Development ofnew biomaterials using intelligent coacervate

• Project/Area Number: 22300173
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: National Institute for Materials Science
• Principal Investigator: AOYAGI Takao 独立行政法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, コーディネーター (40277132)
• Co-Investigator(Kenkyū-buntansha): EBARA Mitsuhiro 独立行政法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, MANA研究者 (10452393) ; 山元 和哉 鹿児島大学, 理工学研究科, 助教 (40347084)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000); Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
• Keywords: コアセルベート / 温度応答性 / 磁性ナノ粒子 / コポリマー / 相分離 / 刺激応答性 / 相分離挙動 / 相転移挙動 / ハイドロゲル / 水和現象 / 脱水和現象 / ゲル

Research Abstract

In this study, we prepared intelligent coacervate using thermoresponsive polymer each having a hydrophilic functional group that we have developed and investigated the possibility of application to a new biomaterial. Actually thermoresponsive coacervates containing magnetic nanoparticles were prepared and their coalescence behavior was studied.

Research Products

• [Journal Article] 温度応答性高分子の構造と機能 (2012)
  • Author(s): 青柳隆夫
  • Journal Title: ぶんせき Volume: 6巻 Pages: 209-303
  • NAID: 10030758467
  • Peer Reviewed
• [Journal Article] スマートバイオマテリアルの応用 (2012)
  • Author(s): 荏原充宏、青柳隆夫
  • Journal Title: ケミカルエンジニアリング Volume: 476巻 Pages: 31-36
• [Journal Article] A 'smart' approach towards the formation of multifunctional nano-assemblies by simple mixing of block copolymers having a common temperature sensitive segment (2012)
  • Author(s): Yohei Kotsuchibashi, Mitsuhiro Ebara, Naokazu Idota, Ravin Narain, Takao
  • Journal Title: Polymer Chemistry Volume: (in press) Issue: 5 Pages: 1150-1157
  • DOI: 10.1039/c2py00589a
  • Peer Reviewed
• [Journal Article] スマートバイオマテリアルの応用 (2012)
  • Author(s): 荏原充宏
  • Journal Title: ケミカルエンジニアリング Volume: 57 Pages: 31-36
• [Journal Article] Tunable stimuli-responsive self-assembly system that forms and stabilizes nanoparticles by simple mixing and heating/cooling of selected block copolymers (2011)
  • Author(s): Y. Kotsuchibashi, M. Ebara, K. Yamamoto, T. Aoyagi
  • Journal Title: Polymer Chemistry Volume: 2 Issue: 6 Pages: 1362-1367
  • DOI: 10.1039/c1py00004g
  • Peer Reviewed
• [Journal Article] Surface design with self-heating smart polymers for on-off switchable trap (2011)
  • Author(s): P.Techawanitchai
  • Journal Title: Science and Technology of Advanced Materials Volume: 12 Issue: 4 Pages: 44-609
  • DOI: 10.1088/1468-6996/12/4/044609
  • Peer Reviewed
• [Journal Article] On?off switching of dynamically controllable self-assembly formation of double-responsive block copolymers with tunable LCSTs (2010)
  • Author(s): Y. Kotsuchibashi, M. Ebara, K. Yamamoto, T. Aoyagi
  • Journal Title: Journal of Polymer Science Part A::Polymer Chemistry Volume: 48, 20 Issue: 20 Pages: 4393-4399
  • DOI: 10.1002/pola.24226
  • Peer Reviewed
• [Journal Article] On-off switching of dynamically controllable self-assembly formation of double-responsive block copolymers with tunable LCSTs (2010)
  • Author(s): Y.Kotsuchibashi
  • Journal Title: Journal of Polymer Science Part A : Polymer Chemistry Volume: 48 Pages: 4393-4399
  • Peer Reviewed
• [Presentation] Design of smart materials in response to indirect stimuli (2012)
  • Author(s): T. Aoyagi
  • Organizer: International Symposium on Stimuli-Responsive Materials
  • Place of Presentation: サンタロザ、アメリカ
• [Presentation] Smart polymers design for biomedical application (2012)
  • Author(s): T. Aoyagi
  • Organizer: E-MRS Fall Meeting
  • Place of Presentation: ワルシャワ、ポーランド
• [Presentation] Molecular design of smart biomaterials for nano life (2012)
  • Author(s): T. Aoyagi
  • Organizer: Trend in NanoTechnology
  • Place of Presentation: マドリッド、スペイン
• [Presentation] Design of smart biomaterials for biomedical application (2012)
  • Author(s): 青柳隆夫
  • Organizer: WMRIF Young Scientists Workshop
  • Place of Presentation: タイサイエンスパーク、Pathumthani、 タイ
  • Invited
• [Presentation] Molecular design of smart biomaterials for nano life (2012)
  • Author(s): 青柳隆夫
  • Organizer: Trend in NanoTechnology
  • Place of Presentation: マドリッド・ポリテク大学、マドリッド、スペイン
  • Invited
• [Presentation] Smart polymers design for biomedical application (2012)
  • Author(s): 青柳隆夫
  • Organizer: E-MRS Fall Meeting
  • Place of Presentation: ワルシャワ工科大学、ワルシャワ、 ポーランド
• [Presentation] Design of smart materials in response to indirect stimuli (2012)
  • Author(s): 青柳隆夫
  • Organizer: International Sｙｍposium on Stimuli-Responsive Materials
  • Place of Presentation: Hilton Sonoma Country、サンタロザ、アメリカ
  • Invited
• [Presentation] Multi-functional nano-associates from simple mixing of well-designed stimuli-responsive block copolymers (2011)
  • Author(s): Takao Aoyagi
  • Organizer: Particles 2011
  • Place of Presentation: ベルリン(ドイツ)(招待講演)
  • Year and Date: 2011-07-10
• [Presentation] 磁場に誘導するスマートコアセルベートの創製I (2011)
  • Author(s): 前田智宏、児玉祐季、山本和哉、青柳隆夫
  • Organizer: 第22回 高分子ゲル研究討論会
  • Place of Presentation: 東京
  • Year and Date: 2011-01-12
• [Presentation] 磁場に誘導するスマートコアセルベートの創製II (2011)
  • Author(s): 児玉祐季、前田智宏、山本和哉、青柳隆夫
  • Organizer: 第22回 高分子ゲル研究討論会
  • Place of Presentation: 東京
  • Year and Date: 2011-01-12
• [Presentation] 磁場に誘導するスマートコアセルベートの創製I (2011)
  • Author(s): 前田智広
  • Organizer: 第22回 高分子ゲル研究討論会
  • Place of Presentation: 東京大学山上会館(東京都)
  • Year and Date: 2011-01-12
• [Presentation] 磁場に誘導するスマートコアセルベートの創製II (2011)
  • Author(s): 児玉祐季
  • Organizer: 第22回高分子ゲル研究討論会
  • Place of Presentation: 東京大学山上会館(東京都)
  • Year and Date: 2011-01-12
• [Presentation] Molecular Design for Functional Thermo-Responsive Polymers and Their Biomedical Application (2010)
  • Author(s): Takao Aoyagi
  • Organizer: International Symposium on Stimuli-Responsive Materials
  • Place of Presentation: 南ミシシッピー大学(米国)
  • Year and Date: 2010-10-27
• [Presentation] Molecular Design for Functional Thermo-Responsive Polymers and Their Biomedical Application (2010)
  • Author(s): Takao Aoyagi
  • Organizer: International Symposium on Stimuli-Responsive Materials
  • Place of Presentation: 南ミシシッピー、アメリカ
• [Remarks]
  • URL: http://www.nims.go.jp/bmc/group/smartbiomaterials/
• [Remarks] SMART BIOMATERIALS GROUP
  • URL: http://www.nims.go.jp/bmc/group/smartbiomaterials/index.html
• [Remarks]
  • URL: http://www.nims.go.jp/bmc/group/smartbiomaterials/