A study on the mechanisms explaining effects of exercise and physical activity on prevention of colon cancer
| Project/Area Number |
22300241
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
TABATA Izumi 立命館大学, スポーツ健康科学部, 教授 (20188402)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2011: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
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| Keywords | 運動 / 身体活動 / 大腸がん / 予防 / 大腸ガン / ACF / プロテオミクス法 |
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| Research Abstract |
The present investigation demonstrated that high intensity intermittent swimming exercise decreases number of aberrant crypt foci (ACF), which is the first step of colon cancer induction, in the colonic mucosa of rat injected 1,2-dimethylhydrazine (DMH). Furthermore, the results suggested that intensity-related signals in skeletal muscle recruited during exercise and physical activities is involved in the mechanisms explaining prevention of colon cancer by exercise and physical activity.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Associations among objectively measured physical activity,fasting plasma homocysteine concentration, and MTHFR C677T genotype.2011
Author(s)
Murakami H, M Iemitsu, K Sanada, Y Gando, Y Ohmori, R Kawakami, S Sasaki, I Tabata, M Miyachi.
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Journal Title
Eur J Appl Physiol
Volume: 111(12)
Issue: 12
Pages: 2997-3005
DOI
Related Report
Peer Reviewed
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