| Project/Area Number |
22300255
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General human life sciences
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| Research Institution | National Institute of Public Health |
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Principal Investigator |
KUNUGITA Naoki 国立保健医療科学院, 生活環境研究部, 部長 (90178020)
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| Co-Investigator(Kenkyū-buntansha) |
USHIYAMA Akira 国立保健医療科学院, 生活環境研究部, 上席主任研究官 (60291118)
TIN・TIN WIN Shwe 独立行政法人国立環境研究所, 環境リスク研究センター, フェロー (00391128)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
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| Keywords | 電磁界 / 中間周波 / IH クッキング / マウス / 生体影響 / 突然変異 / 中枢神経系 / 住環境 / IHクッキング / 免疫系 |
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| Research Abstract |
Recently, a cooking appliance based on the principle of electromagnetic induction has come to be used domestically on a widespread basis; this induction heating cooking hob mainly generates intermediate-frequency magnetic fields (IF-MF). However, whether electromagnetic fields originating from household appliances represent a health risk remains uncertain. We investigated the effect of IF-MF on the expressions of memory function-related genes and related transduction molecules in the mouse hippocampus. Male and female C57BL/6J mice were allotted to a control (sham-exposed), an exposure, or a recovery (one week after exposure) group and were exposed to IF-MF (21 kHz, 3.8 mT) one hour per day for 2 weeks. Twenty-four hour after final exposure, the expression levels of memory function-related genes and the mRNA levels for signal transduction pathway molecules in the hippocampi were examined using real-time RT-PCR. The relative mRNA expression levels of the N-methyl-D aspartate (NMDA) receptor subunits NR1, NR2A, and NR2B as well as transcription factors (calcium/calmodulin-dependent protein kinase [CaMK] -IV, cyclic AMP responsive element binding protein [CREB] -1) and neurotrophins (nerve growth factor [NGF], and brain-derived neurotrophic factors [BDNF]) were not significantly altered in the IF-MF-exposed mice. We also examined the morphology of the hippocampus using a histological analysis, but no changes in the IF-MF-exposed mice were seen. The present findings suggest that IF-MF exposure may not affect cognitive function in the present animal model.
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