• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular mechanisms underlying the effects of molecular hydrogen on health promotion and disease control

Research Project

Project/Area Number 22300244
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionTokyo Metropolitan Geriatric Hospital and Institute of Gerontology (2011-2012)
Institute of Applied Biochemistry (2010)

Principal Investigator

ITO Masafumi  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (80393114)

Co-Investigator(Kenkyū-buntansha) OHNO Kinji  名古屋大学, 大学院・医学系研究科, 教授 (80397455)
OHGUHCI Kenji  椙山女学園大学, 生活科学部, 准教授 (80359257)
FUJITA Yasunori  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (30515888)
ITOH Tomohiro  近畿大学, 農学部, 講師 (30435854)
IIO Akio  愛知県心身障害者コロニー発達障害研究所, 発生障害学部, リサーチレジデント (80344349)
ITO Mikako  名古屋大学, 大学院・医学系研究科, 助教 (60444402)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Keywords水素 / シグナル伝達 / 酸化ストレス
Research Abstract

The effects of molecular hydrogen have been reported in various diseases. A selective scavenging of hydroxyl radicals was proposed as an underlying mechanism of the hydrogen effects and indeed a reduction of the oxidative damage by hydrogen has been observed. In cell culture models of inflammation and fatty liver as well as type I allergy, we have demonstrated that hydrogen does not affect the oxidative signal that is physiologically important but inhibits the intracellular signal transduction, thereby exerting beneficial effects. Based on these findings, we have established the modulation of signal transduction as a novel mechanism of the effects of hydrogen.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (45 results)

All 2013 2012 2011 2010

All Journal Article (30 results) (of which Peer Reviewed: 30 results) Presentation (15 results) (of which Invited: 3 results)

  • [Journal Article] Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 expression in HepG2 cells.2013

    • Author(s)
      Iio A, Ito M, Itoh T, Terazawa R, Fujita Y, Nozawa Y, Ohsawa I, Ohno K, Ito M.
    • Journal Title

      Med Gas Res

      Volume: 3 Pages: 6-6

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinically applicable antianginal agents suppress osteoblastic transformation of myogenic cells and heterotopic ossifications in mice.2013

    • Author(s)
      Yamamoto R, Matsushita M, Kitoh H, Masuda A, Ito M, Katagiri T, Kawai T, Ishiguro N, Ohno K.
    • Journal Title

      J Bone Miner Metab

      Volume: 31 Pages: 26-33

    • NAID

      10031168834

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 expression in HepG2 cells2013

    • Author(s)
      Iio A, Ito M, Itoh T, Terazawa R, Fujita Y, Nozawa Y, Ohsawa I, Ohno K, Ito M
    • Journal Title

      Med Gas Res

      Volume: 3 Issue: 1 Pages: 6-6

    • DOI

      10.1186/2045-9912-3-6

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinically applicable antianginal agents suppress osteoblastic transformation of myogenic cells and heterotopic ossifications in mice2013

    • Author(s)
      Yamamoto R, Matsushita M, Kitoh H, Masuda A, Ito M, Katagiri T, Kawai T, Ishiguro N, Ohno K
    • Journal Title

      J Bone Miner Metab

      Volume: 31 Pages: 26-33

    • DOI

      10.1007/s00774-012-0380-2

    • NAID

      10031168834

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases.2012

    • Author(s)
      Ohno K, Ito M, Ichihara M, Ito M.
    • Journal Title

      Oxid Med Cell Longev

      Volume: 2012 Pages: 353152-353152

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Metabolomic profiling rationalized pyruvate efficacy in cybrid cells harboring MELAS mitochondrial DNA mutations.2012

    • Author(s)
      Kami K, Fujita Y, Igarashi S, Koike S, Sugawara S, Ikeda S, Sato N, Ito M, Tanaka M, Tomita M, Soga T.
    • Journal Title

      Mitochondrion

      Volume: 12 Pages: 644-644

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson's disease in rats.2012

    • Author(s)
      Ito M, Hirayama M, Yamai K, Goto S, Ito M, Ichihara M, Ohno K.
    • Journal Title

      Med Gas Res

      Volume: 2 Pages: 15-15

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hesperetin upregulates ABCA1 expression and promotes cholesterol efflux from THP-1 macrophages.2012

    • Author(s)
      Iio A, Ohguchi K, Iinuma M, Nozawa Y, Ito M.
    • Journal Title

      J Nat Prod

      Volume: 75 Pages: 563-566

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ethanolic extracts of Brazilian red propolis increase ABCA1 expression and promote cholesterol efflux from THP-1 macrophages.2012

    • Author(s)
      Iio A, Ohguchi K, Maruyama H, Tazawa S, Araki Y, Ichihara K, Nozawa Y, Ito M.
    • Journal Title

      Phytomedicine

      Volume: 19 Pages: 383-388

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson's disease in rats2012

    • Author(s)
      Ito M, Hirayama M, Yamai K, Goto S, Ito M, Ichihara M, Ohno K
    • Journal Title

      Med Gas Res

      Volume: 2 Issue: 1 Pages: 15-15

    • DOI

      10.1186/2045-9912-2-15

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases2012

    • Author(s)
      Ohno K, Ito M, Ichihara M, Ito M
    • Journal Title

      Oxid Med Cell Longev

      Volume: 2012 Pages: 353152-353152

    • DOI

      10.1155/2012/353152

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolomic profiling rationalized pyruvate efficacy in cybrid cells harboring MELAS mitochondrial DNA mutations2012

    • Author(s)
      Kami K, Fujita Y, Igarashi S, Koike S, Sugawara S, Ikeda S, Sato N, Ito M, Tanaka M, Tomita M, Soga T
    • Journal Title

      Mitochondrion

      Volume: 12 Issue: 6 Pages: 644-644

    • DOI

      10.1016/j.mito.2012.07.113

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hesperetin upregulates ABCA1 expression and promotes cholesterol efflux from THP-1 macrophages2012

    • Author(s)
      Iio A, Ohguchi K, Iinuma M, Nozawa Y, Ito M
    • Journal Title

      J Nat Prod

      Volume: 75 Issue: 4 Pages: 563-566

    • DOI

      10.1021/np200696r

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CUGBP1 and MBNL1 preferentially bind to 3’ UTRs and facilitate mRNA decay2012

    • Author(s)
      Masuda A, Andersen HS, Doktor TK, Okamoto T, Ito M, Andresen BS, Ohno K
    • Journal Title

      Sci Rep

      Volume: 2 Issue: 1 Pages: 209-209

    • DOI

      10.1038/srep00209

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein-anchoring strategy for delivering acetylcholinesterase to the neuromuscular junction2012

    • Author(s)
      Ito M, Suzuki Y, Okada T, Fukudome T, Yoshimura T, Masuda A, Takeda S, Krejci E, Ohno K
    • Journal Title

      Mol Ther

      Volume: (印刷中) Issue: 7 Pages: 1384-1392

    • DOI

      10.1038/mt.2012.34

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies.2011

    • Author(s)
      Ito M, Ibi T, Sahashi K, Ichihara M, Ito M, Ohno K.
    • Journal Title

      Med Gas Res

      Volume: 1 Pages: 24-24

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cisplatin induces production of reactive oxygen species via NADPH oxidase activation in human prostate cancer cells.2011

    • Author(s)
      Itoh T, Terazawa R, Kojima K, Nakane K, Deguchi T, Ando M, Tsukamasa Y, Ito M, Nozawa Y.
    • Journal Title

      Free Radic Res

      Volume: 2011 Pages: 1033-1039

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular hydrogen inhibits lipopolysaccharide/interferon γ-induced nitric oxide production through modulation of signal transduction in macrophages.2011

    • Author(s)
      Itoh T, Hamada N, Terazawa R, Ito M, Ohno K, Ichihara M, Nozawa Y, Ito M.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 411 Pages: 143-149

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of heme oxygenase-1 induction via Nrf2/ARE activation in protection against H_2O_2-induced PC12 cell death by a metabolite of sesamin contained in sesame seeds.2011

    • Author(s)
      Hamada N, Tanaka A, Fujita Y, Itoh T, Ono Y, Kitagawa Y, Tomimori N, Kiso Y, Akao Y, Nozawa Y, Ito M.
    • Journal Title

      Bioorg Med Chem

      Volume: 19 Pages: 1959-1965

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular hydrogen inhibits lipopolysaccharide/interferon gamma-induced nitric oxide production through modulation of signal transduction in macrophages2011

    • Author(s)
      Itoh T, Hamada N, Terazawa R, Ito M, Ohno K, Ichihara M, Nozawa Y, Ito M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 411 Issue: 1 Pages: 143-149

    • DOI

      10.1016/j.bbrc.2011.06.116

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies2011

    • Author(s)
      Ito M, Ibi T, Sahashi K, Ichihara M, Ito M, Ohno K
    • Journal Title

      Med Gas Res

      Volume: 1 Issue: 1 Pages: 24-24

    • DOI

      10.1186/2045-9912-1-24

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The 2011 Medical Molecular Hydrogen Symposium : An inaugural symposium of the journal Medical Gas Research2011

    • Author(s)
      Ohta S, Nakao A, Ohno K
    • Journal Title

      Med Gas Res

      Volume: 1 Issue: 1 Pages: 10-10

    • DOI

      10.1186/2045-9912-1-10

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cisplatin induces production of reactive oxygen species via NADPH oxidase activation in human prostate cancer cells2011

    • Author(s)
      Itoh T, Terazawa R, Kojima K, Nakane K, Deguchi T, Ando M, Tsukamasa Y, Ito M, Nozawa Y
    • Journal Title

      Free Radic Res

      Volume: 45 Issue: 9 Pages: 1033-1039

    • DOI

      10.3109/10715762.2011.591391

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Urinary 8-hydroxydeoxyguanosine correlate with hallucinations rather than motor symptoms in Parkinson's disease2011

    • Author(s)
      Hirayama M, Nakamura T, Watanabe H, Uchida K, Hama T, Hara T, Niimi Y, Ito M, Ohno K, Sobue G
    • Journal Title

      Parkinsonism and Related Disorders

      Volume: 17 Issue: 1 Pages: 46-49

    • DOI

      10.1016/j.parkreldis.2010.11.004

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of heme oxygenase-1 induction via Nrfl/ARE activation in protection against H_2O_2-induced PC12 cell death by a metabolite of sesamin contained in sesame seeds.2011

    • Author(s)
      Hamada N, Tanaka A, Fujita Y, Itoh T, Ono Y, Kitagawa Y, Tomimori N, Kiso Y, Akao Y, Nozawa Y, Ito M
    • Journal Title

      Bioorg Med Chem

      Volume: 19 Pages: 1959-1965

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effects of whisky congeners on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice.2010

    • Author(s)
      Itoh T, Tsukane M, Koike M, Nakamura C, Ohguchi K, Ito M, Akao Y, Nozawa Y, Wakimoto T, Nukaya H, Suwa Y.
    • Journal Title

      J Agrci Food Chem

      Volume: 58 Pages: 7149-7157

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel kavalactone derivative protects against H2O2-induced PC12 cell death via Nrf2/ARE activation.2010

    • Author(s)
      Tanaka A, Hamada N, Fujita Y, Itoh T, Nozawa Y, Iinuma M, Ito M.
    • Journal Title

      Bioorg Med Chem

      Volume: 18 Pages: 3133-3139

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ethanolic extracts of Brazilian red propolis promote adipocyte differentiation through PPARγ activation.2010

    • Author(s)
      Iio A, Ohguchi K, Inoue H, Yoko A, Nozawa Y, Ito M.
    • Journal Title

      Phytomedicine

      Volume: 17 Pages: 974-979

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effects of flavonoid glycosides isolated from the peel of Japanese persimmon (Diospyros kaki 'Fuyu') on melanin biosynthesis.2010

    • Author(s)
      Ohguchi K, Nakajima C, Oyama M, Iinuma M, Itoh T, Akao Y, Nozawa Y, Ito M.
    • Journal Title

      Biol Pharm Bull

      Volume: 3 Pages: 122-124

    • NAID

      130000140204

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of organoselenium compounds that possess chemopreventive properties in human prostate cancer LNCaP cells.2010

    • Author(s)
      Terazawa R, Garud DR, Hamada N, Fujita Y, Itoh T, Nozawa Y, Nakane K, Deguchi T, Koketsu M, Ito M
    • Journal Title

      Bioorg Med Chem

      Volume: 18 Pages: 7001-7008

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Symposium : Molecular mechanisms of oxidative stress resistance induced by a new gas mediator : Molecular mechanism of the inhibitory effect of hydrogen on inflammation.2013

    • Author(s)
      Ito M, Itoh T, Ohno K, Nozawa Y.
    • Organizer
      90^<th> Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] シンポジウム : 水素によるシグナル伝達の制御 抗酸化とシグナル伝-水素の作用機序解明を目指して : 水素によるシグナル伝達の制御2013

    • Author(s)
      伊藤雅史
    • Organizer
      第3回分子状水素医学シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 水素によるシグナル伝達の制御2013

    • Author(s)
      伊藤雅史
    • Organizer
      第3回分子状水素医学シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Molecular mechanism of the inhibitory effect of hydrogen on inflammation2013

    • Author(s)
      Ito M, Itoh T, Ohno K, Nozawa Y
    • Organizer
      90th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 分子状水素はシグナル伝達の抑制を介してLPS/IFN-γにより誘導されるNOの産生を抑制する2012

    • Author(s)
      伊藤雅史、伊藤智広、伊藤美佳子、大野欽司、野澤義則
    • Organizer
      第2回分子状水素医学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2012-02-11
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Molecular hydrogen alters signaling pathways and gene expression profiles in multiple mouse organs.2012

    • Author(s)
      Sobue S, Yamai K, Ito M, Ohno K, Ito M, Ohkuwa T, Ichihara M.
    • Organizer
      52nd Annual Meeting of the American Society for Cell Biology
    • Place of Presentation
      San Francisco, USA.
    • Related Report
      2012 Final Research Report
  • [Presentation] Molecular hydrogen alters signaling pathways and gene expression profiles in multiple mouse organs2012

    • Author(s)
      Sobue S, Yamai K, Ito M, Ohno K, Ito M, Ohkuwa T, Ichihara M
    • Organizer
      American Society for Cell Biology, Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Congenital defects of neuromuscular signal transduction2012

    • Author(s)
      Ohno K
    • Organizer
      3rd Berlin Summer School for Myology
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 水素水飲用をシュミレーションする水素ガス間欠投与は水素ガス持続投与よりもパーキンソンモデルラットに対して有効である2011

    • Author(s)
      伊藤美佳子、市原正智、伊藤雅史、大野欽司
    • Organizer
      第2回分子状水素医学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-02-11
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 分子状水素による炎症反応抑制の分子機構2011

    • Author(s)
      伊藤雅史、伊藤智広、伊藤美佳子、大野欽司、野澤義則
    • Organizer
      第34回日本基礎老化学会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 筋疾患における水素水経口投与の臨床効果2011

    • Author(s)
      衣斐達、佐橋功、大野欽司、小澤史子、伊藤雅史
    • Organizer
      分子状水素医学シンポジウム
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] ワークショップ:水素医学の展開:分子状水素による細胞内シグナル伝達の調節2010

    • Author(s)
      伊藤雅史、伊藤智広、野澤義則、伊藤美佳子、大野欽司
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 分子状水素による1型アレルギー抑制機構0)解明2010

    • Author(s)
      伊藤智広、藤田泰典、伊藤美佳子、増田章男、市原正智、小島俊男、野澤義則、大野欽司、伊藤雅史
    • Organizer
      第33回日本基礎老化学会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-06-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 水素医学の展開 : 分子状水素による細胞内シグナル伝達の調節2010

    • Author(s)
      伊藤雅史、伊藤智広、野澤義則、伊藤美佳子、大野欽司
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] 分子状水素によるI 型アレルギー抑制機構の解明2010

    • Author(s)
      伊藤智広、藤田泰典、伊藤美佳子、増田章男、市原正智、小島俊男、野澤義則、大野欽司、伊藤雅史
    • Organizer
      第33回日本基礎老化学会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi