| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
|
|---|
| Research Abstract |
Vasohibin family is composed with 2 proteins, vasohibin-1 (VASH1) and vasohibin-2 (VASH2). VASH1 is an angiogenesis inhibitor induced in endothelial cells (ECs) by pro-angiogenic stimuli. Our recent analysis revealed that VASH1 is expressed in ECs of tumor vessels, and this endogenous VASH1 inhibits tumor growth by its anti-angiogenic activity. In the present study, we showed that endogenous VASH1 is also responsible for the inhibition of cancer metastasis. In contrast to VASH1, our present study revealed that VASH2 is expressed in cancer cells. This cancer cell-produced VASH2 augments cancer growth by stimulating angiogenesis. From these results, we proposed that the balance between VASH1 and VASH2 is critical for cancer progression.
|
