyoto University (2010) |
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Principal Investigator |
KATO Koichi 広島大学, 大学院・医歯薬保健学研究院, 教授 (50283875)
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| Co-Investigator(Kenkyū-buntansha) |
IWATA Hiroo 京都大学, 再生医科学研究所, 教授 (30160120)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
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| Keywords | タンパク質工学 / 中枢神経 / 再生医療 / 神経幹細胞 / 移植補助材料 / 細胞チップ / コラーゲン / 細胞増殖因子 / インテグリン / キメラ蛋白質 / 移植補材料 |
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| Research Abstract |
In an attempt to design biomaterials capable of controlling functions of neural progenitor cells, various protein factors, such as growth factors, neurotrophic factors, integrin ligands, etc., were tested alone or in combination of these factors for their ability to control proliferation and differentiation of neural progenitor cells obtained from the rat fetal brain. These experiments provided systematic information on the effects of various protein factors. Attempts were also made to design modular factors that carried a fused peptide having an affinity for base materials as cell carriers. It was demonstrated that survival and differentiation of neural progenitors could be suitably controlled in cell carries incorporating modular factors.
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