|Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
：The reduction of skeletal muscle loss in pathological states, such as muscle disuse, has considerable effects in terms of rehabilitation and quality of life. Skeletal muscle and its microvasculature can exhibit remarkable plasticity in response to decreased functional demand, i.e., muscle disuse. In addition, disturbed redox signaling, due to increased production of reactive oxygen species (ROS), is an important regulator of cell signaling pathways that control both proteolysis and protein synthesis, and capillarity in skeletal muscle. Therefore, the purpose of this report is to investigate the effects of exercise with nutrition supports, e.g., anti-oxidant action, on atrophy and capillary regression in skeletal muscle. Exercise attenuated the atrophy in skeletal muscle. However, Exercise and loading could not attenuate the capillary regression in skeletal muscle. Anti-oxidant supplementation, i.e., astaxanthin, attenuated the capillary regression by decreasing the oxidative-stress. In addition, exercise combined with licorice flavonoid oil effectively reduced visceral adipose tissue, because exercise and licorice flavonoid oil enhanced the muscular and hepatic lipid metabolism, respectively. These results suggested that exercise combined with licorice flavonoid oil supplementation might be effective to decrease the risk from obesity. These results indicate that exercise combined with nutrition supports, i.e., nutrition supplementation, might be effective to prevent atrophy, capillary regression and metabolism disturbance in skeletal muscle.