| Project/Area Number |
22300260
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHODA Junichi 筑波大学, 医学医療系, 教授 (90241827)
YANAGAWA Toru 筑波大学, 医学医療系, 准教授 (10312852)
UTSUNOMIYA Hirotoshi 和歌山県立医科大学, 医学部, 准教授 (60264876)
OKAMOTO Yoshikazu 筑波大学, 医学医療系, 講師 (90420083)
ISHII Tetshurou 筑波大学, 医学医療系, 教授 (20111370)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Keywords | 肥満 / 脂肪性肝疾患 / 自然免疫 / 転写因子 / 酸化ストレス / 機能性食品 / Nrf2 / 生活習慣病 / 脂肪性肝炎 / 分子標的治療 |
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| Research Abstract |
In Keap1-kd mice (with Nrf2 overexpression) fed an MCD diet, steatohepatitis did not develop over the observation periods. However, in Nrf2-null mice fed the diet, the pathological state of the steatohepatitis was aggravated. Iron accumulation was greater in the livers of the Nrf2-null mice compared to those of the WT mice, and it was not observed in Keap1-kd mice. Further, the iron release from the isolated hepatocyte of Nrf2-null mice was significantly decreased. Sulforaphane, an activator of Nrf2, suppressed the pathological states and oxidative stress in the livers.Nrf2 has protective roles against nutritional steatohepatitis through inhibition of hepatic iron accumulation and counteraction against oxidative stress-induced liver injury.
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