| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2012: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Research Abstract |
We identified SKAP2 as a tyrosine-phosphorylated protein in glioma. Unexpectedly, SKAP2 suppressed invasion of glioma cell through down-regulating actin assembly and stabilizing the cell membrane. On the other hand, SKAP2 accelerates invasion of macrophages via association with the specific adaptor, which suggests SKAP2 promotes inflammatory cancers by activation of cancer associated macrophages. In addition, we identified that N-cadherin and Nm23H1 plays pivotal roles for establishment of "contact inhibition of locomotion", which is a fundamental mechanism of collective migration of the cells.
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