Mitochondria Treatment by Antioxidant with Multi-enzyme Activity
| Project/Area Number |
22300166
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tokyo Metropolitan University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ASAYAMA Shoichiro 首都大学東京, 都市環境科学研究科, 准教授 (90315755)
SHIMIZU Takahiko 千葉大学, 医学研究科, 客員准教授 (40301791)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Keywords | 酵素 / 抗酸化 / キャリア / ミトコンドリア |
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| Research Abstract |
In this research, we have prepared the Mn-porphyrin-dimer-loaded liposomes for the rescue of H2O2-damaged cells. Furthermore, the antioxidative effect of the Mn-porphyrin dimer on the SOD-deficient cells and mice was examined. Moreover, we have synthesized a new Mn-porphyrin dimer to switch the enzyme activity by biological stimuli.
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Report
(4 results)
Research Products
(12 results)
