Molecular mechanisms regulating dissemination and collective migration of cancer cells
| Project/Area Number |
22300324
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Akita University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2012: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Keywords | 播種 / 集団移動 / チロシンリン酸化 / 細胞接触阻止 / 神経膠腫 / シグナル伝達 / リン酸化 / スキルス胃癌 / 神経膠芽腫 / 癌 / 発生・分化 / 細胞・組織 |
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| Research Abstract |
We identified SKAP2 as a tyrosine-phosphorylated protein in glioma. Unexpectedly, SKAP2 suppressed invasion of glioma cell through down-regulating actin assembly and stabilizing the cell membrane. On the other hand, SKAP2 accelerates invasion of macrophages via association with the specific adaptor, which suggests SKAP2 promotes inflammatory cancers by activation of cancer associated macrophages. In addition, we identified that N-cadherin and Nm23H1 plays pivotal roles for establishment of "contact inhibition of locomotion", which is a fundamental mechanism of collective migration of the cells.
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Report
(4 results)
Research Products
(31 results)
