| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2010: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
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| Research Abstract |
In diabetes mellitus force production in skeletal muscle is impaired and muscle fragility are increased, consequent to impaired calcium ion homeostasis. This study found that diabetes perturbs the calcium ion regulatory system such that resting calcium homeostasis following muscle contractions is compromised and elevations of calcium are exacerbated. This study considers the impact of diabetes on the capacity of skeletal muscle to regulate calcium, following muscle contractions and, in particular, the relationship between muscle fatigue and elevated calcium ion in a highly ecologically relevant circulation-intact environment. Given the profound microcirculatory dysfunction in diabetes this preparation presents the exciting imperative to investigate the relationships among microvascular function, blood-myocyte oxygen flux and calcium homeostasis as they relate to enhanced muscle fatigability and exercise intolerance.
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