| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2010: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Research Abstract |
The aim of this study is to identify the role of perlecan, a multifunctional glycoprotein, in skeletal muscle hypertrophy induced by mechanical stress such as exercise training. We found that in perlecan deficient mice, skeletal muscle hypertrophy was promoted with increased growth factor and myostatin signaling under the mechanical stress. Our findings reveal the important regulatory role of perlecan in muscle hypertrophy induced by mechanical stress.
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