| Project/Area Number |
22300186
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Nagoya University |
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Principal Investigator |
YAMADA Sumio 名古屋大学, 医学系研究科(保健), 教授 (80359752)
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| Co-Investigator(Kenkyū-buntansha) |
KAWABE Tsutomu 名古屋大学, 医学部, 教授 (20378219)
USUI Akihiko 名古屋大学, 医学部, 教授 (30283443)
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| Co-Investigator(Renkei-kenkyūsha) |
KONDO Takaaki 名古屋大学, 医学部, 教授 (00195900)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2012: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Keywords | 心大血管術後患者 / 異化亢進 / 筋タンパク分解 / 電気刺激介入 / 実行可能性 / 心大血管術後 / 骨格筋タンパク分解 / 尿中3-methylhistidine / 心臓外科術後 / バイオマーカー / リハビリテーション |
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| Research Abstract |
[Study 1] We investigated skeletal muscle proteolysis and postoperative muscle weakness immediately after cardiovascular surgery(CVS) based on 24 hour urinary 3-methylhistidine/Creatinine(24h-u3MH/Cre). [Methods]Thirty seven patients underwent CVS were enrolled. Iterleukin-6(IL-6) production, cortisol, growth hormone(GH), IGF-1, BCAA, AAA, respiratory muscle power, grasp strength, knee extension strength and 24h-u3MH were measured. [Results]IL-6 and cortisol increased immediately after the CVS and IGF-1/GH and BCAA/AAA decreased, showing postoperative hypercatabolism. 24h-u3MH/Cre successively increased and peak out at 4th postoperative day and cumulative value during 5 days significantly correlated with IL-6 production and the magnitude of decrease in knee extension muscle strength. [Conclusions] Hyper-catabolism due to CVS correlates with postsurgical muscle proteolysis and muscle weakness.[Study 2] We investigated the feasibility of electrical stimulation (ES) intervention and the preventive effect of ES on postoperative muscle proteolysis in patients immediately after cardiovascular surgery by nonrandomized controlled trial.-Feasibility study; Sixty eight patients were consecutively recruited to the study from November 2011. Patients received ES from postoperative day (POD) 1 for 2 weeks and we found no clinical adverse event and they cleared criteria for success of feasibility.-Nonrandomized controlled trial; We compared 32 patients who received ES group with 32 patients who didn’t by group matching based on obesity and IL-6 immediate after surgery. The values of 3MH/Cre on POD4 and POD5 adjusted by that of POD1 were significantly low in ES group. We also found little reduction (
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