The microRNAsfor the diagnosis and treatment of uppergastro-intestinal malignancy - application of appatite-nanocarrier -

• Project/Area Number: 22300169
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Keio University
• Principal Investigator: SUZUKI Hidekazu 慶應義塾大学, 医学部, 准教授 (70255454)
• Co-Investigator(Kenkyū-buntansha): SAITO Yoshimasa 慶應義塾大学, 薬学部, 准教授 (90360114) ; AKAIKE Toshihiro 東京工業大学, 生命理工学部, 教授 (30101207) ; KANAI Yae 国立がん研究センター, 研究所, 副所長 (00260315) ; ONISHI Yasuyuki 実験動物中央研究所, 研究員 (70201382)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000); Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
• Keywords: マイクロRNA / アパタイトナノキャリア / がん遺伝子 / 胃がん / 担がん動物 / 細胞内導入 / 胃癌 / シスプラチン / 5-FU / NOGマウス / 癌幹細胞 / 食道腺癌 / 癌遺伝子 / 担癌動物

Research Abstract

The microRNAs (miRNAs) regulate both tumor development and progression by acting on tumor promoter or suppressor genes. Here, a delivery mechanism to introduce miRNA into the cytoplasm by using apatite nanoparticle is applied. 1) An miRNA microarray analy

Research Products

• [Journal Article] Helicobacter pyloriinfection in functional dyspepsia. (2013)
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  • Journal Title: Nat. Rev. Gastroenterol. Hepatol. Volume: 10(3) Issue: 3 Pages: 168-74
  • DOI: 10.1038/nrgastro.2013.9
  • Peer Reviewed
• [Journal Article] The role of microRNAin gastric malignancy. (2013)
  • Author(s): Nishizawa, T., Suzuki, H
  • Journal Title: Int. J. Mol. Sci. Volume: 14(5) Issue: 5 Pages: 9487-9496
  • DOI: 10.3390/ijms14059487
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• [Journal Article] The tumor suppressor microRNA -29c is downregulated and restored by celecoxib in human gastric cancer cells (2013)
  • Author(s): Saito Y, Suzuki H, Imaeda H, Matsuzaki J, et al.
  • Journal Title: International Journal of Cancer Volume: 132 Issue: 8 Pages: 1751-1760
  • DOI: 10.1002/ijc.27862
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• [Journal Article] Attenuation of acetic acid-induced gastric ulcer formation in rats by glucosylceramide synthase inhibitors. (2013)
  • Author(s): Manabu Nakashita
  • Journal Title: Dig. Dis. Sci. Volume: 58 Pages: 354-62
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• [Journal Article] Minimally invasive surgery for esophageal epiphrenic diverticulum – the results of our experience and 133 patients in 25 published series. (2013)
  • Author(s): Yuki Hirano
  • Journal Title: Surgery Today Volume: 43 Issue: 1 Pages: 1-7
  • DOI: 10.1007/s00595-012-0386-3
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• [Journal Article] Effect of ursodeoxycholic acid and endoscopic sphincterotomy in long-term stenting for common bile duct stones. (2013)
  • Author(s): Toshihiro Nishizawa
  • Journal Title: J. Gastroenterol. Hepatol. Volume: 28 Issue: 1 Pages: 63-7
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• [Journal Article] Improvement of reflux symptom related quality of life after <i>Helicobacter pylori</i> eradication therapy (2013)
  • Author(s): Kenro Hirata
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 52 Issue: 2 Pages: 172-178
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  • NAID: 130004466704
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• [Journal Article] Musashi-1 post-transcriptionally enhances phosphotyrosine-binding domain- containing m-Numb protein expression in regenerating gastric mucosa. (2013)
  • Author(s): Tetsufumi Takahashi
  • Journal Title: PLoS One Volume: 8 Issue: 1 Pages: 1-13
  • DOI: 10.1371/journal.pone.0053540
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• [Journal Article] Impaired heme oxygenase-1 induction in the gastric antrum induces disruption of the interstitial cells of Cajal network in a rat model of streptozotocin-induced diabetes. (2013)
  • Author(s): Sachiko Mogami
  • Journal Title: Neurogastroenterol. Motil. Volume: in press Issue: 7 Pages: 609-609
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• [Journal Article] Validation of the GerdQ questionnaire for the management of gastro-oesophageal reflux disease in Japan (2013)
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  • Journal Title: United European Gastroenterology Journal Volume: (印刷中) Issue: 3 Pages: 175-183
  • DOI: 10.1177/2050640613485238
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• [Journal Article] FecA1, a bacterial iron transporter, determines the survival of Helicobacter pylori in the stomach (2012)
  • Author(s): Tsugawa H, Suzuki H, Matsuzaki J, et al
  • Journal Title: Free Radic Biol Med Volume: 52 Issue: 6 Pages: 1003-1010
  • DOI: 10.1016/j.freeradbiomed.2011.12.011
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• [Journal Article] Low-density lipoprotein receptorrelated protein-1 (LRP-1) mediates autophagy and apoptosis caused by Helicobacter pyloriVacA (2012)
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  • Journal Title: J. Biol. Chem Volume: 287(37) Issue: 37 Pages: 31104-15
  • DOI: 10.1074/jbc.m112.387498
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• [Journal Article] Development of a novel microRNA promoter microarray for ChIP-on chip assay to identify epigenetically regulated microRNAs (2012)
  • Author(s): Saito Y, Suzuki H, Taya T, Nishizawa M, Tsugawa H, Matsuzaki J, et al.
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 426 Issue: 1 Pages: 33-37
  • DOI: 10.1016/j.bbrc.2012.08.012
  • Peer Reviewed
• [Journal Article] Overexpression of miR-142-5p and miR-155 in Gastric Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma Resistant to Helicobacter pylori Eradication (2012)
  • Author(s): Saito y, Suzuki H, Tsugawa H, Imaeda H, Matsuzaki J, et al.
  • Journal Title: PLoS One Volume: 7 Issue: 11 Pages: e47396-e47396
  • DOI: 10.1371/journal.pone.0047396
  • Peer Reviewed
• [Journal Article] Reactive Oxygen Species-Induced Autophagic Degradation of Helicobacter pylori CagA Is Specifically Suppressed in Cancer Stem-like Cells (2012)
  • Author(s): Tsugawa H, Suzuki H, Saya H, Hatakeyama M, Hirayama T, Hirata K, Nagano 0, Matsuzaki J, et al.
  • Journal Title: Cell Host & Microbe Volume: 12 Issue: 6 Pages: 764-777
  • DOI: 10.1016/j.chom.2012.10.014
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• [Journal Article] CDX1 directs gastric intestinal metaplasia via induction of stemness-associated reprogramming factors SALL4 and KLF5 (2012)
  • Author(s): Fujii, Y.
  • Journal Title: Proc. Natl. Acad. Sci.USA Volume: 109 Issue: 50 Pages: 20584-20589
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• [Journal Article] Enhanced gastric ghrelin production and secretion in rats with gastric outlet obstruction. (2012)
  • Author(s): Iwasaki E
  • Journal Title: Dig Dis Sci Volume: 57 Issue: 4 Pages: 858-864
  • DOI: 10.1007/s10620-011-1953-y
  • Peer Reviewed
• [Journal Article] Reduced ghrelin production induced anorexia after rat gastric ischemia and reperfusion (2012)
  • Author(s): Mogami S, Suzuki H, Fukuhara S, Matsuzaki J, et al
  • Journal Title: Am J Physiol Gastrointest Liver Physiol Volume: 302 Issue: 3 Pages: G359-G364
  • DOI: 10.1152/ajpgi.00297.2011
  • Peer Reviewed
• [Journal Article] Proton pump inhibitor-amoxicillin-clarithromycin versus proton pump inhibitor-amoxicillin-metronidazole as first-line <i>Helicobacter pylori</i> eradication therapy (2012)
  • Author(s): Toshihiro Nishizawa
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 51 Issue: 2 Pages: 114-116
  • DOI: 10.3164/jcbn.D-11-00029R1
  • NAID: 130004879303
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed
• [Journal Article] Efficacy of sitafloxacin-based rescue therapy for Helicobacter pylori after failures of first- and second-line therapies. (2012)
  • Author(s): Juntaro Matsuzaki
  • Journal Title: Antimicrob. Agent Chemother. Volume: 56 Issue: 3 Pages: 1643-45
  • DOI: 10.1128/aac.05941-11
  • Peer Reviewed
• [Journal Article] Capsule endoscopy assists in the complete deworming of parasites. (2012)
  • Author(s): Shinsuke Kobayashi
  • Journal Title: J. Gastroenterol. Hepatol. Volume: 27 Issue: 7 Pages: 1253-1253
  • DOI: 10.1111/j.1440-1746.2012.07154.x
  • Peer Reviewed
• [Journal Article] Classification of functional dyspepsia based on concomitant bowel symptoms (2012)
  • Author(s): Matsuzaki J, Suzuki H, Asakura K, et al
  • Journal Title: Neurogastroenterol Motil Volume: 24 Issue: 4 Pages: 1643-1645
  • DOI: 10.1111/j.1365-2982.2011.01859.x
  • Peer Reviewed
• [Journal Article] Effects of β-(1,3-1,6)-D-glucan on irritable bowel syndrome-related colonic hypersensitivity (2012)
  • Author(s): Asano, T., Suzuki, H., et al
  • Journal Title: Biochem.Biophys.Res.Com. Volume: 420(2) Issue: 2 Pages: 444-449
  • DOI: 10.1016/j.bbrc.2012.03.015
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• [Journal Article] Dual therapy for third-line H. pylori eradication and urea breath test prediction. (2012)
  • Author(s): Toshihiro Nishizawa
  • Journal Title: World J. Gastroenterol. Volume: 18 Issue: 21 Pages: 2735-2738
  • DOI: 10.3748/wjg.v18.i21.2735
  • Peer Reviewed
• [Journal Article] Efficacy of Solifenacin on Irritable Bowel Syndrome With Diarrhea : Open-label Prospective Pilot Trial. (2012)
  • Author(s): Fukushima Y, Suzuki H, Matsuzaki J, et al.
  • Journal Title: Journal of Neurogastroenterology and Motility Volume: 18 Issue: 3 Pages: 317-323
  • DOI: 10.5056/jnm.2012.18.3.317
  • Peer Reviewed
• [Journal Article] High frequency of overlap between functional dyspepsia and overactive bladder (2012)
  • Author(s): Matsuzaki J, Suzuki H, Fukushima Y, et al.
  • Journal Title: Neurogastroenterology and Motility Volume: 24 Issue: 9 Pages: 821-827
  • DOI: 10.1111/j.1365-2982.2012.01939.x
  • Peer Reviewed
• [Journal Article] Transmural pressure loading enhances gastric mucosal proliferation. (2012)
  • Author(s): Hiromasa Nakamizo
  • Journal Title: Dig. Dis. Sci. Volume: 57 Pages: 2545-2554
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• [Journal Article] A Questionnaire-Based Survey on Screening for gastric and colorectal cancer by physicians in East Asian countries in 2010. (2012)
  • Author(s): Yuji Naito
  • Journal Title: Digestion Volume: 86 Issue: 2 Pages: 94-106
  • DOI: 10.1159/000339342
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• [Journal Article] Questionnaire-based survey conducted in 2011 concerning endoscopic management of Barrett’s esophagus in East Asian countries. (2012)
  • Author(s): Norihisa Ishimura
  • Journal Title: Digestion Volume: 86 Issue: 2 Pages: 136-146
  • DOI: 10.1159/000339778
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• [Journal Article] Are solifenacin and ramosetron really ideal to treat irritable bowel syndrome?: Author’s Reply. (2012)
  • Author(s): Hidekazu Suzuki
  • Journal Title: J. Neurogastroenterol. Motil. Volume: 18 Issue: 4 Pages: 459-459
  • DOI: 10.5056/jnm.2012.18.4.459
  • Peer Reviewed
• [Journal Article] Identification of a unique nsaid, fluoro-loxoprofen with gastroprotective activity. (2012)
  • Author(s): Suemasu S., et al.
  • Journal Title: Biochem Pharmacol. Volume: 84 Issue: 11 Pages: 1470-1481
  • DOI: 10.1016/j.bcp.2012.09.016
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• [Journal Article] Molecular approaches and modern clinical strategies for the management of Helicobacter pylori infection in Japan. (2012)
  • Author(s): Hidekazu Suzuki
  • Journal Title: Keio J. Med. Volume: 61 Pages: 109-119
  • NAID: 10031140763
  • Peer Reviewed
• [Journal Article] Enhanced gastric ghrelin induced c-kit protein expression in rats with gastric outlet obstruction. (2012)
  • Author(s): Eisuke Iwasaki
  • Journal Title: Dig. Dis. Sci. Volume: 57 Issue: 12 Pages: 3308-3309
  • DOI: 10.1007/s10620-012-2451-6
  • Peer Reviewed
• [Journal Article] Biliary Findings Assist in Predicting Enlargement of Intraductal Papillary Mucinous Neoplasms of the Pancreas (2012)
  • Author(s): Matsuzaki J, Suzuki H, Okuda S, et al.
  • Journal Title: Clininal Gastroenterology and Hepatology Volume: (印刷中) Issue: 5 Pages: 548-554
  • DOI: 10.1016/j.cgh.2012.11.027
  • Peer Reviewed
• [Journal Article] Capsule endoscopy assists in the complete deworming of parasites (2012)
  • Author(s): Kobayashi, S., Suzuki, H., et al
  • Journal Title: J.Gastroenterol.Hepatol. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Minimally invasive surgery for esophageal epiphrenic diverticulum-the results of our experience and 133 patients in 25 published series (2012)
  • Author(s): Hirano, Y., Suzuki, H., et al
  • Journal Title: Surgery Today Volume: (in press)
  • Peer Reviewed
• [Journal Article] Molecular approaches and modem clinical strategies for the management of Helicobacter pylori infection in Japan (2012)
  • Author(s): Suzuki, H., et al
  • Journal Title: Keio J.Med. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Roles of oxidative stress in stomach disorders (2011)
  • Author(s): Suzuki, H., et al.
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 50 Issue: 1 Pages: 35-39
  • DOI: 10.3164/jcbn.11-115SR
  • NAID: 130004466668
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed
• [Journal Article] Two amino acids mutation of Ferric uptake regulator (Fur) determines Helicobacter pylori resistance to metronidazole. (2011)
  • Author(s): Tsugawa, H., Suzuki, H., Saito, Y., et al.
  • Journal Title: Antioxid. Redox Signal Volume: 14(1) Issue: 1 Pages: 15-23
  • DOI: 10.1089/ars.2010.3146
  • Peer Reviewed
• [Journal Article] Dysfunctional gastric emptying with downregulation of muscle-specific microRNAs in Helicobacter pylori -infected mice. (2011)
  • Author(s): Saito, Y., Suzuki, H., et al.
  • Journal Title: Gastroenterology Volume: 140(1) Issue: 1 Pages: 189-198
  • DOI: 10.1053/j.gastro.2010.08.044
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• [Journal Article] Etiological difference between ultrashort-segment Barrett's esophagus and short-segment Barrett's esophagus in Japan (2011)
  • Author(s): Matsuzaki, J., Suzuki, H., Saito, Y., et al.
  • Journal Title: J. Gastroenterol. Volume: 46(3) Issue: 3 Pages: 332-8
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• [Journal Article] Extragastric manifestations of Helicobacter pylori infection. (2011)
  • Author(s): Suzuki, H., et al.
  • Journal Title: Helicobacter Volume: 16(Suppl.1) Issue: s1 Pages: 65-69
  • DOI: 10.1111/j.1523-5378.2011.00883.x
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• [Journal Article] Effect of lansoprazole versus roxatidine on prevention of bleeding and ulcer healing after endoscopic submucosal dissection for superficial gastric neoplasia (2011)
  • Author(s): Imaeda, H., Suzuki, H., Saito, Y., et al.
  • Journal Title: J. Gastroenterol. Volume: 46(11) Issue: 11 Pages: 1267-72
  • DOI: 10.1007/s00535-011-0447-1
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• [Journal Article] MicroRNAs in hepatobiliary and pancreatic cancers. (2011)
  • Author(s): Saito, Y., Suzuki, H., et al.
  • Journal Title: Front. Gene. Volume: 2 Pages: 66-66
  • DOI: 10.3389/fgene.2011.00066
  • Peer Reviewed
• [Journal Article] Can Helicobacter pylori-associated dyspepsia be categorized as functional dyspepsia? (2011)
  • Author(s): Suzuki, H., et al
  • Journal Title: J.Gastroenterol.Hepatol. Volume: 26(s3) Issue: s3 Pages: 42-45
  • DOI: 10.1111/j.1440-1746.2011.06629.x
  • Peer Reviewed
• [Journal Article] What is the difference between Helicobacter pylori-associated dyspepsia and functional dyspepsia? (2011)
  • Author(s): Suzuki H, Matsuzaki J, Hibi T
  • Journal Title: J Neurogastroentewl Motil Volume: 17 Issue: 2 Pages: 124-130
  • DOI: 10.5056/jnm.2011.17.2.124
  • Peer Reviewed
• [Journal Article] Enhancement of annoxicillin resistance after unsuccessful Helicobacter pylorieradication (2011)
  • Author(s): Nishizawa T, Suzuki H, Tsugawa H, Muraoka H, Matsuzaki J, et al
  • Journal Title: Antimicrob Agents Chemother Volume: 52 Issue: 6 Pages: 3012-3014
  • DOI: 10.1128/aac.00188-11
  • Peer Reviewed
• [Journal Article] Proton pump inhibitors for the treatment of functional dyspepsia (2011)
  • Author(s): Suzuki, H., et al
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  • DOI: 10.1177/1756283x11398735
  • Peer Reviewed
• [Journal Article] Trainee participation during colonoscopy adversely affects the rates of polyp and adenoma detection (2011)
  • Author(s): Nishizawa, T., Suzuki, H., et al
  • Journal Title: Digestion Volume: 84(3) Issue: 3 Pages: 245-246
  • DOI: 10.1159/000330736
  • Peer Reviewed
• [Journal Article] Bovine antibody-based oral immunotherapy for reduction of intragastric Helicobacter pylori colonization : a randomized clinical trial (2011)
  • Author(s): den Hoed, C.M., Suzuki, H., et al
  • Journal Title: Can.J.Gastroenterol. Volume: 25(4) Pages: 207-213
  • Peer Reviewed
• [Journal Article] Helicobacter pylori resistance to rifabutin in the last 7 years (2011)
  • Author(s): Nishizawa T, Suzuki H, Matsuzaki J, et al
  • Journal Title: Antimicrob Agents Chemother Volume: 55 Issue: 11 Pages: 5374-5375
  • DOI: 10.1128/aac.05437-11
  • Peer Reviewed
• [Journal Article] Metronidazole-based quadruple versus standard triple therapy : which is better as first-line therapy for Helicobacter pylori eradication? (2011)
  • Author(s): Suzuki H, Matsuzaki, Hibi T
  • Journal Title: Expert Rev Clin Pharmacol Volume: 4 Issue: 5 Pages: 579-582
  • DOI: 10.1586/ecp.11.34
  • Peer Reviewed
• [Journal Article] Overlap syndrome of functional dyspepsia and irritable bowel syndrome-are both diseases mutually exclusive?- (2011)
  • Author(s): Suzuki, H., Hibi, T.
  • Journal Title: J.Neurogastroenterol.Motil. Volume: 17(4) Issue: 4 Pages: 360-365
  • DOI: 10.5056/jnm.2011.17.4.360
  • Peer Reviewed
• [Journal Article] Dysfunctional gastric emptying with down-regulation of muscle-specific MicroRNAs in Helicobacter pylori-infected mice (2011)
  • Author(s): Saito, Y., Suzuki, H, et al.
  • Journal Title: Gastroenterology Volume: 140(1) Pages: 189-198
  • Peer Reviewed
• [Journal Article] Two amino acids mutation of ferric uptake regulator determines Helicobacter pylori Resistance to Metronidazole. (2011)
  • Author(s): Tsugawa, H., Suzuki, H., et al.
  • Journal Title: Antioxidants and Redox signaling Volume: 14(1) Pages: 15-23
  • Peer Reviewed
• [Journal Article] Enhanced bacterial efflux system is the first step to the development of metronidazole resistance in Helicobacter pylori. (2011)
  • Author(s): Tsugawa, H., Suzuki, H., et al.
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 404(2) Pages: 656-660
  • Peer Reviewed
• [Journal Article] Etiological difference between ultrashort- and short-segment Barrett's esophagus (2011)
  • Author(s): Matsuzaki, J., Suzuki, H., et al.
  • Journal Title: Journal of Gastroenterology Volume: 46(3) Pages: 332-338
  • NAID: 10029027814
  • Peer Reviewed
• [Journal Article] Enhancement of amoxicillin resistance after unsuccessful Helicobacter pylori eradication (2011)
  • Author(s): Nishizawa, T., Suzuki, H., et al.
  • Journal Title: Antimicrobial Agents and Chemotherapy Volume: (In press)
  • Peer Reviewed
• [Journal Article] Gallstones increase the prevalence of Barrett's esophagus. (2010)
  • Author(s): Matsuzaki, J., Suzuki, H., Saito, Y., et al.
  • Journal Title: J. Gastroenterol. Volume: 45(2) Issue: 2 Pages: 171-8
  • DOI: 10.1007/s00535-009-0153-4
  • NAID: 10027214436
  • Peer Reviewed
• [Journal Article] Contribution of efflux pumps to clarithromycin resistance in Helicobacter pylori (2010)
  • Author(s): Hirata, K., Suzuki, H., Saito, Y., et al.
  • Journal Title: J. Gastroenterol. Hepatol. Volume: 25(s1) Issue: s1
  • DOI: 10.1111/j.1440-1746.2009.06220.x
  • Peer Reviewed
• [Journal Article] Ghrelin and oxidative stress in gastrointestinal tract (2010)
  • Author(s): Suzuki, H., et al
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 48 Issue: 2 Pages: 122-125
  • DOI: 10.3164/jcbn.10-16GFR
  • NAID: 130004466636
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed
• [Journal Article] Serum lipid levels are positively associated with non-erosive reflux disease, but not with functional heartburn. (2010)
  • Author(s): Matsuzaki, J., Suzuki, H., et al.
  • Journal Title: Neurogastroenterology and Motility Volume: 22(9) Pages: 965-970
  • Peer Reviewed
• [Journal Article] Acid suppression by proton pump inhibitors enhances aquaporin-4 and kcnq1 expression in gastric fundic parietal cells in mouse. (2010)
  • Author(s): Matsuzaki, J., Suzuki, H., et al.
  • Journal Title: Digestive Diseases and Sciences Volume: 55(12) Pages: 3339-3348
  • Peer Reviewed
• [Presentation] Resistance to oxidative stress is a principal pathway for the survival and disease development of Helicobacter pylori. "Helicobacter pylori and Tissue Injury" (2012)
  • Author(s): Suzuki, H., et al.
  • Organizer: 7th International Symposium on Cell/Tissue Injury and Cytoprotection/Organoprotection
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2012-09-11
• [Presentation] Helicobacter pyloriand gastric cancer. Symposium 7 "Helicobacter pylori-Pathogenesis & Clinical Manifestation-" (2012)
  • Author(s): Suzuki, H.
  • Organizer: The 14th Meeting of International Conference on Ulcer Research (ICUR)
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2012-07-13
• [Presentation] Specific amino acid mutation of p53 enhanced the stability of intracellular cagAby inhibiting autophagy induction. (2012)
  • Author(s): Tsugawa, H., Suzuki, H., et al.
  • Organizer: AGA Research Forum, DDW2012
  • Place of Presentation: San Diego, USA
  • Year and Date: 2012-05-12
• [Presentation] Dysfunctional gastric emptying with downregulation of muscle-specific microRNAs in Helicobacter pylori -infected mice. (2012)
  • Author(s): Saito, Y., Suzuki, H., et al.
  • Organizer: The 2nd Asian Pacific Topic Conference, Asian Pacific Helicobacter pylori Meeting 2012
  • Place of Presentation: Kuala Lumpur, Malaysia
• [Presentation] GERDQ is superior tool for the evaluation of GERD symptoms and unmet medical needs to the Carlsson-Dent questionnaire – a large scale survey – (2012)
  • Author(s): Hidekazu Suzuki
  • Organizer: Digestive Disease Week 2012
  • Place of Presentation: San Diego, USA
• [Presentation] GERDQ is an easy and useful tool for assessing the severity of gastroesophageal reflux disease and identifying patients with “unmet medical needs”. (2012)
  • Author(s): Sawako Okada
  • Organizer: Digestive Disease Week 2012
  • Place of Presentation: San Diego, USA
• [Presentation] Dynamics of aquaporin-4 in gastric parietal cells in the hyperplastic gastric fundic mucosa of histamine type 2 receptor knockout mice. (2012)
  • Author(s): Seiichiro Fukuhara
  • Organizer: Digestive Disease Week 2012
  • Place of Presentation: San Diego, USA
• [Presentation] Specific amino acid mutation of p53 enhanced the stability of intracellular cagA by inhibiting autophagy induction. (2012)
  • Author(s): Hitoshi Tsugawa
  • Organizer: Digestive Disease Week 2012
  • Place of Presentation: San Diego, USA
• [Presentation] MicroRNA-21 expression causes nuclear loss of the tumor suppressor PDCD4 in precancerous gastric adenomas. (2012)
  • Author(s): Kenro Hirata
  • Organizer: Digestive Disease Week 2012
  • Place of Presentation: San Diego, USA
• [Presentation] The extension of mucosal lesions, Helicobacter pylori infection status and API2-MALT1 positivity are associated with the therapeutic response for gastric MALT lymphoma. (2012)
  • Author(s): Sawako Okada
  • Organizer: Digestive Disease Week 2012
  • Place of Presentation: San Diego, USA
• [Presentation] Evaluation of CD44 variant expression as a recurrence marker of gastric cancer after endoscopic submucosal dissection. (2012)
  • Author(s): Kenro Hirata
  • Organizer: The 10th annual meeting of the International Society for Stem Cell Research (ISSCR)
  • Place of Presentation: Tokyo, Japan
• [Presentation] Helicobacter pylori and gastric cancer. Symposium 7 “Helicobacter pylori -Pathogenesis & Clinical Manifestation-“ (2012)
  • Author(s): Hidekazu Suzuki
  • Organizer: The 14th Meeting of International Conference on Ulcer Research (ICUR)
  • Place of Presentation: Tokyo, Japan
• [Presentation] Dynamics of aquaporin-4 in gastric parietal cells in the gastric fundic mucosa of histamine type 2 receptor knockout mice with Helicobacter pylori infection. (2012)
  • Author(s): Seiichiro Fukuhara
  • Organizer: The 14th Meeting of International Conference on Ulcer Research (ICUR)
  • Place of Presentation: Tokyo, Japan
• [Presentation] Impaired heme oxygenase-1 upregulation induced decreased interstitial cells of Cajal in streptozotocin-induced diabetes model. (2012)
  • Author(s): Sachiko Mogami
  • Organizer: The 14th Meeting of International Conference on Ulcer Research (ICUR)
  • Place of Presentation: Tokyo, Japan
• [Presentation] A comprehensive and active educational program for medical students to attract their interests toward research scientists at Keio University School of Medicine in Japan. (2012)
  • Author(s): Michito Hirakata
  • Organizer: AMEE (Association for Medical Education in Europe) 2012
  • Place of Presentation: Lyon, France
• [Presentation] High frequency of overlap between functional dyspepsia, irritable bowel syndrome and overactive bladder. (2012)
  • Author(s): Hidekazu Suzuki
  • Organizer: 2012 Joint International Neurogastroenterology and Motility Meeting (NGM2012)
  • Place of Presentation: Bologna, Italy
• [Presentation] The GerdQ is a useful tool for evaluating the patients’ satisfaction and identifying the patients with “unmet medical needs”. (2012)
  • Author(s): Sawako Okada
  • Organizer: 2012 Joint International Neurogastroenterology and Motility Meeting (NGM2012)
  • Place of Presentation: Bologna, Italy
• [Presentation] Improvement in the quality of life related to reflux symptoms after Helicobacter pylori eradication therapy. (2012)
  • Author(s): Kenro Hirata
  • Organizer: 2012 Joint International Neurogastroenterology and Motility Meeting (NGM2012)
  • Place of Presentation: Bologna, Italy
• [Presentation] Resistance to oxidative stress is a principal pathway for the survival and disease development of Helicobacter pylori. “Helicobacter pylori and Tissue Injury” (2012)
  • Author(s): Hidekazu Suzuki
  • Organizer: 7th International Symposium on Cell/Tissue Injury and Cytoprotection/Organoprotection
  • Place of Presentation: Honolulu, USA
• [Presentation] Predictive Factors for the Increase in Size of Branch Duct-type Intraductal Papillary Mucinous Neoplasms of the Pancreas: A Retrospective Cohort Study with a 6-year Follow-up. (2012)
  • Author(s): Hidekazu Suzuki
  • Organizer: The American College of Gastroenterology Annual Scientific Meeting (ACG2012)
  • Place of Presentation: Las Vegas, USA
• [Presentation] Eradication of Helicobacter pylori with 10-day sitafloxacin-based triple therapy as a third- or fourth-line rescue therapy: preliminary results of open-label randomized trial. (2012)
  • Author(s): Hideki Mori
  • Organizer: The American College of Gastroenterology Annual Scientific Meeting (ACG2012)
  • Place of Presentation: Las Vegas, USA
• [Presentation] Things to consider before submitting papers from Eastern authors to Western Journals – viewpoint of the Associate Editor of the “American Journal of Gastroenterology”. (2012)
  • Author(s): Hidekazu Suzuki
  • Organizer: Seoul International Digestive Disease Symposium 2012 (SIDDS2012)
  • Place of Presentation: Seoul, Korea
• [Presentation] High eradication rates of Helicobacter pylori with sitafloxacin-based 10 days-triple therapy as a third-line treatment. (2012)
  • Author(s): Hideki Mori
  • Organizer: Seoul International Digestive Disease Symposium 2012 (SIDDS2012)
  • Place of Presentation: Seoul, Korea
• [Presentation] The Role of Helicobacter pylori infection in the disease entity of functional dyspepsia. (2012)
  • Author(s): Hidekazu Suzuki
  • Organizer: Seoul International Digestive Disease Symposium 2012 (SIDDS2012)
  • Place of Presentation: Seoul, Korea
• [Presentation] Frequent overlap of overactive bladder with functional dyspepsia and/or irritable bowel syndrome (2011)
  • Author(s): Suzuki, H., et al
  • Organizer: The American College of Gastroenterology Annual Scientific Meeting (ACG2011)
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-10-30
• [Presentation] Proliferation of cdx2-expressing human esophageal cells is enhanced by bile acid with upregulation. (2011)
  • Author(s): Matsuzaki, J., Suzuki, H., Saito, Y., and Akaike, T., et al.
  • Organizer: UEGW2011
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2011-10-25
• [Presentation] GerdQ is superior for the evaluation of age-dependent symptom aggravation and for the reflection of patients' satisfaction with prescribed medications to the carlsson-dent questionnaire (2011)
  • Author(s): Suzuki, H., et al
  • Organizer: 19th United European Gastroenterology Week 2011
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2011-10-24
• [Presentation] Are functional dyspepsia and irritable bowel syndrome mutually exclusive? (2011)
  • Author(s): Suzuki, H.
  • Organizer: The 12th Recent update of Neurogastroenterology & Motility Symposium
  • Place of Presentation: Busan, Korea
  • Year and Date: 2011-06-11
• [Presentation] H.pyloriの病原・薬剤耐性獲得機序-慢性持続性感染による宿主応答から- (2011)
  • Author(s): 鈴木秀和, 津川仁, 日比紀文
  • Organizer: 第97回日本消化器病学会総会
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2011-05-14
• [Presentation] Activation of the tumor suppressor microRNA-29cby the selective cyclooxygenase-2 inhibitor, celecoxib in human gastric cancer. (2011)
  • Author(s): Suzuki, H., Saito, Y., Kanai, Y., et al
  • Organizer: AGA Research Forum DDW2011
  • Place of Presentation: Chicago, USA
  • Year and Date: 2011-05-09
• [Presentation] Activation of the tumor suppressor microRNA-29c by the selective cyclooxygenase-2 inhibitor, celecoxib in human gastric cancer (2011)
  • Author(s): Suzuki, H., et al
  • Organizer: AGA Research Forum "Targeted therapy and GI cancers" Digestive Disease Week 2011
  • Place of Presentation: Chicago, USA
  • Year and Date: 2011-05-09
• [Presentation] H. pylori-Derived Oncoprotein, CagA, is Degraded by Autophagy in Human Gastric Epithelial Cells. (2011)
  • Author(s): Tsugawa, H., Suzuki, H., et al
  • Organizer: AGA Research Forum DDW2011
  • Place of Presentation: Chicago, USA
  • Year and Date: 2011-05-07
• [Presentation] Enhanced Expression of MicroRNA-142-5p and MicroRNA-155 and Suppressed Expression of Tp53inp1 Would Be Novel Molecular Biomarkers for Gastric Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma, Resistant to H. pylori Eradication. (2011)
  • Author(s): Suzuki, H., Saito, Y., et al.
  • Organizer: AGA Research Forum DDW2011
  • Place of Presentation: Chicago, USA
  • Year and Date: 2011-05-07
• [Presentation] Enhanced expression of microRNA-142-5p and microRNA-155 and suppressed expression of TP53INP1 would be novel molecular biomarkers for gastric mucosa-associated lymphoid tissue (MALT) lymphoma, resistant to H.pylori eradication (2011)
  • Author(s): Suzuki, H., et al
  • Organizer: AGA Topic Forum "Biomarkers in GI cancers" Digestive Disease Week 2011
  • Place of Presentation: Chicago, USA
  • Year and Date: 2011-05-07
• [Presentation] The selective cyclooxygenase-2 inhibitor celecoxib activates the tumor suppressor microRNA-29c in human gastric cancer. (2011)
  • Author(s): Saito, Y., Suzuki, H, et al.
  • Organizer: 第7回日本消化管学会, 4^<th> IGICS
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2011-02-19
• [Presentation] Upregulation of oncogenic microRNA-21followed by the downregulation of the tumor suppressor microRNA-29cin the progression of human gastric cancer. (2010)
  • Author(s): Suzuki, H., Saito, Y., Kanai, Y., et al
  • Organizer: UEGW2010
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-10-25
• [Presentation] Upregulation of oncogenic microRNA-21 followed by the downregulation of the tumor suppressor microRNA-29c in the progression of human gastric cancer. (2010)
  • Author(s): Suzuki, H.
  • Organizer: 18th United European Gastroenterology Week (UEGW2010)
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-10-25
• [Presentation] Gastric cancer development - from the aspects of sonic hedgehog and microRNAs-. (2010)
  • Author(s): Suzuki, H.
  • Organizer: Gachon International Gastric Cancer Symposium 2010
  • Place of Presentation: Incheon, Korea
  • Year and Date: 2010-10-09
• [Presentation] Gastric cancer development-from the aspects of sonic hedgehog and microRNAs-. (2010)
  • Author(s): Suzuki, H.
  • Organizer: Gachon International Gastric Cancer Symposium 2010
  • Place of Presentation: Incheon, Korea
  • Year and Date: 2010-10-09
• [Presentation] Nitric oxide involvement in gastric disorders. (2010)
  • Author(s): Suzuki, H. (invited), Saito, Y., et al
  • Organizer: Symposium SP-04 "Nitrosative stress in the gastrointestinal tract", The 6thInternational Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-06-15
• [Presentation] Nitric oxide involvement in gastric disorders. (2010)
  • Author(s): Suzuki, H
  • Organizer: The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2010-06-15
• [Presentation] Downregulation of the tumor suppressor microRNA-29c plays a critical role in the progression of human gastric cancer. (2010)
  • Author(s): Saito, Y., Suzuki, H, et al.
  • Organizer: Digestive Disease Week 2010
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2010-05-05
• [Presentation] microRNA-21 plays a critical role in Helicobacter pylori-associated gastric cancer by suppressing BTG2. (2010)
  • Author(s): Ikura, A., Suzuki, H, et al.
  • Organizer: Digestive Disease Week 2010
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2010-05-05
• [Presentation] Gastric Cancer Screening in Japanese. (2010)
  • Author(s): Suzuki, H.
  • Organizer: Digestive Disease Week 2010
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2010-05-03
• [Presentation] High prevalence of lower gastrointestinal (GI) symptoms in functionaldyspepsia : a factor and cluster analysis in the general population (2010)
  • Author(s): Suzuki, H., et al.
  • Organizer: Digestive Disease Week 2010
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2010-05-03
• [Presentation] Sitafloxacin-based third-line eradication of H.pylori. (2010)
  • Author(s): Suzuki.H., et al.
  • Organizer: Digestive Disease Week 2010
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2010-05-03
• [Presentation] Increased Expression of microRNA-21 is an early event in human gastric carcinogenesis. (2010)
  • Author(s): Hirata, K., Suzuki, H, et al.
  • Organizer: Digestive Disease Week 2010
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2010-05-03
• [Presentation] Overexpression of miR-142-5p and miR-155 and suppression of tumor protein 53-induced nuclear protein 1 in gastric mucosa-associated lymphoid tissue lymphoma. (2010)
  • Author(s): Saito, Y., Suzuki, H., et al.
  • Organizer: Digestive Disease Week 2010
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2010-05-02
• [Presentation] Chronic infection with Helicobacter pylori induces downregulation of muscle-specific microRNAs and smooth muscle hypertrophy of the mouse stomach. (2010)
  • Author(s): Saito, Y., Suzuki, H., et al.
  • Organizer: Digestive Disease Week 2010
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2010-05-02
• [Presentation] Caudal-related homeobox 2 (Cdx2) suppresses stratification of esophageal squamous epithelial cells by down-regulating microRNA-221/222 (2010)
  • Author(s): Matsuzaki, J., Suzuki, H, et al.
  • Organizer: Digestive Disease Week 2010
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2010-05-02
• [Presentation] マイクロRNAを介した胃癌に対するエピジェネティック治療 (2010)
  • Author(s): 斎藤義正, 鈴木秀和, ら
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟市
  • Year and Date: 2010-04-23
• [Presentation] Gastric Cancer Screening in Japanese (2010)
  • Author(s): Suzuki, H.
  • Organizer: ASGE Clinical Symposium DDW2010
  • Place of Presentation: New Orleans, USA
• [Presentation] Overexpression of miR-142-5pand miR-155and suppression of tumor protein 53-induced nuclear protein 1 in gastric mucosa-associated lymphoid tissue lymphoma. (2010)
  • Author(s): Saito, Y., Suzuki, H., et al.
  • Organizer: AGA Research Forum DDW2010
  • Place of Presentation: New Orleans, USA
• [Presentation] Chronic infection with Helicobacter pylori induces downregulation of muscle-specific microRNAs and smooth muscle hypertrophy of the mouse stomach. (2010)
  • Author(s): Saito, Y., Suzuki, H., et al
  • Organizer: AGA Research Forum DDW2010
  • Place of Presentation: New Orleans, USA
• [Presentation] Induction of H. pylori resistance to metronidazole through enhanced expression of a bacterial efflux pump (2010)
  • Author(s): Tsugawa, H., Suzuki, H.Saito, Y., et al
  • Organizer: AGA Research Forum DDW2010
  • Place of Presentation: New Orleans, USA
• [Presentation] The role of the Ferric uptake regulator (Fur) in Helicobacter pylori resistance to metronidazole. (2010)
  • Author(s): Tsugawa, H., Suzuki, H., Saito, Y., et al.
  • Organizer: AGA Research Forum DDW2010
  • Place of Presentation: New Orleans, USA
• [Presentation] Caudal-related homeobox 2 (Cdx2) suppresses stratification of esophageal squamous epithelial cells by down-regulating microRNA-221/222 (2010)
  • Author(s): Matsuzaki, J., Suzuki, H., Saito, Y., et al.
  • Organizer: DDW2010
  • Place of Presentation: New Orleans, USA
• [Presentation] Downregulation of the tumor suppressor microRNA-29cplays a critical role in the progression of human gastric cancer. (2010)
  • Author(s): Saito, Y., Suzuki, H., et al.
  • Organizer: DDW2010
  • Place of Presentation: New Orleans, USA
• [Book] eBook: Helicobacter pylori : a worldwide perspective 2012 (2013)
  • Author(s): Hidekazu Suzuki
  • Publisher: Bentham Science Publishers
• [Book] eBook: OXIDATIVE STRESS AND DIETARY ANTIOXIDANTS (2013)
  • Author(s): Hidekazu Suzuki
  • Publisher: Academic Press
• [Book] ヘリコバクターピロリ感染症の徹底検証 (2012)
  • Author(s): 鈴木秀和編集
  • Total Pages: 93
  • Publisher: ライフ・サイエンス社
• [Book] Free Radical Biology in Digestive Diseases (2011)
  • Author(s): Suzuki, H., Nishizawa, T., Tsugawa, H., Hibi, T.(eds.) Naito, Y., Suematsu, M., Yoshikawa, T., Karger, Basel
  • Publisher: Front. Gastrointest. Res.
• [Book] Chapter 5: MicroRNAs in Gastric Cancer. MicroRNAs in Cancer Translational Research (2011)
  • Author(s): Suzuki, H., Saito, Y., Hibi, T.(eds.) William C.S. Cho
  • Publisher: Springer
• [Remarks] http://www.keio-med.jp/gastro/ugt/index.html
• [Remarks]
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