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CEREBRAL BLOOD FLOW REGULATION DURING EXERCISE IN TWO ROOTS OF BRAIN ARTERY

Research Project

Project/Area Number 22300205
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Physical education
Research InstitutionJapan Women's College of Physical Education

Principal Investigator

SADAMOTO Tomoko  日本女子体育大学, 体育学部, 教授 (30201528)

Co-Investigator(Kenkyū-buntansha) OGO Shigehiko  東洋大学, 理工学部, 教授 (80553841)
Co-Investigator(Renkei-kenkyūsha) SATO Kouhei  日本女子体育大学, 体育学部, 准教授 (00409278)
OOUE Anna  日本女子体育大学, 附属基礎体力研究所, 助教 (00550104)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Keywords前頭部脳循環 / 後頭部脳循環 / 内頸動脈 / 椎骨動脈 / 中大脳動脈 / 超音波法 / 動脈 CO_2 / 自動調節 / 内頸動脈血流量 / 上大静脈血流量 / 鎖骨下静脈血流量 / 静脈閉塞 / 高炭酸ガス / 椎骨動脈血流量 / 外頸動脈血流量 / CO_2感受性 / 超音波ドップラー法 / 静的運動 / 運動後筋虚血 / 血管抵抗 / 二酸化炭素濃度
Research Abstract

Blood supply to the brain originates from two roots, the internal carotid arteries (ICA) and the vertebral arteries (VA). ICA provides blood to cerebral cortex forming the anterior cerebral circulation, while VA supplies blood to occipital cortex, cerebellum, and brainstem forming the posterior cerebral circulation. Although previous studies assumed that the cerebral blood flow in two roots were similar during exercise, the present study demonstrated that there are different responses between two roots indicating regional differences in the brain circulation. Further, difference in arterial CO_2 reactivity found to be a mediator for the regional difference in the brain circulation.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (28 results)

All 2012 2011 2010 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (16 results)

  • [Journal Article] Differential blood flow responses to CO_2 in human internal and external carotid and vertebral arteries2012

    • Author(s)
      Sato, K., Sadamoto,T. ,Hirasawa, A., Oue, A., Subudhi, A.W., Miyazawa, T. and Ogoh, S.
    • Journal Title

      J Physiol

      Volume: 590 Pages: 3277-3290

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blood flow in internal carotid and vertebral arteries during orthostatic stress.2012

    • Author(s)
      Sato, K., Fisher, JP., Seifert, T., Overgaard, M., Secher, N.H. and Ogoh, S.
    • Journal Title

      Exp. Physiol.

      Volume: 97 Issue: 12 Pages: 1272-1280

    • DOI

      10.1113/expphysiol.2012.064774

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential blood flow responses to CO2 in human internal and external carotid and vertebral arteries.2012

    • Author(s)
      Sato, K. Sadamoto, T., Hirasawa, A., Oue, A., Subudhi, A.W., Miyazawa, T. and Ogoh, S.
    • Journal Title

      J. Physiol.

      Volume: 590 Issue: 14 Pages: 3277-3290

    • DOI

      10.1113/jphysiol.2012.230425

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Arterial baroreflex regulation of cerebral blood flow in humans.2012

    • Author(s)
      Ogoh, S.Hirasawa, A. and Fishe, J.P.
    • Journal Title

      J Phys Fitness Sports Med

      Volume: 1 Pages: 631-636

    • NAID

      10031158999

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Central command and vertebral artery blood flow during static arm exercise in women2012

    • Author(s)
      Sato, K., Hirasawa, A., Ooue, A., Yoneya, M., Sadamoto, T.
    • Journal Title

      Journal of Exercise Science

      Volume: 21 Pages: 6-13

    • NAID

      40019236380

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The distribution of blood flow in the carotid and vertebral arteries during dynamicexercise in humans.2011

    • Author(s)
      Sato, K., Ogoh, S., Hirasawa, A., Oue, A., Sadamoto, T.
    • Journal Title

      J Physiol

      Volume: 589 Issue: 11 Pages: 2847-2856

    • DOI

      10.1113/jphysiol.2010.204461

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The distribution of blood flow in the carotid and vertebral arteries during dynamic exercise in humans2011

    • Author(s)
      Sato, K., Ogoh, S., Hirasawa, A., Oue, A., Sadamoto, T.
    • Journal Title

      The Journal of Physiology (London)

      Volume: 589 Pages: 2847-2856

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Different blood flow responses to dynamic exercise between internal carotid artery and vertebral artery in women.2010

    • Author(s)
      Sato, K. and Sadamoto, T.
    • Journal Title

      J Appl Physiol

      Volume: 109 Issue: 3 Pages: 864-869

    • DOI

      10.1152/japplphysiol.01359.2009

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cerebrovascular response during heavyupper body exercise: effect of mode of ventilation on blood flow velocity in the middle cerebral artery.2010

    • Author(s)
      Sato, K., Hirasawa, A., Tsunoda, N., Taniguchi, Y. and Sadamoto, T.
    • Journal Title

      Adv Exp Med Biol

      Volume: 66 Pages: 347-352

    • DOI

      10.1007/978-1-4419-1241-1_50

    • ISBN
      9781441912398, 9781441912411
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic cerebral autoregulation during and after handgrip exercise in humans.2010

    • Author(s)
      Ogoh, S., Sato, K., Akimoto, T.,Oue, A., Hirasawa, A. and Sadamoto, T.
    • Journal Title

      J Appl Physiol

      Volume: 108 Pages: 1701-1705

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Different blood flow responses to dynamic exercise between internal carotid artery and vertebral artery in women2010

    • Author(s)
      Sato K, Sadamoto T
    • Journal Title

      Journal of Applied Physiology

      Volume: 109 Pages: 864-869

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential blood flow responses to CO2 in human internal and external carotid and vertebral arteries

    • Author(s)
      Sato, K., Sadamoto, T., Hirasawa, A., Oue, A., Subudhi, A., Miyazawa, T., Ogoh, S.
    • Journal Title

      The Journal of Physiology (London)

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 動的運動時における頭部静脈血流応答特性2012

    • Author(s)
      大上安奈,平澤愛,佐藤耕平,米谷茉里奈,定本朋子
    • Organizer
      第20回日本運動生理学会大会
    • Place of Presentation
      茨城
    • Year and Date
      2012-07-29
    • Related Report
      2012 Final Research Report
  • [Presentation] Cerebral blood flow regulation in internal carotid and vertebral arteries during orthostatic stress.2012

    • Author(s)
      Ogoh, S., Sato ,K., Fisher,J.P., Seifert, T., Overgaard, M. and Secher, N.H.
    • Organizer
      The 17th Annual Congress of the European College of Sport Science
    • Place of Presentation
      Bruges, Belgium
    • Year and Date
      2012-07-06
    • Related Report
      2012 Final Research Report
  • [Presentation] 動的運動時における頭部静脈血流応答特性.2012

    • Author(s)
      大上安奈,佐藤耕平, 平澤 愛, 米谷茉里奈, 定本朋子
    • Organizer
      第20回日本運動生理学会大会
    • Place of Presentation
      筑波大学 茨城県
    • Related Report
      2012 Annual Research Report
  • [Presentation] 運動時脳血流のCO2 reactivity指標に及ぼす持久性トレーニングの影響.2012

    • Author(s)
      米谷茉里奈, 佐藤耕平, 大上安奈, 平澤 愛, 定本朋子
    • Organizer
      第67回日本体力医学会大会
    • Place of Presentation
      長良川国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] 4週間の持久性トレーニングが運動時の脳血流動態へ及ぼす影響2011

    • Author(s)
      米谷茉里奈,佐藤耕平,大上安奈,平澤愛,定本朋子
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      山口
    • Year and Date
      2011-09-17
    • Related Report
      2012 Final Research Report
  • [Presentation] 4週間の持久性トレーニングが運動時の脳血流動態へ及ぼす影響2011

    • Author(s)
      米谷茉里奈, 佐藤耕平, 大上安奈, 平澤愛, 定本朋子
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      下関,山口県
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] アドレナリン作動薬が動静脈脳血流量に及ぼす影響2011

    • Author(s)
      小河繁彦,佐藤平,Fisher J.P.,Secher,N.H.
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      山口
    • Year and Date
      2011-09-16
    • Related Report
      2012 Final Research Report
  • [Presentation] 運動時脳血流のCO_2reactivity指標に及ぼす持久性トレーニングの影響2011

    • Author(s)
      米谷茉里奈,佐藤耕平,大上安奈,平澤愛,定本朋子
    • Organizer
      第67回日本体力医学会大会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-09-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 起立ストレスによる中枢性呼吸反射変化のメカニズム2011

    • Author(s)
      小河繁彦,岡崎和伸,中原秀英,宮本忠吉
    • Organizer
      第25回呼吸研究会
    • Place of Presentation
      山口
    • Year and Date
      2011-09-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Elevation blood flow in common carotid artery with aerobic fitness in elderly women2011

    • Author(s)
      Hirasawa, A., Sato, K., Ooue, A., Nakamura, I., Sadamoto, T.
    • Organizer
      The 16th Annual Congress of the European College of Sport Science
    • Place of Presentation
      Liverpool UK.
    • Year and Date
      2011-07-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Heterogeneous cerebrovascular responses to dynamic exercise in anatomically distinct cerebral arteries2011

    • Author(s)
      Sato, K., Hirasawa, A., Oue, A., Ogoh, S., Sadamoto, T.
    • Organizer
      The 16th Annual Congress of the European College of Sport Science
    • Place of Presentation
      Liverpool, UK
    • Year and Date
      2011-07-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] Heterogeneous cerebrovascular responses to dynamicexercise in anatomically distinct cerebral arteries.2011

    • Author(s)
      Sato, K., Hirasawa, A., Oue, A., Ogoh, S., Sadamoto, T.
    • Organizer
      The 57th American College of Sports Medicine
    • Place of Presentation
      Denver, USA
    • Year and Date
      2011-06-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Heterogeneous cerebrovascular responses to dynamic exercise in anatomically distinct cerebral arteries2011

    • Author(s)
      Sato, K., Hirasawa, A., Oue, A., Ogoh, S., Sadamoto, T.
    • Organizer
      The 57th American College of Sports Medicine
    • Place of Presentation
      Denver, Colorado USA
    • Year and Date
      2011-06-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 1週間の高強度レジスタンストレーニングが静的運動時の中大脳動脈に及ぼす影響2010

    • Author(s)
      米谷茉里奈,大上安奈,平澤愛,佐藤耕平,定本朋子
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      千葉
    • Year and Date
      2010-09-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Central command and vertebral blood flow during static arm exercise in humans2010

    • Author(s)
      Sato, K. and Sadamoto, T.
    • Organizer
      The 57th American College of Sports Medicine
    • Place of Presentation
      Baltimore,USA
    • Year and Date
      2010-06-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Central command and vertebral blood flow during static arm exercise in humans2010

    • Author(s)
      Sato K, Sadamoto T
    • Organizer
      The 57th American College of sports Medicine
    • Place of Presentation
      Baltimore, USA
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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