A study on the mechanisms explaining effects of exercise and physical activity on prevention of colon cancer

• Project/Area Number: 22300241
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied health science
• Research Institution: Ritsumeikan University
• Principal Investigator: TABATA Izumi 立命館大学, スポーツ健康科学部, 教授 (20188402)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000); Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2011: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
• Keywords: 運動 / 身体活動 / 大腸がん / 予防 / 大腸ガン / ACF / プロテオミクス法

Research Abstract

The present investigation demonstrated that high intensity intermittent swimming exercise decreases number of aberrant crypt foci (ACF), which is the first step of colon cancer induction, in the colonic mucosa of rat injected 1,2-dimethylhydrazine (DMH). Furthermore, the results suggested that intensity-related signals in skeletal muscle recruited during exercise and physical activities is involved in the mechanisms explaining prevention of colon cancer by exercise and physical activity.

Research Products

• [Journal Article] Relationship between predicted oxygen uptake and cigarette smoking in Japanese men (2012)
  • Author(s): Miyatake N, T Numata, Cao ZB, M Miyachi, I Tabata.
  • Journal Title: Health Volume: 4(7) Pages: 423-428
  • Peer Reviewed
• [Journal Article] Adverse effects of coexistene of sarcopenia and metabolic syndrome in Japanese wemen (2012)
  • Author(s): Sanada K
  • Journal Title: Eur J Clin Nutri Volume: 66 Pages: 1093-1098
  • Peer Reviewed
• [Journal Article] Association between dietary intake of micronutrients and cardiorespiratory fitness in Japanese men (2012)
  • Author(s): Cao ZB
  • Journal Title: J Nutri Sci Volume: 1
  • Peer Reviewed
• [Journal Article] Validation and comparison of three accelerometers for measuring physical activity intensity during nonlocomotive activities and locomotive movements (2012)
  • Author(s): Hikihara Y
  • Journal Title: J Phys Act Health Volume: 9 Pages: 935-943
  • Peer Reviewed
• [Journal Article] Relationship between predicted oxygen uptake and cigarette smoking in Japanese men (2012)
  • Author(s): Miyatake N
  • Journal Title: Health Volume: 4 Pages: 423-428
  • Peer Reviewed
• [Journal Article] Chair-rising and 3-min walk:A simple screening test for functional mobility (2012)
  • Author(s): Oh T-W
  • Journal Title: Open J Prev Med Volume: 2 Pages: 93-97
  • Peer Reviewed
• [Journal Article] Change in PGC-1α expression in rat skeletal muscle after low-intensity prolonged swimming exercise. (2011)
  • Author(s): Fujimoto E, W Yamaguchi, S Terada, M Higuchi, I Tabata.
  • Journal Title: J Physiological Anthropology Volume: 30 Pages: 23-27
  • NAID: 10027419011
  • Peer Reviewed
• [Journal Article] PPAR γ 2 C1431T genotype increases metabolic syndrome risk in young men with owcardiorespiratory fitness (2011)
  • Author(s): Sanada K, M Iemitsu, H Murakami, I Tabata, K Yamamoto, Y Gand, K Suzuki, M Higuchi, M Miyachi.
  • Journal Title: PhysiolGenomics Volume: 43 Issue: 3 Pages: 103-109
  • DOI: 10.1152/physiolgenomics.00129.2010
  • Peer Reviewed
• [Journal Article] Attenuated age-related carotid arterial remodeling ub adults with high leval of cardiorespirator fitness. (2011)
  • Author(s): Gando Y, K Yamamoto, H Kawano, H Murakami,Y Ohmori, R Kawakami, K Sanada, M Higuchi, I Tabata, M Miyachi.
  • Journal Title: J AtherosclerThromb Volume: 18(3) Pages: 248-254
  • Peer Reviewed
• [Journal Article] 低強度・長時間水泳運動トレーニングによりラット骨格筋で発現するタンパク質のプロテオミクス;2D-DIGE解析 (2011)
  • Author(s): 山口航,藤本恵理,樋口満,田畑泉
  • Journal Title: 体力科学 Volume: 60(5) Pages: 511-518
  • NAID: 10030027192
  • Peer Reviewed
• [Journal Article] Associations among objectively measured physical activity,fasting plasma homocysteine concentration, and MTHFR C677T genotype. (2011)
  • Author(s): Murakami H, M Iemitsu, K Sanada, Y Gando, Y Ohmori, R Kawakami, S Sasaki, I Tabata, M Miyachi.
  • Journal Title: Eur J Appl Physiol Volume: 111(12) Issue: 12 Pages: 2997-3005
  • DOI: 10.1007/s00421-011-1926-z
  • Peer Reviewed
• [Journal Article] 低強度・長時間水泳運動トレーニングによりラット骨格筋で発現するタンパク質のプロテオミクス;2D-DIGE解析 (2011)
  • Author(s): 山口航, 藤本恵理, 樋口満, 田畑泉
  • Journal Title: 体力科学 Volume: 60 Pages: 511-518
  • NAID: 10030027192
  • Peer Reviewed
• [Journal Article] Change in PGC-1α expression in rat skeletal muscle after low-intensity prolonged swimming exercise. (2011)
  • Author(s): Fujimoto E, W Yamaguchi, S Terada, M Higuchi, I Tabata
  • Journal Title: Journal of Physiological Anthropology Volume: 30 Pages: 23-27
  • NAID: 10027419011
  • Peer Reviewed
• [Journal Article] Effects of nonexhaustive bouts of high-intensity intermittent swimming training on GLUT-4 expression in rat skeletal muscle (2010)
  • Author(s): Fujimoto E, S Machida S, M Higuchi, I Tabata.
  • Journal Title: J Physiol Sci Volume: 60(2) Issue: 2 Pages: 95-101
  • DOI: 10.1007/s12576-009-0072-4
  • NAID: 10027711432
  • Peer Reviewed
• [Journal Article] Chnages in metabolic syndrome and its components with lifestyle modification Japanese men (2010)
  • Author(s): Miyatake N, M Fujii, M Miyachi, I Tabata, T Suzue, T Hirano, T Numata.
  • Journal Title: Inter Med Volume: 49(4) Pages: 261-265
  • Peer Reviewed
• [Journal Article] Classifying lifestyle and locomotive activities using a triaxial accelerometer. (2010)
  • Author(s): Oshima Y, K Kawaguchi, S Tanaka, K Ohkawara, Y Hikihara, K Ishikawa-Takata, I Tabata.
  • Journal Title: Gait and Posture31 Volume: 31(3) Issue: 3 Pages: 370-374
  • DOI: 10.1016/j.gaitpost.2010.01.005
  • Peer Reviewed
• [Journal Article] A DIGE proteomic analysis for high-intensity exercise-trained rat skeletal muscle. (2010)
  • Author(s): Yamaguchi W, E Fujimoto, M Higuchi, I Tabata.
  • Journal Title: J Biochemistry(Tokyo) Volume: 148 Issue: 3 Pages: 327-333
  • DOI: 10.1093/jb/mvq073
  • NAID: 10027878311
  • Peer Reviewed
• [Journal Article] A DIGE proteomic analysis for high-intensity exercise-trained rat skeletal muscle (2010)
  • Author(s): Yamaguchi W, E Fujimoto, M Higuchi, I Tabata.
  • Journal Title: Journal of Biochemistry(Tokyo) Volume: 148 Pages: 327-333
  • NAID: 10027878311
  • Peer Reviewed
• [Journal Article] Effects of nonexhaustive bouts of high-intensity intermittent swimming training on GLUT-4 expression in rat skeletal muscle. (2010)
  • Author(s): Fujimoto E, S Machida S, M Higuchi, I Tabata
  • Journal Title: Journal of Physiological Science Volume: 60 Pages: 95-101
  • NAID: 10027711432
  • Peer Reviewed
• [Presentation] 高強度間欠的トレーニングにおける大腸ガンの予防効果 (2011)
  • Author(s): 松生香里,街勝憲,劉辛,田畑泉
  • Organizer: 第66回日本体力医学会大会.海峡メッセ下関・下関生涯学習プラザ
  • Place of Presentation: 山口県
  • Year and Date: 2011-09-18
• [Presentation] 高強度間欠的トレーニングにおける大腸ガンの予防効果 (2011)
  • Author(s): 松生香里, 街勝憲, 劉辛, 田畑泉
  • Organizer: 第66回日本体力医学会大会
  • Place of Presentation: 海峡メッセ下関(山口県)
  • Year and Date: 2011-09-18
• [Presentation] High-intensity intermittent swimming training reduced in DMH-induced aberrant cript foci in rat colon. (2011)
  • Author(s): Kaori M, K Tsuji, X Liu, I Tabata
  • Organizer: Annual meeting of European College of Sport Sciences
  • Place of Presentation: Liverpool, England
  • Year and Date: 2011-07-07
• [Presentation] High-intensity Intermittent Swimming Training reduces DMH-induced Aberrant Crypt Foci in Rat Colon (2011)
  • Author(s): K Matsuo, I Tabata
  • Organizer: European College of Sport Sciences
  • Place of Presentation: 英国リバプール市
  • Year and Date: 2011-07-05