Basic investigation for regeneration using mesenchymal stem cells with multi-potency and immunological tolerance

• Project/Area Number: 22300185
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Nagoya University
• Principal Investigator: TORIHASHI Shigeko 名古屋大学, 医学(系)研究科(研究院), 教授 (90112961)
• Co-Investigator(Kenkyū-buntansha): HIRATA Hitoshi 名古屋大学, 大学院医学系研究科, 教授 (80173243) ; KAWABE Tsutomu 名古屋大学, 大学院医学系研究科, 教授 (20378219) ; ISHIDA Kazuto 名古屋大学, 大学院医学系研究科, 講師 (10303653)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2010: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
• Keywords: 間葉系幹細胞 / 骨格筋 / 再生 / 移植 / ES細胞 / iPS細胞 / CD105 / 骨格筋の機能評価 / TSG6 / ラットiPS細胞 / 移植細胞の足場形成 / 分化誘導 / 筋再生 / 機能回復 / 組織再生 / 細胞移植 / 再生医療 / 骨格筋再生 / 歩行運動解析 / リハビリテーション / 発生分化

Research Abstract

We developed mesenchymal stem cells (MSCs) expressing CD105 from mouse ES cells during induction to adipose cells. We investigated MSCs and obtained valuable results as follows: (1) Our MSCs showed higher telomerase activity than that of tissue MSCs. However,their immunological tolerance was not high enough for transplantation across species. (2) MSCs showed more than 96% of purity and laser irradiation to unlabeled cells improved the purity. (3) MSCs demonstrated high potential for differentiation into skeletal muscle and their transplantation intoinjured muscles accelerated functional recovery of damaged muscles. (4) Injured skeletal muscles cells up-regulated the expression of TSG6 in MSCs. It formed the foothold of MSCs after transplantation. (5) We established iPS cells from MSCs in human metabolic syndrome model rats. Adipose cells from the iPS cells showed pathophysiological state similar to human metabolic syndrome.

Research Products

• [Journal Article] Transplantation of Mesenchymal Stem Cells Derived from ES Cells Promotes Muscle Regeneration and Accelerates Functional Recovery of Injured Skeletal Muscle (2013)
  • Author(s): Nana Takenaka-Ninagawa, Eri Isobe, Yuri Hirayama, Rumi Murakami, Kasumi Komatsu, Masataka Nagai, Mami Kobayashi, Yuka Kawabata, Shigeko Torihash
  • Journal Title: BioResearch Open Access Volume: 2巻, 4号 Issue: 4 Pages: 295-306
  • DOI: 10.1089/biores.2013.0012
  • Peer Reviewed
• [Journal Article] 「基礎研究から考える理学療法の現状と今後の展開－移植・再生医療と理学療法－」 (2013)
  • Author(s): 蜷川菜々
  • Journal Title: 日本基礎理学療法学会雑誌 Volume: 16
  • Peer Reviewed
• [Journal Article] Investigation of VEGF and PDGF signals in vascular formation by 3D culture models using mouse ES cells (2012)
  • Author(s): Hitomi Hosoe
  • Journal Title: Stem Cell Discovery Volume: 2 Issue: 02 Pages: 70-77
  • DOI: 10.4236/scd.2012.22011
  • Peer Reviewed
• [Journal Article] Investigation of VEGF and PDGF signals in vascular formation by 3D culture models using mouse ES cells (2012)
  • Author(s): Hitomi Hosoe, et al
  • Journal Title: Stem Cell Discovery Volume: (印刷中)(in press)
  • Peer Reviewed
• [Journal Article] Mesenchymal stem cells originating from ES cells show high telomerase activity and therapeutic benefits (2011)
  • Author(s): Nana Ninagawa, Rumi Murakami, Eri Isobe, Yusuke Tanaka, Hiroki Nakagawa, Shigeko Torihashi
  • Journal Title: Differentiation Volume: 82(3) Issue: 3 Pages: 153-164
  • DOI: 10.1016/j.diff.2011.07.001
  • Peer Reviewed
• [Journal Article] Mesenchymal stem cells originating from ES cells show high telomerase activity and therapeutic benefits (2011)
  • Author(s): Nana Ninagawa, et al
  • Journal Title: Differentiation Volume: 82 Pages: 153-164
  • Peer Reviewed
• [Journal Article] カハールの介在細胞、平滑筋の発生と異常 (2011)
  • Author(s): 鳥橋茂子
  • Journal Title: 医学のあゆみ Volume: 238 Pages: 925-929
• [Journal Article] Attenuation of TGF-β-Stimulated Collagen Production in Fibroblasts by Quercetin-Induced HO-1. (2011)
  • Author(s): Nakamura T, Matsushima M, Hayashi Y, Shibasaki M, Imaizumi K, Hashimoto N, Shimokata K, Hasegawa Y, Kawabe T
  • Journal Title: Am J Respir Cell Mol Biol Volume: (印刷中,未定)
  • Peer Reviewed
• [Journal Article] Comparison of salivary cortisol, heart rate, and oxygen saturation between early skin-to-skin contact with different initiation and duration times in healthy, full-term infants (2011)
  • Author(s): Takahashi Y, Tamakoshi K, Matsushima M, Kawabe T.
  • Journal Title: Early Hum Dev Volume: (印刷中,未定)
  • NAID: 120003059531
  • Peer Reviewed
• [Journal Article] Minor neuronal damage and recovered cellular proliferation in the hippocampus after continuous unilateral forelimb restraint in normal rats. (2011)
  • Author(s): Ishida A, Ueda Y, Ishida K, Misumi, S, Masuda T, Fujita M, Hida H
  • Journal Title: J Neurosc Res Volume: 89 Pages: 457-465
  • Peer Reviewed
• [Journal Article] マウスES 細胞由来間葉系幹細胞の作成とその特異的分化能 (Differentiation potential of mesenchymal stem cells originating from mouse ES cells, in vitro) (2010)
  • Author(s): 蜷川菜々、村上留美、田中優介、中川寛紀、鳥橋茂子
  • Journal Title: 組織培養研究(Tissue Culture Research Communication) Volume: 29巻, 2号 Pages: 155-165
  • Peer Reviewed
• [Journal Article] マウスES細胞由来間葉系幹細胞の作成とその特異的分化能 (2010)
  • Author(s): 蜷川菜々、村上留美、田中優介、中川寛紀、鳥橋茂子
  • Journal Title: 組織培養研究 Volume: 29 Pages: 155-165
  • NAID: 10027882312
  • Peer Reviewed
• [Journal Article] Endothelial-mesenchymal transition in bleomycin-induced pulmonary fibrosis (2010)
  • Author(s): Hashimoto N, Phan SH, Imaizumi K, Matsuo M, Nakashima H, Kawabe T, Shimokata K, Hasegawa Y
  • Journal Title: Am J Respir Cell Mol Biol Volume: 43 Pages: 161-72
  • Peer Reviewed
• [Journal Article] Ghrelin and obestatin promote the allergic action in rat peritoneal mast cells as basic secretagogues. (2010)
  • Author(s): Hirayama T, Kawabe T, Matsushima M, Nishimura Y, Kobe Y, Ota Y, Baba K, Takagi K.
  • Journal Title: Peptides Volume: 31 Pages: 2109-13
  • Peer Reviewed
• [Journal Article] Characteristics of an optimized catheter-type thermal flow sensor for measuring reciprocating airflows in bronchial pathways (2010)
  • Author(s): Shikida M, Yokota T, Kawabe T, Funaki T, Matsushima M, Iwai S, Matsunaga N , Sato K.
  • Journal Title: Micromech. Microeng
  • Peer Reviewed
• [Journal Article] Treadmill running improves motor function and alters dendritic morphology in the striatum after collagenase induced intracerebral hemorrhage in rats. (2010)
  • Author(s): Takamatsu Y, Ishida A, Hamakawa M, Tamakoshi K, Jung Cha-Gyun, Ishida K
  • Journal Title: Brain Res Volume: 1355 Pages: 165-173
  • Peer Reviewed
• [Presentation] 骨格筋細胞との共培養がマウスES細胞由来運動神経細胞の分化過程に与える影響 ―新規共培養方法を用いた解析― (2014)
  • Author(s): 川端佑果，小林麻美，竹中菜々、田口季依，鳥橋茂子
  • Organizer: 第13回日本再生医療学会総会
  • Place of Presentation: 京都国際会館
• [Presentation] ラット間葉系幹細胞由来iPS細胞の樹立（メタボリックシンドロームモデルラットのiPS細胞） (2014)
  • Author(s): 竹中 菜々, 川端 佑果, 永田 浩三, 鳥橋 茂子
  • Organizer: 第13回日本再生医療学会総会
  • Place of Presentation: 京都国際会館
  • Invited
• [Presentation] 移植した間葉系幹細胞の生着に関与するTSG6 (TNF- α stimulated gene 6 product) (2014)
  • Author(s): 鳥橋 茂子、帆 澪子、川窪 雄二、永井 将貴、小松 佳純、平山 由梨、竹中 菜々、木全 弘治
  • Organizer: 第１１９回日本解剖学会総会
  • Place of Presentation: 自治医科大学
• [Presentation] Interactions between skeletal muscle cells and motor neurons derived from mouse ES cells ― Analysis by a unique co-culture system ― (2014)
  • Author(s): Yuka Kawabata, Mami Kobayashi, Kie Taguchi, Nana Takenaka, Shigeko Torihashi
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Generation of Induced Pluripotent Stem Cells using Rat Mesenchymal Stromal Cells Originated from a New Model of Metabolic Syndrome (2013)
  • Author(s): Nana Takenaka, Mami Kobayashi, Yuka Kawabata, Kohzo Nagata, Shigeko Torihashi
  • Organizer: 11th ISSCR(国際幹細胞学会)
• [Presentation] Generation of Induced Pluripotent Stem Cells using Rat Mesenchymal Stromal Cells Originated from a New Model of Metabolic Syndrome (2013)
  • Author(s): Nana Takenaka, Mami Kobayashi, Yuka Kawabata, Kohzo Nagata, Shigeko Torihashi
  • Organizer: ISSCR 11th
  • Place of Presentation: Boston Convention and Exhibition Center (BCEC)
• [Presentation] A unique co-culture system of differentiating motor neurons and skeletal muscle myoblasts (2013)
  • Author(s): Yuka Kawabata, Mami Kobayashi, Nana Ninagawa, Shigeko Torihashi
  • Organizer: ISSCR 11th
  • Place of Presentation: Boston Convention and Exhibition Center (BCEC)
• [Presentation] Effects of skeletal muscle cells on the growth of motor neurons derived from mouse ES cells -analyzed by a unique co-culture system (2013)
  • Author(s): Yuka Kawabata, Mami Kobayashi, Nana Ninagawa, Shigeko Torihashi
  • Organizer: 第36回日本神経科学大会（合同）
  • Place of Presentation: 京都国際会館
• [Presentation] Effects of extracellular direct current electrical stimulation on neuron/neural progenitor cells derived from mouse ES cells (2013)
  • Author(s): Mami Kobayashi, Yuka Kawabata, Nana Ninagawa and Shigeko Torihashi
  • Organizer: 第36回日本神経科学大会（合同）
  • Place of Presentation: 京都国際会館
• [Presentation] マウスES細胞由来神経前駆細胞に対する細胞外直流電流負荷の効果 (2013)
  • Author(s): 小林麻美
  • Organizer: 第12回日本再生医療学会総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 骨格筋細胞によるマウスES細胞由来運動神経細胞への作用―生体外共培養法による解析― (2013)
  • Author(s): 川端佑果
  • Organizer: 第12回日本再生医療学会総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Generation of Induced Pluripotent Stem Cells using Rat Mesenchymal Stromal Cells Originated from a New Model of Metabolic Syndrome (2013)
  • Author(s): Nana Takenaka,
  • Organizer: 11th ISSCR
  • Place of Presentation: Boston Convention and Exhibition Center (BCEC)
• [Presentation] A unique co-culture system of differentiating motor neurons and skeletal muscle myoblasts (2013)
  • Author(s): Yuka Kawabata
  • Organizer: 11th ISSCR
  • Place of Presentation: Boston Convention and Exhibition Center (BCEC)
• [Presentation] マウスES細胞由来間葉系幹細胞の損傷骨格筋再生能 (2012)
  • Author(s): 蜷川菜々、鳥橋茂子, 他
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学甲府キャンパス
  • Year and Date: 2012-03-28
• [Presentation] Transplantation of Mesenchymal Stem Cells Derived from ES Cells Promotes Muscle Regeneration; Re-innervation and Thereby Accelerates Functional Recovery of Injured Skeletal Muscle (2012)
  • Author(s): Nana Ninagawa, Eri Isobe, Yuri Hirayama, Mami Kobayashi, Yuka Kawabata, Shigeko Torihashi
  • Organizer: 10th ISSCR (国際幹細胞学会)
• [Presentation] ES細胞由来間葉系幹細胞（E-MSCs）は損傷骨格筋の機能回復を促進する (2012)
  • Author(s): 蜷川菜々
  • Organizer: 第47回日本理学療法学術大会
  • Place of Presentation: 神戸ポートピアホテル
• [Presentation] 移植した間葉系幹細胞の細胞分化に影響する損傷骨格筋と正常骨格筋の生体内環境の違い (2012)
  • Author(s): 平山由梨
  • Organizer: 第47回日本理学療法学術大会
  • Place of Presentation: 神戸ポートピアホテル
• [Presentation] マウスES細胞由来運動神経細胞と骨格筋細胞を用いた生体外共培養方法の検討 (2012)
  • Author(s): 川端佑果
  • Organizer: 第47回日本理学療法学術大会
  • Place of Presentation: 神戸ポートピアホテル
• [Presentation] Transplantation of Mesenchymal Stem Cells Derived from ES Cells Promotes Re-innervation and Accelerates Functional Recovery of Injured Skeletal Muscle (2012)
  • Author(s): Nana Ninagawa
  • Organizer: 45th JSDB 2012
  • Place of Presentation: 神戸国際展示場
• [Presentation] マウスES細胞由来運動神経細胞と骨格筋細胞の生体外共培養方法における運動神経細胞の動態 (2012)
  • Author(s): 川端佑果
  • Organizer: 第11回日本再生医療学会総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] マウスES細胞由来神経前駆細胞／運動神経細胞に対する電気刺激の効果 (2012)
  • Author(s): 小林麻美
  • Organizer: 第11回日本再生医療学会総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Transplantation of Mesenchymal Stem Cells Derived from ES Cells Promotes Muscle Regeneration; Re-innervation and Thereby Accelerates Functional Recovery of Injured Skeletal Muscle (2012)
  • Author(s): Nana Ninagawa
  • Organizer: 10th ISSCR
  • Place of Presentation: パシフィコ横浜
• [Presentation] Gut organ Development―Investigation using in vitro system― (2012)
  • Author(s): Shigeko Torihashi
  • Organizer: 7th International Symposium on Interstitial cells of Cajal
  • Place of Presentation: Hotel Albani (Firenze Italy)
  • Invited
• [Presentation] Effects of direct current electrical fields on neural cells and their progenitors derived from mouse ES cells (2012)
  • Author(s): Mami Kobayashi
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] ES細胞由来間葉系幹細胞移植による損傷骨格筋の再生促進効果 (2012)
  • Author(s): 蜷川菜々
  • Organizer: 日本解剖学会第72回中部支部学術集会
  • Place of Presentation: じゅろくプラザ
• [Presentation] Transplantation of Mesenchymal stem Cells (MSCs) from Mouse ES CellsPromote Skeletal Muscle Regeneration and Improve Functional Recovery (2011)
  • Author(s): Nana Ninagawa, Shigeko Torihashi, et al
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-12-13
• [Presentation] 損傷骨格筋へのマウスES細胞由来間葉系幹細胞の移植 (2011)
  • Author(s): 蜷川菜々、鳥橋茂子, 他
  • Organizer: 第71回日本解剖学会中部支部学術集会
  • Place of Presentation: 名古屋大学医学部付属病院
  • Year and Date: 2011-10-15
• [Presentation] マウスES細胞由来間葉系幹細胞は移植先で損傷骨格筋再生に寄与する (2011)
  • Author(s): 蜷川菜々、鳥橋茂子, 他
  • Organizer: コメディカル形態機能学会第10回学術総会・集会
  • Place of Presentation: 中部大学
  • Year and Date: 2011-09-17
• [Presentation] 細胞培養技術におけるLaser Microdissection の有効利用法 (2011)
  • Author(s): 鳥橋茂子
  • Organizer: Leica Laser Microdissection 研究会
  • Place of Presentation: 神戸ポートアイランドセンター(招待講演)
  • Year and Date: 2011-08-25
• [Presentation] Transplantation of Mesenchymal Stem Cells from Mouse ES Cells after Muscle Injuries Promotes Skeletal Muscle Regenerati on and Improves Functional Recovery (2011)
  • Author(s): Nana Ninagawa, Eri Isobe, Rumi Murakami, Mami Kobayashi, Shigeko Torihashi
  • Organizer: 9th ISSCR (International Society for Stem cell Research)
  • Place of Presentation: Metro Toronto Convention Center (Canada)
  • Year and Date: 2011-06-18
• [Presentation] マウスES細胞由来間葉系幹細胞は生体内で骨格筋へ分化し、損傷骨格筋の機能回復を促進する (2011)
  • Author(s): 蜷川菜々、鳥橋茂子, 他
  • Organizer: 第1回理学療法の医学的基礎学会
  • Place of Presentation: 宮崎シーガイア
  • Year and Date: 2011-05-30
• [Presentation] Transplantation of Mesenchymal stem Cells from Mouse ES Cells into Injured Muscles Promotes Skeletal Muscle Regeneration and Improves Functional Recovery (2011)
  • Author(s): Nana Ninagawa, Shigeko Toriahshi, et al
  • Organizer: 44th JSBD (Asia-pacific Developmental Biology Network)
  • Place of Presentation: Okinawa Convention Center
  • Year and Date: 2011-05-19
• [Presentation] マウスES細胞由来間葉系幹細胞(MSCs)が示す高い骨格筋への分化能 (2011)
  • Author(s): 蜷川菜々、磯部恵里、村神瑠美、鳥橋茂子
  • Organizer: 第10回日本再生医療学会
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2011-03-11
• [Presentation] Transplantation of Mesenchymal Stem Cells from Mouse ES Cells after Muscle Injuries Promotes Skeletal Muscle Regeneration and Improves Functional Recovery (2011)
  • Author(s): Nana Ninagawa, Eri Isobe, Rumi Murakami, Mami Kobayashi, Shigeko Torihashi
  • Organizer: 9th ISSCR(国際幹細胞学会)
• [Presentation] Transplantation of Mesenchymal Stem Cells (MSCs) from Mouse ES CellsPromote Skeletal Muscle Regeneration and Improve Functional Recovery (2011)
  • Author(s): Nana Ninagawa, Mami Kobayashi, Eri Isobe, Yuri Hirayama, Yuka Kawabata, Shigeko Torihashi
  • Organizer: 第34回日本分子生物学会年会
• [Presentation] マウスES細胞由来間葉系幹細胞(E-MSCs)が示す骨格筋への高い分化能 (2011)
  • Author(s): 蜷川菜々、鳥橋茂子, 他
  • Organizer: 第46回日本理学療法学術大会
  • Place of Presentation: 宮崎シーガイア
• [Presentation] マウスES細胞におけるアテロコラーゲン三次元脈管形成モデル (2011)
  • Author(s): 細江民美、鳥橋茂子, 他
  • Organizer: 第46回日本理学療法学術大会
  • Place of Presentation: 宮崎シーガイア
• [Presentation] ES細胞から分化誘導した神経系細胞の電気刺激およびラミニンコートの効果 (2011)
  • Author(s): 小林麻美、鳥橋茂子, 他
  • Organizer: 第46回日本理学療法学術大会
  • Place of Presentation: 宮崎シーガイア
• [Presentation] ES細胞を用いた運動神経細胞の分化誘導法 (2011)
  • Author(s): 小玉学、鳥橋茂子, 他
  • Organizer: 第46回日本理学療法学術大会
  • Place of Presentation: 宮崎シーガイア
• [Presentation] ES細胞から作成した間葉系幹細胞の生体内における骨格筋形成能 (2011)
  • Author(s): 磯部恵里、鳥橋茂子, 他
  • Organizer: 第46回日本理学療法学術大会
  • Place of Presentation: 宮崎シーガイア
• [Presentation] Transplantation of Mesenchymal stem Cells from Mouse ES Cells after Muscle Injuries Promotes Skeletal Muscle Regeneration and Improves Functional Recovery (2011)
  • Author(s): Nana Ninagawa, Shigeko Toriashi, et al
  • Organizer: 9th ISSCR(国際幹細胞学会)
  • Place of Presentation: Metro Toront Convention Center Toront, Ontario Canada
• [Presentation] CD105 Positive Adipose Tissue-Derived Mesenchymal Stern Cells from Mouse ES Cells (2010)
  • Author(s): Shigeko Torihashi, Nana Ninagawa
  • Organizer: 43rd Annual Meeting for the Japanese Society of Developmental Biologist Jointly Sponsored by the Asia-Pacific Developmental Biology Network
  • Place of Presentation: 京都国際会議場(京都府)
  • Year and Date: 2010-06-22
• [Presentation] Differentiation of GI muscle in vivo and in vitro (2010)
  • Author(s): Shieeko Torihashi, Nana Ninagawa, Masaaki Kurahashi
  • Organizer: 第116回日本解剖学会総会・全国学術集会、第88回日本生理学会大会合同
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2010-03-30
• [Presentation] Mesenchymal stem cells derived from ES cells have a great potential for differentiation into skeletal muscles in vivo and in vitro (2010)
  • Author(s): Nana Ninagawa, Eri Isobe, Rumi Murakami, Shigeko Torihashi
  • Organizer: 第116回日本解剖学会総会・全国学術集会、第88回日本生理学会大会合同
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2010-03-28
• [Presentation] CD105 Positive Adipose Tissue-Derived Mesenchymal Stem Cells from Mouse ES Cells (2010)
  • Author(s): Shigeko Torihashi, Nana Ninagawa
  • Organizer: 43rd Annual Meeting for the Japanese Society of Developmental Biologist Jointly Sponsored by the Asia-Pacofoc Developmental Biology Network
• [Remarks]
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• [Remarks] 鳥橋 茂子 ホームページ
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• [Remarks] 鳥橋 茂子
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• [Remarks]
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• [Remarks]
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• [Patent(Industrial Property Rights)] メタボリックシンドロームモデルラット誘導多能性幹細胞及び製造方法 (2013)
  • Inventor(s): 鳥橋 茂子、永田 浩三、竹中 菜々、川端 佑果
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-100645
  • Filing Date: 2013-05-13
• [Patent(Industrial Property Rights)] 間葉系幹細胞およびその産生方法 (2013)
  • Inventor(s): 鳥橋 茂子、蜷川 菜々
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Rights Type: 特許
  • Acquisition Date: 2013-12-13
• [Patent(Industrial Property Rights)] Mesenchymal stem cell and method for production thereof (2013)
  • Inventor(s): 鳥橋 茂子、蜷川 菜々
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Rights Type: 特許
  • Acquisition Date: 2013-06-25
  • Overseas
• [Patent(Industrial Property Rights)] 間葉系幹細胞およびその産生方法 (2013)
  • Inventor(s): 鳥橋 茂子、 蜷川 菜々
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-06-25
  • Acquisition Date: 2013-12-13
• [Patent(Industrial Property Rights)] メタボリックシンドロームモデルラット誘導多能性幹細胞及び製造方法 (2013)
  • Inventor(s): 鳥橋 茂子、 永田 浩三、竹中 菜々、 川端 佑果
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-100645
  • Filing Date: 2013-05-13
• [Patent(Industrial Property Rights)] Mesenchymal stem Cell and method for production therof (2011)
  • Inventor(s): 鳥橋茂子、蜷川菜々
  • Industrial Property Rights Holder: 名古屋大学
  • Filing Date: 2011-10-11
  • Overseas
• [Patent(Industrial Property Rights)] Mesenchymal stem cell and mdethod for production thereof (2010)
  • Inventor(s): 鳥橋 茂子、蜷川 菜々
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2010-12-28
  • Acquisition Date: 2013-06-25
  • Overseas
• [Patent(Industrial Property Rights)] 間葉系幹細胞およびその生産方法(Mesenchymal stem cell and mdethod for production thereof) (2010)
  • Inventor(s): 鳥橋 茂子、蜷川 菜々
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2010-12-28
  • Acquisition Date: 2013-03-14
  • Overseas
• [Patent(Industrial Property Rights)] 間葉系幹細胞およびその生産方法 (2010)
  • Inventor(s): 鳥橋茂子、蜷川菜々
  • Industrial Property Rights Holder: 名古屋大学
  • Filing Date: 2010-10-18
  • Overseas