Correlation between vasohibin family and tumor angiogenesis/cancer stem cell
| Project/Area Number |
22300323
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Tohoku University |
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Principal Investigator |
YASUFUMI Sato 東北大学, 加齢医学研究所, 教授 (50178779)
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| Co-Investigator(Kenkyū-buntansha) |
HIROKI Miyashita 東北大学, 加齢医学研究所, 助教 (80302222)
YASUHIRO Suzuki 東北大学, 加齢医学研究所, 助教 (60332277)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | VASH1 / VASH2 / 血管内皮細胞 / がん細胞 / 血管新生 / がん転移 / 卵巣がん / 肝臓がん / mir-200b / 腫瘍血管新生 / リンパ管新生 / 血管内侵入 / タイトジャンクション / microRNA / Minマウス / モノクローナル抗体 |
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| Research Abstract |
Vasohibin family is composed with 2 proteins, vasohibin-1 (VASH1) and vasohibin-2 (VASH2). VASH1 is an angiogenesis inhibitor induced in endothelial cells (ECs) by pro-angiogenic stimuli. Our recent analysis revealed that VASH1 is expressed in ECs of tumor vessels, and this endogenous VASH1 inhibits tumor growth by its anti-angiogenic activity. In the present study, we showed that endogenous VASH1 is also responsible for the inhibition of cancer metastasis. In contrast to VASH1, our present study revealed that VASH2 is expressed in cancer cells. This cancer cell-produced VASH2 augments cancer growth by stimulating angiogenesis. From these results, we proposed that the balance between VASH1 and VASH2 is critical for cancer progression.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Vasohibin 2 is transcriptionally activated and promotes angiogenesis in hepatocellular carcinoma2013
Author(s)
Xue X, Gao W, Sun B, Xu Y, Han B, Wang F, Zhang Y, Sun J, Wei J, Lu Z, Zhu Y, Sato Y, Sekido Y, Miao Y, Kondo Y
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Journal Title
Oncogene
Volume: 32
Issue: 13
Pages: 1724-1734
DOI
Related Report
Peer Reviewed
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[Journal Article] The prognostic significance of vasohibin-1 expression in patients with upper urinary tracturothelial carcinoma2012
Author(s)
Miyazaki Y, Kosaka T, Mikami S, Kikuchi E, Tanaka N, Maeda T, Ishida M, Miyajima A, Nakagawa K, Okada Y, Sato Y, Oya M
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Journal Title
Clin Cancer Res
Volume: 18
Issue: 15
Pages: 4145-4153
DOI
Related Report
Peer Reviewed
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[Journal Article] Roles of intrinsic angiogenesis inhibitor, vasohibin, in cervical carcinomas2011
Author(s)
Yoshinaga K, Ito K, Moriya T, Nagase S, Takano T, Niikura H, Sasano H, Yaegashi N, Sato Y
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Journal Title
Cancer Sci
Volume: 102
Issue: 2
Pages: 446-51
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Suppression of Choroidal Neovascularization by Vasohibin-1, Vascular Endothelium-derived Angiogenic Inhibitor2011
Author(s)
Wakusawa R, Abe T, Sato H, Sonoda H, Sato M, Mitsuda Y, Takakura T, Fukushima T, Onami H, Nagai N, Ishikawa Y, Nishida K, Sato Y
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 52
Pages: 3272-3280
Related Report
Peer Reviewed
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