Smart-ageing Evaluation of Skin by Acoustic Radiation Force Tracked with High Frequency Ultrasound

• Project/Area Number: 22300175
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical systems
• Research Institution: Tohoku University
• Principal Investigator: SAIJO Yoshifumi 東北大学, 大学院・医工学研究科, 教授 (00292277)
• Co-Investigator(Kenkyū-buntansha): KANAI Hiroshi 東北大学, 大学院・工学研究科, 教授 (10185895) ; HOZUMI Naohiro 豊橋技術科学大学, 工学教育国際協力研究 センター, 教授 (30314090)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000); Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2010: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
• Keywords: 超音波 / 音響放射圧 / 位相差トラッキング / 皮膚 / スマート・エイジング / 高周波数超音波 / 粘弾性

Research Abstract

Acoustic radiation force (ARF) was applied to the object with 1 MHz ultrasound applicator and the small displacement was measured by phase tracking method of 120 MHz ultrasound. The viscoelastic properties were obtained by analyzing the temporal response of the object to ARF. The efficacy of the method was validated by the measurement of artificial skin with three-layered structure. The method may contribute to smart-ageing evaluation of skin.

Research Products

• [Journal Article] High-resolution ultrasound imaging of human skin in vivo by using three-dimensional ultrasound microscopy (2012)
  • Author(s): Kumagai K, Koike H, Nagaoka R, Sakai S, Kobayashi K, Saijo Y
  • Journal Title: Ultrasound Med Biol Volume: Vol. 38, No. 10 Issue: 10 Pages: 1833-8
  • DOI: 10.1016/j.ultrasmedbio.2012.05.012
  • Peer Reviewed
• [Journal Article] Coexistence of fibrotic and chondrogenic process in the capsule of idiopathic frozen shoulders (2012)
  • Author(s): Hagiwara Y, Ando A, Onoda Y, Takemura T, Minowa T, Hanagata N, Tsuchiya M, Watanabe T, Chimoto E, Suda H, Takahashi N, Sugaya H, Saijo Y, Itoi E
  • Journal Title: Osteoarthritis Cartilage Volume: Vol. 20, No. 3 Issue: 3 Pages: 241-9
  • DOI: 10.1016/j.joca.2011.12.008
  • Peer Reviewed
• [Journal Article] Comparison of articular cartilage images assessed by high-frequency ultrasound microscope and scanning acoustic microscope (2012)
  • Author(s): Hagiwara Y, Saijo Y, Ando A, Onoda Y, Suda H, Chimoto E, Hatori K, Itoi E
  • Journal Title: Int Orthop Volume: Vol. 6, No. 1 Issue: 1 Pages: 185-90
  • DOI: 10.1007/s00264-011-1263-1
  • Peer Reviewed
• [Journal Article] Echogenicity in transrectal ultrasound is determined by sound speed of prostate tissue components (2012)
  • Author(s): Tanoue H, Hagiwara Y, Kobayashi K, Saijo Y
  • Journal Title: Conf Proc 34th IEEE Eng Med Biol Soc Volume: 1 Pages: 460-463
  • DOI: 10.1109/embc.2012.6345967
  • Peer Reviewed
• [Journal Article] Evaluation of vortex flow in left ventricle by echo-dynamography and phase contrast magnetic resonance angiography (2012)
  • Author(s): Kojima T, Kameyama T, Nakajima H, Khmyrova E, Kurokawa T, Saijo Y
  • Journal Title: Conf Proc 34th IEEE Eng Med Biol Soc Volume: 1 Pages: 2676-2679
  • DOI: 10.1109/embc.2012.6346515
  • Peer Reviewed
• [Journal Article] Imaging of sebaceous glands of human skin by three-dimensional ultrasound microscopy and its relation to elasticity (2011)
  • Author(s): Kumagai K, Koike H, Kudo Y, Nagaoka R, Kubo K, Kobayashi K, Saijo Y
  • Journal Title: Conf Proc 33rd IEEE Eng Med Biol Soc Volume: 1 Pages: 7199-7202
  • DOI: 10.1109/iembs.2011.6091819
  • Peer Reviewed
• [Journal Article] Ultrasonic tissue characterization of prostate biopsy tissues by ultrasound speed microscope (2011)
  • Author(s): Tanoue H, Hagiwara Y, Kobayashi K, Saijo Y
  • Journal Title: Conf Proc 33rd IEEE Eng Med Biol Soc Volume: 1 Pages: 8499-8402
  • DOI: 10.1109/iembs.2011.6092097
  • Peer Reviewed
• [Journal Article] Location of flow axis line in the left ventricle and its interaction with local myocardial motion. (2011)
  • Author(s): Nakajima H, Sugawara S, Kameyama T, Tabuchi H, Ohtsuki S, Tanaka M Saijo Y
  • Journal Title: J Echocardiogr Volume: 9 Pages: 24-27
  • NAID: 10029728113
  • Peer Reviewed
• [Presentation] Feasibility of echo-dynamography in comparison of blood flow vectors obtained from echocardiography and phase contrast magnetic resonance angiography (2013)
  • Author(s): Saijo Y, Kojima T, Khmyrova E, Omori A, Nakajima H, Kurokawa T, Tabuchi H, Kameyama T, Tanaka M
  • Organizer: Asian Pacific Society of Cardiology 2013 Congress
  • Place of Presentation: Pattaya, Thailand
• [Presentation] Evaluation of tissue components, biomechanics and blood flow by high frequency ultrasound (2012)
  • Author(s): Saijo Y
  • Organizer: 2012 AIUM Annual Convention
  • Place of Presentation: Phoenix, AZ, USA(招待講演)
  • Year and Date: 2012-03-31
• [Presentation] Sebaceous gland size influences viscoelasticity of the skin - Comparison of 3D ultrasound microscope imaging and biomechanical measurements (2012)
  • Author(s): Saijo Y, Nagaoka R, Kubo K
  • Organizer: World Congress of the International Society for Biophysics and Imaging of the Skin (ISBS)
  • Place of Presentation: Copenhagen, Denmark
• [Presentation] 音響放射圧によるPVAの微小変位の計測-レーザードップラー法と高周波数超音波法による比較 (2012)
  • Author(s): 長岡亮,和泉拓哉,小松洋介,小林和人,西條芳文
  • Organizer: 第33回超音波エレクトロニクスの基礎と応用に関するシンポジウム
  • Place of Presentation: 千葉
• [Presentation] Application of acoustic microscopy for prostate biopsy tissues. Key Note Lecture (2012)
  • Author(s): Saijo Y
  • Organizer: 8th International Symposium on Ultrasonic Biomedical Microscanning
  • Place of Presentation: St- Paulin, Quebec, Canada
• [Presentation] Recent development on biomedical acoustic microscopy. International Conference on Sensing (2012)
  • Author(s): Saijo Y
  • Organizer: Imaging and Signal Processing
  • Place of Presentation: Santa Barbara, CA, USA
• [Presentation] 高周波数超音波による人工皮膚の弾性計測 (2012)
  • Author(s): 長岡亮,西條芳文,和泉拓哉,久保聖乃,小島貴則,工藤千奈,小林和人
  • Organizer: 日本超音波医学会第85回学術集会
  • Place of Presentation: 東京
• [Presentation] High resolution biomedical imaging - Multimodal ultrasound microscope and combination with optics. Invited Paper in The Acoustics2012 Hong Kong conference consisting a joint meeting of the 163rd meeting of the Acoustical Society of America (ASA) (2012)
  • Author(s): Saijo Y
  • Organizer: the 8th meeting of the Acoustical Society of China (ASC), the11th Western Pacific Acoustics Conference (WESPAC) and the Hong Kong Institute of Acoustics (HKIOA) organized by the Hong Kong Institute of Acoustics
  • Place of Presentation: Hong Kong, China
• [Presentation] Evaluation of tissuecomponents, biomechanics and blood flow by high frequency ultrasound (2012)
  • Author(s): Saijo Y
  • Organizer: Invited Lecture in American Institute of Ultrasound in Medicine (AIUM)2012 Annual Convention
  • Place of Presentation: Phoenix, AZ, USA
• [Presentation] Evaluation of tissue components, biomechanics and blood flow by high frequency ultrasound (2012)
  • Author(s): Saijo Y
  • Organizer: American Institute of Ultrasound in Medicine (AIUM) 2012 Annual Convention
  • Place of Presentation: Phoenix, AZ, USA
  • Invited
• [Presentation] High resolution biomedical imaging - Multimodal ultrasound microscope and combination with optics (2012)
  • Author(s): Saijo Y
  • Organizer: The Acoustics 2012 Hong Kong conference consisting a joint meeting of the 163rd meeting of the Acoustical Society of America (ASA)
  • Place of Presentation: Hong Kong, China
  • Invited
• [Presentation] Application of acoustic microscopy for prostate biopsy tissues (2012)
  • Author(s): Saijo Y
  • Organizer: 8th International Symposium on Ultrasonic Biomedical Microscanning
  • Place of Presentation: St-Paulin, Quebec, Canada
  • Invited
• [Presentation] Recent development on biomedical acoustic microscopy (2012)
  • Author(s): Saijo Y
  • Organizer: International Conference on Sensing, Imaging and Signal Processing
  • Place of Presentation: Santa Barbara, CA, USA
  • Invited
• [Presentation] IVUS is still alive (2011)
  • Author(s): Saijo Y
  • Organizer: 2011 IEEE International Ultrasonics Symposium
  • Place of Presentation: Orlando, MI, USA(招待講演)
  • Year and Date: 2011-10-20
• [Presentation] Assessment of aging of skin by high frequency ultrasound and biomech anical testing (2010)
  • Author(s): Saijo Y
  • Organizer: 9th Congress of Asian Federation of Societies for Ultrasound in Medicine & Biology
  • Place of Presentation: New Delhi, India
  • Year and Date: 2010-11-20
• [Book] Color dependence of photoacoustic micro imaging. Andrzej Nowicki, Jerzy Litniewski, Tamara Kujawska eds (2012)
  • Author(s): Saijo Y, Koike H, Izumi T, Miida Y, Matsuura Y, Hozumi N
  • Publisher: Acoustical Imaging Vol 31, Springer
• [Book] Ultrasonic and Electromagnetic NDE for Structure and Material Characterization: Engineering and Biomedical Applications CRC Press (2012)
  • Author(s): Saijo Y
  • Publisher: Clinical applications of ultrasonic nondestructive evaluation. Tribikram Kundu ed
• [Book] Jinlong Wu ed. Technological Advancements in Biomedicine for Healthcare Applications, IGI Global (2012)
  • Author(s): Saijo Y
  • Publisher: Biomedical application of multimodal ultrasound microscope
• [Book] Acoustical Imaging (2012)
  • Author(s): Saijo Y, Koike H, Izumi T, Miida Y, Matsuura Y, Hozumi N
  • Publisher: Color dependence of photoacoustic micro imaging
• [Book] Ultrasonic and Electromagnetic NDE for Structure and Material Characterization: Engineering and Biomedical Applications (2012)
  • Author(s): Clinical applications of ultrasonic nondestructive evaluation
  • Publisher: Saijo Y
• [Book] Technological Advancements in Biomedicine for Healthcare Applications (2012)
  • Author(s): Saijo Y
  • Publisher: Biomedical application of multimodal ultrasound microscope
• [Remarks] 西條研究室
  • URL: http://www.ecei.tohoku.ac.jp/imaging/
• [Remarks] 西條研究室
  • URL: http://www.ecei.tohoku.ac.jp/imaging/
• [Remarks]
  • URL: http://www.ecei.tohoku.ac.jp/imaging/
• [Remarks]
  • URL: http://www.ecei.tohoku.ac.jp/imaging/index