Inhalation of antitubercular agents for efficient treatment of tuberculosis

• Project/Area Number: 22300171
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Tokyo University of Science
• Principal Investigator: TERADA Hiroshi 東京理科大学, 総合研究機構, 教授 (00035544)
• Co-Investigator(Kenkyū-buntansha): HIROTA Keiji 東京理科大学, 薬学部, 助教 (50516359) ; TOMODA Keishiro 東京理科大学, 薬学部, 助教 (70516400)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000); Fiscal Year 2012: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2010: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
• Keywords: ドラッグデリバリー / 肺結核 / マクロファージ / 貪食 / DDS / 経気道投与 / 肺胞マクロファージ / 貧食 / 蓄肺投与 / 人工呼吸器 / ナノコンポジット / 慢性結核モデル / 結核治療 / PLGA

Research Abstract

We found that intratracheal administration apparatus was beneficial to local delivery of antituberculosis agent formulated into dry powder microparticles to the lung of laboratory animals. The dry powders consisted of poly(glycolic-co-lactic) acid (PLGA) and the antitubercular agent rifampicin showed high antituberculosis activity in intracelluarly residing Mycobacterium bovisBCG by their efficient taken up by the macrophages in such a way that the powders were distributed widely in the alveoli region. We succeeded in developing the intratracheal administration apparatus based on Venturi effect and homogeneous delivery of the dry powders into the lung of rats, the volume of which was in a range of only several milliliters.

Research Products

• [Journal Article] Distribution and deposition of respirable PLGA microspheres in lung alveoli (2013)
  • Author(s): Keiji Hirota, Tadafumi Kawamoto, Takehisa Nakajima, Kimiko Makino, Hiroshi Terada
  • Journal Title: Colloids and Surfaces B-Biointerfaces Volume: 105巻 Pages: 92-97
  • Peer Reviewed
• [Journal Article] Distribution and Deposition of Respirable PLGA Microspheres in Lung Alveoli (2013)
  • Author(s): Keiji Hirota, Tadafumi Kawamoto, Takehisa Nakajima, Kimiko Makino, and Hiroshi Terada
  • Journal Title: Colloids and Surfaces B-Biointerfaces Volume: 105 Pages: 92-97
  • Peer Reviewed
• [Journal Article] Endocytosis of particle formulations by macrophages and its application to clinical treatment molecular (2012)
  • Author(s): Keiji Hirota, Hiroshi Terada
  • Journal Title: regulation of endocytosis Volume: 16巻 Pages: 413-428
  • Peer Reviewed
• [Journal Article] Endocytosis of Particle Formulations by Macrophages and Its Application to Clinical Treatment (2012)
  • Author(s): Keiji Hirota, and Hiroshi Terada
  • Journal Title: Molecular Regulation of Endocytosis Volume: 16 Pages: 413-428
  • Peer Reviewed
• [Journal Article] Phagostimulatory effect of uptake of PLGA microspheres loaded with rifampicin on alveolar (2011)
  • Author(s): Keiji Hirota, Taizo Hasegawa, Takehisa Nakajima, Kimiko Makino Hiroshi Terada
  • Journal Title: macrophagesColloidsandSurfaces B-Biointerfaces Volume: 87巻 Pages: 293-298
  • Peer Reviewed
• [Journal Article] EffectoftheGc-derivedmacrophage-activating factor precursor (preGcMAF) on phagocytic activation of mouse peritoneal macrophages (2011)
  • Author(s): Yoshihiro Uto, Syota Yamamoto, Ryota Takeuchi, Yoshinori Nakagawa, Keiji Hirota, Hiroshi Terada, Shinya Onizuka, Eiji Nakata, Hitoshi Hori
  • Journal Title: Anticancer Research Volume: 31巻7号 Pages: 2489-2492
  • Peer Reviewed
• [Journal Article] Fourie and Paolo Colombo (2011)
  • Author(s): Amit Misra, Anthony J. Hickey, Carlo Rossi, Gerrit Borchard, Hiroshi Terada, Kimiko Makino, P. Bernard
  • Journal Title: Inhaled drug therapy for treatment of tuberculosis Tuberculosis Volume: 91巻 Pages: 71-81
  • Peer Reviewed
• [Journal Article] Role of lipid rafts in innate immunity and phagocytosis of polystyrenelatex microspheres (2011)
  • Author(s): Goshi Nagao, Kazuo Ishii, Keiji Hirota, Kimiko Makino, Hiroshi Terada
  • Journal Title: ColloidsandSurfaces B:Biointerfaces Volume: 84巻 Pages: 317-324
  • Peer Reviewed
• [Journal Article] Phagostimulatory effect of uptake of PLGA microspheres loaded with rifampicin on alveolar macrophages (2011)
  • Author(s): Keiji Hirota, Hiroshi Terada, et al
  • Journal Title: Colloids and Surfaces B-Biointerfaces Volume: 87巻 Pages: 293-298
  • Peer Reviewed
• [Journal Article] Effect of the Gc-derived macrophage-activating factor precursor (preGcMAF) on phagocytic activation of mouse peritoneal macrophages (2011)
  • Author(s): Yoshihiro Uto, Hiroshi Terada, et al
  • Journal Title: Anticancer Research Volume: 31巻7号 Pages: 2489-2492
  • Peer Reviewed
• [Journal Article] Inhaled drug therapy for treatment of tuberculosis (2011)
  • Author(s): Amit Misra, Hiroshi Terada, et al
  • Journal Title: Tuberculosis Volume: 91巻 Pages: 71-81
  • Peer Reviewed
• [Journal Article] Role of lipid rafts in innate immunity and phagocytosis of polystyrene latex microspheres (2011)
  • Author(s): Goshi Nagao, Hiroshi Terada, et al.
  • Journal Title: Colloids and Surfaces B : Biointerfaces Volume: 84巻 Pages: 317-324
  • Peer Reviewed
• [Journal Article] Role of lipid rafts in phagocytic uptake of polystyrene latex microspheres by macrophages (2010)
  • Author(s): Goshi Nagao, Kazuo Ishii, Keiji Hirota, Kimiko Makino, Hiroshi Terada
  • Journal Title: Anticancer Research Volume: 30巻 Pages: 3167-3176
  • Peer Reviewed
• [Journal Article] The behavior of PLGA microspheres containing rifampicin in alveolar macrophages (2010)
  • Author(s): Tomoya Onoshita, Yuta Shimizu, Naomitsu Yamaya, Masakazu Miyazaki, Mihoko Yokoyama, Naruyoshi Fujiwara, Takehisa Nakajima, Kimiko Makino, Hiroshi Terada, Makoto Haga
  • Journal Title: Colloidsand Surfaces B; Biointerfaces Volume: 76巻 Pages: 151-157
  • Peer Reviewed
• [Journal Article] Delivery of rifampicin -PLGA microspheres into alveolar macrophages is promising for treatment of tuberculosis (2010)
  • Author(s): Keiji Hirota, Taizo Hasegawa, Takehisa Nakajima, Hiroyuki Inagawa, Chie Kohchi, Gen-Ichiro Soma, Kimiko Makino Hiroshi Terada
  • Journal Title: J. Controlled Release Volume: 142巻 Pages: 339-346
  • Peer Reviewed
• [Journal Article] Role of lipid rafts in phagocytic uptake of polystyrene latex microspheres by macrophages (2010)
  • Author(s): Goshi Nagao, Hiroshi Terada, et al.
  • Journal Title: Anticancer-Research Volume: 30巻 Pages: 3167-3176
  • Peer Reviewed
• [Journal Article] The behavior of PLGA microspheres containing rifampicin in alveolar macrophages (2010)
  • Author(s): Tomoya Onoshita, Hiroshi Terada, et al.
  • Journal Title: Colloids and Surfaces B ; Biointerfaces Volume: 76巻 Pages: 151-157
  • Peer Reviewed
• [Journal Article] Delivery of rifampicin-PLGA microspheres into alveolar macrophages is promising for treatment of tuberculosis (2010)
  • Author(s): Keiji Hirota. Hiroshi Terada, et al.
  • Journal Title: J. Controlled Release Volume: 142巻 Pages: 339-346
  • Peer Reviewed
• [Presentation] 慢性結核モデルラットに対する微粒子製剤の肺内投与による治療効果 (2013)
  • Author(s): 福原いづみ
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] マクロファージによるナノ微粒子およびマイクロ微粒子の取り込み活性 (2013)
  • Author(s): 廣田慶司
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 慢性肺結核モデルマウスにおける肉芽腫内結核菌への微粒子製剤の送達性 (2013)
  • Author(s): 山田莉世
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 慢性肺結核モデルマウスにおける肉芽腫内結核菌への微粒子製剤の送達性 (2013)
  • Author(s): 山田莉世, 福原いづみ, 廣田慶司, 寺田 弘
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: Tokyo Morito Hall
• [Presentation] 新しい医療ニーズを目指した 新しい治療法について (2012)
  • Author(s): 牧野公子
  • Organizer: 第4回粉末吸入剤研究会シンポジウム
  • Place of Presentation: ANAクラウンプラザホテル富山
  • Year and Date: 2012-11-16
• [Presentation] Delivery of Nano- and Micro-particles to the Lung of Chronic Tuberculosis Model Mice (2012)
  • Author(s): Riyo Yamada
  • Organizer: 4th Indo-Japanese International Joint Symposium on Overcoming Intractable Infectious Diseases Prevalent in Asian Countries
  • Place of Presentation: Tokyo Morito Hall
  • Year and Date: 2012-10-29
• [Presentation] 4th Indo-Japanese International Joint Symposium on Overcoming (2012)
  • Author(s): Keita Yaginuma, Size-dependent Uptake of Polystyrene Latex Particles by Alveolar Macrophages
  • Organizer: Infectious Diseases Prevalent in Asian Countries
  • Place of Presentation: Tokyo Morito Hall
  • Year and Date: 2012-10-29
• [Presentation] Venturi Insufflator Optimizes Mycobactericidal Effect of Rifampicin-incorporated PLGA Dry Powders (2012)
  • Author(s): Keiji Hirota
  • Organizer: 4th Indo-Japanese International Joint Symposium on Overcoming Intractable Infectious Diseases Prevalent in Asian Countries
  • Place of Presentation: Tokyo Morito Hall
  • Year and Date: 2012-10-29
• [Presentation] 1s1sおよび22型Gc proteinの脱ガラクトース体におけるマクロファージ活性化能の評価 (2012)
  • Author(s): 向井大貴, 寺田弘, 他
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 北海道大学(北海道)
  • Year and Date: 2012-03-30
• [Presentation] 簡便な結核菌数測定法の開発 (2012)
  • Author(s): 新井優子, 廣田慶司, 寺田弘
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 北海道大学(北海道)
  • Year and Date: 2012-03-30
• [Presentation] 粉末微粒子製剤を肺へ均一に噴霧できるVenturi型デバイスの開発と肺結核治療への応用 (2012)
  • Author(s): 廣田慶司, 寺田弘, 他
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 北海道大学(北海道)
  • Year and Date: 2012-03-30
• [Presentation] 肺結核治療における新たな標的細胞としての肺間質マクロファージ (2012)
  • Author(s): 竹前秀紀, 寺田弘, 他
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 北海道大学(北海道)
  • Year and Date: 2012-03-30
• [Presentation] ビスベンジルイソキノリン誘導体の立体構造とラジカル消去活性の相関 (2012)
  • Author(s): 松本嵩史, 寺田弘, 他
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 北海道大学(北海道)
  • Year and Date: 2012-03-30
• [Presentation] プロテオミクスで解き明かすミトコンドリアからのシトクロムc放出機構 (2012)
  • Author(s): 山本武範, 寺田弘, 他
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 北海道大学(北海道)
  • Year and Date: 2012-03-29
• [Presentation] Effect of particle size on endocytic uptake by alveolar macrophage cells (2012)
  • Author(s): Keiji Hirota
  • Organizer: 39th Annual Meeting of the Controlled Release Society
  • Place of Presentation: Quebec Canada
• [Presentation] マクロファージの微粒子取り込みに対するサイズの影響 (2012)
  • Author(s): 廣田慶司
  • Organizer: 第28回日本DDS学会学術集会
  • Place of Presentation: 札幌コンベンションセンター
• [Presentation] Effect of particle size on endocytic uptake by alveolar macrophage cells (2012)
  • Author(s): Keiji Hirota, Shuntaro Shirai, Shun-Ichi Kimura, Hiroshi Terada
  • Organizer: 39th Annual Meeting of the Controlled Release Society
  • Place of Presentation: Quebec
• [Presentation] Effective drug delivery system to overcome intractable infectious diseases (2012)
  • Author(s): Kimiko Makino, Hiroshi Terada, et al
  • Organizer: Japan-India Joint Workshop on Biomedical Research
  • Place of Presentation: Center for Advanced Biomedical Sciences, Waseda Oniversity, Twins, Tokyo
• [Presentation] β-ガラクトシダーゼによる糖鎖修飾を受けた1s1sおよび22型Gcグロブリンのマクロファージ活性化能の評価 (2011)
  • Author(s): 宇都義浩, 寺田弘, 他
  • Organizer: 第15回バイオ治療法研究会
  • Place of Presentation: 福岡大学病院福大メディカルホール(福岡県)
  • Year and Date: 2011-12-03
• [Presentation] 肉芽腫を伴う慢性結核モデルラットに対する抗結核薬含有微粒子製剤の吸入による結核治療 (2011)
  • Author(s): 福原いづみ, 廣田慶司, 寺田弘
  • Organizer: 第2回東京理科大学総合研究機構戦略的物理製剤学研究基盤センターシンポジウム第9回東京理科大学薬学部DDS研究センターシンポジウム
  • Place of Presentation: 東京理科大学森戸記念館(東京都)
  • Year and Date: 2011-11-04
• [Presentation] 迅速的な結核菌数測定法の確立 (2011)
  • Author(s): 新井優子, 廣田慶司, 寺田弘
  • Organizer: 第2回東京理科大学総合研究機構戦略的物理製剤学研究基盤センターシンポジウム第9回東京理科大学薬学部DDS研究センターシンポジウム
  • Place of Presentation: 東京理科大学森戸記念館(東京都)
  • Year and Date: 2011-11-04
• [Presentation] 肺における結核菌の感染部位に関する検討 (2011)
  • Author(s): 竹前秀紀, 寺田弘, 他
  • Organizer: 第2回東京理科大学総合研究機構戦略的物理製剤学研究基盤センターシンポジウム第9回東京理科大学薬学部DDS研究センターシンポジウム
  • Place of Presentation: 東京理科大学森戸記念館(東京都)
  • Year and Date: 2011-11-04
• [Presentation] 微粒子製の肺への送達による結核治療法の展開と問題点 (2011)
  • Author(s): 廣田慶司, 寺田弘
  • Organizer: 第2回東京理科大学総合研究機構戦略的物理製剤学研究基盤センターシンポジウム第9回東京理科大学薬学部DDS研究センターシンポジウム
  • Place of Presentation: 東京理科大学森戸記念館(東京都)
  • Year and Date: 2011-11-04
• [Presentation] 難治性肺疾患の薬物療法を目指した微粒子製剤の条件検討 (2011)
  • Author(s): 白井俊太郎, 寺田弘, 他
  • Organizer: 第2回東京理科大学総合研究機構戦略的物理製剤学研究基盤センターシンポジウム第9回東京理科大学薬学部DDS研究センターシンポジウム
  • Place of Presentation: 東京理科大学森戸記念館(東京都)
  • Year and Date: 2011-11-04
• [Presentation] 肺胞マクロファージによる粒子取り込みに与える表面物性の影響 (2011)
  • Author(s): 牧野公子, 寺田弘, 大島広行
  • Organizer: 第63回コロイドおよび界面化学討論会
  • Place of Presentation: 京都大学吉田キャンパス(京都府)
• [Presentation] Potent antituberculosis activity by pulmonary delivery of PLGA microspheres loaded with the antituberculosis agent rifampicin (2011)
  • Author(s): Keiji Hirota, Hiroshi Terada, et al
  • Organizer: The 38th Annual Meeting and Exposition of the Controlled Release Society
  • Place of Presentation: National Harbor, Maryland U.S.A., Gaylord National Hotel
• [Presentation] ベンチュリ効果を利用した微粒子製剤のエアロゾル化と肺胞への送達 (2011)
  • Author(s): 廣田慶司, 寺田弘, 他
  • Organizer: 第27回日本DDS学会学術集会
  • Place of Presentation: 東京大学本郷キャンパス(東京都)
• [Presentation] 肺胞マクロファージの活性化による抗結核菌作用の誘導 (2010)
  • Author(s): 廣田慶司、寺田弘, 他
  • Organizer: 第14回バイオ治療法研究会学術集会
  • Place of Presentation: 福岡、福岡大学七隈キャンパス
  • Year and Date: 2010-12-11
• [Presentation] 蓄肺投与を目的としたナノ粒子製剤 (2010)
  • Author(s): 友田敬士郎、寺田弘, 他
  • Organizer: オレオナノサイエンスシンポジウム2010
  • Place of Presentation: 東京、森戸記念館
  • Year and Date: 2010-11-04
• [Presentation] 人工呼吸式蓄肺投与デバイスを用いた肺結核治療 (2010)
  • Author(s): 廣田慶司、寺田弘, 他
  • Organizer: 第8回東京理科大学DDS研究センターシンポジウム
  • Place of Presentation: 東京、森戸記念館
  • Year and Date: 2010-10-15
• [Presentation] 肺胞マクロファージの微粒子貧食による誘導される遺伝子の発現解析 (2010)
  • Author(s): 木村俊一、寺田弘, 他
  • Organizer: 第8回東京理科大学DDS研究センターシンポジウム
  • Place of Presentation: 東京、森戸記念館
  • Year and Date: 2010-10-15
• [Presentation] 結核菌感染モデルラット作成に関する検討 (2010)
  • Author(s): 竹前秀紀、廣田慶司、寺田弘
  • Organizer: 第8回東京理科大学DDS研究センターシンポジウム
  • Place of Presentation: 東京、森戸記念館
  • Year and Date: 2010-10-15
• [Presentation] ナノDDS:最近の進歩と今後の課題 (2010)
  • Author(s): 寺田弘
  • Organizer: 日本油化学会第49回年会ランチョンセミナー
  • Place of Presentation: 北海道、北海道大学函館キャンパス
  • Year and Date: 2010-09-16
• [Presentation] 経肺投与による肺結核治療における新たな標的細胞 (2010)
  • Author(s): 廣田慶司、寺田弘, 他
  • Organizer: 第26回日本DDS学会
  • Place of Presentation: 大阪、大阪国際交流センター
  • Year and Date: 2010-06-17
• [Presentation] Phagocytosis of PLGA particles by alveolar macrophages for application to clinical treatment, for tuberculosis (2010)
  • Author(s): Hiroshi Terada
  • Organizer: First World Conference on Nanomedicine and Drug Delivery (WCN-2010)
  • Place of Presentation: Windsor Castle Hotel Kottayam India
• [Presentation] Uptake of PLGA microspheres by alveolar macrophages in association with tuberculosis therapy (2010)
  • Author(s): Hiroshi Terada
  • Organizer: 6th International Symposium on Innovations in Pharmaceutical Sciences and Technology
  • Place of Presentation: Hotel Cambay Grand, India
• [Presentation] Pulmonary drug delivery system for efficient treatment of tuberculosis (2010)
  • Author(s): Keishiro Tomoda, Hiroshi Terada, et al.
  • Organizer: Third Indo-Japan International Joint Symposium on Overcoming Intractable Infectious Diseases Prevalent in Asian Countries
  • Place of Presentation: 東京、森戸記念館
• [Presentation] Potent anti-tuberculosis activity achieved by inhalation of rifampicin-loaded PLGA microspheres with a use of venturi-type insufflator (2010)
  • Author(s): Keiji Hirota, Hiroshi Terada, et al.
  • Organizer: Third Indo-Japan International Joint Symposium on Overcoming Intractable Infectious Diseases Prevalent in Asian Countries
  • Place of Presentation: 東京、森戸記念館
• [Presentation] Gene expressions of alveolar macrophages induced by phagocytosis of artificial microspheres (2010)
  • Author(s): Shun-Ichi Kimura, Hiroshi Terada, et al.
  • Organizer: Third Indo-Japan International Joint Symposium on Overcoming Intractable Infectious Diseases Prevalent in Asian Countries
  • Place of Presentation: 東京、森戸記念館
• [Presentation] Inhalable nanocomposite particles for cure for tuberculosis (2010)
  • Author(s): Sinichi Fukunaga, Hiroshi Terada, et al.
  • Organizer: Third Indo-Japan International Joint Symposium on Overcoming Intractable Infectious Diseases Prevalent in Asian Countries
  • Place of Presentation: 東京、森戸記念館
• [Presentation] Development of pulmonary tuberculosis model with granulomas in a short term using bacille calmette-guerin (2010)
  • Author(s): Hideki Takemae, Hiroshi Terada, et al.
  • Organizer: Third Indo-Japan International Joint Symposium on Overcoming Intractable Infectious Diseases Prevalent in Asian Countries
  • Place of Presentation: 東京、森戸記念館
• [Presentation] 新しい医療ニーズを目指した新しい治療法について
  • Author(s): 牧野公子･寺田 弘
  • Organizer: 第４回粉末吸入剤研究会シンポジウム
  • Place of Presentation: ANAｸﾗｳﾝﾌﾟﾗｻﾞﾎﾃﾙ富山
  • Invited
• [Presentation] Delivery of Nano- and Micro-particles to the Lung of Chronic Tuberculosis Model Mice
  • Author(s): Riyo Yamada, Izumi Fukuhara, Keiji Hirota, Hiroshi Terada
  • Organizer: 4th Indo-Japanese International Joint Symposium on Overcoming Intractable Infectious Diseases Prevalent in Asian Countries
  • Place of Presentation: Tokyo Morito Hall
• [Presentation] Size-dependent Uptake of Polystyrene Latex Particles by Alveolar Macrophages
  • Author(s): Keita Yaginuma, Shuntaro Shirai, Shun-Ichi Kimura, Keiji Hirota, Hiroshi Terada
  • Organizer: 4th Indo-Japanese International Joint Symposium on Overcoming Intractable Infectious Diseases Prevalent in Asian Countries
  • Place of Presentation: Tokyo Morito Hall
• [Presentation] Venturi Insufflator Optimizes Mycobactericidal Effect of Rifampicin-incorporated PLGA Dry Powders
  • Author(s): Keiji Hirota, Yutaka Hirai, Takehisa Nakajima, Kimiko Makino, Hiroshi Terada
  • Organizer: 4th Indo-Japanese International Joint Symposium on Overcoming Intractable Infectious Diseases Prevalent in Asian Countries
  • Place of Presentation: Tokyo Morito Hall
• [Book] 難吸収性薬物の吸収性改善と新規 投与製剤の開発 (2012)
  • Author(s): 牧野公子・寺田 弘
  • Total Pages: 7
  • Publisher: シーエムシー出版
• [Book] 難吸収性薬物の吸収性改善と新規投与製剤の開発 (2012)
  • Author(s): 牧野公子･寺田 弘
  • Total Pages: 7
  • Publisher: シーエムシー出版
• [Remarks]
  • URL: https://sites.google.com/site/telabo/
• [Remarks]
  • URL: https://sites.google.com/site/telabo/
• [Patent(Industrial Property Rights)] 経肺薬剤投与器具および経肺 薬剤投与装置 (2010)
  • Inventor(s): 寺田弘、廣田慶司、牧野公 子、中嶋武尚、平井裕
  • Industrial Property Rights Holder: 寺田弘、廣田慶司、牧野公 子、中嶋武尚、平井裕
  • Filing Date: 2010-05-18
• [Patent(Industrial Property Rights)] 経肺薬剤投与器具および経肺薬剤投与装置 (2010)
  • Inventor(s): 寺田弘、廣田慶司、牧野公子、中嶋武尚、平井裕
  • Industrial Property Rights Holder: 寺田弘、廣田慶司、牧野公子、中嶋武尚、平井裕
  • Industrial Property Number: 2010-114759
  • Filing Date: 2010-05-18