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Molecular basisfor the integral regulatory system ofnutritional homeostasis and its role in the life-style related diseases.

Research Project

Project/Area Number 22300237
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionThe University of Tokushima

Principal Investigator

TAKETANI Yutaka  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (30263825)

Research Collaborator WATARI Eriko  徳島大学, 大学院・栄養生命科学教育部, 大学院生
KITAMURA Tomoyo  徳島大学, 大学院・栄養生命科学教育部, 大学院生
SHIOTA Asuka  徳島大学, 大学院・栄養生命科学教育部, 大学院生
TAN Vu Van  徳島大学, 大学院・栄養生命科学教育部, 大学院生
AMO Kikuko  徳島大学, 大学院・栄養生命科学教育部, 大学院・生
OHMINAMI Hirokazu  徳島大学, 大学院・栄養生命科学教育部, 大学院・生
HORIE Daisuke  徳島大学, 大学院・栄養生命科学教育部, 大学院・生
YAMADA Fumiyo  徳島大学, 大学院・栄養生命科学教育部, 大学院・生
TANIMURA Ayako  徳島大学, 大学院・栄養生命科学教育部, 大学院・生
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Keywordsシグナル伝達 / リン、血管内皮機能 / 高リン血症 / 肥満 / 心血管疾患 / 慢性腎臓病 / 生活習慣病 / グリセミックインデックス / 高リン食 / 栄養学 / 血管内皮機能 / リン / 栄養素代謝 / インスリン感受性 / 代謝バランス / 循環器疾患 / プロテオーム / 糖質 / 脂質
Research Abstract

Although molecular mechanisms for life-style related diseases have been clarified, interaction between nutrients has not been elucidated yet. In this study, we attempted to understand how disturbance of phosphorus metabolism can affect energy metabolism, resulted in various life-style related diseases including obesity, atherosclerosis, diabetes. Here, we identified key molecules to regulate both phosphorus and energy metabolism in cellular levels. In addition, we found that disturbance of phosphorus metabolism can affect energy expenditure and endothelial function in animal model and human study.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (45 results)

All 2013 2012 2011 2010

All Journal Article (21 results) (of which Peer Reviewed: 21 results) Presentation (22 results) Book (2 results)

  • [Journal Article] Thyroid hormones decrease plasma 1a,25-dihydroxyvitamin D levels through transcriptional repression of the renal 25-hydroxyvitamin D-1a-hydroxylase gene (CYP27B1)2013

    • Author(s)
      Kozai M, Ishiguro M, Harada N.Masuda M, Kagawa T, Takei Y, Ohtani A, Nakahashi O, Ikeda S, Taketani Y.Miyamoto K, Takeyama K, Kato S, Takeda E
    • Journal Title

      Endocrinology

      Volume: 154 Issue: 2 Pages: 609-622

    • DOI

      10.1210/en.2012-1647

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of serine 249 of ezrin in the regulation of sodium-dependent phosphate transporter NaPi-IIa activity in renal proximal tubular cells2013

    • Author(s)
      Yamada-Kamada F, Horie D, Nakamura A, Tanimura A, Yamamoto H, Segawa H, Ito M, Miyamoto K, Taketani Y, Takeda E
    • Journal Title

      J Med Invest

      Volume: 60 Pages: 27-34

    • NAID

      130004465290

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of serine 249 of ezrin in the regulation of sodium-dependent phosphate transporter NaPi-IIa activity in renal proximal tubular cells2013

    • Author(s)
      Yamada F
    • Journal Title

      Journal of Medical Investigation

      Volume: 60 Pages: 27-34

    • NAID

      130004465290

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dietary phosphorus in bone health and quality of life2012

    • Author(s)
      Takeda E.Yamamoto H.Yamanaka-Okumura H, Taketani Y
    • Journal Title

      Nutr Rev

      Volume: 70 Pages: 311-321

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulation of stanniocalcin 1 expression by 1,25-dihydroxy vitamin D<sub>3</sub> and parathyroid hormone in renal proximal tubular cells2012

    • Author(s)
      Hung NT, Yamamoto H, Takei Y, Masuda M, Otani A, Kozai M, Ikeda S, Nakahashi O, Tanaka S, Taketani Y, Takeda E
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 50 Issue: 3 Pages: 227-233

    • DOI

      10.3164/jcbn.11-99

    • NAID

      130004879277

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dietary phosphate restriction ameliorates endothelial dysfunction in adenine-induced kidney disease rats2012

    • Author(s)
      Vu Van T, Watari E, Taketani Y, Kitamura T, Shiota A, Tanaka T, Tanimura A, Harada N, Nakaya Y, Yamamoto H, Miyamoto K, Takeda E
    • Journal Title

      J Clin Biochem Nutr

      Volume: 51 Pages: 27-32

    • NAID

      130004879287

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] nate restriction ameliorates endothelial dysfunction in adenine-induced kidney2012

    • Author(s)
      Vu Van T, et al
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Natto and viscous vegetables in a Japanese-style breakfast improved insulin sensitivity2011

    • Author(s)
      Taniguchi-Fukatsu A, Yamanaka-Okumura H, Naniwa-Kuroki Y, Nishida Y, Yamamoto H, Taketani Y, Takeda E
    • Journal Title

      lipid metabolism and oxidative stress in overweight subjects with impaired glucose tolerance

      Volume: 7 Issue: 8 Pages: 1-8

    • DOI

      10.1017/s0007114511004156

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Paradoxical Regulation of Human FGF21 by Both Fasting and Feeding Signals : Is FGF21 a Nutritional Adaptation Factor?2011

    • Author(s)
      Uebanso T, Taketani Y, Yamamoto H, Amo K, Ominami H, Arai H, Takei Y, Masuda M, Tanimura A, Harada N, Yamanaka-Okumura H, Takeda E
    • Journal Title

      PLoS One

      Volume: 6(8) Issue: 8 Pages: 22976-22976

    • DOI

      10.1371/journal.pone.0022976

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Liver X receptor negatively regulates fibroblast growth factor 21 in the fatty liver induced by cholesterol-enriched diet2011

    • Author(s)
      Uebanso T, Taketani Y, Yamamoto H, Amo K, Tanaka S, Arai H, Takei Y, Masuda M, Yamanaka-Okumura H, Takeda E
    • Journal Title

      J Nutr Biochem

      Volume: 23 Issue: 7 Pages: 785-790

    • DOI

      10.1016/j.jnutbio.2011.03.023

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of xylitol on metabolic parameters and visceral fat accumulation2011

    • Author(s)
      Amo K, Arai H, Uebanso T, Fukaya M, Koganei M, Sasaki H, Yamamoto H, Taketani Y, Takeda E
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 49 Issue: 1 Pages: 1-7

    • DOI

      10.3164/jcbn.10-111

    • NAID

      130004879256

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of different complexes of type IIa sodium-dependent phosphate transporter in rat renal cortex using blue-native polyacrylamide gel electrophoresis.2011

    • Author(s)
      Tanimura A, Yamada F, Saito A, Ito M, Kimura T, Anzai N, Horie D, Yamamoto H, Miyamoto K, Taketani Y, Takeda E
    • Journal Title

      J Med Invest

      Volume: 59 Pages: 140-147

    • NAID

      130004465236

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] High phosphate diet reduces atherosclerosis formation in apolipoprotein E-deficient mice2011

    • Author(s)
      Shiota A, Taketani Y, Maekawa Y, Yasutomo K, Sata M, Sakai T, Mizuno R, Isshiki M, Yamamoto H, Takeda E
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 49 Issue: 2 Pages: 109-114

    • DOI

      10.3164/jcbn.10-150

    • NAID

      130004466642

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] High phosphate diet reduces atherosclerosis formation in Apolipoprotein E-deficient mice2011

    • Author(s)
      Shiota A, et al.
    • Journal Title

      J Clin Biochem Nutr

      Volume: 50(in press)

    • NAID

      130004466642

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of different complexes of type IIa sodium-dependent phosphate transporter in rat renal cortex using blue-native polyacrylamide gel electrophoresis.2011

    • Author(s)
      Tanimura A, et al.
    • Journal Title

      J Med Invest

      Volume: 58 Pages: 140-147

    • NAID

      130004465236

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of renal sodium-dependent phosphate co-transporter genes (Npt2a and Npt2c) by all-trans-retinoic acid and its receptors2010

    • Author(s)
      Masuda M, Yamamoto H, Kozai M, Tanaka S, Ishiguro M, Takei Y, Nakahashi O, Ikeda S, Uebanso T, Taketani Y, Segawa H, Miyamoto K, Takeda E.
    • Journal Title

      Biochem J.

      Volume: 492 Issue: 3 Pages: 583-592

    • DOI

      10.1042/bj20100484

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] An apical expression signal of the renal type IIc Na+-dependent phosphate cotransporter in renal epithelial cells.2010

    • Author(s)
      Ito M, Sakurai A, Hayashi K, Ohi A, Kangawa N, Nishiyama T, Sugino S, Uehata Y, Kamahara A, Sakata M, Tatumi S, Kuwahata M, Taketani Y,Segawa H, Miyamoto K.
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 299 Issue: 1 Pages: F243-F254

    • DOI

      10.1152/ajprenal.00189.2009

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thyroid hormones regulate phosphate homeostasis through transcriptional control of the renal type IIa sodium-dependent phosphate co-transporter (Npt2a) gene2010

    • Author(s)
      Ishiguro M, Yamamoto H, Masuda M, Kozai M, Takei Y, Tanaka S, Sato Y, Segawa H, Taketani Y, Arai H, Miyamoto K, Takeda E
    • Journal Title

      Biochem J.

      Volume: 427 Issue: 1 Pages: 161-169

    • DOI

      10.1042/bj20090671

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thyroid hormones regulate phosphate homeostasis through transcriptional control of the renal type IIa sodium-dependent phosphate co-transporter (Npt2a) gene.2010

    • Author(s)
      Ishiguro M, et al.
    • Journal Title

      Biochem J

      Volume: 427 Pages: 161-169

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An apical expression signal of the renal type IIc Na+-dependent phosphate cotransporter in renal epithelial cells.2010

    • Author(s)
      Ito M, et al.
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 299

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of renal sodium-dependent phosphate co-transporter genes (Npt2a and Npt2c) by all-trans-retinoic acid and its receptors.2010

    • Author(s)
      Masuda M, et al.
    • Journal Title

      Biochem J

      Volume: 429 Pages: 583-592

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 肝臓の脂質代謝を制御する胎生期栄養環境2012

    • Author(s)
      大南 博和
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 炎症性腸疾患の発症および治癒過程におけるリン摂取量の重要性2012

    • Author(s)
      十河 未来
    • Organizer
      第66回日本栄養・食糧学会大会
    • Place of Presentation
      東北大学川内北キャンパス(宮城県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] リン制限食摂取による腎性貧血の改善効果2012

    • Author(s)
      中尾 真理
    • Organizer
      第66回日本栄養・食糧学会大会
    • Place of Presentation
      東北大学川内北キャンパス(宮城県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 24 時間蓄尿を用いたリン摂取量の把握と妥当性の検討2012

    • Author(s)
      森本 優香
    • Organizer
      第66回日本栄養・食糧学会大会
    • Place of Presentation
      東北大学川内北キャンパス(宮城県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] CKDモデルラットにおける血管内皮機能障害に対する炭酸ランタンの効果2012

    • Author(s)
      上田 遙香
    • Organizer
      日本腎臓学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] リン・ビタミンD代謝の概日リズムの解析2012

    • Author(s)
      向原 理恵
    • Organizer
      日本ビタミン学会第64回大会
    • Place of Presentation
      長良川国際会議場(岐阜県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] INTERACTION BETWEEN DIETARY PHOSPHATE AND CARBOHYDRATE ON GLUCOSE AND PHOSPHATE METABOLISMS IN HEALTHY YOUNG MEN2012

    • Author(s)
      Yutaka Taketani
    • Organizer
      16th International Congress on Nutrition and Metabolism in Renal Disease 2012
    • Place of Presentation
      Hilton Hawaiian Village (U.S.A.)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Role of Akt-eNOS Signal Pathway in the Endothelial Dysfunction induced by Chronic Kidney Disease with Hyperphosphatemia2011

    • Author(s)
      Vu van T, et al
    • Organizer
      American Soceiety for Bone and Mineral Research 2011 Annual Meeting
    • Place of Presentation
      San Diego, CA, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] Hyperphosphatemia Causes Endothelial Dysfunction by Inhibiting Akt-Endothelial Nitric Oxide Synthase Pathway in Chronic Kidney Disease Rats2011

    • Author(s)
      Taketani Y, et al
    • Organizer
      American Heart Association Scientific Session 2011
    • Place of Presentation
      Orlando, FL, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] リン代謝制御の破綻と疾患2011

    • Author(s)
      竹谷豊
    • Organizer
      第63回日本ビタミン学会大会
    • Place of Presentation
      広島市(安田女子大学)(シンポジウム)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] アデニン誘発性CKDモデルラットにおける食餌性リン制限は血管内皮機能を改善する2011

    • Author(s)
      田中輝実, 他
    • Organizer
      第65回日本栄養・食糧学会大会
    • Place of Presentation
      東京都(お茶の水大学)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Klotho変異マウスにおけるビタミンD合成酵素CYP27B1発現と異所性石灰化発生機序の解明2011

    • Author(s)
      大谷彩子, 他
    • Organizer
      第63回日本ビタミン学会大会
    • Place of Presentation
      広島市(安田女子大学)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 血管内皮細胞におけるリン負荷誘導性細胞内シグナル伝達経路の解析2011

    • Author(s)
      竹谷豊, 他
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      札幌市(北海道大学)
    • Related Report
      2011 Annual Research Report
  • [Presentation] リン制限食はアデニン誘発性CKDモデルラットにおける血管内皮機能障害を改善する2011

    • Author(s)
      竹谷豊, 他
    • Organizer
      第29回日本骨代謝学会学術集会
    • Place of Presentation
      大阪市(大阪国際会議場)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 慢性腎臓病モデルラットにおけるリン摂取制限による血管内皮機能改善効果2011

    • Author(s)
      竹谷豊, 他
    • Organizer
      第58回日本栄養改善学会学術総会
    • Place of Presentation
      広島市(広島国際会議場)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Na依存性リン酸トランスポーターとezrinとの新たな相互作用2011

    • Author(s)
      堀江大輔, 他
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都市(国立京都国際会館)
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒトFGF21は絶食・飽食シグナルを感知する栄養代謝の変化に応答する因子である2011

    • Author(s)
      竹谷豊, 他
    • Organizer
      第32回日本肥満学会
    • Place of Presentation
      淡路市(淡路夢舞台国際会議場)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 出生後の代謝応答を調節する胎児栄養状態の重要性2011

    • Author(s)
      大南博和, 他
    • Organizer
      第32回日本肥満学会
    • Place of Presentation
      淡路市(淡路夢舞台国際会議場)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Dietary Phosphate Restriction Ameliorates Endothelial Function in Adenine-Induced Chronic Kidney Disease Model Rats2010

    • Author(s)
      Vu Van T, et al.
    • Organizer
      American Society of Nephrology Renal Week 2010
    • Place of Presentation
      Colorado Convention Center (Denver, CO, USA)
    • Year and Date
      2010-11-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Phosphoproteomic Analysis in the Endothelial Cells Damaged by Hyper phosphatemia2010

    • Author(s)
      Kitamura T, et al.
    • Organizer
      American Heart Association Scientific Session 2010
    • Place of Presentation
      McCormick Place (Chicago IL USA)
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 生活習慣病の病態における栄養素トランスポーターの役割2010

    • Author(s)
      竹谷豊, 他
    • Organizer
      第64回日本栄養・食糧学会大会
    • Place of Presentation
      アスティ徳島(徳島県)
    • Year and Date
      2010-05-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] リンの過剰摂取は高脂血症モデルマウスのアテロニム病変形成を減少させる2010

    • Author(s)
      塩田あすか, 他
    • Organizer
      第64回日本栄養・食糧学会大会
    • Place of Presentation
      アスティ徳島(徳島県)
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report
  • [Book] 栄養・食品機能とトランスポータ2011

    • Author(s)
      竹谷豊、
    • Total Pages
      292
    • Publisher
      建帛社
    • Related Report
      2012 Final Research Report
  • [Book] 栄養・食品機能とトランスポーター2011

    • Author(s)
      竹谷豊, 他
    • Total Pages
      292
    • Publisher
      建帛社
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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