| Project/Area Number |
22300261
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Gunma University |
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Principal Investigator |
EMOTO Masashi 群馬大学, 保健学研究科, 教授 (70232981)
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| Co-Investigator(Renkei-kenkyūsha) |
NAIKI Yoshikazu 愛知医科大学, 医学部, 助教 (10434622)
FUJIMURA Takao 北里大学, 医学部, 講師 (50209087)
KITA Eiji 奈良県立医科大学, 医学部, 教授 (90133199)
FUKUDA Toshio 群馬大学, 大学院保健学研究科, 教授 (00173352)
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| Research Collaborator |
EMOTO Yoshiko
WATANABE Kazuki
KOYAMA Yu-ichi
NYU Kiyosato
KIYAMA Takajyu
NISHIO Kazumasa
HURWITZ Robert
KAUFMANN Stefan H.E.
MOLLENKOPF Hans
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | Invariant NKT cell / Natural ligand / Sphingoglycolipid / Rice bran / 米糠 / スフィンゴ糖脂質 / 構造 / インバリアントNKT細胞 / ナチュラルリガンド / リガンド |
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| Outline of Final Research Achievements |
I found that sphingoglycolipids purified from rice bran contain molecules which strongly inhibit tumor metastasis and that several natural ligands for invariant NKT cells exist therein. Interestingly, I found that natural ligand for invariant NKT cells does not exist in a major sphingoglycolipid in rice bran. Moreover, I found that more than 10 sphingoglycolipds exist in rice bran and that the natural ligands for invariant NKT cells exist in these sphingoglycolipids. In addition, I found that one of thees ligands is a new molecule.
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