Role of perlecan in muscle hypertrophy induced by mechanical-stress
| Project/Area Number |
22300223
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Juntendo University |
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Principal Investigator |
HIRASAWA Eri 順天堂大学, 大学院・医学研究科, 准教授 (50245718)
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| Co-Investigator(Kenkyū-buntansha) |
NAITO Hisashi 順天堂大学, スポーツ健康科学研究科, 教授 (70188861)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2010: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | メカニカルストレス / サルコペニア / ミオスタチ / パールカン / 筋肥大 / ミオスタチン |
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| Research Abstract |
The aim of this study is to identify the role of perlecan, a multifunctional glycoprotein, in skeletal muscle hypertrophy induced by mechanical stress such as exercise training. We found that in perlecan deficient mice, skeletal muscle hypertrophy was promoted with increased growth factor and myostatin signaling under the mechanical stress. Our findings reveal the important regulatory role of perlecan in muscle hypertrophy induced by mechanical stress.
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Report
(4 results)
Research Products
(51 results)
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[Journal Article] Laminin a1 is essential for mouse cerebellar development2012
Author(s)
Ichikawa-Tomikawa N, Ogawa J, Douet V, Xu Z, Kamikubo Y, Sakurai,T, Kohsaka S, Chiba H, Hattori H, Yamada Y, and Arikawa-Hirasawa E
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Journal Title
Matrix Biol
Volume: 311
Pages: 17-28
Related Report
Peer Reviewed
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[Journal Article] A novel mutation in SCN4A causes severe myotonia and school-age-onset paralytic episodes.2012
Author(s)
Yoshinaga H, Sakoda,S Good JM, Takahashi MP, Kubota T, Arikawa-Hirasawa E, Nakata T, Ohno K, Kitamura T, Kobayashi K, and Ohtsuka Y
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Journal Title
Journal of the Neurological Sciences
Volume: Apr 15;315(1-2)
Pages: 15-9
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Peer Reviewed
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[Journal Article] Association of the HSPG2 gene withneuroleptic-induced tardive dyskinesia2010
Author(s)
Syu A, Ishiguro H, Inada T, Horiuchi Y, Tanaka S, Ishikawa M, Arai M, Itokawa M, Niizato K, Iritani S, Ozaki N, Takahashi M, Kakita A, Takahashi H, Nawa H, Keino-Masu K, Arikawa-Hirasawa E, Arinami T
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Journal Title
Neuropsychopharmacolog
Volume: 35(5)
Pages: 1155-64
Related Report
Peer Reviewed
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[Journal Article] Pigment epithelium-derived factor up-regulation induced by memantine,an N-methyl-d-aspartate receptor antagonist, is involved in increased proliferation of hippocampal progenitor cells2010
Author(s)
Namba T, Yabe T, Gonda Y, Ichikawa N, Sanagi T, Arikawa-Hirasawa E,Mochizuki H, Kohsaka S, Uchino S
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Journal Title
Neuroscience
Volume: 167(2)
Pages: 372-83
Related Report
Peer Reviewed
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[Journal Article] Correlations between both the expression levels of inflammatory mediators and growth factor in medial perimeniscal synovial tissue and the severity of medial knee osteoarthritis2010
Author(s)
Ning L, Ishijima M, Kaneko H, Kurihara H, Arikawa-Hirasawa E,Kubota M, Liu L, Xu Z, Futami I, Yusup A, Miyahara K, Xu S, Kaneko K, Kurosawa H
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Journal Title
Int. Orthop
Volume: 35(6)
Pages: 931-8
Related Report
Peer Reviewed
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[Journal Article] Perlecan deficiency causes muscle hypertrophy, a decrease in myostatin expression, and changes in muscle fiber composition2010
Author(s)
Zhuo Xu, Naoki Ichikawa, Keisuk Kosaki, Yoshihiko Yamada, Takako Sasaki, Lynn Y.Sakai, Hisashi Kurosawa, Nobutaka Hattori, Eri Arikawa-Hirasawa
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Journal Title
Matrix Biology
Volume: 29
Pages: 461-470
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Peer Reviewed
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